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The map label for this gene is cocE [H]

Identifier: 116621132

GI number: 116621132

Start: 2546956

End: 2548644

Strand: Direct

Name: cocE [H]

Synonym: Acid_2013

Alternate gene names: 116621132

Gene position: 2546956-2548644 (Clockwise)

Preceding gene: 116621131

Following gene: 116621135

Centisome position: 25.56

GC content: 63.23

Gene sequence:

>1689_bases
GTGCGCAAGCTGTATCTAGTTCTGGCCGGATGCGCGTGCCTGGCGCACGCGGCGCAGAAGCCTGTCTTTAAATATCTCAG
CGTGCCCGTCCCCATGCGCGATGGCGTCCGCCTCTTTGCCAACGTCTATCTTCCGAGCGAAACTTCCCGCACCCCGGCCA
TCCTGGTGCGCACCCCGTATGGAAAGGGCGCTGATATCAACGCCAATTATGAGGCCTTCGTGGAGCACGGCTACGCCGTC
GTCGTACAGGACGTGCGCGGCCGCTATGAGAGCGAAGGCGCCTTCCAGCCCCTCACCCAGGAGACCGCCGATGGCGACGA
TACCCTGAACTGGGTCGCGCGCCAACCCTGGTGCAACGGAAAAATCGGCATGATGGGCGGCTCCTACGTTGGTATCGTGC
AGTGGAAGGCCGCGCTCGCCAACAATCCTCACCTTAAGGCCATCTTCCCCGTGGTCTCCGGCTACGACGATTACCGCGAT
CGCTACTACTCCACCGGCGGCGCCCTCAAACTCGGCAACCGCCTCGAATGGATGGCCGAGAACCTGCGCGCCCCCGGCTA
CCACCAGGATTTCGCCAGGTTCGTGCTCCACCTCCCCGTGCGCAGCTGCGACATCGCCGCCCTCGGCTGGACCTCGCCGA
TGTACCGCGACATCATCGAGCACCCCTCCTTCGACGCCTTCTGGCGCGCCATCAGCACCAAAGAGCACCTCGACAAAATC
AAGGTCCCCGTATTTTCCGTCGGCGGCTGGTACGACAATTTCGTCCAGAGCGATCTCGAAGCCTATGCCGCCCGCCGCAA
ATCCGGCGGCTTGAACCGGATTCTCATCGGACCCTGGGCGCACAACATGTCCCTGCCCTTTCAGGACGTGACTTTCGGCG
ACGATTCCAGCGTCCCCGTGCGCGCCCTGCAATTGGAATGGTTCGACCAGTTCCTGATGGGCAAGGATTCGCCCTTACTC
TCCCAGCCTCCGGTCAAGATCTTCGTGATGGGCGCCAACAAGTGGCGTGAGGCAACTGCGTGGCCTCCCGAACAGGCGCG
CACCAAACTCTTCTATCTGGAAAGCGGCGGCAAGGCCAACTCGGTCGCGGGCGATGGTAGCCTCAACGACGGTCCCGCGC
GCAAGACCGCTGCCGATCAGTTCGTCTTCGACCCGTACACTCCCGTGCCCACCCGCGGCGGCTCCGTCTGCTGCAATCCC
AAAGTCTTTCCCTGGGGACCGCTGGACCAGCGCCCCATCGAGCAGCGCAAGGACGTACTCGTCTACTCCACCCCGCCGCT
CAAGCATGAGGTGGAGGTCATCGGCCCCGTGCAGGCCGTCCTCTACGTGGCCTCCAGCGCGCGCGACACCGATTTCACCG
CCAAACTGGTGGACGTCTTCCCCGATGGCACCGCGCGCATCCTCACCGACGGCATCCTTCGTCTCCGCTACCGCAACTCG
CTCGAGAAGCCCGAACTCCTCAAAGCGGGTGAAGTCTATCGCGTCACAGTGGACGCCGGCGTCACCAGCAACGTCTTCCT
GAAGGGCCACCGTATCCGCGTCGAGATCTCCAGCAGCAACTTCCCCCGCTTCGATCGCAACGCAAACACCGGCGGGCTTG
TCGAGCAGGCCGCCAAACTCCTCAAGGCCAGCCAGACCATCTACCACGACCCCGCCCACCCTTCCTGCCTTGTACTGAAA
GTCATGTAG

Upstream 100 bases:

>100_bases
CGTTTCCAAGGGTATCCAGTGCCTTGGGCCGCCGGGGGGCCGCGCACGTCGAAACCTGTCACTGTGTGAAACAAGCAGGC
AAGAAATATTGGGACCTTTT

Downstream 100 bases:

>100_bases
GAACGGCCTCCCGCCGGTCCATTAATCTGTTTTTCTCTCCCGCAGCGCCGCCAGCCTTTCCCTGCACGCCGCCACCGACC
CGCTCGTCCCCGGCTGCCGG

Product: X-Pro dipeptidyl-peptidase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MRKLYLVLAGCACLAHAAQKPVFKYLSVPVPMRDGVRLFANVYLPSETSRTPAILVRTPYGKGADINANYEAFVEHGYAV
VVQDVRGRYESEGAFQPLTQETADGDDTLNWVARQPWCNGKIGMMGGSYVGIVQWKAALANNPHLKAIFPVVSGYDDYRD
RYYSTGGALKLGNRLEWMAENLRAPGYHQDFARFVLHLPVRSCDIAALGWTSPMYRDIIEHPSFDAFWRAISTKEHLDKI
KVPVFSVGGWYDNFVQSDLEAYAARRKSGGLNRILIGPWAHNMSLPFQDVTFGDDSSVPVRALQLEWFDQFLMGKDSPLL
SQPPVKIFVMGANKWREATAWPPEQARTKLFYLESGGKANSVAGDGSLNDGPARKTAADQFVFDPYTPVPTRGGSVCCNP
KVFPWGPLDQRPIEQRKDVLVYSTPPLKHEVEVIGPVQAVLYVASSARDTDFTAKLVDVFPDGTARILTDGILRLRYRNS
LEKPELLKAGEVYRVTVDAGVTSNVFLKGHRIRVEISSSNFPRFDRNANTGGLVEQAAKLLKASQTIYHDPAHPSCLVLK
VM

Sequences:

>Translated_562_residues
MRKLYLVLAGCACLAHAAQKPVFKYLSVPVPMRDGVRLFANVYLPSETSRTPAILVRTPYGKGADINANYEAFVEHGYAV
VVQDVRGRYESEGAFQPLTQETADGDDTLNWVARQPWCNGKIGMMGGSYVGIVQWKAALANNPHLKAIFPVVSGYDDYRD
RYYSTGGALKLGNRLEWMAENLRAPGYHQDFARFVLHLPVRSCDIAALGWTSPMYRDIIEHPSFDAFWRAISTKEHLDKI
KVPVFSVGGWYDNFVQSDLEAYAARRKSGGLNRILIGPWAHNMSLPFQDVTFGDDSSVPVRALQLEWFDQFLMGKDSPLL
SQPPVKIFVMGANKWREATAWPPEQARTKLFYLESGGKANSVAGDGSLNDGPARKTAADQFVFDPYTPVPTRGGSVCCNP
KVFPWGPLDQRPIEQRKDVLVYSTPPLKHEVEVIGPVQAVLYVASSARDTDFTAKLVDVFPDGTARILTDGILRLRYRNS
LEKPELLKAGEVYRVTVDAGVTSNVFLKGHRIRVEISSSNFPRFDRNANTGGLVEQAAKLLKASQTIYHDPAHPSCLVLK
VM
>Mature_562_residues
MRKLYLVLAGCACLAHAAQKPVFKYLSVPVPMRDGVRLFANVYLPSETSRTPAILVRTPYGKGADINANYEAFVEHGYAV
VVQDVRGRYESEGAFQPLTQETADGDDTLNWVARQPWCNGKIGMMGGSYVGIVQWKAALANNPHLKAIFPVVSGYDDYRD
RYYSTGGALKLGNRLEWMAENLRAPGYHQDFARFVLHLPVRSCDIAALGWTSPMYRDIIEHPSFDAFWRAISTKEHLDKI
KVPVFSVGGWYDNFVQSDLEAYAARRKSGGLNRILIGPWAHNMSLPFQDVTFGDDSSVPVRALQLEWFDQFLMGKDSPLL
SQPPVKIFVMGANKWREATAWPPEQARTKLFYLESGGKANSVAGDGSLNDGPARKTAADQFVFDPYTPVPTRGGSVCCNP
KVFPWGPLDQRPIEQRKDVLVYSTPPLKHEVEVIGPVQAVLYVASSARDTDFTAKLVDVFPDGTARILTDGILRLRYRNS
LEKPELLKAGEVYRVTVDAGVTSNVFLKGHRIRVEISSSNFPRFDRNANTGGLVEQAAKLLKASQTIYHDPAHPSCLVLK
VM

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 62506; Mature: 62506

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLYLVLAGCACLAHAAQKPVFKYLSVPVPMRDGVRLFANVYLPSETSRTPAILVRTPY
CCEEEEEHHHHHHHHHHHHCCHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCC
GKGADINANYEAFVEHGYAVVVQDVRGRYESEGAFQPLTQETADGDDTLNWVARQPWCNG
CCCCCCCCCHHHHHHCCEEEEEEHHHCCCCCCCCCCCCHHCCCCCCCHHHHHCCCCCCCC
KIGMMGGSYVGIVQWKAALANNPHLKAIFPVVSGYDDYRDRYYSTGGALKLGNRLEWMAE
EEECCCCCEEEEEEEEHHHCCCCCEEEEEHHHCCCHHHHHHHCCCCCCEEECCHHHHHHH
NLRAPGYHQDFARFVLHLPVRSCDIAALGWTSPMYRDIIEHPSFDAFWRAISTKEHLDKI
HCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHCCHHHHHHH
KVPVFSVGGWYDNFVQSDLEAYAARRKSGGLNRILIGPWAHNMSLPFQDVTFGDDSSVPV
CCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEECCCCCCCCE
RALQLEWFDQFLMGKDSPLLSQPPVKIFVMGANKWREATAWPPEQARTKLFYLESGGKAN
EEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHCEEEEEEECCCCCC
SVAGDGSLNDGPARKTAADQFVFDPYTPVPTRGGSVCCNPKVFPWGPLDQRPIEQRKDVL
CCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHCCEE
VYSTPPLKHEVEVIGPVQAVLYVASSARDTDFTAKLVDVFPDGTARILTDGILRLRYRNS
EECCCCCCCCEEEHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCC
LEKPELLKAGEVYRVTVDAGVTSNVFLKGHRIRVEISSSNFPRFDRNANTGGLVEQAAKL
CCCCCHHCCCCEEEEEEECCCCCCEEEECEEEEEEECCCCCCCCCCCCCCCHHHHHHHHH
LKASQTIYHDPAHPSCLVLKVM
HHHHHHHCCCCCCCCEEEEEEC
>Mature Secondary Structure
MRKLYLVLAGCACLAHAAQKPVFKYLSVPVPMRDGVRLFANVYLPSETSRTPAILVRTPY
CCEEEEEHHHHHHHHHHHHCCHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCC
GKGADINANYEAFVEHGYAVVVQDVRGRYESEGAFQPLTQETADGDDTLNWVARQPWCNG
CCCCCCCCCHHHHHHCCEEEEEEHHHCCCCCCCCCCCCHHCCCCCCCHHHHHCCCCCCCC
KIGMMGGSYVGIVQWKAALANNPHLKAIFPVVSGYDDYRDRYYSTGGALKLGNRLEWMAE
EEECCCCCEEEEEEEEHHHCCCCCEEEEEHHHCCCHHHHHHHCCCCCCEEECCHHHHHHH
NLRAPGYHQDFARFVLHLPVRSCDIAALGWTSPMYRDIIEHPSFDAFWRAISTKEHLDKI
HCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHCCHHHHHHH
KVPVFSVGGWYDNFVQSDLEAYAARRKSGGLNRILIGPWAHNMSLPFQDVTFGDDSSVPV
CCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEECCCCCCCCE
RALQLEWFDQFLMGKDSPLLSQPPVKIFVMGANKWREATAWPPEQARTKLFYLESGGKAN
EEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHCEEEEEEECCCCCC
SVAGDGSLNDGPARKTAADQFVFDPYTPVPTRGGSVCCNPKVFPWGPLDQRPIEQRKDVL
CCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHCCEE
VYSTPPLKHEVEVIGPVQAVLYVASSARDTDFTAKLVDVFPDGTARILTDGILRLRYRNS
EECCCCCCCCEEEHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCC
LEKPELLKAGEVYRVTVDAGVTSNVFLKGHRIRVEISSSNFPRFDRNANTGGLVEQAAKL
CCCCCHHCCCCEEEEEEECCCCCCEEEECEEEEEEECCCCCCCCCCCCCCCHHHHHHHHH
LKASQTIYHDPAHPSCLVLKVM
HHHHHHHCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]