Click here to switch to the map view.

The map label for this gene is lldD [C]

Identifier: 116620898

GI number: 116620898

Start: 2214756

End: 2215955

Strand: Direct

Name: lldD [C]

Synonym: Acid_1779

Alternate gene names: 116620898

Gene position: 2214756-2215955 (Clockwise)

Preceding gene: 116620897

Following gene: 116620900

Centisome position: 22.22

GC content: 65.17

Gene sequence:

>1200_bases
ATGGACTCTCACCGCGGGCGCCGCGCCTTCCTTCGATTTCTCGCCGCCAGCCCCTATGTCGCCGCGCTTGGCGGCATCCG
CGAATTCGCCGAAGGCGCGCCGGAGATCGCCAATTCGAGCGAGGCGCACAGCGTGATGGATTTCGAGGATGTCGCCCGCC
GCAAGGTCACGCCGGTCCACTGGGCGTTCATCGCCAGCGGAGTGGACGACGACGCGACCCTGCGCGCCAATCGCGAAGGC
TTCCAACACGTTCAACTGCGCCCCCGGCGCCTGTGCGACGCGACTCATCTCGACATGCGGACGGATTTGTTCGGCACGGT
GTACGCCAGCCCCATCTTCACCTGTCCCACTTCGGGCGAGAAGTTTCTCGACCCCGCCGGCGAGCTCGCGGTCGCGCGCG
CAACCAAAGCGCACGGCGCCATGCAGATGCTTTCAAACTCCACCTCAACGGCGCTGGAAGAGGTGAACTCCGCGCACGGC
CGGCCGGTCTGGTTTCAGCTCTATGCTCCCAGCGCGTGGCAGGCCTGCGAGAAAATTATCCGCCGCGTCGAAGCGGCGGG
TTGTCCGGTCATCGCCCTCACCGTCGATAGCACTACGGGCCGGAACAGCGAGACCTATCTGCGTGCCCTCCCCAAAAACC
TCCAGCCCTGCCTCTCCTGCCATGCAGCCGGATTGGGCCCGAGCGTCGAGGGCCGGAAGATGTACGACGGTATCGATATG
AAGGGCGTCGCCCTGCGAAATCCGGCCATGACCTGGGAGTTTGTCGATCGCCTGCGAAAGGCGACGTCGTTGAAGCTCCT
CCTCAAAGGCGTCGACACCCGCGAAGACGCGCGACTCGCCGTGGAGCATGGCATCGATGGCATCCTCGTCTCGAATCACG
GAGGCCGTGCCACCGAGACCGGACGGTCCACCATTGAGGCGCTCCCCGAAGTCGTGACCGAGGTCGGCGGCCGTATCCCT
GTATTCCTGGACGGCGGCGTTCGCCGCGGAACCGACGTTTTTAAAGCGCTCGCGCTGGGCGCCAAAGCCGTGGGCATCGG
CCGCCCGTACCTCTGGGGCTTGGGGGCGTTCGGCCAGGCCGGCGTCGAGCGAGTGCTCGAAATTGTTCAAGGCGAGCTGA
AACTGGCAATGGGAAACTGCGGCACGCCGACGGTGGCCGCCATTGACCGCTCCTACGTTGCGAAGAGATTGAGCTGGTAA

Upstream 100 bases:

>100_bases
CCAGTGTCATGAAGAATGGCGAGGTTCACTTCTTCCGCGACATCTATGGCGAAGATGCAGTCCTCGAAAAAGAGCTGGCC
GCGCGCCGGAAATAATTGTC

Downstream 100 bases:

>100_bases
GCTCTTATCGTGGAGCATCGGGGACGTGAACCACGATACGTTGCGGGCCGCACCCGAGGGCGATTGCCCCCGGCCGCGGC
CCGTATGCTTCAAGAGGTAG

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: Lactate oxidase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MDSHRGRRAFLRFLAASPYVAALGGIREFAEGAPEIANSSEAHSVMDFEDVARRKVTPVHWAFIASGVDDDATLRANREG
FQHVQLRPRRLCDATHLDMRTDLFGTVYASPIFTCPTSGEKFLDPAGELAVARATKAHGAMQMLSNSTSTALEEVNSAHG
RPVWFQLYAPSAWQACEKIIRRVEAAGCPVIALTVDSTTGRNSETYLRALPKNLQPCLSCHAAGLGPSVEGRKMYDGIDM
KGVALRNPAMTWEFVDRLRKATSLKLLLKGVDTREDARLAVEHGIDGILVSNHGGRATETGRSTIEALPEVVTEVGGRIP
VFLDGGVRRGTDVFKALALGAKAVGIGRPYLWGLGAFGQAGVERVLEIVQGELKLAMGNCGTPTVAAIDRSYVAKRLSW

Sequences:

>Translated_399_residues
MDSHRGRRAFLRFLAASPYVAALGGIREFAEGAPEIANSSEAHSVMDFEDVARRKVTPVHWAFIASGVDDDATLRANREG
FQHVQLRPRRLCDATHLDMRTDLFGTVYASPIFTCPTSGEKFLDPAGELAVARATKAHGAMQMLSNSTSTALEEVNSAHG
RPVWFQLYAPSAWQACEKIIRRVEAAGCPVIALTVDSTTGRNSETYLRALPKNLQPCLSCHAAGLGPSVEGRKMYDGIDM
KGVALRNPAMTWEFVDRLRKATSLKLLLKGVDTREDARLAVEHGIDGILVSNHGGRATETGRSTIEALPEVVTEVGGRIP
VFLDGGVRRGTDVFKALALGAKAVGIGRPYLWGLGAFGQAGVERVLEIVQGELKLAMGNCGTPTVAAIDRSYVAKRLSW
>Mature_399_residues
MDSHRGRRAFLRFLAASPYVAALGGIREFAEGAPEIANSSEAHSVMDFEDVARRKVTPVHWAFIASGVDDDATLRANREG
FQHVQLRPRRLCDATHLDMRTDLFGTVYASPIFTCPTSGEKFLDPAGELAVARATKAHGAMQMLSNSTSTALEEVNSAHG
RPVWFQLYAPSAWQACEKIIRRVEAAGCPVIALTVDSTTGRNSETYLRALPKNLQPCLSCHAAGLGPSVEGRKMYDGIDM
KGVALRNPAMTWEFVDRLRKATSLKLLLKGVDTREDARLAVEHGIDGILVSNHGGRATETGRSTIEALPEVVTEVGGRIP
VFLDGGVRRGTDVFKALALGAKAVGIGRPYLWGLGAFGQAGVERVLEIVQGELKLAMGNCGTPTVAAIDRSYVAKRLSW

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI54234014, Length=351, Percent_Identity=37.037037037037, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI7705393, Length=351, Percent_Identity=37.037037037037, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI11068137, Length=356, Percent_Identity=37.9213483146067, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI1790033, Length=377, Percent_Identity=32.0954907161804, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193208036, Length=350, Percent_Identity=34.8571428571429, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI32566217, Length=266, Percent_Identity=29.6992481203008, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323587, Length=359, Percent_Identity=31.1977715877437, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI78707188, Length=357, Percent_Identity=37.5350140056022, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI281363140, Length=357, Percent_Identity=37.5350140056022, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI78707190, Length=357, Percent_Identity=37.5350140056022, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.13.12.4 [H]

Molecular weight: Translated: 43096; Mature: 43096

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSHRGRRAFLRFLAASPYVAALGGIREFAEGAPEIANSSEAHSVMDFEDVARRKVTPVH
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHHHHHCCCCHH
WAFIASGVDDDATLRANREGFQHVQLRPRRLCDATHLDMRTDLFGTVYASPIFTCPTSGE
HHHHCCCCCCCHHEECCCCCCHHHHCCHHHHCCHHHCCHHHHHHHHHHCCCEEECCCCCC
KFLDPAGELAVARATKAHGAMQMLSNSTSTALEEVNSAHGRPVWFQLYAPSAWQACEKII
HHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHH
RRVEAAGCPVIALTVDSTTGRNSETYLRALPKNLQPCLSCHAAGLGPSVEGRKMYDGIDM
HHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCC
KGVALRNPAMTWEFVDRLRKATSLKLLLKGVDTREDARLAVEHGIDGILVSNHGGRATET
CCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCCCCCHH
GRSTIEALPEVVTEVGGRIPVFLDGGVRRGTDVFKALALGAKAVGIGRPYLWGLGAFGQA
HHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCHHEECCCCHHHCCCCCCHH
GVERVLEIVQGELKLAMGNCGTPTVAAIDRSYVAKRLSW
HHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDSHRGRRAFLRFLAASPYVAALGGIREFAEGAPEIANSSEAHSVMDFEDVARRKVTPVH
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHHHHHCCCCHH
WAFIASGVDDDATLRANREGFQHVQLRPRRLCDATHLDMRTDLFGTVYASPIFTCPTSGE
HHHHCCCCCCCHHEECCCCCCHHHHCCHHHHCCHHHCCHHHHHHHHHHCCCEEECCCCCC
KFLDPAGELAVARATKAHGAMQMLSNSTSTALEEVNSAHGRPVWFQLYAPSAWQACEKII
HHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHH
RRVEAAGCPVIALTVDSTTGRNSETYLRALPKNLQPCLSCHAAGLGPSVEGRKMYDGIDM
HHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCC
KGVALRNPAMTWEFVDRLRKATSLKLLLKGVDTREDARLAVEHGIDGILVSNHGGRATET
CCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCCCCCHH
GRSTIEALPEVVTEVGGRIPVFLDGGVRRGTDVFKALALGAKAVGIGRPYLWGLGAFGQA
HHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCHHEECCCCHHHCCCCCCHH
GVERVLEIVQGELKLAMGNCGTPTVAAIDRSYVAKRLSW
HHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2324094; 3571231 [H]