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The map label for this gene is 116620854

Identifier: 116620854

GI number: 116620854

Start: 2154623

End: 2155417

Strand: Reverse

Name: 116620854

Synonym: Acid_1735

Alternate gene names: NA

Gene position: 2155417-2154623 (Counterclockwise)

Preceding gene: 116620857

Following gene: 116620852

Centisome position: 21.63

GC content: 64.28

Gene sequence:

>795_bases
ATGCGGCAAGTCCGCGTAGAATGCAAGAGGATGTTGACGGCGATCACGCGGGCGGTGAGCCCATCGATGGACAAGTGCGA
ACTTTCTTTCATTGCGCGGCAGGCGATCGACATCGCGCGCGCGAAGGAGCAGCATGCAGCGTACGAAGTGTGCCTGTGGG
AACTGGGGGTGAGGGTGATTTCGCTGCCGTCAGAGGCGGAGTACCCGGACGCGGTGTTCGTGGAGGATCCTGCGATCGTG
CTGGATGAGATCGCGGTGATGACGCGGCCGGGGGCGGAGTCGCGACGCGGGGAGGCGGCGTCACTGGCTCGGGTGTTGGA
AGGCTATCGCGAGCTGCGATGGATGCGCGAGCCGGCCACGCTGGATGGCGGCGACGTGATGCTCGCAGAGCGGACGCTCT
ACGTGGGCAATTCGGGGCGGACGAGCGCGGCGGGGATTGGACAGCTGGCGGCAGAGGTCGCAGAGTTCGGGTACGACGTG
CGGGCGATGGCGGTGCAGGGATGCCTGCATTTGAAATCGGCGTGCAGTTATTTGGGCGATGGGATGGTGCTGGCGTACCG
GCCGTGGGTGCAGGCCGAGTTTGAAGGACTGAAGGTGATCGAGGCTCCGGATGCGGAGGCGGTGAATGTGCTGCGCGTCG
GGGATACGGTGCTGGTGGCGGCCGGGTTTCCGCGGACGGTGGAAACGATCTCGAGGCTGGGACTGCGAGTGAGGGCGCTC
GACAATTCGGAGCTGCGAAAAGCCGAGGGGGCCCTCACTTGCTGCAGTCTACTGTTTAAGGCAACAACTGATTAG

Upstream 100 bases:

>100_bases
CATAGCCATGCATGACGCCGCGGCTGAGCGTCTTGAGAATCAACATGTCGAGCGTGCCCTGCATGAGCGCTTTGTCTCCC
ATAATTCTCTTAGGGGAAGT

Downstream 100 bases:

>100_bases
TGCGCCGGCTGAAAGCCGGCGGCAGCCAGGATTGGCTGCCGCACAAGGCGGCAGGCCGCAAAAAACGGACGCTCCTTCAC
GGTCGCGCGGCTCGTTCCTA

Product: dimethylargininase

Products: NA

Alternate protein names: DDAH; Dimethylarginine dimethylaminohydrolase; Dimethylargininase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MRQVRVECKRMLTAITRAVSPSMDKCELSFIARQAIDIARAKEQHAAYEVCLWELGVRVISLPSEAEYPDAVFVEDPAIV
LDEIAVMTRPGAESRRGEAASLARVLEGYRELRWMREPATLDGGDVMLAERTLYVGNSGRTSAAGIGQLAAEVAEFGYDV
RAMAVQGCLHLKSACSYLGDGMVLAYRPWVQAEFEGLKVIEAPDAEAVNVLRVGDTVLVAAGFPRTVETISRLGLRVRAL
DNSELRKAEGALTCCSLLFKATTD

Sequences:

>Translated_264_residues
MRQVRVECKRMLTAITRAVSPSMDKCELSFIARQAIDIARAKEQHAAYEVCLWELGVRVISLPSEAEYPDAVFVEDPAIV
LDEIAVMTRPGAESRRGEAASLARVLEGYRELRWMREPATLDGGDVMLAERTLYVGNSGRTSAAGIGQLAAEVAEFGYDV
RAMAVQGCLHLKSACSYLGDGMVLAYRPWVQAEFEGLKVIEAPDAEAVNVLRVGDTVLVAAGFPRTVETISRLGLRVRAL
DNSELRKAEGALTCCSLLFKATTD
>Mature_264_residues
MRQVRVECKRMLTAITRAVSPSMDKCELSFIARQAIDIARAKEQHAAYEVCLWELGVRVISLPSEAEYPDAVFVEDPAIV
LDEIAVMTRPGAESRRGEAASLARVLEGYRELRWMREPATLDGGDVMLAERTLYVGNSGRTSAAGIGQLAAEVAEFGYDV
RAMAVQGCLHLKSACSYLGDGMVLAYRPWVQAEFEGLKVIEAPDAEAVNVLRVGDTVLVAAGFPRTVETISRLGLRVRAL
DNSELRKAEGALTCCSLLFKATTD

Specific function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS [H]

COG id: COG1834

COG function: function code E; N-Dimethylarginine dimethylaminohydrolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DDAH family [H]

Homologues:

Organism=Homo sapiens, GI6912328, Length=275, Percent_Identity=33.8181818181818, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18859791, Length=240, Percent_Identity=27.9166666666667, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003198 [H]

Pfam domain/function: PF02274 Amidinotransf [H]

EC number: =3.5.3.18 [H]

Molecular weight: Translated: 28784; Mature: 28784

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQVRVECKRMLTAITRAVSPSMDKCELSFIARQAIDIARAKEQHAAYEVCLWELGVRVI
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
SLPSEAEYPDAVFVEDPAIVLDEIAVMTRPGAESRRGEAASLARVLEGYRELRWMREPAT
ECCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
LDGGDVMLAERTLYVGNSGRTSAAGIGQLAAEVAEFGYDVRAMAVQGCLHLKSACSYLGD
CCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GMVLAYRPWVQAEFEGLKVIEAPDAEAVNVLRVGDTVLVAAGFPRTVETISRLGLRVRAL
CEEEEECCCHHHCCCCEEEEECCCCCCEEEEEECCEEEEECCCCHHHHHHHHCCEEEEEC
DNSELRKAEGALTCCSLLFKATTD
CCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRQVRVECKRMLTAITRAVSPSMDKCELSFIARQAIDIARAKEQHAAYEVCLWELGVRVI
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
SLPSEAEYPDAVFVEDPAIVLDEIAVMTRPGAESRRGEAASLARVLEGYRELRWMREPAT
ECCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
LDGGDVMLAERTLYVGNSGRTSAAGIGQLAAEVAEFGYDVRAMAVQGCLHLKSACSYLGD
CCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GMVLAYRPWVQAEFEGLKVIEAPDAEAVNVLRVGDTVLVAAGFPRTVETISRLGLRVRAL
CEEEEECCCHHHCCCCEEEEECCCCCCEEEEEECCEEEEECCCCHHHHHHHHCCEEEEEC
DNSELRKAEGALTCCSLLFKATTD
CCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 11473257 [H]