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The map label for this gene is serA [H]

Identifier: 116620780

GI number: 116620780

Start: 2058210

End: 2059787

Strand: Direct

Name: serA [H]

Synonym: Acid_1661

Alternate gene names: 116620780

Gene position: 2058210-2059787 (Clockwise)

Preceding gene: 116620779

Following gene: 116620784

Centisome position: 20.65

GC content: 63.62

Gene sequence:

>1578_bases
ATGAACATCCTCATCGCGGAGCCTCTCGCAGCTGCCGGGATCGAGTTATTCCAATCCCAGCCGGGCTGGAACGTCATCGT
TTCCAGTCCCAAGGAGTACGCCCAGCACCTGGCGACGGCCGATGCCCTCTTGGTGAGGAGCGTAGTTCAAGTCAACCAGT
CCGTGCTCGAGAAAGGGCCGAAACTGCGCGTCATCGGGCGCGCCGGGGTTGGGGTGGACAACGTCGATCTGGAGGCTGCC
ACCGCGGCCGGCGTGCTGGTAATGAATACGCCGGGCGGCAACGCGATCTCCGTCGCCGAGCATACCCTGGCGCTCATGCT
GGCAATGGCACGCCACATTCCGCAGGCCACCGCGAGCACCTGCGGCGGTAAGTGGGAAAAGAAGAAGTTCATGGGTAACG
AGCTGCGCGGCAAGACTCTGGGCGTGGTCGGGTTAGGCAGCATCGGCCGCGAGGTGGTGAAGCGCGCGCGGGCCTTTGAG
ATGCGGATAGTGGCGCACGATCCGTACGTGACGTCGGCCATCGCGCACGATCTGGGCGTTGAGCTCGTGGATCTTGCGCA
ACTCTTCCGGCAGAGCGATTACCTCACGCTGCATGTGGCGGCGACGCCGGAGACGCAGGGTATGCTATCGCGCGAAGCCT
TCGCGCAAATGAAGGATGGCGTGCGCATCGTCAATTGCGCGCGCGGGGAGCTGGTGGACGAAGCAGCGCTGGCGGAGGCG
CTGGCCAGCGGCAAAGTCGCCGACGCGTCGCTCGACGTCTTCAGTGTGGAACCGCCGCCGGCCGGTTTTCCGCTATTCGC
GCTGAATGGAGTGCTGGCAACCCCGCACATCGGCGGGTCCACGGAAGAGGCGCAGGAAATCGTGGGCGTGCGTATTGCCG
AGCAGGTGGTGGAATATCTCACGCACGGAATGGCGACGAACGCGGTGAATATGCCGCCGATGTCGCCGGAGCAATTCAAG
GCGCTGAGCCCTTACGCGACGCTGGCCGACCGTTTGGGAAATTTCGCGGCGCATATGGCAACGGGCCATCCGCACACGGT
ACGGCTGCACTACTTCGGCAAGATCGCCGACAATGCGACGAGTTTGCTGCGCAACGCCGGCCTCGCGGGGGTGCTGAGCC
GCTCGACTTCGCGCAAGGCGAATTTGATCAATGCGCTACAGATCGCCGAGCAGCGCGGGTGGGACGTGGTGGAGCGCCAC
GATAAGCGCAGCGTACATACGGATTCGATCCGCATCGACGTGGAGACCGACTTGGGTGTGACCACAGTAGAAGGCGCGGT
AGTGCTGGATAAGCCGCGGTTGTTACAGGTGGACGGCATTTACTGCGAGGCGGCGCTCTGCGGTTTCCTGATCGTGATGA
AGAACCAGGATGTCCCGGGCGTGATCGGGCACGTGGGCACGGTGCTCGGGAAGAACTGCATCAACATTGCGAATTTCTCG
CTGGGGCGGCGTGAGGGCACGCCGGAGGCGGTCGCGCTGGTGTCGACAGACGGGCTAGTGCCGGAGAGCGTGCTGCTGCA
ATTGAAAGAGCACGCCGCGGTCAAGTTCGCGCGCAGCGTGGAATTCCACGGCTGCTGA

Upstream 100 bases:

>100_bases
ATTATCTTGAACGCGAACGGTCACCCGGTGCAGTACGGGGCGGGCGTTGCCGCGGCGCAGGAAGTATACGCACAGGCGAC
AGTACCAGCGTTGAAATAAA

Downstream 100 bases:

>100_bases
GCGGGATCCCCAATTCTCCCGGGGCTTCTTTTCCATGTTGTCGACAATTACACCGTCGAGCAGCATTTTCCGGGACTCCA
GTTTGAGGCCGAGTTGCTCT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MNILIAEPLAAAGIELFQSQPGWNVIVSSPKEYAQHLATADALLVRSVVQVNQSVLEKGPKLRVIGRAGVGVDNVDLEAA
TAAGVLVMNTPGGNAISVAEHTLALMLAMARHIPQATASTCGGKWEKKKFMGNELRGKTLGVVGLGSIGREVVKRARAFE
MRIVAHDPYVTSAIAHDLGVELVDLAQLFRQSDYLTLHVAATPETQGMLSREAFAQMKDGVRIVNCARGELVDEAALAEA
LASGKVADASLDVFSVEPPPAGFPLFALNGVLATPHIGGSTEEAQEIVGVRIAEQVVEYLTHGMATNAVNMPPMSPEQFK
ALSPYATLADRLGNFAAHMATGHPHTVRLHYFGKIADNATSLLRNAGLAGVLSRSTSRKANLINALQIAEQRGWDVVERH
DKRSVHTDSIRIDVETDLGVTTVEGAVVLDKPRLLQVDGIYCEAALCGFLIVMKNQDVPGVIGHVGTVLGKNCINIANFS
LGRREGTPEAVALVSTDGLVPESVLLQLKEHAAVKFARSVEFHGC

Sequences:

>Translated_525_residues
MNILIAEPLAAAGIELFQSQPGWNVIVSSPKEYAQHLATADALLVRSVVQVNQSVLEKGPKLRVIGRAGVGVDNVDLEAA
TAAGVLVMNTPGGNAISVAEHTLALMLAMARHIPQATASTCGGKWEKKKFMGNELRGKTLGVVGLGSIGREVVKRARAFE
MRIVAHDPYVTSAIAHDLGVELVDLAQLFRQSDYLTLHVAATPETQGMLSREAFAQMKDGVRIVNCARGELVDEAALAEA
LASGKVADASLDVFSVEPPPAGFPLFALNGVLATPHIGGSTEEAQEIVGVRIAEQVVEYLTHGMATNAVNMPPMSPEQFK
ALSPYATLADRLGNFAAHMATGHPHTVRLHYFGKIADNATSLLRNAGLAGVLSRSTSRKANLINALQIAEQRGWDVVERH
DKRSVHTDSIRIDVETDLGVTTVEGAVVLDKPRLLQVDGIYCEAALCGFLIVMKNQDVPGVIGHVGTVLGKNCINIANFS
LGRREGTPEAVALVSTDGLVPESVLLQLKEHAAVKFARSVEFHGC
>Mature_525_residues
MNILIAEPLAAAGIELFQSQPGWNVIVSSPKEYAQHLATADALLVRSVVQVNQSVLEKGPKLRVIGRAGVGVDNVDLEAA
TAAGVLVMNTPGGNAISVAEHTLALMLAMARHIPQATASTCGGKWEKKKFMGNELRGKTLGVVGLGSIGREVVKRARAFE
MRIVAHDPYVTSAIAHDLGVELVDLAQLFRQSDYLTLHVAATPETQGMLSREAFAQMKDGVRIVNCARGELVDEAALAEA
LASGKVADASLDVFSVEPPPAGFPLFALNGVLATPHIGGSTEEAQEIVGVRIAEQVVEYLTHGMATNAVNMPPMSPEQFK
ALSPYATLADRLGNFAAHMATGHPHTVRLHYFGKIADNATSLLRNAGLAGVLSRSTSRKANLINALQIAEQRGWDVVERH
DKRSVHTDSIRIDVETDLGVTTVEGAVVLDKPRLLQVDGIYCEAALCGFLIVMKNQDVPGVIGHVGTVLGKNCINIANFS
LGRREGTPEAVALVSTDGLVPESVLLQLKEHAAVKFARSVEFHGC

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=373, Percent_Identity=42.3592493297587, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI6912396, Length=272, Percent_Identity=31.25, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI145580578, Length=250, Percent_Identity=34, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI4557499, Length=250, Percent_Identity=34, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI61743967, Length=250, Percent_Identity=32.8, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI4557497, Length=250, Percent_Identity=32.8, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI145580575, Length=252, Percent_Identity=33.7301587301587, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1789279, Length=275, Percent_Identity=36.3636363636364, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI87082289, Length=289, Percent_Identity=34.2560553633218, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1787645, Length=205, Percent_Identity=40.4878048780488, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1788660, Length=400, Percent_Identity=28.25, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081824, Length=246, Percent_Identity=27.2357723577236, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=42.2950819672131, Blast_Score=237, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI25147481, Length=351, Percent_Identity=30.1994301994302, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=331, Percent_Identity=34.7432024169184, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6320925, Length=339, Percent_Identity=34.8082595870207, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6324964, Length=305, Percent_Identity=27.8688524590164, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=249, Percent_Identity=31.3253012048193, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6325144, Length=170, Percent_Identity=33.5294117647059, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=182, Percent_Identity=28.021978021978, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921140, Length=270, Percent_Identity=45.1851851851852, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24646446, Length=277, Percent_Identity=35.0180505415162, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646448, Length=277, Percent_Identity=35.0180505415162, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646452, Length=277, Percent_Identity=35.0180505415162, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646450, Length=277, Percent_Identity=35.0180505415162, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI62472511, Length=277, Percent_Identity=35.0180505415162, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574286, Length=283, Percent_Identity=30.0353356890459, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24585516, Length=323, Percent_Identity=27.8637770897833, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28571528, Length=287, Percent_Identity=32.404181184669, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI45552429, Length=232, Percent_Identity=29.7413793103448, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45551003, Length=232, Percent_Identity=29.7413793103448, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585514, Length=232, Percent_Identity=29.7413793103448, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574282, Length=232, Percent_Identity=29.7413793103448, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574284, Length=232, Percent_Identity=29.7413793103448, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55826; Mature: 55826

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00626 RCC1_2 ; PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILIAEPLAAAGIELFQSQPGWNVIVSSPKEYAQHLATADALLVRSVVQVNQSVLEKGP
CCEEECCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLRVIGRAGVGVDNVDLEAATAAGVLVMNTPGGNAISVAEHTLALMLAMARHIPQATAST
CEEEEEECCCCCCCCCCCHHHHCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCHHHHH
CGGKWEKKKFMGNELRGKTLGVVGLGSIGREVVKRARAFEMRIVAHDPYVTSAIAHDLGV
CCCCHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHCH
ELVDLAQLFRQSDYLTLHVAATPETQGMLSREAFAQMKDGVRIVNCARGELVDEAALAEA
HHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
LASGKVADASLDVFSVEPPPAGFPLFALNGVLATPHIGGSTEEAQEIVGVRIAEQVVEYL
HHCCCCCCCCEEEEECCCCCCCCCHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
THGMATNAVNMPPMSPEQFKALSPYATLADRLGNFAAHMATGHPHTVRLHYFGKIADNAT
HCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHH
SLLRNAGLAGVLSRSTSRKANLINALQIAEQRGWDVVERHDKRSVHTDSIRIDVETDLGV
HHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCEECCEEEEEEECCCCE
TTVEGAVVLDKPRLLQVDGIYCEAALCGFLIVMKNQDVPGVIGHVGTVLGKNCINIANFS
EEECCEEEECCCCEEEECCEEHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCHHHHHCCC
LGRREGTPEAVALVSTDGLVPESVLLQLKEHAAVKFARSVEFHGC
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNILIAEPLAAAGIELFQSQPGWNVIVSSPKEYAQHLATADALLVRSVVQVNQSVLEKGP
CCEEECCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLRVIGRAGVGVDNVDLEAATAAGVLVMNTPGGNAISVAEHTLALMLAMARHIPQATAST
CEEEEEECCCCCCCCCCCHHHHCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCHHHHH
CGGKWEKKKFMGNELRGKTLGVVGLGSIGREVVKRARAFEMRIVAHDPYVTSAIAHDLGV
CCCCHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHCH
ELVDLAQLFRQSDYLTLHVAATPETQGMLSREAFAQMKDGVRIVNCARGELVDEAALAEA
HHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
LASGKVADASLDVFSVEPPPAGFPLFALNGVLATPHIGGSTEEAQEIVGVRIAEQVVEYL
HHCCCCCCCCEEEEECCCCCCCCCHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
THGMATNAVNMPPMSPEQFKALSPYATLADRLGNFAAHMATGHPHTVRLHYFGKIADNAT
HCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHH
SLLRNAGLAGVLSRSTSRKANLINALQIAEQRGWDVVERHDKRSVHTDSIRIDVETDLGV
HHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCEECCEEEEEEECCCCE
TTVEGAVVLDKPRLLQVDGIYCEAALCGFLIVMKNQDVPGVIGHVGTVLGKNCINIANFS
EEECCEEEECCCCEEEECCEEHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCHHHHHCCC
LGRREGTPEAVALVSTDGLVPESVLLQLKEHAAVKFARSVEFHGC
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]