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The map label for this gene is degS [H]

Identifier: 116620724

GI number: 116620724

Start: 1977160

End: 1978473

Strand: Reverse

Name: degS [H]

Synonym: Acid_1604

Alternate gene names: 116620724

Gene position: 1978473-1977160 (Counterclockwise)

Preceding gene: 116620728

Following gene: 116620723

Centisome position: 19.85

GC content: 63.01

Gene sequence:

>1314_bases
GTGGCCAACAGCCGCACCGTGCTGGTCGCCGGTTTCGGTGGACTGCTCGTCCTGATGGCATTCGCGGGGCTCGATGGCAT
CCAGGCCCTCCGTCAGATTCAAACCTCCAACGACAATATCCGCGAGGATTTTCTGCTGCGCACTCGTCTGCTCGAGCGCA
TCCGCGGCGATGTCTATGTCTCCGGCACCTATGTGCGCGATTACCTCTTGGAGCCGGAAAGCGGCAAGGCCGAAGGCCAC
CGCTACAGCCTGCTGGAGGCGCGCACCGATATGGACGCGGCTCTCGCCGCGTACCGCGCCCTGCTCACCAGCCCTGAAAC
GGGACCGTTTCAAGTGCTCACGCGCGAACTGGCGATCTACTGGAGCGTGCTCGAGCCGGTCTTCGAATGGACTCCCCAAC
AGCGCCGCACACGCGGGTACCCGTTCCTTCGTGATGAGGTCTTTCCGCGGCGCATGGCAATGCTCGGAATCGCCGACCAG
ATCCGCGCGCTCAATGAATCGCAATTGCACGACGGCAAGCTGCGCGTGGAAGCGCTGTTCTCGCAGTACGGCCGGCGCCT
GGCGGTAACGATCGCGCTTGTGATCGGGTTGGGTTTGGTGCTGGCCGCCTTCAGTATCCGCAAGATTCTCGCGCTCGAGA
ACGCGAGCTCCGCGTCGCAGGAAGCGCTGAAACACCTCTCCGCGCGCCTCGTCGAAGCCCAGGAAGACGAGCGCCGCTCG
ATTTCGCGGGAGTTGCACGACGAAGTGGGCCAGTCGCTCACCGGGGTGCTGCTCGAAATGGCGAATCTCTCCAAGCTGAT
TCGCACTCGCGATCCGGAATCCGTCGCGGCCAAAGCCGCTGAAATCAAGCGTGAGGTGGAAAACTCCATCGGTGTAGTTC
GCAATATGGCGCTGCTCCTGCGGCCCTCTATGCTCGACGATCTCGGTCTCGTGCCGGCCCTGCAGTGGCAGGCGCGTGAG
GTTTCCAAACGCAGCGGCCTCTGGGTTTCGGTGGACGCCGCATCCGTTTCTGAAGATCTCCCGGAAGAACACAAGACCTG
TATTTATCGCATCGTCCAGGAGGCGTTGCACAACGCCGTGCAGCACGCGGGCGCACGCCACGTAAAGGTCGCGGTGGAGC
AGCAGCCCGACGAATTGCGGCTCGCGATCGAGGACGATGGCAAGGGCTTCGACGCGCAGCAGGGGCGCGGTATGGGACTC
TTAGGGATACAGGAACGGGTGGGCTATCTCGGCGGTAAGTTCGAGGTGGGCTCGGCGCCCGGCAAGGGTACCGCGCTCAA
AGTGACCCTTCCCCTGGTTCGCAAATACGCATGA

Upstream 100 bases:

>100_bases
CCAGCGTTCCCAACGTCACATTCCGAGCATAATAGAAGTAGACCTCCACGGTATGGACGAAAGTCAACTATCCCTTTCGC
TGCGCCGCACCGGAGCGCGC

Downstream 100 bases:

>100_bases
AGACAATCCGCATTCTTCTCGCCGACGATCACACTGTGGTTCGCAAAGGCTTGCGCCTGCTGCTCGAAAGCCATCCCGGA
TTTCAGGTCATCGGCGACGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MANSRTVLVAGFGGLLVLMAFAGLDGIQALRQIQTSNDNIREDFLLRTRLLERIRGDVYVSGTYVRDYLLEPESGKAEGH
RYSLLEARTDMDAALAAYRALLTSPETGPFQVLTRELAIYWSVLEPVFEWTPQQRRTRGYPFLRDEVFPRRMAMLGIADQ
IRALNESQLHDGKLRVEALFSQYGRRLAVTIALVIGLGLVLAAFSIRKILALENASSASQEALKHLSARLVEAQEDERRS
ISRELHDEVGQSLTGVLLEMANLSKLIRTRDPESVAAKAAEIKREVENSIGVVRNMALLLRPSMLDDLGLVPALQWQARE
VSKRSGLWVSVDAASVSEDLPEEHKTCIYRIVQEALHNAVQHAGARHVKVAVEQQPDELRLAIEDDGKGFDAQQGRGMGL
LGIQERVGYLGGKFEVGSAPGKGTALKVTLPLVRKYA

Sequences:

>Translated_437_residues
MANSRTVLVAGFGGLLVLMAFAGLDGIQALRQIQTSNDNIREDFLLRTRLLERIRGDVYVSGTYVRDYLLEPESGKAEGH
RYSLLEARTDMDAALAAYRALLTSPETGPFQVLTRELAIYWSVLEPVFEWTPQQRRTRGYPFLRDEVFPRRMAMLGIADQ
IRALNESQLHDGKLRVEALFSQYGRRLAVTIALVIGLGLVLAAFSIRKILALENASSASQEALKHLSARLVEAQEDERRS
ISRELHDEVGQSLTGVLLEMANLSKLIRTRDPESVAAKAAEIKREVENSIGVVRNMALLLRPSMLDDLGLVPALQWQARE
VSKRSGLWVSVDAASVSEDLPEEHKTCIYRIVQEALHNAVQHAGARHVKVAVEQQPDELRLAIEDDGKGFDAQQGRGMGL
LGIQERVGYLGGKFEVGSAPGKGTALKVTLPLVRKYA
>Mature_436_residues
ANSRTVLVAGFGGLLVLMAFAGLDGIQALRQIQTSNDNIREDFLLRTRLLERIRGDVYVSGTYVRDYLLEPESGKAEGHR
YSLLEARTDMDAALAAYRALLTSPETGPFQVLTRELAIYWSVLEPVFEWTPQQRRTRGYPFLRDEVFPRRMAMLGIADQI
RALNESQLHDGKLRVEALFSQYGRRLAVTIALVIGLGLVLAAFSIRKILALENASSASQEALKHLSARLVEAQEDERRSI
SRELHDEVGQSLTGVLLEMANLSKLIRTRDPESVAAKAAEIKREVENSIGVVRNMALLLRPSMLDDLGLVPALQWQAREV
SKRSGLWVSVDAASVSEDLPEEHKTCIYRIVQEALHNAVQHAGARHVKVAVEQQPDELRLAIEDDGKGFDAQQGRGMGLL
GIQERVGYLGGKFEVGSAPGKGTALKVTLPLVRKYA

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=240, Percent_Identity=33.75, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787474, Length=197, Percent_Identity=29.4416243654822, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48400; Mature: 48269

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSRTVLVAGFGGLLVLMAFAGLDGIQALRQIQTSNDNIREDFLLRTRLLERIRGDVYV
CCCCCEEEEECHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEE
SGTYVRDYLLEPESGKAEGHRYSLLEARTDMDAALAAYRALLTSPETGPFQVLTRELAIY
ECHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
WSVLEPVFEWTPQQRRTRGYPFLRDEVFPRRMAMLGIADQIRALNESQLHDGKLRVEALF
HHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHH
SQYGRRLAVTIALVIGLGLVLAAFSIRKILALENASSASQEALKHLSARLVEAQEDERRS
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ISRELHDEVGQSLTGVLLEMANLSKLIRTRDPESVAAKAAEIKREVENSIGVVRNMALLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPSMLDDLGLVPALQWQAREVSKRSGLWVSVDAASVSEDLPEEHKTCIYRIVQEALHNAV
CCHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QHAGARHVKVAVEQQPDELRLAIEDDGKGFDAQQGRGMGLLGIQERVGYLGGKFEVGSAP
HHCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHCCCCEEECCCC
GKGTALKVTLPLVRKYA
CCCCEEEEEHHHHHHCC
>Mature Secondary Structure 
ANSRTVLVAGFGGLLVLMAFAGLDGIQALRQIQTSNDNIREDFLLRTRLLERIRGDVYV
CCCCEEEEECHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEE
SGTYVRDYLLEPESGKAEGHRYSLLEARTDMDAALAAYRALLTSPETGPFQVLTRELAIY
ECHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
WSVLEPVFEWTPQQRRTRGYPFLRDEVFPRRMAMLGIADQIRALNESQLHDGKLRVEALF
HHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHH
SQYGRRLAVTIALVIGLGLVLAAFSIRKILALENASSASQEALKHLSARLVEAQEDERRS
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ISRELHDEVGQSLTGVLLEMANLSKLIRTRDPESVAAKAAEIKREVENSIGVVRNMALLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPSMLDDLGLVPALQWQAREVSKRSGLWVSVDAASVSEDLPEEHKTCIYRIVQEALHNAV
CCHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QHAGARHVKVAVEQQPDELRLAIEDDGKGFDAQQGRGMGLLGIQERVGYLGGKFEVGSAP
HHCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHCCCCEEECCCC
GKGTALKVTLPLVRKYA
CCCCEEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]