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The map label for this gene is aspS [H]

Identifier: 116620658

GI number: 116620658

Start: 1888641

End: 1890416

Strand: Direct

Name: aspS [H]

Synonym: Acid_1538

Alternate gene names: 116620658

Gene position: 1888641-1890416 (Clockwise)

Preceding gene: 116620657

Following gene: 116620659

Centisome position: 18.95

GC content: 61.66

Gene sequence:

>1776_bases
ATGGAAACCTCTGTTGCACTGGATTTTCTGGGCGACCTTCGCCGCACTCACATGTGCGGCGAACTTCGCGCTTCGAACGC
GGGCCAAAAGGTCCTTCTTATGGGATGGGCGCATCGCCGCCGCGATCACGGAGCCGTGATCTTTGTCGATATGCGCGATC
GCACCGGCCACACCCAGGCTATCTTCCACGAAGACGTTGACCCCGCCATCCACAAGCGCGCCGAAGAAGTCCGCGCCGAA
TATGTGATCGCCGTGGAAGGCGTAGTCTCCCTGCGTTCGGCCGCCACCGTGAATCCGAATATGCCGACCGGCGAGGTGGA
AGTCGTCGCCTCCAAAATCTGGATTCTGAATGAATCGCGGACGCCGCCCTTCCCCATGGAAGAGCACGTGGACGTCGCCG
AAGACGTGCGCCTGAAGTATCGGTACGTCGATCTGCGCCGTCCGCAGATGCAGCGTAACGTGATCATGCGTTCGCAGATT
TCCTTTGCCGTGCGCGAGTTCCTCTACTCCGAAGGCTTCCTCGAAATCGAAACGCCGTTCATGACGCGCAGCACTCCCGA
GGGAGCGCGCGATTACCTGGTTCCCAGTCGCGTACAGCCCGGCACCTTCTACGCGCTGCCGCAATCGCCGCAGATTTTTA
AGCAGCTCCTGATGATCAGCGGTTTCGAAAAGTATTTCCAGATTGTGCGCTGTTTCCGAGATGAAGATCTCCGCGCCGAT
CGCCAACCCGAATTCACCCAGATCGATCTGGAGATGAGCTTCCCGCAGCAGGCGCAGATCTTCGCTGTCATCGAGCCGCT
AATCCAAAAGGTCTGTAAGGTGGCCGGATTTGATGTTCCTGCCACCTTCCCGCGCATCACCTACGCGGAAGCGATGCGCA
ACTATGGCATCGATAAGCCCGACACCCGCATCCCCCCGATGCACCCGGTTGGCGACCTCATGCCCGAATTGGCGAACCTG
GGCTTGCCGCTGGTGGCGATCCACATTCCCGCCTGCGGTACGCCAAGCCGTAAGGAGCGCGACGAATTCAAGGCCGTCGG
CCAGGAAAAAGGTCTGCGCGTATACGACGACCCCAAGCGTCTCGAACGCGACTACCCCGAACAGATGGCTAAGGTCCGCG
AACGCTGCGGCGCCAAAGAAGACAGCCTCCTCGTGCTCGCCACCTGGGGCGGAGCCGAAGCGCCGGTGCGTCGTCCCGAA
GAGACGGTCTACCAGGCCTGCGGCCAGTTGCGGCTCGTTCTCGCGAGCAAGTTCAACGACCGGCACAAGCTCCTCGATCC
CAAGAATTTCCAGTTCCTCTGGGTCGTCGATTTCCCGATGTTCGAATGGAACGAGGAAGACAACCGTTGGGTCGCCGCGC
ATCATCCGTTCACCTCGGTGCACGATGAGGATATCGACCTGCTTACTGCCGACCCGGCGAAGTGCCGCGCCAAGAGCTAC
GACCTCGTGCTCAACGGCGTCGAATTAGGCTCGGGCTCGATTCGTATCCACCGCCGCGACGTACAGGCCAAGGTCTTCGC
CGCCGTTGGCTTCAGCGACGACGAAGCCCGCCGCCGCTTCGGCTACCTGCTCGAAGCGCTCGAGTACGGTGCGCCGCCGC
ACGGCGGTATCGCTCTCGGCCTGGACCGCCTGGTCATGATCCTCGCCGGCGAAACCTCGATTCGCGAAGTCATTCCGTTC
CCCAAGACGGCCCGCGGCACCGACCTCATGTCGGACGCCCCCGCCCCCGTTCCCGACCGCGCCCTAAAGGAACTCGGCAT
CGCCCTTCGCAAGTAG

Upstream 100 bases:

>100_bases
CGCTATGCGCTCAAGAACATGGCCACGGGCGAACAAGTGGAATTGACGCGAGACGAAATTGCCGCTCGGCTCGACGCGGC
CTCAAACTGAAAAGACCGAT

Downstream 100 bases:

>100_bases
TATTACACTGCCCTTGTTTGCTCGCAGACCGCAAACATCCGCACCGGAATATTCGCTGCCCCATCAGAGCCGCGACCGTG
AGGGAGCGTCCGTTGTACGT

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
METSVALDFLGDLRRTHMCGELRASNAGQKVLLMGWAHRRRDHGAVIFVDMRDRTGHTQAIFHEDVDPAIHKRAEEVRAE
YVIAVEGVVSLRSAATVNPNMPTGEVEVVASKIWILNESRTPPFPMEEHVDVAEDVRLKYRYVDLRRPQMQRNVIMRSQI
SFAVREFLYSEGFLEIETPFMTRSTPEGARDYLVPSRVQPGTFYALPQSPQIFKQLLMISGFEKYFQIVRCFRDEDLRAD
RQPEFTQIDLEMSFPQQAQIFAVIEPLIQKVCKVAGFDVPATFPRITYAEAMRNYGIDKPDTRIPPMHPVGDLMPELANL
GLPLVAIHIPACGTPSRKERDEFKAVGQEKGLRVYDDPKRLERDYPEQMAKVRERCGAKEDSLLVLATWGGAEAPVRRPE
ETVYQACGQLRLVLASKFNDRHKLLDPKNFQFLWVVDFPMFEWNEEDNRWVAAHHPFTSVHDEDIDLLTADPAKCRAKSY
DLVLNGVELGSGSIRIHRRDVQAKVFAAVGFSDDEARRRFGYLLEALEYGAPPHGGIALGLDRLVMILAGETSIREVIPF
PKTARGTDLMSDAPAPVPDRALKELGIALRK

Sequences:

>Translated_591_residues
METSVALDFLGDLRRTHMCGELRASNAGQKVLLMGWAHRRRDHGAVIFVDMRDRTGHTQAIFHEDVDPAIHKRAEEVRAE
YVIAVEGVVSLRSAATVNPNMPTGEVEVVASKIWILNESRTPPFPMEEHVDVAEDVRLKYRYVDLRRPQMQRNVIMRSQI
SFAVREFLYSEGFLEIETPFMTRSTPEGARDYLVPSRVQPGTFYALPQSPQIFKQLLMISGFEKYFQIVRCFRDEDLRAD
RQPEFTQIDLEMSFPQQAQIFAVIEPLIQKVCKVAGFDVPATFPRITYAEAMRNYGIDKPDTRIPPMHPVGDLMPELANL
GLPLVAIHIPACGTPSRKERDEFKAVGQEKGLRVYDDPKRLERDYPEQMAKVRERCGAKEDSLLVLATWGGAEAPVRRPE
ETVYQACGQLRLVLASKFNDRHKLLDPKNFQFLWVVDFPMFEWNEEDNRWVAAHHPFTSVHDEDIDLLTADPAKCRAKSY
DLVLNGVELGSGSIRIHRRDVQAKVFAAVGFSDDEARRRFGYLLEALEYGAPPHGGIALGLDRLVMILAGETSIREVIPF
PKTARGTDLMSDAPAPVPDRALKELGIALRK
>Mature_591_residues
METSVALDFLGDLRRTHMCGELRASNAGQKVLLMGWAHRRRDHGAVIFVDMRDRTGHTQAIFHEDVDPAIHKRAEEVRAE
YVIAVEGVVSLRSAATVNPNMPTGEVEVVASKIWILNESRTPPFPMEEHVDVAEDVRLKYRYVDLRRPQMQRNVIMRSQI
SFAVREFLYSEGFLEIETPFMTRSTPEGARDYLVPSRVQPGTFYALPQSPQIFKQLLMISGFEKYFQIVRCFRDEDLRAD
RQPEFTQIDLEMSFPQQAQIFAVIEPLIQKVCKVAGFDVPATFPRITYAEAMRNYGIDKPDTRIPPMHPVGDLMPELANL
GLPLVAIHIPACGTPSRKERDEFKAVGQEKGLRVYDDPKRLERDYPEQMAKVRERCGAKEDSLLVLATWGGAEAPVRRPE
ETVYQACGQLRLVLASKFNDRHKLLDPKNFQFLWVVDFPMFEWNEEDNRWVAAHHPFTSVHDEDIDLLTADPAKCRAKSY
DLVLNGVELGSGSIRIHRRDVQAKVFAAVGFSDDEARRRFGYLLEALEYGAPPHGGIALGLDRLVMILAGETSIREVIPF
PKTARGTDLMSDAPAPVPDRALKELGIALRK

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI40789249, Length=614, Percent_Identity=42.671009771987, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI45439306, Length=251, Percent_Identity=28.2868525896414, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194272210, Length=246, Percent_Identity=25.609756097561, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI5031815, Length=246, Percent_Identity=25.609756097561, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1788173, Length=602, Percent_Identity=45.514950166113, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1789256, Length=325, Percent_Identity=25.2307692307692, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790571, Length=320, Percent_Identity=25.625, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI32566633, Length=604, Percent_Identity=37.5827814569536, Blast_Score=352, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI71994340, Length=253, Percent_Identity=25.296442687747, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535927, Length=253, Percent_Identity=25.296442687747, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535925, Length=253, Percent_Identity=25.296442687747, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551876, Length=259, Percent_Identity=28.1853281853282, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325153, Length=638, Percent_Identity=32.6018808777429, Blast_Score=295, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6323011, Length=314, Percent_Identity=24.8407643312102, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320242, Length=253, Percent_Identity=23.3201581027668, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24584738, Length=599, Percent_Identity=38.2303839732888, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI17136276, Length=254, Percent_Identity=24.8031496062992, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24640849, Length=254, Percent_Identity=25.1968503937008, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640851, Length=254, Percent_Identity=25.1968503937008, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.12 [H]

Molecular weight: Translated: 67050; Mature: 67050

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METSVALDFLGDLRRTHMCGELRASNAGQKVLLMGWAHRRRDHGAVIFVDMRDRTGHTQA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHCCCCCEEEEEEECCCCCCCCE
IFHEDVDPAIHKRAEEVRAEYVIAVEGVVSLRSAATVNPNMPTGEVEVVASKIWILNESR
EECCCCCHHHHHHHHHHHHHEEEEEHHHHHHHHCCCCCCCCCCCHHEEEEEEEEEEECCC
TPPFPMEEHVDVAEDVRLKYRYVDLRRPQMQRNVIMRSQISFAVREFLYSEGFLEIETPF
CCCCCCHHCCCHHHHCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
MTRSTPEGARDYLVPSRVQPGTFYALPQSPQIFKQLLMISGFEKYFQIVRCFRDEDLRAD
CCCCCCCCCHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCC
RQPEFTQIDLEMSFPQQAQIFAVIEPLIQKVCKVAGFDVPATFPRITYAEAMRNYGIDKP
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCC
DTRIPPMHPVGDLMPELANLGLPLVAIHIPACGTPSRKERDEFKAVGQEKGLRVYDDPKR
CCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEECCHHH
LERDYPEQMAKVRERCGAKEDSLLVLATWGGAEAPVRRPEETVYQACGQLRLVLASKFND
HHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHEEHHHHCCCC
RHKLLDPKNFQFLWVVDFPMFEWNEEDNRWVAAHHPFTSVHDEDIDLLTADPAKCRAKSY
HHHCCCCCCCEEEEEEECCCEECCCCCCCEEEEECCCCCCCCCCCEEEECCCHHHCCCCC
DLVLNGVELGSGSIRIHRRDVQAKVFAAVGFSDDEARRRFGYLLEALEYGAPPHGGIALG
EEEEEEEEECCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
LDRLVMILAGETSIREVIPFPKTARGTDLMSDAPAPVPDRALKELGIALRK
HHHHEEHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
METSVALDFLGDLRRTHMCGELRASNAGQKVLLMGWAHRRRDHGAVIFVDMRDRTGHTQA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHCCCCCEEEEEEECCCCCCCCE
IFHEDVDPAIHKRAEEVRAEYVIAVEGVVSLRSAATVNPNMPTGEVEVVASKIWILNESR
EECCCCCHHHHHHHHHHHHHEEEEEHHHHHHHHCCCCCCCCCCCHHEEEEEEEEEEECCC
TPPFPMEEHVDVAEDVRLKYRYVDLRRPQMQRNVIMRSQISFAVREFLYSEGFLEIETPF
CCCCCCHHCCCHHHHCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
MTRSTPEGARDYLVPSRVQPGTFYALPQSPQIFKQLLMISGFEKYFQIVRCFRDEDLRAD
CCCCCCCCCHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCC
RQPEFTQIDLEMSFPQQAQIFAVIEPLIQKVCKVAGFDVPATFPRITYAEAMRNYGIDKP
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCC
DTRIPPMHPVGDLMPELANLGLPLVAIHIPACGTPSRKERDEFKAVGQEKGLRVYDDPKR
CCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEECCHHH
LERDYPEQMAKVRERCGAKEDSLLVLATWGGAEAPVRRPEETVYQACGQLRLVLASKFND
HHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHEEHHHHCCCC
RHKLLDPKNFQFLWVVDFPMFEWNEEDNRWVAAHHPFTSVHDEDIDLLTADPAKCRAKSY
HHHCCCCCCCEEEEEEECCCEECCCCCCCEEEEECCCCCCCCCCCEEEECCCHHHCCCCC
DLVLNGVELGSGSIRIHRRDVQAKVFAAVGFSDDEARRRFGYLLEALEYGAPPHGGIALG
EEEEEEEEECCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
LDRLVMILAGETSIREVIPFPKTARGTDLMSDAPAPVPDRALKELGIALRK
HHHHEEHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA