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The map label for this gene is recQ [H]

Identifier: 116620087

GI number: 116620087

Start: 1197201

End: 1199009

Strand: Direct

Name: recQ [H]

Synonym: Acid_0959

Alternate gene names: 116620087

Gene position: 1197201-1199009 (Clockwise)

Preceding gene: 116620086

Following gene: 116620093

Centisome position: 12.01

GC content: 65.73

Gene sequence:

>1809_bases
GTGGAAGATCTTCACTCGGCCCTGAAGCGCTACTGGGGATACGACACCTTCCGCCCCATGCAGGAGCGCATCATTCAGAG
CCTGATGGGCGGCGCGGACGTGGCGGTCGTGATGCCCACCGGCGGCGGGAAATCGCTCTGCTACCAATTGCCGGCGCTCG
CGCTCGGGCAGACGGTGGTCGTCATCTCGCCTTTGATCGCGCTCATGCAGGACCAGGTGGCACAGCTCGCCGACATGGGC
GTCCCGGCCGCGCTGATCAACAGCTCGCAGGCTTCGGACGAACAGCGAGAAGTGATGCGCGCGGCGACGGAGGGGGCGTT
TCGCCTGATCTACATTTCGCCCGAGCGCCTCGCCCGCCAGGACACCATCGGCTGGCTGCAACGCATCCCGCTGGCCTTCT
TCGCCATCGACGAGGCGCACTGCATCTCTGAATGGGGCCACGAATTCCGTCCCGAGTACCGGCAGCTCAGCTCGCTGCGC
GAGAACTTCCCGGATCACCCGATCGCCGCCTTCACGGCGAGCGCGACGCAGCGGGTGCGCCACGACATTCTCGCGCAGCT
TCGCCTGCGCCAGCCGCACAAGTTCATCGCCAGCTTCCATCGCGCGAACCTGCGCTACGTGACGCACCGGTGCGATAAGG
AGACGCACCAGCAGCTTCTGCTCGCCGCGATGCGCGCCTATGAGGGCGAGAGCGTGATCGTCTACGCACCCACCATCGCG
GCAGTGGAGCAGACGGTGGACTTCCTGGAAGGCCAGCGCATTGCCGCCGTACCCTATCACGGCCAGATGGATAACGGCAT
TCGCCGCCGCAACCAGGAACGCTGGATGAACGACGAAGTTCGCGTCATGGTAGGCACCATCGCTTTCGGTCTCGGCATCA
ACAAGCCGGCGGTGCGGGCGGTGATTCACACATCGCTGCCCAAATCGATCGAGCAGTATTACCAGGAGGCCGGACGCGCG
GGGCGCGACGGGCTTCCGGCCGATTGCGTGGTGCTCTGGCAGGCTCGCGATGCAGGGCTGCTCGCCTACTTCATCAACCA
GCTGCAGGACCCGGTGGAGAAGGAACGCGGCTGGGAGCGCTACCGCACTATCCGCCGCTTCGTGGAGAGCGCCGATTGCC
GCCACCTGCAGATCTGCACCCATTTCGGCCAGGTCCCGAAGTGGACCCGCTGCGAGATGTGCGACGCCTGCGGCAACGCT
CCGGAGTGGCTTTCGACGCCCACGGCGACACCGGTCAGTTTGCCGAAGGGCGATCGCGAGCTGGTGGCGTTGTTCAAGGA
GTGGCGATGGAGGACGGCGCAGCGCATGGGAGTGCCGGCCTATGTCGTGCTCAACGACGCGTCGCTCGAGGACCTCTGCC
ACAAGCGCCCCGCGCAGTTGCGCGAACTCACCAGCGTCACCGGCATTGGCGAACGTAAGGCCGAGCTGTATGGCGTCGAG
ATCCTGGCCGTCTTCGAAGCGTATGCCAAGGGAGCCCGCGCAGAAGTGCGCGAGACGACGCGCGTATCTCCCGCCGACGA
GACCTTACGCCTGCTCGCCGAGGGCAAGAGCTTCGACGAGATCGCCCAAATCCGCGGCCGCCAACGCAGCACCGTCGTGA
GCCAGGTGGCGGAGCTCGTCGAGAGCGGTCGTCTCGCGTATCGGGTGGACTGGCTCGGCGAAGAGAGTCACGAAAAGATC
GTCGAAGCCGCCGGCCGCTTCGGCTCGGAGCGGCTCAAGCCTCTCCGCGAAGCCCTGCCCGCGGAGATCAGTTACGACCA
GATCCGCCTCGGTGTAGCTTACGTCCGCAACCGCGAAGCCCAAAGCTAG

Upstream 100 bases:

>100_bases
CTGGCGGTCGCGGCTCTGATGCGAATCTTCGCGGGCTGCGAACAGACAGATCTCCCTCACGGGCGCGGCTCGTTGGCTTG
GTACACTTTTAGTTCAATAC

Downstream 100 bases:

>100_bases
CTTGCCCGGCCCCGCCAGCGGGAAACCAGTTCGCGGGCGGCCGCGGGCCACTCGGGGAATAGGAACGTGAAGCCCGCGTC
GAGCAGACGACCCGGCACCA

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MEDLHSALKRYWGYDTFRPMQERIIQSLMGGADVAVVMPTGGGKSLCYQLPALALGQTVVVISPLIALMQDQVAQLADMG
VPAALINSSQASDEQREVMRAATEGAFRLIYISPERLARQDTIGWLQRIPLAFFAIDEAHCISEWGHEFRPEYRQLSSLR
ENFPDHPIAAFTASATQRVRHDILAQLRLRQPHKFIASFHRANLRYVTHRCDKETHQQLLLAAMRAYEGESVIVYAPTIA
AVEQTVDFLEGQRIAAVPYHGQMDNGIRRRNQERWMNDEVRVMVGTIAFGLGINKPAVRAVIHTSLPKSIEQYYQEAGRA
GRDGLPADCVVLWQARDAGLLAYFINQLQDPVEKERGWERYRTIRRFVESADCRHLQICTHFGQVPKWTRCEMCDACGNA
PEWLSTPTATPVSLPKGDRELVALFKEWRWRTAQRMGVPAYVVLNDASLEDLCHKRPAQLRELTSVTGIGERKAELYGVE
ILAVFEAYAKGARAEVRETTRVSPADETLRLLAEGKSFDEIAQIRGRQRSTVVSQVAELVESGRLAYRVDWLGEESHEKI
VEAAGRFGSERLKPLREALPAEISYDQIRLGVAYVRNREAQS

Sequences:

>Translated_602_residues
MEDLHSALKRYWGYDTFRPMQERIIQSLMGGADVAVVMPTGGGKSLCYQLPALALGQTVVVISPLIALMQDQVAQLADMG
VPAALINSSQASDEQREVMRAATEGAFRLIYISPERLARQDTIGWLQRIPLAFFAIDEAHCISEWGHEFRPEYRQLSSLR
ENFPDHPIAAFTASATQRVRHDILAQLRLRQPHKFIASFHRANLRYVTHRCDKETHQQLLLAAMRAYEGESVIVYAPTIA
AVEQTVDFLEGQRIAAVPYHGQMDNGIRRRNQERWMNDEVRVMVGTIAFGLGINKPAVRAVIHTSLPKSIEQYYQEAGRA
GRDGLPADCVVLWQARDAGLLAYFINQLQDPVEKERGWERYRTIRRFVESADCRHLQICTHFGQVPKWTRCEMCDACGNA
PEWLSTPTATPVSLPKGDRELVALFKEWRWRTAQRMGVPAYVVLNDASLEDLCHKRPAQLRELTSVTGIGERKAELYGVE
ILAVFEAYAKGARAEVRETTRVSPADETLRLLAEGKSFDEIAQIRGRQRSTVVSQVAELVESGRLAYRVDWLGEESHEKI
VEAAGRFGSERLKPLREALPAEISYDQIRLGVAYVRNREAQS
>Mature_602_residues
MEDLHSALKRYWGYDTFRPMQERIIQSLMGGADVAVVMPTGGGKSLCYQLPALALGQTVVVISPLIALMQDQVAQLADMG
VPAALINSSQASDEQREVMRAATEGAFRLIYISPERLARQDTIGWLQRIPLAFFAIDEAHCISEWGHEFRPEYRQLSSLR
ENFPDHPIAAFTASATQRVRHDILAQLRLRQPHKFIASFHRANLRYVTHRCDKETHQQLLLAAMRAYEGESVIVYAPTIA
AVEQTVDFLEGQRIAAVPYHGQMDNGIRRRNQERWMNDEVRVMVGTIAFGLGINKPAVRAVIHTSLPKSIEQYYQEAGRA
GRDGLPADCVVLWQARDAGLLAYFINQLQDPVEKERGWERYRTIRRFVESADCRHLQICTHFGQVPKWTRCEMCDACGNA
PEWLSTPTATPVSLPKGDRELVALFKEWRWRTAQRMGVPAYVVLNDASLEDLCHKRPAQLRELTSVTGIGERKAELYGVE
ILAVFEAYAKGARAEVRETTRVSPADETLRLLAEGKSFDEIAQIRGRQRSTVVSQVAELVESGRLAYRVDWLGEESHEKI
VEAAGRFGSERLKPLREALPAEISYDQIRLGVAYVRNREAQS

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=412, Percent_Identity=35.4368932038835, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI110735439, Length=410, Percent_Identity=36.5853658536585, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI169218196, Length=410, Percent_Identity=36.5853658536585, Blast_Score=269, Evalue=7e-72,
Organism=Homo sapiens, GI14591902, Length=405, Percent_Identity=35.0617283950617, Blast_Score=262, Evalue=7e-70,
Organism=Homo sapiens, GI14591904, Length=405, Percent_Identity=35.0617283950617, Blast_Score=262, Evalue=7e-70,
Organism=Homo sapiens, GI148612816, Length=423, Percent_Identity=35.9338061465721, Blast_Score=243, Evalue=5e-64,
Organism=Homo sapiens, GI51242943, Length=372, Percent_Identity=37.3655913978495, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI51242947, Length=370, Percent_Identity=37.5675675675676, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI284005309, Length=350, Percent_Identity=34.8571428571429, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI222352149, Length=371, Percent_Identity=23.1805929919137, Blast_Score=77, Evalue=7e-14,
Organism=Escherichia coli, GI48994977, Length=485, Percent_Identity=39.3814432989691, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI87082221, Length=352, Percent_Identity=21.5909090909091, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71987997, Length=437, Percent_Identity=34.7826086956522, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71987993, Length=437, Percent_Identity=34.7826086956522, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI32564293, Length=409, Percent_Identity=37.1638141809291, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI25145561, Length=411, Percent_Identity=36.0097323600973, Blast_Score=265, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI17552866, Length=403, Percent_Identity=36.9727047146402, Blast_Score=260, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17510307, Length=362, Percent_Identity=22.3756906077348, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17510309, Length=362, Percent_Identity=22.3756906077348, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71995514, Length=362, Percent_Identity=22.3756906077348, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=397, Percent_Identity=36.272040302267, Blast_Score=276, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6323947, Length=336, Percent_Identity=25, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324217, Length=345, Percent_Identity=21.4492753623188, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646066, Length=412, Percent_Identity=38.1067961165049, Blast_Score=278, Evalue=9e-75,
Organism=Drosophila melanogaster, GI24664226, Length=429, Percent_Identity=35.8974358974359, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI62472181, Length=429, Percent_Identity=35.8974358974359, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24664230, Length=429, Percent_Identity=35.8974358974359, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI21358123, Length=371, Percent_Identity=34.5013477088949, Blast_Score=198, Evalue=9e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 68008; Mature: 68008

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDLHSALKRYWGYDTFRPMQERIIQSLMGGADVAVVMPTGGGKSLCYQLPALALGQTVV
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCHHH
VISPLIALMQDQVAQLADMGVPAALINSSQASDEQREVMRAATEGAFRLIYISPERLARQ
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECHHHHHHH
DTIGWLQRIPLAFFAIDEAHCISEWGHEFRPEYRQLSSLRENFPDHPIAAFTASATQRVR
HHHHHHHHCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
HDILAQLRLRQPHKFIASFHRANLRYVTHRCDKETHQQLLLAAMRAYEGESVIVYAPTIA
HHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCHHH
AVEQTVDFLEGQRIAAVPYHGQMDNGIRRRNQERWMNDEVRVMVGTIAFGLGINKPAVRA
HHHHHHHHHCCCEEEECCCCCCCCHHHHHCCHHHCCCCHHHHHHHHHHHHCCCCCHHHHH
VIHTSLPKSIEQYYQEAGRAGRDGLPADCVVLWQARDAGLLAYFINQLQDPVEKERGWER
HHHHHCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
YRTIRRFVESADCRHLQICTHFGQVPKWTRCEMCDACGNAPEWLSTPTATPVSLPKGDRE
HHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
LVALFKEWRWRTAQRMGVPAYVVLNDASLEDLCHKRPAQLRELTSVTGIGERKAELYGVE
HHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHH
ILAVFEAYAKGARAEVRETTRVSPADETLRLLAEGKSFDEIAQIRGRQRSTVVSQVAELV
HHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHH
ESGRLAYRVDWLGEESHEKIVEAAGRFGSERLKPLREALPAEISYDQIRLGVAYVRNREA
HCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
QS
CC
>Mature Secondary Structure
MEDLHSALKRYWGYDTFRPMQERIIQSLMGGADVAVVMPTGGGKSLCYQLPALALGQTVV
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCHHH
VISPLIALMQDQVAQLADMGVPAALINSSQASDEQREVMRAATEGAFRLIYISPERLARQ
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECHHHHHHH
DTIGWLQRIPLAFFAIDEAHCISEWGHEFRPEYRQLSSLRENFPDHPIAAFTASATQRVR
HHHHHHHHCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
HDILAQLRLRQPHKFIASFHRANLRYVTHRCDKETHQQLLLAAMRAYEGESVIVYAPTIA
HHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCHHH
AVEQTVDFLEGQRIAAVPYHGQMDNGIRRRNQERWMNDEVRVMVGTIAFGLGINKPAVRA
HHHHHHHHHCCCEEEECCCCCCCCHHHHHCCHHHCCCCHHHHHHHHHHHHCCCCCHHHHH
VIHTSLPKSIEQYYQEAGRAGRDGLPADCVVLWQARDAGLLAYFINQLQDPVEKERGWER
HHHHHCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
YRTIRRFVESADCRHLQICTHFGQVPKWTRCEMCDACGNAPEWLSTPTATPVSLPKGDRE
HHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
LVALFKEWRWRTAQRMGVPAYVVLNDASLEDLCHKRPAQLRELTSVTGIGERKAELYGVE
HHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHH
ILAVFEAYAKGARAEVRETTRVSPADETLRLLAEGKSFDEIAQIRGRQRSTVVSQVAELV
HHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHH
ESGRLAYRVDWLGEESHEKIVEAAGRFGSERLKPLREALPAEISYDQIRLGVAYVRNREA
HCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
QS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]