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The map label for this gene is ywaD [H]

Identifier: 116620008

GI number: 116620008

Start: 1100170

End: 1101804

Strand: Direct

Name: ywaD [H]

Synonym: Acid_0880

Alternate gene names: 116620008

Gene position: 1100170-1101804 (Clockwise)

Preceding gene: 116620007

Following gene: 116620012

Centisome position: 11.04

GC content: 63.55

Gene sequence:

>1635_bases
ATGAGAAAAATCGCCGTCGTCCTGCTCCTCTCCGCCCTGCCCGCGCTCTGTCAGGAACGCGTAGACCTCGGTGTGGTCGA
TCGAATCAAAGCCGAGGCCTTCGAGCATTCCAGGGTGATGGAGACCTTGCGCAACCTCACGGACGTTCGCGGTCCAAGGC
TCACCGGCTCCCCCGGCTTCGAAGCCGCGGCGCGTTGGGCCGTGGGCGAGCTCAACGGATACGGACTGGAAAAGGTGCAC
CTGGAAAAGTGGGGTCCCTTCGGACGCGCGTGGACGCTGGAACAGTCGTCACTCGAATTGTTGGAGCCGGGTTACCAGCA
GCTGACCGCGGTGCCGCTGGCCTGGAGTTCCTCCACCAATGGCCCCGTAACGGGCGATCTGGTACTCGCGCCGTTGCGCG
TATCTTTCCGCGATGGTCCCAGGAAACTTGAGGCGGCGATGCAGGCCTATCGCGCGCAGTGGTCTGGAAAGCTGCGCGGC
AAGATCGTCTTAATCAGCGCTCCCAAGGTGCCTCCCCAGCAGACCAGCCCCCAGTTCCGCCGCTATACCGCGGCCGAGCT
CGCGGACATGATGAATGCGCCCGCGCCCGCGGCAAGGATCACGGCGAAGAAGCTGGACGAACTGGATTGGCCCGAGGATC
CCGCGGATATCGGCAAGTTCTTCGGCAGCCTGCCCAATTCGCTGATGGAACAACTCTACGACTTGTACGACGAGGCCATT
GCCAAACGCGCTGAGTTCTTCGCCAAAGAAGGCGTGGCCGGCGGGTTGCAGCTCGACGACCGCGCCCACACCGGCATGCT
CTTCGCCGAGGCCGCCGGCGGATTCAAGGCTGCGGGCACACCGGCCCCGCCGACCTTCGTGGTGACCGCCGAACAATACA
ACCGGATCGGCCGGCTCTTAGAGAAGAAGAGTCCCGTCCGCGTCCGCATGAATCTGAAGGCCGCCATGTCGGACCGCGAC
CAGGACGGTTTGAATATCGTGGGTGAACTGCCCGGCGGCGATCGCAAGGATGAGATCGTGATGGTCGGCGCCCACTTCGA
TTCCTGGCACACCGGCACCGGCGCCACCGACAATGGCGCGGGTAGCGCCGTGATGATGGAGGTGATGCGCATTCTGAAGG
CGCTCAACCTCAAGCTCGATCGCACCGTCCGCATCGGTCTGTGGGGCGGCGAGGAAGAAGGACTGTTCGGTTCCCGCGCC
TATGTGAAAGAGCACTTCGCCGATCCCAAGACCATGCAGGTCACCAGCGACCACGCCAGGCTATCCGGCTATTTCAACCT
CGATAACGGCAGCGGCAAAATTCGCGGCGTCTACCTGCAGGGCCACGAAGCCATGCGCCCGATTTTCGAATCCTGGCTGG
CGCCCTTCCGCGACATGGGCGTGACCACCGTCACCATCCGCAACACTGGCGGCACCGATCACCTCAGCTTCGCCGCCGTC
GGACTGCCGGGCTTTCAGTTCATCCAGGATCCGCTGGATTACAGCACCATCACGCATCACTCCGATATGGATACCTGGGA
CCACGCGGTGCCCGAGGACCTGATGCAGGCCTCCGCCGTGATCGCGACCGTCGTCTACCAGACCGCGACCCGCAAGGAGC
TGCTGCCGCGGCGTGAACTGCCGAAACCCGAGTAA

Upstream 100 bases:

>100_bases
GCGGAACCTCCGGCGCACCCACGCTAATCTCGTCGATGAGCTGCTCACCGATCTGCACCGCTGGCACGACGCCCTGCCGA
AGTAACTGTATACTGCGGAA

Downstream 100 bases:

>100_bases
TGAACCTCGAAGAGGCCAGGGCGTACGCCGGCGAGTGCGCGGATTGCCGCTTCGCACGCGTCAACCGCAGCGACCGCGGC
GCCGTCTTCTACCAGTGCGG

Product: peptidase M28

Products: NA

Alternate protein names: Arginyl aminopeptidase; BSAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MRKIAVVLLLSALPALCQERVDLGVVDRIKAEAFEHSRVMETLRNLTDVRGPRLTGSPGFEAAARWAVGELNGYGLEKVH
LEKWGPFGRAWTLEQSSLELLEPGYQQLTAVPLAWSSSTNGPVTGDLVLAPLRVSFRDGPRKLEAAMQAYRAQWSGKLRG
KIVLISAPKVPPQQTSPQFRRYTAAELADMMNAPAPAARITAKKLDELDWPEDPADIGKFFGSLPNSLMEQLYDLYDEAI
AKRAEFFAKEGVAGGLQLDDRAHTGMLFAEAAGGFKAAGTPAPPTFVVTAEQYNRIGRLLEKKSPVRVRMNLKAAMSDRD
QDGLNIVGELPGGDRKDEIVMVGAHFDSWHTGTGATDNGAGSAVMMEVMRILKALNLKLDRTVRIGLWGGEEEGLFGSRA
YVKEHFADPKTMQVTSDHARLSGYFNLDNGSGKIRGVYLQGHEAMRPIFESWLAPFRDMGVTTVTIRNTGGTDHLSFAAV
GLPGFQFIQDPLDYSTITHHSDMDTWDHAVPEDLMQASAVIATVVYQTATRKELLPRRELPKPE

Sequences:

>Translated_544_residues
MRKIAVVLLLSALPALCQERVDLGVVDRIKAEAFEHSRVMETLRNLTDVRGPRLTGSPGFEAAARWAVGELNGYGLEKVH
LEKWGPFGRAWTLEQSSLELLEPGYQQLTAVPLAWSSSTNGPVTGDLVLAPLRVSFRDGPRKLEAAMQAYRAQWSGKLRG
KIVLISAPKVPPQQTSPQFRRYTAAELADMMNAPAPAARITAKKLDELDWPEDPADIGKFFGSLPNSLMEQLYDLYDEAI
AKRAEFFAKEGVAGGLQLDDRAHTGMLFAEAAGGFKAAGTPAPPTFVVTAEQYNRIGRLLEKKSPVRVRMNLKAAMSDRD
QDGLNIVGELPGGDRKDEIVMVGAHFDSWHTGTGATDNGAGSAVMMEVMRILKALNLKLDRTVRIGLWGGEEEGLFGSRA
YVKEHFADPKTMQVTSDHARLSGYFNLDNGSGKIRGVYLQGHEAMRPIFESWLAPFRDMGVTTVTIRNTGGTDHLSFAAV
GLPGFQFIQDPLDYSTITHHSDMDTWDHAVPEDLMQASAVIATVVYQTATRKELLPRRELPKPE
>Mature_544_residues
MRKIAVVLLLSALPALCQERVDLGVVDRIKAEAFEHSRVMETLRNLTDVRGPRLTGSPGFEAAARWAVGELNGYGLEKVH
LEKWGPFGRAWTLEQSSLELLEPGYQQLTAVPLAWSSSTNGPVTGDLVLAPLRVSFRDGPRKLEAAMQAYRAQWSGKLRG
KIVLISAPKVPPQQTSPQFRRYTAAELADMMNAPAPAARITAKKLDELDWPEDPADIGKFFGSLPNSLMEQLYDLYDEAI
AKRAEFFAKEGVAGGLQLDDRAHTGMLFAEAAGGFKAAGTPAPPTFVVTAEQYNRIGRLLEKKSPVRVRMNLKAAMSDRD
QDGLNIVGELPGGDRKDEIVMVGAHFDSWHTGTGATDNGAGSAVMMEVMRILKALNLKLDRTVRIGLWGGEEEGLFGSRA
YVKEHFADPKTMQVTSDHARLSGYFNLDNGSGKIRGVYLQGHEAMRPIFESWLAPFRDMGVTTVTIRNTGGTDHLSFAAV
GLPGFQFIQDPLDYSTITHHSDMDTWDHAVPEDLMQASAVIATVVYQTATRKELLPRRELPKPE

Specific function: Catalyzes the hydrolysis of a range of N-terminal amino acids [H]

COG id: COG2234

COG function: function code R; Predicted aminopeptidases

Gene ontology:

Cell location: Secreted (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M28 family. M28B subfamily [H]

Homologues:

Organism=Homo sapiens, GI7706387, Length=259, Percent_Identity=29.3436293436293, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007484
- InterPro:   IPR003137 [H]

Pfam domain/function: PF02225 PA; PF04389 Peptidase_M28 [H]

EC number: =3.4.11.6; =3.4.11.10 [H]

Molecular weight: Translated: 59783; Mature: 59783

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIAVVLLLSALPALCQERVDLGVVDRIKAEAFEHSRVMETLRNLTDVRGPRLTGSPGF
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
EAAARWAVGELNGYGLEKVHLEKWGPFGRAWTLEQSSLELLEPGYQQLTAVPLAWSSSTN
HHHHHHHHCCCCCCCCCEEEHHHCCCCCCEEEECCCCHHHHCCCHHHHEEEEEEECCCCC
GPVTGDLVLAPLRVSFRDGPRKLEAAMQAYRAQWSGKLRGKIVLISAPKVPPQQTSPQFR
CCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHH
RYTAAELADMMNAPAPAARITAKKLDELDWPEDPADIGKFFGSLPNSLMEQLYDLYDEAI
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHH
AKRAEFFAKEGVAGGLQLDDRAHTGMLFAEAAGGFKAAGTPAPPTFVVTAEQYNRIGRLL
HHHHHHHHHCCCCCCCEECCCCCCCEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
EKKSPVRVRMNLKAAMSDRDQDGLNIVGELPGGDRKDEIVMVGAHFDSWHTGTGATDNGA
HCCCCEEEEEEEHHHHCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
GSAVMMEVMRILKALNLKLDRTVRIGLWGGEEEGLFGSRAYVKEHFADPKTMQVTSDHAR
CHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEEECCCCE
LSGYFNLDNGSGKIRGVYLQGHEAMRPIFESWLAPFRDMGVTTVTIRNTGGTDHLSFAAV
EEEEEEECCCCCEEEEEEEECHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEEE
GLPGFQFIQDPLDYSTITHHSDMDTWDHAVPEDLMQASAVIATVVYQTATRKELLPRREL
CCCCHHHHHCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PKPE
CCCC
>Mature Secondary Structure
MRKIAVVLLLSALPALCQERVDLGVVDRIKAEAFEHSRVMETLRNLTDVRGPRLTGSPGF
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
EAAARWAVGELNGYGLEKVHLEKWGPFGRAWTLEQSSLELLEPGYQQLTAVPLAWSSSTN
HHHHHHHHCCCCCCCCCEEEHHHCCCCCCEEEECCCCHHHHCCCHHHHEEEEEEECCCCC
GPVTGDLVLAPLRVSFRDGPRKLEAAMQAYRAQWSGKLRGKIVLISAPKVPPQQTSPQFR
CCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHH
RYTAAELADMMNAPAPAARITAKKLDELDWPEDPADIGKFFGSLPNSLMEQLYDLYDEAI
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHH
AKRAEFFAKEGVAGGLQLDDRAHTGMLFAEAAGGFKAAGTPAPPTFVVTAEQYNRIGRLL
HHHHHHHHHCCCCCCCEECCCCCCCEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
EKKSPVRVRMNLKAAMSDRDQDGLNIVGELPGGDRKDEIVMVGAHFDSWHTGTGATDNGA
HCCCCEEEEEEEHHHHCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
GSAVMMEVMRILKALNLKLDRTVRIGLWGGEEEGLFGSRAYVKEHFADPKTMQVTSDHAR
CHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEEECCCCE
LSGYFNLDNGSGKIRGVYLQGHEAMRPIFESWLAPFRDMGVTTVTIRNTGGTDHLSFAAV
EEEEEEECCCCCEEEEEEEECHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEEE
GLPGFQFIQDPLDYSTITHHSDMDTWDHAVPEDLMQASAVIATVVYQTATRKELLPRREL
CCCCHHHHHCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PKPE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377; 1806041 [H]