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The map label for this gene is polX [H]

Identifier: 116619976

GI number: 116619976

Start: 1051266

End: 1053011

Strand: Direct

Name: polX [H]

Synonym: Acid_0848

Alternate gene names: 116619976

Gene position: 1051266-1053011 (Clockwise)

Preceding gene: 116619973

Following gene: 116619977

Centisome position: 10.55

GC content: 64.2

Gene sequence:

>1746_bases
ATGCAGGAGCGAGGCTTGGAGAATAAGGAAATCGCGCGCGTGCTCTGGGAGACCGCCGACCTGATGGAGATTGCCGGCGA
AGATGGGTTCCGCATCCGCAGCTATCGCAACGGCGCGACTGCCGTGGAAGGTTATCCCGAACGCATCGTCGATATTTTGC
GCGACGCCGCGCGCAAGGTGACCGACATTCCGGGAATTGGCAAGGGCCTGGCGCAGGTACTCATCGAGATCACCGAGCGA
GGCTCCTGCGAACGCCGCGATCTTCTGCTCGCCAAATTTCCGCCAACCGCTCTCGAATTCCTCAAGATTCAGGGCCTCGG
CCCTAAGAGCATCGCGCTCATCTTCGAACACTTTCGCACCAGCACCATCGATGAGCTGGAGCGGCTGTGTCAGGAGCAGA
AGCTGCGTGACTTGCCGCGCATGGGCGCCAAGCTCGAAGAGAAGGTGCTGCGCAGCATCGCGCAATACCGCCAGCGCACC
GGCCGCTACCTGTTGAGCTATGCCGAAGGCATGGCGCAGGAACTCGCGGAGGTGCTCGGCAAGACGCCGGGAGTGGACCG
GGTGACCACGGCCGGGAGCCTGCGCCGGGGCCGCGAGACCGTCGGCGACCTGGACCTGCTGGTCACCGGACCCGCGCCCA
CCGCGGCGCTGGACGTCTTCGTGGCCTACCCGCGCGTGGAGGAGGTGCTCGGCCACGGCGAAAACAAGGCCAGCGCCAAA
GTCGGCCGCGAAGGGCTGCAGGTCGATGTCCGCACGCTGCCGCCGGAGAGCTTCGGCGCGGCCATGCAGTATTTCACCGG
CAGCAAAGATCACAATGTCGCGATCCGCATGCGCGCGGTGAAGATGGGTCTGAAGCTCAATGAATATGGCCTCTTCCGCG
TGGAGGACGAGGCCAGGGTGGCCGGCGAAACCGAGGAAGGCATCTACCGGGCGCTCGGTCTGCCGTGGATCCCGCCGGAG
CTGCGCGAGAATACCGGCGAGATTGAAGCCGCCGAACAGGGCCGCCTGCCGGAGCTGGTGACGCTGGCTGAGATCCGCGG
CGATCTTCACATGCACACCACCGAGACCGATGGCCGCGCCACGCTCGAGGAAATGGCCGAGGCCGCACGCGAAAAAGGCT
ACGAATACATCGCCATCACGGACCATTCCAAAGCGCTCTCCATGACCAACGGGCTCGATGAAAAGCGCGTGGTGGAGTTC
GCGCGGCGCGTGCGGGAGATCAATCGCGCCGGCCTGGGCATCCGCATCTTCAGCGGCATCGAGTGCGACATTCTCAAGGA
TGGCGCCATGGATTTGGAAAATGACGCGCTGGCCGAGCTCGATCTCGTGATCGGCAGCGTTCACAGTCATATGAACCAGG
AGGGGGCCGAGATGACGGACCGGTTGCTGCGCGCGCTGGAATGCCCCCACCTGCGCATCCTCGGGCATCCCACGGGCCGC
ATTCTGTTGCACCGCGACCCGTTCCCGTTCGATTTCGACCGTATCGCAACCGAAGCCGTGCGCCGCGGCGTGTGGCTCGA
AATCAACGCCAGCCCGGAACGGCTGGATCTGCACGGCACGCTGATCCGCACCGCCAAAGCCAAAGGCGCGAGGTTCACTA
TCTCGACTGACGCGCACCATCCCAAGCACCTCGGCAGCATGCGATATGGCGTGCTCACCGCGCGCCGCGGCTGGCTTGGC
CCAGACGATATTTTGAATACGCGTAACGCCGGCGAGTTCGCCAAGGCGCTCCAAACAAGATCATGA

Upstream 100 bases:

>100_bases
TCAAGAGAATTACCGATTGAACCGAAAGATGACGCACATCCCTGATGACGCGCACGCTGGGCAAAAAGACTCTTTTCCGC
GGTCCGACTCGTTACAATTG

Downstream 100 bases:

>100_bases
AAATCACATCTTCCAAGCAGGTCTACGATTGCGGCCTCTTCCGCGTCACTGAGGATAGGGCGGTCGATCCGAAAACCAAG
TTCGAGATCAAGCGCAGTGT

Product: phosphotransferase domain-containing protein

Products: NA

Alternate protein names: DNA polymerase type-X; 3'-5' exodeoxyribonuclease; 3'-5' exonuclease [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MQERGLENKEIARVLWETADLMEIAGEDGFRIRSYRNGATAVEGYPERIVDILRDAARKVTDIPGIGKGLAQVLIEITER
GSCERRDLLLAKFPPTALEFLKIQGLGPKSIALIFEHFRTSTIDELERLCQEQKLRDLPRMGAKLEEKVLRSIAQYRQRT
GRYLLSYAEGMAQELAEVLGKTPGVDRVTTAGSLRRGRETVGDLDLLVTGPAPTAALDVFVAYPRVEEVLGHGENKASAK
VGREGLQVDVRTLPPESFGAAMQYFTGSKDHNVAIRMRAVKMGLKLNEYGLFRVEDEARVAGETEEGIYRALGLPWIPPE
LRENTGEIEAAEQGRLPELVTLAEIRGDLHMHTTETDGRATLEEMAEAAREKGYEYIAITDHSKALSMTNGLDEKRVVEF
ARRVREINRAGLGIRIFSGIECDILKDGAMDLENDALAELDLVIGSVHSHMNQEGAEMTDRLLRALECPHLRILGHPTGR
ILLHRDPFPFDFDRIATEAVRRGVWLEINASPERLDLHGTLIRTAKAKGARFTISTDAHHPKHLGSMRYGVLTARRGWLG
PDDILNTRNAGEFAKALQTRS

Sequences:

>Translated_581_residues
MQERGLENKEIARVLWETADLMEIAGEDGFRIRSYRNGATAVEGYPERIVDILRDAARKVTDIPGIGKGLAQVLIEITER
GSCERRDLLLAKFPPTALEFLKIQGLGPKSIALIFEHFRTSTIDELERLCQEQKLRDLPRMGAKLEEKVLRSIAQYRQRT
GRYLLSYAEGMAQELAEVLGKTPGVDRVTTAGSLRRGRETVGDLDLLVTGPAPTAALDVFVAYPRVEEVLGHGENKASAK
VGREGLQVDVRTLPPESFGAAMQYFTGSKDHNVAIRMRAVKMGLKLNEYGLFRVEDEARVAGETEEGIYRALGLPWIPPE
LRENTGEIEAAEQGRLPELVTLAEIRGDLHMHTTETDGRATLEEMAEAAREKGYEYIAITDHSKALSMTNGLDEKRVVEF
ARRVREINRAGLGIRIFSGIECDILKDGAMDLENDALAELDLVIGSVHSHMNQEGAEMTDRLLRALECPHLRILGHPTGR
ILLHRDPFPFDFDRIATEAVRRGVWLEINASPERLDLHGTLIRTAKAKGARFTISTDAHHPKHLGSMRYGVLTARRGWLG
PDDILNTRNAGEFAKALQTRS
>Mature_581_residues
MQERGLENKEIARVLWETADLMEIAGEDGFRIRSYRNGATAVEGYPERIVDILRDAARKVTDIPGIGKGLAQVLIEITER
GSCERRDLLLAKFPPTALEFLKIQGLGPKSIALIFEHFRTSTIDELERLCQEQKLRDLPRMGAKLEEKVLRSIAQYRQRT
GRYLLSYAEGMAQELAEVLGKTPGVDRVTTAGSLRRGRETVGDLDLLVTGPAPTAALDVFVAYPRVEEVLGHGENKASAK
VGREGLQVDVRTLPPESFGAAMQYFTGSKDHNVAIRMRAVKMGLKLNEYGLFRVEDEARVAGETEEGIYRALGLPWIPPE
LRENTGEIEAAEQGRLPELVTLAEIRGDLHMHTTETDGRATLEEMAEAAREKGYEYIAITDHSKALSMTNGLDEKRVVEF
ARRVREINRAGLGIRIFSGIECDILKDGAMDLENDALAELDLVIGSVHSHMNQEGAEMTDRLLRALECPHLRILGHPTGR
ILLHRDPFPFDFDRIATEAVRRGVWLEINASPERLDLHGTLIRTAKAKGARFTISTDAHHPKHLGSMRYGVLTARRGWLG
PDDILNTRNAGEFAKALQTRS

Specific function: Strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. The fact that PolX is able to conduct filling of a sing

COG id: COG1796

COG function: function code L; DNA polymerase IV (family X)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PHP family [H]

Homologues:

Organism=Homo sapiens, GI4505931, Length=308, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI7019491, Length=324, Percent_Identity=25, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI291463287, Length=324, Percent_Identity=25, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI291463291, Length=294, Percent_Identity=26.1904761904762, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002054
- InterPro:   IPR010996
- InterPro:   IPR003583
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR022311 [H]

Pfam domain/function: PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 64731; Mature: 64731

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQERGLENKEIARVLWETADLMEIAGEDGFRIRSYRNGATAVEGYPERIVDILRDAARKV
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
TDIPGIGKGLAQVLIEITERGSCERRDLLLAKFPPTALEFLKIQGLGPKSIALIFEHFRT
HCCCCCHHHHHHHHHHHHHCCCCCHHCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHC
STIDELERLCQEQKLRDLPRMGAKLEEKVLRSIAQYRQRTGRYLLSYAEGMAQELAEVLG
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KTPGVDRVTTAGSLRRGRETVGDLDLLVTGPAPTAALDVFVAYPRVEEVLGHGENKASAK
CCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCHHHHHHHCCCCCCHHHH
VGREGLQVDVRTLPPESFGAAMQYFTGSKDHNVAIRMRAVKMGLKLNEYGLFRVEDEARV
HCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEEEHHHCCEECCCCEEEECCHHHH
AGETEEGIYRALGLPWIPPELRENTGEIEAAEQGRLPELVTLAEIRGDLHMHTTETDGRA
CCCCHHHHHHHCCCCCCCHHHHCCCCCEEEHHCCCCCHHHHHHHHCCCEEEEECCCCCHH
TLEEMAEAAREKGYEYIAITDHSKALSMTNGLDEKRVVEFARRVREINRAGLGIRIFSGI
HHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCC
ECDILKDGAMDLENDALAELDLVIGSVHSHMNQEGAEMTDRLLRALECPHLRILGHPTGR
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCE
ILLHRDPFPFDFDRIATEAVRRGVWLEINASPERLDLHGTLIRTAKAKGARFTISTDAHH
EEEECCCCCCCHHHHHHHHHHCCEEEEECCCCCEEECCHHHHHHHCCCCCEEEEECCCCC
PKHLGSMRYGVLTARRGWLGPDDILNTRNAGEFAKALQTRS
CHHHCCHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MQERGLENKEIARVLWETADLMEIAGEDGFRIRSYRNGATAVEGYPERIVDILRDAARKV
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
TDIPGIGKGLAQVLIEITERGSCERRDLLLAKFPPTALEFLKIQGLGPKSIALIFEHFRT
HCCCCCHHHHHHHHHHHHHCCCCCHHCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHC
STIDELERLCQEQKLRDLPRMGAKLEEKVLRSIAQYRQRTGRYLLSYAEGMAQELAEVLG
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KTPGVDRVTTAGSLRRGRETVGDLDLLVTGPAPTAALDVFVAYPRVEEVLGHGENKASAK
CCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCHHHHHHHCCCCCCHHHH
VGREGLQVDVRTLPPESFGAAMQYFTGSKDHNVAIRMRAVKMGLKLNEYGLFRVEDEARV
HCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEEEHHHCCEECCCCEEEECCHHHH
AGETEEGIYRALGLPWIPPELRENTGEIEAAEQGRLPELVTLAEIRGDLHMHTTETDGRA
CCCCHHHHHHHCCCCCCCHHHHCCCCCEEEHHCCCCCHHHHHHHHCCCEEEEECCCCCHH
TLEEMAEAAREKGYEYIAITDHSKALSMTNGLDEKRVVEFARRVREINRAGLGIRIFSGI
HHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCC
ECDILKDGAMDLENDALAELDLVIGSVHSHMNQEGAEMTDRLLRALECPHLRILGHPTGR
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCE
ILLHRDPFPFDFDRIATEAVRRGVWLEINASPERLDLHGTLIRTAKAKGARFTISTDAHH
EEEECCCCCCCHHHHHHHHHHCCEEEEECCCCCEEECCHHHHHHHCCCCCEEEEECCCCC
PKHLGSMRYGVLTARRGWLGPDDILNTRNAGEFAKALQTRS
CHHHCCHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]