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The map label for this gene is rsbRA [H]

Identifier: 116619664

GI number: 116619664

Start: 638336

End: 639244

Strand: Direct

Name: rsbRA [H]

Synonym: Acid_0527

Alternate gene names: 116619664

Gene position: 638336-639244 (Clockwise)

Preceding gene: 116619660

Following gene: 116619665

Centisome position: 6.41

GC content: 60.73

Gene sequence:

>909_bases
ATGAATCCAACCCAGAATTCCCAAACGCGGATTCCCGAATTGCTCAACCGCGACCAACCTGCCCTACTTCAGGAATGGCT
GCGAAATCAGAATCGCAGCCGCGGATCGCGCATCAGCGAAGCCGAGCTGCGCGACGAATCCCGCAACCTGCTCGAAGCCA
TAGCCGCCGCCGCCACGGCATCCAAAGGCCGCCTCGATGAAGTCTCCGGTCCCGAATGGACTCCAGTGCGCGACCTGCTC
ACTCAGGTCTCCCATTCGCGGGCGAGGGCTGGTTTCTCCCAATCCGACACCGCCCGCTTCGTCTTTTCCCTGAAGCAGGC
CATCTTCACCCTTCTTCAGGCGGAACTGCAATCCGACCCCAAGTCCCTCGCCGATGAAACCTGGGTCGCCAGCACGCTCA
TCGATAACCTCGGGTTGCTCACCACCGAAGCCTACCTCAAGGCTCGCGAATCGGTCATTCAGCGCCAGCAGCAGGAAATG
CTCGAGCTCTCCACGCCGGTCGTCAAACTCTGGGATGGCATCGTTGCCGTACCCCTGATCGGCACGCTGGATAGCGAGCG
CACGCAAATCGTGATGGAAAGCCTCCTCCAGCAGGTGGTGGACACCGGAGCCTCCATCGCCATCATCGATATCACCGGAG
TTCCCACGGTCGATACGCTCGTCGCGCAGCACCTGCTGAAGACCGTCGCCGCCGCTCGCCTCATGGGCGCCGATTGCATC
ATCAGCGGCATTCGCCCCCAAATCGCCGCCACCATCGTTCACCTCGGCGTCGATCTCGGCAACGTGATCACTAAGGCCAC
TCTCGCCGACGCGTTTCGACTCGCCCTGCGCCGCCTTGGTCTGGCTGTGAAAATTGCGCCGCAAAATCTCCCCGTCAAGG
AAACTCATGGAACGGATTCCAATACTTAA

Upstream 100 bases:

>100_bases
CAAGGCGCTCCTGTTCTCCAGCGAACATTCCGTCGGACGCTATCCCTTAACATCCTGCTAACCTGCGACCGTAACAGCGG
GCCCCCCAGGCAACAAACAA

Downstream 100 bases:

>100_bases
GATGGGAAGATTCCTCCTGGTCACCATCCAGGTGGATATGCACGATCGTCTTGCCATGACCTTGCAGGACGACCTGACCA
CCATGATCTCCAAGATCTCA

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MNPTQNSQTRIPELLNRDQPALLQEWLRNQNRSRGSRISEAELRDESRNLLEAIAAAATASKGRLDEVSGPEWTPVRDLL
TQVSHSRARAGFSQSDTARFVFSLKQAIFTLLQAELQSDPKSLADETWVASTLIDNLGLLTTEAYLKARESVIQRQQQEM
LELSTPVVKLWDGIVAVPLIGTLDSERTQIVMESLLQQVVDTGASIAIIDITGVPTVDTLVAQHLLKTVAAARLMGADCI
ISGIRPQIAATIVHLGVDLGNVITKATLADAFRLALRRLGLAVKIAPQNLPVKETHGTDSNT

Sequences:

>Translated_302_residues
MNPTQNSQTRIPELLNRDQPALLQEWLRNQNRSRGSRISEAELRDESRNLLEAIAAAATASKGRLDEVSGPEWTPVRDLL
TQVSHSRARAGFSQSDTARFVFSLKQAIFTLLQAELQSDPKSLADETWVASTLIDNLGLLTTEAYLKARESVIQRQQQEM
LELSTPVVKLWDGIVAVPLIGTLDSERTQIVMESLLQQVVDTGASIAIIDITGVPTVDTLVAQHLLKTVAAARLMGADCI
ISGIRPQIAATIVHLGVDLGNVITKATLADAFRLALRRLGLAVKIAPQNLPVKETHGTDSNT
>Mature_302_residues
MNPTQNSQTRIPELLNRDQPALLQEWLRNQNRSRGSRISEAELRDESRNLLEAIAAAATASKGRLDEVSGPEWTPVRDLL
TQVSHSRARAGFSQSDTARFVFSLKQAIFTLLQAELQSDPKSLADETWVASTLIDNLGLLTTEAYLKARESVIQRQQQEM
LELSTPVVKLWDGIVAVPLIGTLDSERTQIVMESLLQQVVDTGASIAIIDITGVPTVDTLVAQHLLKTVAAARLMGADCI
ISGIRPQIAATIVHLGVDLGNVITKATLADAFRLALRRLGLAVKIAPQNLPVKETHGTDSNT

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 32908; Mature: 32908

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTQNSQTRIPELLNRDQPALLQEWLRNQNRSRGSRISEAELRDESRNLLEAIAAAATA
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SKGRLDEVSGPEWTPVRDLLTQVSHSRARAGFSQSDTARFVFSLKQAIFTLLQAELQSDP
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
KSLADETWVASTLIDNLGLLTTEAYLKARESVIQRQQQEMLELSTPVVKLWDGIVAVPLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHH
GTLDSERTQIVMESLLQQVVDTGASIAIIDITGVPTVDTLVAQHLLKTVAAARLMGADCI
HCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ISGIRPQIAATIVHLGVDLGNVITKATLADAFRLALRRLGLAVKIAPQNLPVKETHGTDS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCC
NT
CC
>Mature Secondary Structure
MNPTQNSQTRIPELLNRDQPALLQEWLRNQNRSRGSRISEAELRDESRNLLEAIAAAATA
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SKGRLDEVSGPEWTPVRDLLTQVSHSRARAGFSQSDTARFVFSLKQAIFTLLQAELQSDP
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
KSLADETWVASTLIDNLGLLTTEAYLKARESVIQRQQQEMLELSTPVVKLWDGIVAVPLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHH
GTLDSERTQIVMESLLQQVVDTGASIAIIDITGVPTVDTLVAQHLLKTVAAARLMGADCI
HCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ISGIRPQIAATIVHLGVDLGNVITKATLADAFRLALRRLGLAVKIAPQNLPVKETHGTDS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCC
NT
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]