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The map label for this gene is trxB [H]

Identifier: 116619576

GI number: 116619576

Start: 543150

End: 544823

Strand: Direct

Name: trxB [H]

Synonym: Acid_0437

Alternate gene names: 116619576

Gene position: 543150-544823 (Clockwise)

Preceding gene: 116619572

Following gene: 116619577

Centisome position: 5.45

GC content: 63.92

Gene sequence:

>1674_bases
GTGCCGAGTAAACCTGTATTGCTGGCGGTAGATGATGACACCGATGTGCTGCGTTCGGTGGAGAGCGACCTTCGCAAACA
CTACGCCAGGAAGTTTCGAATTGTCAGCGCCTCGTCCGGTAAAGCTGCGCTGGATGTGGTGGCCCGCCTGCGCACTCGCA
ACGAGGCGATCGCGCTTTTCCTGGTCGATTATCGGATGCCGCAGATGAATGGGATCGAGTTCCTGTCACAGGCTATCGCG
CAGAGTCCTGATGCCAAGCGAGTGCTGCTCACGGCCTATGCCGATACCGAGGCCGCGCTCCGCGCGATCAACGAAATTCA
TCTTAACCATTACCTGCTGAAACCCTGGAATCCGCCGGACCAGAACCTCTTCCCGGTGCTGGACGATCTGTTGGAGGATT
GGATGGCCAATTACCATCCGCCTTTCGAGGGCATCCGCGTGGTCGGTCCGCGATGGTCCCCGCACACCTACGAGCTGCGA
GCCTTCCTGGCCAAGAACTCCGTGCCCTACCGCTGGCTCGATGCCGATACCGCGGACCGCGACCCGGAGGTAAAGCGCGC
CCTGGATTCCCTACCCGCCGGAACTGCCCTGCCCGTCCTGATCTGCGAGGATGGCACGCAGCTTTCACAGCCCACCCCAG
GCGCGGTTGCCGCCCGCATCGGTCTGCGCACCCACTCCGAGACGCCGTTCTACGACCTGGTGATTGTCGGCGGGGGCCCG
GCCGGACTGGCTGCCGCGGTCTACGGGGCTTCCGAAGGATTGCGCACTGTAATCATCGAGCGGGACGCCCCCGGCGGACA
GGCCGGCCTGAGTTCGCGGATCGAAAATTACCTCGGCTTTCCTTCGGGCCTGAGCGGCGGCGATCTGGCGCGACGAGGTG
TCGCGCAGGCGCGCCGCTTTGGCGCCGAAATCCTTTCGCCGCAGCAGGCCGTGGGCATCCGGCAGGAAGGGCCTTATCGC
TATATCAAGCTGGCCGATGGCAACGAACTCTCCTGCCACGCGCTCTTGATCGCGACCGGCGTGCAGTGGCGCAAGCTCGA
CGTGCCCGGGATGGCGGCGCTGAACGGCGCCGGTGTCTACTACGGCGCTGGCCCCTACGAAGCCAACTCGTGCGATGGAG
AAGACGTCTATGTGGTGGGGGGAGCCAACTCCGCCGGGCAGGCGGCCATCAACTTTGCCCGCCACGCGCGCCGCGTGATC
ATGCTGATTCGCGGCCAGAGCTTGAATGCCACCATGTCGCAATATTTGATCGACGAGATTTCGCATACCCCGAACATCGA
AGTGCACGTGCAGTCGCGTGTGGTGGAAGTCCAGGGCAAGGAGCGCCTGGAATCCATCTCGATCGCCTGCCTCGGCGGCG
AGGTGCAGAACGTTGCGGCCAGCGCCCTCTACATCTTCATTGGCGCCGAGCCCAGCACCGAGTGGCTGGCGGGCTTTGTG
GAGCGCGATGAACGCGGATACCTGATTACCGGAAGCGACCTGATGCACAATGGCAAGCGGCCGTCCGGCTGGACGCTCGA
CCGCGATCCCGGCCTGCTCGAAACCAGCGTGCCCGGCGTCTTCGCGGTCGGCGATGTGCGCGCCGGGTCGGTCAAGCGTG
TTGCCTCCGGCGTGGGAGAGGGTTCTATCGCCATTCAATTCGTTCACCAGTACCTGGCGAAGGTGGCGGCATGA

Upstream 100 bases:

>100_bases
ATCATACCGAGCAGGAACTTCATGCCTGCATCGTATCGCGCGAAACTTCATCAGTAATAGGACTTGGAGTACATTCAGCA
TAAACGTCCTTGGAGGGTAG

Downstream 100 bases:

>100_bases
GCGACCTCGCCGCGGAATTGCGCGCCATCCCCGCTTTCTCGGAGCTCACCGGCGACGCGATCGATTGGCTCGCCGCCCAC
ATGGAGACCCTCTCCTTCGC

Product: response regulator receiver modulated FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MPSKPVLLAVDDDTDVLRSVESDLRKHYARKFRIVSASSGKAALDVVARLRTRNEAIALFLVDYRMPQMNGIEFLSQAIA
QSPDAKRVLLTAYADTEAALRAINEIHLNHYLLKPWNPPDQNLFPVLDDLLEDWMANYHPPFEGIRVVGPRWSPHTYELR
AFLAKNSVPYRWLDADTADRDPEVKRALDSLPAGTALPVLICEDGTQLSQPTPGAVAARIGLRTHSETPFYDLVIVGGGP
AGLAAAVYGASEGLRTVIIERDAPGGQAGLSSRIENYLGFPSGLSGGDLARRGVAQARRFGAEILSPQQAVGIRQEGPYR
YIKLADGNELSCHALLIATGVQWRKLDVPGMAALNGAGVYYGAGPYEANSCDGEDVYVVGGANSAGQAAINFARHARRVI
MLIRGQSLNATMSQYLIDEISHTPNIEVHVQSRVVEVQGKERLESISIACLGGEVQNVAASALYIFIGAEPSTEWLAGFV
ERDERGYLITGSDLMHNGKRPSGWTLDRDPGLLETSVPGVFAVGDVRAGSVKRVASGVGEGSIAIQFVHQYLAKVAA

Sequences:

>Translated_557_residues
MPSKPVLLAVDDDTDVLRSVESDLRKHYARKFRIVSASSGKAALDVVARLRTRNEAIALFLVDYRMPQMNGIEFLSQAIA
QSPDAKRVLLTAYADTEAALRAINEIHLNHYLLKPWNPPDQNLFPVLDDLLEDWMANYHPPFEGIRVVGPRWSPHTYELR
AFLAKNSVPYRWLDADTADRDPEVKRALDSLPAGTALPVLICEDGTQLSQPTPGAVAARIGLRTHSETPFYDLVIVGGGP
AGLAAAVYGASEGLRTVIIERDAPGGQAGLSSRIENYLGFPSGLSGGDLARRGVAQARRFGAEILSPQQAVGIRQEGPYR
YIKLADGNELSCHALLIATGVQWRKLDVPGMAALNGAGVYYGAGPYEANSCDGEDVYVVGGANSAGQAAINFARHARRVI
MLIRGQSLNATMSQYLIDEISHTPNIEVHVQSRVVEVQGKERLESISIACLGGEVQNVAASALYIFIGAEPSTEWLAGFV
ERDERGYLITGSDLMHNGKRPSGWTLDRDPGLLETSVPGVFAVGDVRAGSVKRVASGVGEGSIAIQFVHQYLAKVAA
>Mature_556_residues
PSKPVLLAVDDDTDVLRSVESDLRKHYARKFRIVSASSGKAALDVVARLRTRNEAIALFLVDYRMPQMNGIEFLSQAIAQ
SPDAKRVLLTAYADTEAALRAINEIHLNHYLLKPWNPPDQNLFPVLDDLLEDWMANYHPPFEGIRVVGPRWSPHTYELRA
FLAKNSVPYRWLDADTADRDPEVKRALDSLPAGTALPVLICEDGTQLSQPTPGAVAARIGLRTHSETPFYDLVIVGGGPA
GLAAAVYGASEGLRTVIIERDAPGGQAGLSSRIENYLGFPSGLSGGDLARRGVAQARRFGAEILSPQQAVGIRQEGPYRY
IKLADGNELSCHALLIATGVQWRKLDVPGMAALNGAGVYYGAGPYEANSCDGEDVYVVGGANSAGQAAINFARHARRVIM
LIRGQSLNATMSQYLIDEISHTPNIEVHVQSRVVEVQGKERLESISIACLGGEVQNVAASALYIFIGAEPSTEWLAGFVE
RDERGYLITGSDLMHNGKRPSGWTLDRDPGLLETSVPGVFAVGDVRAGSVKRVASGVGEGSIAIQFVHQYLAKVAA

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=342, Percent_Identity=30.1169590643275, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI87081763, Length=341, Percent_Identity=30.791788856305, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320560, Length=339, Percent_Identity=27.7286135693215, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6321898, Length=339, Percent_Identity=27.7286135693215, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 60129; Mature: 59998

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSKPVLLAVDDDTDVLRSVESDLRKHYARKFRIVSASSGKAALDVVARLRTRNEAIALF
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCEEEEE
LVDYRMPQMNGIEFLSQAIAQSPDAKRVLLTAYADTEAALRAINEIHLNHYLLKPWNPPD
EEECCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHCEEEECCCCCCC
QNLFPVLDDLLEDWMANYHPPFEGIRVVGPRWSPHTYELRAFLAKNSVPYRWLDADTADR
CCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCCC
DPEVKRALDSLPAGTALPVLICEDGTQLSQPTPGAVAARIGLRTHSETPFYDLVIVGGGP
CHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHEEEEECEECCCCCEEEEEEECCCC
AGLAAAVYGASEGLRTVIIERDAPGGQAGLSSRIENYLGFPSGLSGGDLARRGVAQARRF
HHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
GAEILSPQQAVGIRQEGPYRYIKLADGNELSCHALLIATGVQWRKLDVPGMAALNGAGVY
HHHHCCCHHHCCCCCCCCEEEEEEECCCCCEEEEEEEECCCEEEEECCCCCEEECCCEEE
YGAGPYEANSCDGEDVYVVGGANSAGQAAINFARHARRVIMLIRGQSLNATMSQYLIDEI
ECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHH
SHTPNIEVHVQSRVVEVQGKERLESISIACLGGEVQNVAASALYIFIGAEPSTEWLAGFV
CCCCCEEEEEEEEEEEECCHHHHHHEEEEEECCHHHHHEEEEEEEEEECCCCHHHHHHHH
ERDERGYLITGSDLMHNGKRPSGWTLDRDPGLLETSVPGVFAVGDVRAGSVKRVASGVGE
HCCCCCEEEECHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEECCCCCCCHHHHHHCCCC
GSIAIQFVHQYLAKVAA
CHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSKPVLLAVDDDTDVLRSVESDLRKHYARKFRIVSASSGKAALDVVARLRTRNEAIALF
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCEEEEE
LVDYRMPQMNGIEFLSQAIAQSPDAKRVLLTAYADTEAALRAINEIHLNHYLLKPWNPPD
EEECCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHCEEEECCCCCCC
QNLFPVLDDLLEDWMANYHPPFEGIRVVGPRWSPHTYELRAFLAKNSVPYRWLDADTADR
CCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCCC
DPEVKRALDSLPAGTALPVLICEDGTQLSQPTPGAVAARIGLRTHSETPFYDLVIVGGGP
CHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHEEEEECEECCCCCEEEEEEECCCC
AGLAAAVYGASEGLRTVIIERDAPGGQAGLSSRIENYLGFPSGLSGGDLARRGVAQARRF
HHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
GAEILSPQQAVGIRQEGPYRYIKLADGNELSCHALLIATGVQWRKLDVPGMAALNGAGVY
HHHHCCCHHHCCCCCCCCEEEEEEECCCCCEEEEEEEECCCEEEEECCCCCEEECCCEEE
YGAGPYEANSCDGEDVYVVGGANSAGQAAINFARHARRVIMLIRGQSLNATMSQYLIDEI
ECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHH
SHTPNIEVHVQSRVVEVQGKERLESISIACLGGEVQNVAASALYIFIGAEPSTEWLAGFV
CCCCCEEEEEEEEEEEECCHHHHHHEEEEEECCHHHHHEEEEEEEEEECCCCHHHHHHHH
ERDERGYLITGSDLMHNGKRPSGWTLDRDPGLLETSVPGVFAVGDVRAGSVKRVASGVGE
HCCCCCEEEECHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEECCCCCCCHHHHHHCCCC
GSIAIQFVHQYLAKVAA
CHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA