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The map label for this gene is zraR [H]

Identifier: 116619535

GI number: 116619535

Start: 496160

End: 497515

Strand: Direct

Name: zraR [H]

Synonym: Acid_0394

Alternate gene names: 116619535

Gene position: 496160-497515 (Clockwise)

Preceding gene: 116619534

Following gene: 116619536

Centisome position: 4.98

GC content: 61.87

Gene sequence:

>1356_bases
ATGAAGAGCCATTGGCAGATCCTCGTCGTCGATGACGAAGAGATCATGTGCGAATCGCTGGCCGCCTGGCTGCGTGAAGA
CGGGTACGGCGTGGATACCGCCTCCTCGGGCCGCGAGGCGGTGGAGAAATCACGGCTCAAGGACTTCGCGATTTATTTCG
TCGATCTCAAAATGCCCGGCGGCATGGACGGCATCGAGACCATGATGCAGATCCGCAAACTGCGGCCGGAGGCGTCGATT
ATCATCATTACGGCTTACGCCACCGTGGACACGGCGATCACCGCGATGAAAGAGGGCGCGCAGGAGTACATCGTCAAGCC
GTGCAATCCGGAAGAGATCTCGCTGCTGGTCAACCGCATCATCAAGGTGAAGAACCTACAGCGGGAGAATACGATTCTGC
GCAAGAAGCTGACGCGCCAGTATAGCGTGCACGACGTGATCAGCAAGAATCCGCGCATGCGCGAGATCATGGAGTTGGCA
TCCGAAGTCGCCAGCCTGCGCAGCACGGTGTTGATCCAGGGAGAGAGCGGAACCGGCAAAGAACTGGTGGCACGCGCGCT
GCACAATGCGGGCGACCGGGCCTCGAAACCCTTTGTGGCCGTGAGCTGCGCGGCGTTGGCGGAGACCCTGCTCGAGAGCG
AGCTTTTCGGCCATGAAAAGGGATCGTTCACGGGGGCCAATCAGCAGAAGCAGGGAAAGTTCGAGATGGCCGACGGCGGC
ACGATCTTCCTGGACGAGATCGGCGACATCTCGCCCAAGCTCCAGGTGGACCTGCTGCGGGTGCTGCAGGACCGCGCCTT
CTATCGCGTGGGCGGCAGTCAGGAAGTGCGCGTGGACGTGCGAGTGGTGGCGGCGACGCACGTGAACTTACAACAGGCCG
TGGCCGACGGCAAGTTCCGCGACGATCTGTTCTACCGGCTCAACGTGATCGAGATCCGCATTCCTCCGCTGCGTGAGCGG
CGTGAGGATATCCCGTTGTTGGCGGGACACTTCGTAGAGCGGGTGGCGCACGAACTGGGGCGCAACGTGAACGAGCTGAG
CGAGGGGGCGATGCGCCGCCTGCTGGACCACAACTGGCCGGGCAATGTGCGCGAGTTGGAGAACGCGGTTGAACGCGCGA
TCGTCACCTGCCGCGGAAGAATTCTGACGGAAGAGGATTTCGGATTCCTGGCCCAAACCGCGGCAGCGCCGGCGTGGTCC
ATTCCGCCGGGGGCCACGATTCAGGATATGGAGAAGGCGCTGATCACGGTCACGATCCAGCGCACGCAGGGCAATATCAA
GGAAGCGGCGGCGGTGCTCGGCATCGATCGGTCCACGCTGTACGAGAAGATCAAGCGCTACGAAATCCCGCGGTGA

Upstream 100 bases:

>100_bases
TGTCGCTCGCGACCACGGTCCGGCAGATTGATTTGAAGGACGACGCCTTTTGCGCCTCGTGTGCGGCGCGCTTGCGGCGT
CATCCCGGGGGACCAAACGT

Downstream 100 bases:

>100_bases
ACTATCCTATCTGCTATGCGGTACCGGGAGTTCGCTCCGGGAGAGGAAGCGTCGGGATTCGTCGAATGCTACTGGGTTCT
TGAGGGCGCGGAGCCCGGGA

Product: two component sigma54-specific Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKSHWQILVVDDEEIMCESLAAWLREDGYGVDTASSGREAVEKSRLKDFAIYFVDLKMPGGMDGIETMMQIRKLRPEASI
IIITAYATVDTAITAMKEGAQEYIVKPCNPEEISLLVNRIIKVKNLQRENTILRKKLTRQYSVHDVISKNPRMREIMELA
SEVASLRSTVLIQGESGTGKELVARALHNAGDRASKPFVAVSCAALAETLLESELFGHEKGSFTGANQQKQGKFEMADGG
TIFLDEIGDISPKLQVDLLRVLQDRAFYRVGGSQEVRVDVRVVAATHVNLQQAVADGKFRDDLFYRLNVIEIRIPPLRER
REDIPLLAGHFVERVAHELGRNVNELSEGAMRRLLDHNWPGNVRELENAVERAIVTCRGRILTEEDFGFLAQTAAAPAWS
IPPGATIQDMEKALITVTIQRTQGNIKEAAAVLGIDRSTLYEKIKRYEIPR

Sequences:

>Translated_451_residues
MKSHWQILVVDDEEIMCESLAAWLREDGYGVDTASSGREAVEKSRLKDFAIYFVDLKMPGGMDGIETMMQIRKLRPEASI
IIITAYATVDTAITAMKEGAQEYIVKPCNPEEISLLVNRIIKVKNLQRENTILRKKLTRQYSVHDVISKNPRMREIMELA
SEVASLRSTVLIQGESGTGKELVARALHNAGDRASKPFVAVSCAALAETLLESELFGHEKGSFTGANQQKQGKFEMADGG
TIFLDEIGDISPKLQVDLLRVLQDRAFYRVGGSQEVRVDVRVVAATHVNLQQAVADGKFRDDLFYRLNVIEIRIPPLRER
REDIPLLAGHFVERVAHELGRNVNELSEGAMRRLLDHNWPGNVRELENAVERAIVTCRGRILTEEDFGFLAQTAAAPAWS
IPPGATIQDMEKALITVTIQRTQGNIKEAAAVLGIDRSTLYEKIKRYEIPR
>Mature_451_residues
MKSHWQILVVDDEEIMCESLAAWLREDGYGVDTASSGREAVEKSRLKDFAIYFVDLKMPGGMDGIETMMQIRKLRPEASI
IIITAYATVDTAITAMKEGAQEYIVKPCNPEEISLLVNRIIKVKNLQRENTILRKKLTRQYSVHDVISKNPRMREIMELA
SEVASLRSTVLIQGESGTGKELVARALHNAGDRASKPFVAVSCAALAETLLESELFGHEKGSFTGANQQKQGKFEMADGG
TIFLDEIGDISPKLQVDLLRVLQDRAFYRVGGSQEVRVDVRVVAATHVNLQQAVADGKFRDDLFYRLNVIEIRIPPLRER
REDIPLLAGHFVERVAHELGRNVNELSEGAMRRLLDHNWPGNVRELENAVERAIVTCRGRILTEEDFGFLAQTAAAPAWS
IPPGATIQDMEKALITVTIQRTQGNIKEAAAVLGIDRSTLYEKIKRYEIPR

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=440, Percent_Identity=45.9090909090909, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=40.929203539823, Blast_Score=355, Evalue=4e-99,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=42.6439232409382, Blast_Score=335, Evalue=5e-93,
Organism=Escherichia coli, GI1788905, Length=445, Percent_Identity=36.6292134831461, Blast_Score=304, Evalue=6e-84,
Organism=Escherichia coli, GI87082117, Length=343, Percent_Identity=43.731778425656, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1789087, Length=356, Percent_Identity=42.1348314606742, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1789233, Length=312, Percent_Identity=43.2692307692308, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI87082152, Length=313, Percent_Identity=43.7699680511182, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1786524, Length=336, Percent_Identity=38.0952380952381, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1787583, Length=313, Percent_Identity=38.9776357827476, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI87081872, Length=309, Percent_Identity=39.8058252427184, Blast_Score=214, Evalue=9e-57,
Organism=Escherichia coli, GI87081858, Length=305, Percent_Identity=32.7868852459016, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789828, Length=292, Percent_Identity=35.6164383561644, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1790552, Length=201, Percent_Identity=22.8855721393035, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082012, Length=108, Percent_Identity=30.5555555555556, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50465; Mature: 50465

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSHWQILVVDDEEIMCESLAAWLREDGYGVDTASSGREAVEKSRLKDFAIYFVDLKMPG
CCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEEEEEEEEECCC
GMDGIETMMQIRKLRPEASIIIITAYATVDTAITAMKEGAQEYIVKPCNPEEISLLVNRI
CCHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHH
IKVKNLQRENTILRKKLTRQYSVHDVISKNPRMREIMELASEVASLRSTVLIQGESGTGK
HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCH
ELVARALHNAGDRASKPFVAVSCAALAETLLESELFGHEKGSFTGANQQKQGKFEMADGG
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCC
TIFLDEIGDISPKLQVDLLRVLQDRAFYRVGGSQEVRVDVRVVAATHVNLQQAVADGKFR
EEEEECCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEEEEEEEEHHHHHHHHHHCCCCC
DDLFYRLNVIEIRIPPLRERREDIPLLAGHFVERVAHELGRNVNELSEGAMRRLLDHNWP
CCCEEEEEEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
GNVRELENAVERAIVTCRGRILTEEDFGFLAQTAAAPAWSIPPGATIQDMEKALITVTIQ
CCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCCCCCCCHHHHHHEEEEEEEE
RTQGNIKEAAAVLGIDRSTLYEKIKRYEIPR
CCCCCHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKSHWQILVVDDEEIMCESLAAWLREDGYGVDTASSGREAVEKSRLKDFAIYFVDLKMPG
CCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEEEEEEEEECCC
GMDGIETMMQIRKLRPEASIIIITAYATVDTAITAMKEGAQEYIVKPCNPEEISLLVNRI
CCHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHH
IKVKNLQRENTILRKKLTRQYSVHDVISKNPRMREIMELASEVASLRSTVLIQGESGTGK
HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCH
ELVARALHNAGDRASKPFVAVSCAALAETLLESELFGHEKGSFTGANQQKQGKFEMADGG
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCC
TIFLDEIGDISPKLQVDLLRVLQDRAFYRVGGSQEVRVDVRVVAATHVNLQQAVADGKFR
EEEEECCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEEEEEEEEHHHHHHHHHHCCCCC
DDLFYRLNVIEIRIPPLRERREDIPLLAGHFVERVAHELGRNVNELSEGAMRRLLDHNWP
CCCEEEEEEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
GNVRELENAVERAIVTCRGRILTEEDFGFLAQTAAAPAWSIPPGATIQDMEKALITVTIQ
CCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCCCCCCCHHHHHHEEEEEEEE
RTQGNIKEAAAVLGIDRSTLYEKIKRYEIPR
CCCCCHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]