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The map label for this gene is pdxA [H]

Identifier: 116619531

GI number: 116619531

Start: 491532

End: 492551

Strand: Direct

Name: pdxA [H]

Synonym: Acid_0390

Alternate gene names: 116619531

Gene position: 491532-492551 (Clockwise)

Preceding gene: 116619530

Following gene: 116619533

Centisome position: 4.93

GC content: 65.29

Gene sequence:

>1020_bases
ATGCTCGAATCCAAAGTAGACAACCGGCCCGTGATCGCCCTGACAATGGGGGATCCCGCGGGGATTGGTCCCGAAATCGT
GCTGCAGGCCGTAGCCGACCCCGACTTGGCGCCGCTGGCGCGGTGGATCGTGGTGGGCGACGGCGAGGTGCTGGAGCAAG
CCAGCCGGATAACGGGAATCGGCCTGCAGGCGAAGCTGCACGATGCACGGGCGCTCGCGGATATCGACCAGTTCATGTTC
GGCCGGCTGGACGCGCGCTGCGGTATAGCCGCGGTGGAGTATGTGCGGATCGCGACGGAGATGTGCCTGGCGGGCGAGGC
CGAGGCCATCGTGACGGCGCCGCTCAATAAGGAGGCGGTCACGCTCTCGGGGCGGCCCTTCACGGGGCATACCGAATACA
TCGCGGAGCTCTGCGGCGCTACGGAATCCCGAATGCTGCTGTGCAGCGAGCGGCTCTCTACGATTCACGTGACTACGCAC
GTGGCGCTGCGCACGGCGTGCGAGACCGGCACGGCGCGCATCCTGCGCACGATCGAGTTGGGCAACGACGCGATGAAGCT
GCTCGGAAAAAGCGAGCCGCGCATTGCCGTGTGCGGACTCAATCCGCATGCCGGAGAGCATGGGCTGTTCGGCGATGAAG
ACCAGCGCGTGATCGTCCCGGCAGTTGAGGCCGCGCGCGCAAAGGGCATTGCGTGCAGCGGTCCGCACGCGCCCGATACG
GTCTTCCTGCAGGCGGTGCGCGGCGCGTACGACCTGGTGGTGGCGATGTATCACGACCAGGGACACATACCGATGAAGCT
GATCGATTTCGAAGGCACGGTGAATATTTCGCTGGGGATTCCGATTATTCGAACGTCGGTGGATCACGGAACGGCCTTCG
ACATCGCGGGCAAGGGCCGGGCAGATGCGCGGAGTATAAAGCAGGCCATGCGGATCGCTGCCCGCATGGCAGCTACGCGA
CGCTACTTGCGGTGCAACGGGATCGCCAGCGATCCGAGTGCGCCGCTGCCGCGATCGTAG

Upstream 100 bases:

>100_bases
GAATTCTCCGCGGCGGAGAGTTCGATGGGATCCCGGTCGTGACCAAGTCCGGCGGTTTCGGCGATCGCGACACCCTGATT
CACGTAGCGGACTTTTTTGC

Downstream 100 bases:

>100_bases
ACCACCACGCGCAGTGTTTGCACGCCGTCGGTGAGGGTGAGACGCTTCCCGGTAAGGATCGGCTCGCCTGGCTTCGGCGT
CACCTCTTCCACAGGGAACA

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MLESKVDNRPVIALTMGDPAGIGPEIVLQAVADPDLAPLARWIVVGDGEVLEQASRITGIGLQAKLHDARALADIDQFMF
GRLDARCGIAAVEYVRIATEMCLAGEAEAIVTAPLNKEAVTLSGRPFTGHTEYIAELCGATESRMLLCSERLSTIHVTTH
VALRTACETGTARILRTIELGNDAMKLLGKSEPRIAVCGLNPHAGEHGLFGDEDQRVIVPAVEAARAKGIACSGPHAPDT
VFLQAVRGAYDLVVAMYHDQGHIPMKLIDFEGTVNISLGIPIIRTSVDHGTAFDIAGKGRADARSIKQAMRIAARMAATR
RYLRCNGIASDPSAPLPRS

Sequences:

>Translated_339_residues
MLESKVDNRPVIALTMGDPAGIGPEIVLQAVADPDLAPLARWIVVGDGEVLEQASRITGIGLQAKLHDARALADIDQFMF
GRLDARCGIAAVEYVRIATEMCLAGEAEAIVTAPLNKEAVTLSGRPFTGHTEYIAELCGATESRMLLCSERLSTIHVTTH
VALRTACETGTARILRTIELGNDAMKLLGKSEPRIAVCGLNPHAGEHGLFGDEDQRVIVPAVEAARAKGIACSGPHAPDT
VFLQAVRGAYDLVVAMYHDQGHIPMKLIDFEGTVNISLGIPIIRTSVDHGTAFDIAGKGRADARSIKQAMRIAARMAATR
RYLRCNGIASDPSAPLPRS
>Mature_339_residues
MLESKVDNRPVIALTMGDPAGIGPEIVLQAVADPDLAPLARWIVVGDGEVLEQASRITGIGLQAKLHDARALADIDQFMF
GRLDARCGIAAVEYVRIATEMCLAGEAEAIVTAPLNKEAVTLSGRPFTGHTEYIAELCGATESRMLLCSERLSTIHVTTH
VALRTACETGTARILRTIELGNDAMKLLGKSEPRIAVCGLNPHAGEHGLFGDEDQRVIVPAVEAARAKGIACSGPHAPDT
VFLQAVRGAYDLVVAMYHDQGHIPMKLIDFEGTVNISLGIPIIRTSVDHGTAFDIAGKGRADARSIKQAMRIAARMAATR
RYLRCNGIASDPSAPLPRS

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=325, Percent_Identity=36.3076923076923, Blast_Score=190, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 36113; Mature: 36113

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLESKVDNRPVIALTMGDPAGIGPEIVLQAVADPDLAPLARWIVVGDGEVLEQASRITGI
CCCCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCHHHHEEEEEECCHHHHHHHHHHCCC
GLQAKLHDARALADIDQFMFGRLDARCGIAAVEYVRIATEMCLAGEAEAIVTAPLNKEAV
CEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEE
TLSGRPFTGHTEYIAELCGATESRMLLCSERLSTIHVTTHVALRTACETGTARILRTIEL
EECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEEEHHHHHHHHHCCCHHHEEEEECC
GNDAMKLLGKSEPRIAVCGLNPHAGEHGLFGDEDQRVIVPAVEAARAKGIACSGPHAPDT
CCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECHHHHHHCCCEECCCCCCHH
VFLQAVRGAYDLVVAMYHDQGHIPMKLIDFEGTVNISLGIPIIRTSVDHGTAFDIAGKGR
HHHHHHHCCEEEEEEEEECCCCCCEEEEECCCEEEEEECCEEEEEECCCCCEEEECCCCC
ADARSIKQAMRIAARMAATRRYLRCNGIASDPSAPLPRS
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCC
>Mature Secondary Structure
MLESKVDNRPVIALTMGDPAGIGPEIVLQAVADPDLAPLARWIVVGDGEVLEQASRITGI
CCCCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCHHHHEEEEEECCHHHHHHHHHHCCC
GLQAKLHDARALADIDQFMFGRLDARCGIAAVEYVRIATEMCLAGEAEAIVTAPLNKEAV
CEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEE
TLSGRPFTGHTEYIAELCGATESRMLLCSERLSTIHVTTHVALRTACETGTARILRTIEL
EECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEEEHHHHHHHHHCCCHHHEEEEECC
GNDAMKLLGKSEPRIAVCGLNPHAGEHGLFGDEDQRVIVPAVEAARAKGIACSGPHAPDT
CCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECHHHHHHCCCEECCCCCCHH
VFLQAVRGAYDLVVAMYHDQGHIPMKLIDFEGTVNISLGIPIIRTSVDHGTAFDIAGKGR
HHHHHHHCCEEEEEEEEECCCCCCEEEEECCCEEEEEECCEEEEEECCCCCEEEECCCCC
ADARSIKQAMRIAARMAATRRYLRCNGIASDPSAPLPRS
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]