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The map label for this gene is uao [H]

Identifier: 116619500

GI number: 116619500

Start: 459593

End: 460456

Strand: Direct

Name: uao [H]

Synonym: Acid_0359

Alternate gene names: 116619500

Gene position: 459593-460456 (Clockwise)

Preceding gene: 116619499

Following gene: 116619501

Centisome position: 4.61

GC content: 60.76

Gene sequence:

>864_bases
ATGGAACGCTTTGCGAGCGGTTGGAAGCAGAACTACTACGGAAAGGGCGACGTCATTGTCTATCGGCTCAACCGCGATGG
AGTTGTGCCCCAGGGCTGCTGTCCGGTCTTCGGCGCCAACGTCAAGATGCTGCTTTATGGCGACGCTTTCTGGCCCACCT
ACACTACCGGCGACAACACCAACCTGGTAGCCACCGATTCCATGAAGAATTTCATCCAGCGCGAGACCTGCAATTTTACG
GGTTACGACCTTGAATCCTACTGCGATTTTCTGGCGCGCAAGTTCATGGCGACTTATCCCCACACCGCCGGAATTCAGCT
CTCCGCCAGGCAGGCGCCGTACTCCGGAGTCGCCGAAGGGAAAGTCGCGTTCGCGCCCTCCGGACCCGATGTGGCGACAG
CCTGCGTGGAACTGCGGCGCAACGGAGAAGCGCTCGAATCCGTGGAGGCAAGCTCCGGCATACATGGTTTCCGTCTGCTG
CGGCTCGGCGGCAGCGCCTTCCAGGGCTTCCTGCGCGACCAGTACACCACTCTGCCCGACATTCACAACCGGCCGCTCCA
CATGTGGCTCGATCTCGAATGGCACTACATTGCTCCGGAAGCCGCGCTCACCGGGGGCGAGGTGACGGCGCAAGTGCGCC
GCCTGGTTCACGAGGGTTTCCATTCCTTCGAATCCGGCAGCATCCAGCAGGTGATTTATCAGCTCGGAACCAAAATGCTC
GCGGATATCCCGACGATTTCCGAGGTCCGCCTCGAAGCCAACAACCGGACCTGGGATACCATCGTGGAGCAGGGAGACCG
GCTCGGCGTCTATACGGACGCGCGTCCTCCGTACGGTTGCCTCGGGCTGACTCTCAGGAGATAG

Upstream 100 bases:

>100_bases
CTCACCGGAAGACGAATTTAAGGAAGCCCTCGCGCAGGTTTACCAGATCGCGTCCTTCCGCTTGCGGGACATCGTGCACG
ATTGAATCAGGAGGATATTC

Downstream 100 bases:

>100_bases
CGTGGCTCGTCTTTCCACACACGTTCTGGATACGGCGCGCGGCCAGGCCGCTGCCAATATGAGAGTGGAGTTGTATCGCT
TCGAGAGCGGCGAGCGCGTG

Product: urate oxidase

Products: NA

Alternate protein names: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; Uricase; Urate oxidase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MERFASGWKQNYYGKGDVIVYRLNRDGVVPQGCCPVFGANVKMLLYGDAFWPTYTTGDNTNLVATDSMKNFIQRETCNFT
GYDLESYCDFLARKFMATYPHTAGIQLSARQAPYSGVAEGKVAFAPSGPDVATACVELRRNGEALESVEASSGIHGFRLL
RLGGSAFQGFLRDQYTTLPDIHNRPLHMWLDLEWHYIAPEAALTGGEVTAQVRRLVHEGFHSFESGSIQQVIYQLGTKML
ADIPTISEVRLEANNRTWDTIVEQGDRLGVYTDARPPYGCLGLTLRR

Sequences:

>Translated_287_residues
MERFASGWKQNYYGKGDVIVYRLNRDGVVPQGCCPVFGANVKMLLYGDAFWPTYTTGDNTNLVATDSMKNFIQRETCNFT
GYDLESYCDFLARKFMATYPHTAGIQLSARQAPYSGVAEGKVAFAPSGPDVATACVELRRNGEALESVEASSGIHGFRLL
RLGGSAFQGFLRDQYTTLPDIHNRPLHMWLDLEWHYIAPEAALTGGEVTAQVRRLVHEGFHSFESGSIQQVIYQLGTKML
ADIPTISEVRLEANNRTWDTIVEQGDRLGVYTDARPPYGCLGLTLRR
>Mature_287_residues
MERFASGWKQNYYGKGDVIVYRLNRDGVVPQGCCPVFGANVKMLLYGDAFWPTYTTGDNTNLVATDSMKNFIQRETCNFT
GYDLESYCDFLARKFMATYPHTAGIQLSARQAPYSGVAEGKVAFAPSGPDVATACVELRRNGEALESVEASSGIHGFRLL
RLGGSAFQGFLRDQYTTLPDIHNRPLHMWLDLEWHYIAPEAALTGGEVTAQVRRLVHEGFHSFESGSIQQVIYQLGTKML
ADIPTISEVRLEANNRTWDTIVEQGDRLGVYTDARPPYGCLGLTLRR

Specific function: Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin [H]

COG id: COG3648

COG function: function code Q; Uricase (urate oxidase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the uricase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018020
- InterPro:   IPR017580
- InterPro:   IPR002042
- InterPro:   IPR019842 [H]

Pfam domain/function: PF09349 OHCU_decarbox; PF01014 Uricase [H]

EC number: =1.7.3.3 [H]

Molecular weight: Translated: 31996; Mature: 31996

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERFASGWKQNYYGKGDVIVYRLNRDGVVPQGCCPVFGANVKMLLYGDAFWPTYTTGDNT
CCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCEECCCCC
NLVATDSMKNFIQRETCNFTGYDLESYCDFLARKFMATYPHTAGIQLSARQAPYSGVAEG
CEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
KVAFAPSGPDVATACVELRRNGEALESVEASSGIHGFRLLRLGGSAFQGFLRDQYTTLPD
EEEECCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCCC
IHNRPLHMWLDLEWHYIAPEAALTGGEVTAQVRRLVHEGFHSFESGSIQQVIYQLGTKML
CCCCCEEEEEEEEEEEECCHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ADIPTISEVRLEANNRTWDTIVEQGDRLGVYTDARPPYGCLGLTLRR
HCCCCHHHEEEECCCCHHHHHHHCCCEEEEEECCCCCCCEECCEECC
>Mature Secondary Structure
MERFASGWKQNYYGKGDVIVYRLNRDGVVPQGCCPVFGANVKMLLYGDAFWPTYTTGDNT
CCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCEECCCCC
NLVATDSMKNFIQRETCNFTGYDLESYCDFLARKFMATYPHTAGIQLSARQAPYSGVAEG
CEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
KVAFAPSGPDVATACVELRRNGEALESVEASSGIHGFRLLRLGGSAFQGFLRDQYTTLPD
EEEECCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCCC
IHNRPLHMWLDLEWHYIAPEAALTGGEVTAQVRRLVHEGFHSFESGSIQQVIYQLGTKML
CCCCCEEEEEEEEEEEECCHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ADIPTISEVRLEANNRTWDTIVEQGDRLGVYTDARPPYGCLGLTLRR
HCCCCHHHEEEECCCCHHHHHHHCCCEEEEEECCCCCCCEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8907179 [H]