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The map label for this gene is nqo2 [H]

Identifier: 116619256

GI number: 116619256

Start: 150312

End: 150794

Strand: Direct

Name: nqo2 [H]

Synonym: Acid_0112

Alternate gene names: 116619256

Gene position: 150312-150794 (Clockwise)

Preceding gene: 116619255

Following gene: 116619257

Centisome position: 1.51

GC content: 57.97

Gene sequence:

>483_bases
ATGACTCTTTCTCCACAACTGGAAGCCAGGTTTGAAAAACTGCTGACAAGCTATCCGCCGGGACGGCAGCGGTCGGCGAT
GATTCCGATGCTGATGTACGCGCAGGATGAACTTGGCTGCGTGAGCGATGAACTGATCGCGGAGGTGGCGCGCCGCATCG
GCGTGACCCCGCTGCAGGTCAATGAGGTGCTGACCTACTACTCCATGCTGCACCGCAAGCCGCTGGGCAAATACCACGTC
CAGGTGTGCACCAACATCAGCTGCCTGCTGCACGATGGCGATAAGCTCTACGAGCACACCTGCAAAAAGCTCGGCATCAC
CCACAAGGAAGTCACCGCGGACGGGCAGTTTTCGATCGAGGAAGTGGAGTGCATGGGAGCCTGCAGCTGGGCGCCGGCGA
TCCAGATCAATTACGATTTTCACCACTACGTGACTCCCGAGAAGCTGGACCAGCTGCTGGACGGCTTGAGGAAGAAGCAA
TAA

Upstream 100 bases:

>100_bases
GCAGACGTCATCGCCTCCATCGGCAGCATGGATTTCGTTCTGGGCGACACGGACAGGTAAGAACTCCGGCAGGCCAGGCA
GCCTGCCAAACCGAACATAA

Downstream 100 bases:

>100_bases
CCAATGCTTTTCAACGAACCACATCCGCTGGAAACCAGGGTCCTGACGCGCCGATTTGGTAAGCCGAACTCGGCCGCCAT
CGAGGGGTATCTGGCCGACG

Product: NADH-quinone oxidoreductase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I chain 2; NDH-1 subunit 2 [H]

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MTLSPQLEARFEKLLTSYPPGRQRSAMIPMLMYAQDELGCVSDELIAEVARRIGVTPLQVNEVLTYYSMLHRKPLGKYHV
QVCTNISCLLHDGDKLYEHTCKKLGITHKEVTADGQFSIEEVECMGACSWAPAIQINYDFHHYVTPEKLDQLLDGLRKKQ

Sequences:

>Translated_160_residues
MTLSPQLEARFEKLLTSYPPGRQRSAMIPMLMYAQDELGCVSDELIAEVARRIGVTPLQVNEVLTYYSMLHRKPLGKYHV
QVCTNISCLLHDGDKLYEHTCKKLGITHKEVTADGQFSIEEVECMGACSWAPAIQINYDFHHYVTPEKLDQLLDGLRKKQ
>Mature_159_residues
TLSPQLEARFEKLLTSYPPGRQRSAMIPMLMYAQDELGCVSDELIAEVARRIGVTPLQVNEVLTYYSMLHRKPLGKYHVQ
VCTNISCLLHDGDKLYEHTCKKLGITHKEVTADGQFSIEEVECMGACSWAPAIQINYDFHHYVTPEKLDQLLDGLRKKQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=155, Percent_Identity=39.3548387096774, Blast_Score=130, Evalue=4e-31,
Organism=Escherichia coli, GI1788621, Length=131, Percent_Identity=31.2977099236641, Blast_Score=80, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17561328, Length=148, Percent_Identity=40.5405405405405, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI18859877, Length=148, Percent_Identity=41.2162162162162, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21355353, Length=148, Percent_Identity=36.4864864864865, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18241; Mature: 18110

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSPQLEARFEKLLTSYPPGRQRSAMIPMLMYAQDELGCVSDELIAEVARRIGVTPLQV
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHH
NEVLTYYSMLHRKPLGKYHVQVCTNISCLLHDGDKLYEHTCKKLGITHKEVTADGQFSIE
HHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCHHHCCCCCCCCHH
EVECMGACSWAPAIQINYDFHHYVTPEKLDQLLDGLRKKQ
HHHHHHCCCCCCEEEEECCCHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLSPQLEARFEKLLTSYPPGRQRSAMIPMLMYAQDELGCVSDELIAEVARRIGVTPLQV
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHH
NEVLTYYSMLHRKPLGKYHVQVCTNISCLLHDGDKLYEHTCKKLGITHKEVTADGQFSIE
HHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCHHHCCCCCCCCHH
EVECMGACSWAPAIQINYDFHHYVTPEKLDQLLDGLRKKQ
HHHHHHCCCCCCEEEEECCCHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9020134 [H]