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The map label for this gene is exuT [H]

Identifier: 116619204

GI number: 116619204

Start: 86376

End: 87650

Strand: Direct

Name: exuT [H]

Synonym: Acid_0059

Alternate gene names: 116619204

Gene position: 86376-87650 (Clockwise)

Preceding gene: 116619202

Following gene: 116619205

Centisome position: 0.87

GC content: 61.41

Gene sequence:

>1275_bases
ATGACACCGACTCTCGTCAGGCCCGAGCATTCGCGCTTCCGCTGGACCGTCTGCGCGCTGCTCTTTTTTGCGACCACGAT
CAACTACGTGGACCGGCAAGTTCTGAGCATGCTGGCGGATACCCTGAGGATCCAGATCGGCTGGACGGCGATCGAATACA
GCAGAATCACCACTGCCTTTTCTCTGTCCTACATGTTTGGATTGCTGGGTGCGGGGCGCCTGCTCGATAAATTCGGGACG
CGCATCGGTTTCGCGATTGCGATCACGGTGTGGAGCGTGGCCGCCATGGCGCATGCGTGGGCTACGAGCGCGCTTACGTT
CGGAATCGCCCGCTCCTTGCTGGGGTTGGGCGAAGCCGCGAATTTCCCGGCCTGCATCAAGACCATCGCGGAGTGGTTTC
CCAAGAGGGAGCGCGCGCATGCCACGGGGATCTTCAACTCGGGGTCGAACATCGGCGCGGTGATCGCGCCCATCAGTGTG
CCTTGGCTCGCGACCACGTACGGCTGGCAGTCTGCCTTTCTGATTACGGGCGCGCTGGGTTTCCTGTGGCTGGGCGCGTG
GCTTCTGCTCTACGGACCGCCGCAACTGCACAAGAGCGTATCGGCGGCCGAGTTGAAACTCATCGAGAGCGATCCGCCGG
ACAAGGCGGGCACATACCCGTGGCAGCGTTTGCTCCCTCGCCGGGAGACCTGGGCCTTCGGCCTCGGCAAGTTCCTCACG
GATCCCATCTGGTGGTTTTACCTGTTCTGGCTGCCCATGTATTTCCAGGAGACGTTTCACCTGAAGCTCACCCAACTTCC
GCTTCCCATGCTCGTGATTTACAACGCGTCGAGCGTGGGCAGTATCGGCGGCGGATGGCTCTCCTCGAGCCTGATCAACC
ACGGTTGGACGATCAACCGCGCGCGCAAGATGGCCATGTTGGTTTGCGCCCTTAGCGTGCTGCCGGTGTTCTATGTACCG
TACGCCAATAAGAGCAGCATGTGGGAAGTGGTCGCGGTGCTGAGTCTCGCGATGGCGGCACACCAGGGCTTTAGCGCGAA
TCTCTTCACCACTACGTCCGATATGTTCCCGCGCTCTGCGGTTGGCAGCGTAGTGGGGATCGGCGGCGCCATGGGGGCGC
TCGGCATCGCACTGATGCAGACTCTGGCAGGGTACGTCGTGCAGTTGACGGGAAGCTATTCCGTGCTCTTCATGATTTGC
GCGTCGATGTACCTGGTGGCGCTGGGCGTGATCCAACTTCTGGCGCCGAAGCTCGAACCGGCGAAGCTGGACTAG

Upstream 100 bases:

>100_bases
TAGCCCCACTGGGTGGTGGTGTTCAAGCCCCCAATCTTTCGGTCAAAGGGTTTTTCGGACCGGGTGTACCTTTGCGCCAA
GGGCTATAATCGTTGCTTCC

Downstream 100 bases:

>100_bases
CTGCGTGCTTGCCCGCTGGCGCACACCGGGAGCGCTCTTTGCGCTCTTTCTGCTGACGGCGGGCTTCTACTGGAAGCTCA
CGCTATCCCGTGAATGGACC

Product: major facilitator transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTPTLVRPEHSRFRWTVCALLFFATTINYVDRQVLSMLADTLRIQIGWTAIEYSRITTAFSLSYMFGLLGAGRLLDKFGT
RIGFAIAITVWSVAAMAHAWATSALTFGIARSLLGLGEAANFPACIKTIAEWFPKRERAHATGIFNSGSNIGAVIAPISV
PWLATTYGWQSAFLITGALGFLWLGAWLLLYGPPQLHKSVSAAELKLIESDPPDKAGTYPWQRLLPRRETWAFGLGKFLT
DPIWWFYLFWLPMYFQETFHLKLTQLPLPMLVIYNASSVGSIGGGWLSSSLINHGWTINRARKMAMLVCALSVLPVFYVP
YANKSSMWEVVAVLSLAMAAHQGFSANLFTTTSDMFPRSAVGSVVGIGGAMGALGIALMQTLAGYVVQLTGSYSVLFMIC
ASMYLVALGVIQLLAPKLEPAKLD

Sequences:

>Translated_424_residues
MTPTLVRPEHSRFRWTVCALLFFATTINYVDRQVLSMLADTLRIQIGWTAIEYSRITTAFSLSYMFGLLGAGRLLDKFGT
RIGFAIAITVWSVAAMAHAWATSALTFGIARSLLGLGEAANFPACIKTIAEWFPKRERAHATGIFNSGSNIGAVIAPISV
PWLATTYGWQSAFLITGALGFLWLGAWLLLYGPPQLHKSVSAAELKLIESDPPDKAGTYPWQRLLPRRETWAFGLGKFLT
DPIWWFYLFWLPMYFQETFHLKLTQLPLPMLVIYNASSVGSIGGGWLSSSLINHGWTINRARKMAMLVCALSVLPVFYVP
YANKSSMWEVVAVLSLAMAAHQGFSANLFTTTSDMFPRSAVGSVVGIGGAMGALGIALMQTLAGYVVQLTGSYSVLFMIC
ASMYLVALGVIQLLAPKLEPAKLD
>Mature_423_residues
TPTLVRPEHSRFRWTVCALLFFATTINYVDRQVLSMLADTLRIQIGWTAIEYSRITTAFSLSYMFGLLGAGRLLDKFGTR
IGFAIAITVWSVAAMAHAWATSALTFGIARSLLGLGEAANFPACIKTIAEWFPKRERAHATGIFNSGSNIGAVIAPISVP
WLATTYGWQSAFLITGALGFLWLGAWLLLYGPPQLHKSVSAAELKLIESDPPDKAGTYPWQRLLPRRETWAFGLGKFLTD
PIWWFYLFWLPMYFQETFHLKLTQLPLPMLVIYNASSVGSIGGGWLSSSLINHGWTINRARKMAMLVCALSVLPVFYVPY
ANKSSMWEVVAVLSLAMAAHQGFSANLFTTTSDMFPRSAVGSVVGIGGAMGALGIALMQTLAGYVVQLTGSYSVLFMICA
SMYLVALGVIQLLAPKLEPAKLD

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI154350196, Length=384, Percent_Identity=27.8645833333333, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI9945322, Length=351, Percent_Identity=26.7806267806268, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI9966811, Length=279, Percent_Identity=26.1648745519713, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI21322234, Length=347, Percent_Identity=25.6484149855908, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI2367193, Length=414, Percent_Identity=32.1256038647343, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI87082320, Length=421, Percent_Identity=28.0285035629454, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1789515, Length=429, Percent_Identity=27.7389277389277, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789152, Length=437, Percent_Identity=26.7734553775744, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI2367379, Length=423, Percent_Identity=26.4775413711584, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788573, Length=440, Percent_Identity=20.4545454545455, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082231, Length=165, Percent_Identity=24.8484848484848, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082071, Length=121, Percent_Identity=31.404958677686, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17535049, Length=438, Percent_Identity=24.6575342465753, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71991453, Length=316, Percent_Identity=25.9493670886076, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71991448, Length=316, Percent_Identity=25.9493670886076, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI32565914, Length=215, Percent_Identity=25.1162790697674, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32565916, Length=161, Percent_Identity=27.3291925465839, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560030, Length=321, Percent_Identity=20.2492211838006, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32566703, Length=284, Percent_Identity=24.6478873239437, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17564562, Length=284, Percent_Identity=24.6478873239437, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17552542, Length=354, Percent_Identity=27.683615819209, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554148, Length=405, Percent_Identity=21.7283950617284, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24648416, Length=378, Percent_Identity=26.1904761904762, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21356189, Length=378, Percent_Identity=26.1904761904762, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI19920686, Length=417, Percent_Identity=23.021582733813, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573708, Length=394, Percent_Identity=23.6040609137056, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573707, Length=394, Percent_Identity=23.6040609137056, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24580790, Length=304, Percent_Identity=25.3289473684211, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24641682, Length=253, Percent_Identity=28.8537549407115, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583789, Length=345, Percent_Identity=23.4782608695652, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI62484226, Length=402, Percent_Identity=25.3731343283582, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584153, Length=342, Percent_Identity=23.3918128654971, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI20129235, Length=398, Percent_Identity=24.3718592964824, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24655271, Length=427, Percent_Identity=23.8875878220141, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130135, Length=427, Percent_Identity=24.1217798594848, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573299, Length=432, Percent_Identity=23.3796296296296, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46477; Mature: 46346

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTLVRPEHSRFRWTVCALLFFATTINYVDRQVLSMLADTLRIQIGWTAIEYSRITTAF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEHHHHHHHH
SLSYMFGLLGAGRLLDKFGTRIGFAIAITVWSVAAMAHAWATSALTFGIARSLLGLGEAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NFPACIKTIAEWFPKRERAHATGIFNSGSNIGAVIAPISVPWLATTYGWQSAFLITGALG
CCHHHHHHHHHHCCCHHHHHHCEEECCCCCCCEEEECCCCCHHHHHCCCCHHHHHHHHHH
FLWLGAWLLLYGPPQLHKSVSAAELKLIESDPPDKAGTYPWQRLLPRRETWAFGLGKFLT
HHHHHHHHHHCCCHHHHHCCCHHHEEEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHH
DPIWWFYLFWLPMYFQETFHLKLTQLPLPMLVIYNASSVGSIGGGWLSSSLINHGWTINR
HHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCHHH
ARKMAMLVCALSVLPVFYVPYANKSSMWEVVAVLSLAMAAHQGFSANLFTTTSDMFPRSA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHCCCHHH
VGSVVGIGGAMGALGIALMQTLAGYVVQLTGSYSVLFMICASMYLVALGVIQLLAPKLEP
HHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AKLD
CCCC
>Mature Secondary Structure 
TPTLVRPEHSRFRWTVCALLFFATTINYVDRQVLSMLADTLRIQIGWTAIEYSRITTAF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEHHHHHHHH
SLSYMFGLLGAGRLLDKFGTRIGFAIAITVWSVAAMAHAWATSALTFGIARSLLGLGEAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NFPACIKTIAEWFPKRERAHATGIFNSGSNIGAVIAPISVPWLATTYGWQSAFLITGALG
CCHHHHHHHHHHCCCHHHHHHCEEECCCCCCCEEEECCCCCHHHHHCCCCHHHHHHHHHH
FLWLGAWLLLYGPPQLHKSVSAAELKLIESDPPDKAGTYPWQRLLPRRETWAFGLGKFLT
HHHHHHHHHHCCCHHHHHCCCHHHEEEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHH
DPIWWFYLFWLPMYFQETFHLKLTQLPLPMLVIYNASSVGSIGGGWLSSSLINHGWTINR
HHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCHHH
ARKMAMLVCALSVLPVFYVPYANKSSMWEVVAVLSLAMAAHQGFSANLFTTTSDMFPRSA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHCCCHHH
VGSVVGIGGAMGALGIALMQTLAGYVVQLTGSYSVLFMICASMYLVALGVIQLLAPKLEP
HHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AKLD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]