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The map label for this gene is mmgC [H]

Identifier: 116619185

GI number: 116619185

Start: 62416

End: 63582

Strand: Direct

Name: mmgC [H]

Synonym: Acid_0040

Alternate gene names: 116619185

Gene position: 62416-63582 (Clockwise)

Preceding gene: 116619184

Following gene: 116619186

Centisome position: 0.63

GC content: 62.04

Gene sequence:

>1167_bases
ATGGCTTTTCGAGGCGTAGACTACTTCTGCGTCGACTCGCTCTTTAATGAAGAGGAGTTGATGGTCCGTCAGACCGCGCG
GCGTTTTGCCGAGGAACGGATTCTGCCGCTGATTCGCGATTGCTACCGCGACGCGCGCTTTCCCACGGAACTGGTGCCGG
CCATGGCGGAGCTCGGTTTCCTGGGAGCCAACCTGGAAGGATATGGCTGCGCGGGAATGAGCAACGTGGAATACGGACTC
GTGATGCAGGAACTGGAACGCATCGATTCCGGTGTACGCAGCTTCGTTTCCGTGCAGGGCGCGCTGGTGATGTACCCGAT
CCACCGGTATGGCAGCGAGGAACAGAAACAGCGATGGCTGCCGGCGCTGCAAAGCGGGAAAGCCATCGGGTGCTTCGGGC
TGACCGAGCCCGACTTTGGCTCCAATCCGGCGGGTATGCGGACCACGGCCCGGCGCGACGGCGACGGGTGGGTGTTGAAC
GGTGAGAAGACGTGGATCACGAACGGTTCCATGTCGGATGTCGCGATCGTGTGGGCGCGCGCCGAAGAGGGCATTCTCGG
CTTCCTGGTCGAGCGCGGTACGCCGGGATATACCACTTCCGACATCCACGGCAAGTGGAGCATGCGGGCCTCGGTGACGT
CCAGCCTCTCGCTGGTGGATTGCCGGGTGAAGGACGCCGACCGGTTGCCGGGAGCGCGCGGATTGAAGGGACCGCTCTCC
TGCCTGTCGCAGGCGCGGTACGGCATTGGCTGGGGCGTGGTCGGCGCGGCGATGGATTGCTACGAGACCGCGCGCCAGTA
CGCCATCCTGCGCAAGCAGTTCGACGACCGGCCGATCGCCTCGCACCAACTGGTGCAAGAGAAGCTGGCGTGGATGATCA
CGGAGATCACCAAGGCGCAGCTGCTGGCGGTGCAGGCGGGAAGGTTGAAGGATCAGAAAAAGCTGGAGCCGGCGCATATT
TCGATGCTCAAGCGAAATAACGTGTGGATGGCGCTGGAATGCGCGCGGCTGAGCCGCGACCTGCTGGGTGCGAACGGTAT
CACGGACGAATATCCGATTATGCGTCACCTATGCAACCTGGAAACCGTCAAGACGTACGAAGGGACGGATCATATTCATG
CCCTGGTGATCGGCGAAAAGGTCACTGGAGTGGCGGCGTACAAGTAG

Upstream 100 bases:

>100_bases
AGGCCCCGGGGCCATAAAGCAGCGTGTAACACCACGGGCCGGGCATGCAGGGCGCATGTCCGGCCCGTGCCGTGTTCAAA
TAGGGAGGAAAGAAACCAAA

Downstream 100 bases:

>100_bases
CGGCCGTCCCGTCTTTCGGAGTAAAACTTTTCTAATGATTCTCTATGCATTGACAATTGTGGTGAGCGCCTTTTTGCTGT
TCCAGGTGCAGCCGGTGATT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MAFRGVDYFCVDSLFNEEELMVRQTARRFAEERILPLIRDCYRDARFPTELVPAMAELGFLGANLEGYGCAGMSNVEYGL
VMQELERIDSGVRSFVSVQGALVMYPIHRYGSEEQKQRWLPALQSGKAIGCFGLTEPDFGSNPAGMRTTARRDGDGWVLN
GEKTWITNGSMSDVAIVWARAEEGILGFLVERGTPGYTTSDIHGKWSMRASVTSSLSLVDCRVKDADRLPGARGLKGPLS
CLSQARYGIGWGVVGAAMDCYETARQYAILRKQFDDRPIASHQLVQEKLAWMITEITKAQLLAVQAGRLKDQKKLEPAHI
SMLKRNNVWMALECARLSRDLLGANGITDEYPIMRHLCNLETVKTYEGTDHIHALVIGEKVTGVAAYK

Sequences:

>Translated_388_residues
MAFRGVDYFCVDSLFNEEELMVRQTARRFAEERILPLIRDCYRDARFPTELVPAMAELGFLGANLEGYGCAGMSNVEYGL
VMQELERIDSGVRSFVSVQGALVMYPIHRYGSEEQKQRWLPALQSGKAIGCFGLTEPDFGSNPAGMRTTARRDGDGWVLN
GEKTWITNGSMSDVAIVWARAEEGILGFLVERGTPGYTTSDIHGKWSMRASVTSSLSLVDCRVKDADRLPGARGLKGPLS
CLSQARYGIGWGVVGAAMDCYETARQYAILRKQFDDRPIASHQLVQEKLAWMITEITKAQLLAVQAGRLKDQKKLEPAHI
SMLKRNNVWMALECARLSRDLLGANGITDEYPIMRHLCNLETVKTYEGTDHIHALVIGEKVTGVAAYK
>Mature_387_residues
AFRGVDYFCVDSLFNEEELMVRQTARRFAEERILPLIRDCYRDARFPTELVPAMAELGFLGANLEGYGCAGMSNVEYGLV
MQELERIDSGVRSFVSVQGALVMYPIHRYGSEEQKQRWLPALQSGKAIGCFGLTEPDFGSNPAGMRTTARRDGDGWVLNG
EKTWITNGSMSDVAIVWARAEEGILGFLVERGTPGYTTSDIHGKWSMRASVTSSLSLVDCRVKDADRLPGARGLKGPLSC
LSQARYGIGWGVVGAAMDCYETARQYAILRKQFDDRPIASHQLVQEKLAWMITEITKAQLLAVQAGRLKDQKKLEPAHIS
MLKRNNVWMALECARLSRDLLGANGITDEYPIMRHLCNLETVKTYEGTDHIHALVIGEKVTGVAAYK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=384, Percent_Identity=50.5208333333333, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI7669494, Length=364, Percent_Identity=50.5494505494505, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI4557233, Length=368, Percent_Identity=35.8695652173913, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI4501859, Length=381, Percent_Identity=29.3963254593176, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=29.8666666666667, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI4557231, Length=374, Percent_Identity=28.0748663101604, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI187960098, Length=374, Percent_Identity=28.0748663101604, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4501857, Length=388, Percent_Identity=30.1546391752577, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI226958414, Length=333, Percent_Identity=30.3303303303303, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI21361497, Length=358, Percent_Identity=28.7709497206704, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI7656849, Length=380, Percent_Identity=26.8421052631579, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI76496475, Length=392, Percent_Identity=27.8061224489796, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4557235, Length=392, Percent_Identity=27.8061224489796, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI38505218, Length=344, Percent_Identity=25.5813953488372, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1786223, Length=376, Percent_Identity=24.7340425531915, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081958, Length=380, Percent_Identity=24.7368421052632, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17534353, Length=386, Percent_Identity=50, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=33.1550802139037, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=30.5851063829787, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17538396, Length=386, Percent_Identity=30.3108808290155, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=28.6089238845144, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17534899, Length=369, Percent_Identity=29.5392953929539, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71990804, Length=275, Percent_Identity=33.8181818181818, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=26.1780104712042, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=31.6176470588235, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17533517, Length=365, Percent_Identity=25.7534246575342, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI32563615, Length=234, Percent_Identity=32.4786324786325, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71985184, Length=369, Percent_Identity=26.5582655826558, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=27.8169014084507, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17505929, Length=219, Percent_Identity=26.9406392694064, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551932, Length=226, Percent_Identity=25.6637168141593, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19920834, Length=390, Percent_Identity=48.974358974359, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=31.2997347480106, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=31.0344827586207, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24646207, Length=379, Percent_Identity=31.3984168865435, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24660351, Length=373, Percent_Identity=29.7587131367292, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21355753, Length=391, Percent_Identity=29.6675191815857, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI281363737, Length=374, Percent_Identity=26.7379679144385, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43142; Mature: 43011

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFRGVDYFCVDSLFNEEELMVRQTARRFAEERILPLIRDCYRDARFPTELVPAMAELGF
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LGANLEGYGCAGMSNVEYGLVMQELERIDSGVRSFVSVQGALVMYPIHRYGSEEQKQRWL
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCHHHHHHHH
PALQSGKAIGCFGLTEPDFGSNPAGMRTTARRDGDGWVLNGEKTWITNGSMSDVAIVWAR
HHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCEEEEEEE
AEEGILGFLVERGTPGYTTSDIHGKWSMRASVTSSLSLVDCRVKDADRLPGARGLKGPLS
CCCCEEEEEEECCCCCCCCCCCCCCEEEHHHHHCCCEEEEEECCCHHCCCCCCCCCHHHH
CLSQARYGIGWGVVGAAMDCYETARQYAILRKQFDDRPIASHQLVQEKLAWMITEITKAQ
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLAVQAGRLKDQKKLEPAHISMLKRNNVWMALECARLSRDLLGANGITDEYPIMRHLCNL
HHHHHHHCCCHHHCCCHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCCCHHHHHHCCC
ETVKTYEGTDHIHALVIGEKVTGVAAYK
CCEEECCCCCCEEEEEECCCCCCEECCC
>Mature Secondary Structure 
AFRGVDYFCVDSLFNEEELMVRQTARRFAEERILPLIRDCYRDARFPTELVPAMAELGF
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LGANLEGYGCAGMSNVEYGLVMQELERIDSGVRSFVSVQGALVMYPIHRYGSEEQKQRWL
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCHHHHHHHH
PALQSGKAIGCFGLTEPDFGSNPAGMRTTARRDGDGWVLNGEKTWITNGSMSDVAIVWAR
HHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCEEEEEEE
AEEGILGFLVERGTPGYTTSDIHGKWSMRASVTSSLSLVDCRVKDADRLPGARGLKGPLS
CCCCEEEEEEECCCCCCCCCCCCCCEEEHHHHHCCCEEEEEECCCHHCCCCCCCCCHHHH
CLSQARYGIGWGVVGAAMDCYETARQYAILRKQFDDRPIASHQLVQEKLAWMITEITKAQ
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLAVQAGRLKDQKKLEPAHISMLKRNNVWMALECARLSRDLLGANGITDEYPIMRHLCNL
HHHHHHHCCCHHHCCCHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCCCHHHHHHCCC
ETVKTYEGTDHIHALVIGEKVTGVAAYK
CCEEECCCCCCEEEEEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]