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The map label for this gene is gpo [H]

Identifier: 116516850

GI number: 116516850

Start: 284487

End: 284963

Strand: Reverse

Name: gpo [H]

Synonym: SPD_0286

Alternate gene names: 116516850

Gene position: 284963-284487 (Counterclockwise)

Preceding gene: 116515570

Following gene: 116516191

Centisome position: 13.93

GC content: 42.77

Gene sequence:

>477_bases
ATGACTTCACTTTATGATTTTTCCGTTTTGAACCAAAACAACCAAGCAACTCCCTTGGATAGCTATCGTGGCAAAGTTCT
CTTGATTGTCAACACTGCTACTGGATGTGGTTTAACGCCCCAGTACCAGGGACTTCAAGAACTCTATGAACGCTATCAAG
ATCAGGGCTTCGAAATATTGGATTTCCCTTGCAATCAGTTTATGGGACAAGCACCCGGCAGCGCAGAGGAAATCAACACC
TTCTGTAGCCTACATTTTCAAACCACCTTCCCACGTTTTGCCAAGATTAAGGTCAACGGTAAGGAAGCAGACCCTCTCTA
TGTCTGGTTAAAAGACCATAAATCTGGCCCACTAGGAAAACGAATCGAATGGAATTTCGCTAAGTTTCTCATTGGTCGTG
ATGGGCAAGTCTTTGAACGCTTTTCTTCAAAAACAGACCCAAAACAAATTGAAGAGGCGATACAAACTCTACTATAA

Upstream 100 bases:

>100_bases
TTTCTATCATATTGAGGGCTTATTCTTCAACAATATCTTCCATCCGACTCGACGAAAAAAGTAAAAACTGTTACAATGTA
GAAAAAGAAAAGAGGCCCTC

Downstream 100 bases:

>100_bases
TTCACAATCTCACTATGATTAGGTTTCCTTTAACCTGATGAATAGTGAGATTTTTTGATTGGCTTTGACTTAAATAGAAA
AACACCCCATGATATGAAAC

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MTSLYDFSVLNQNNQATPLDSYRGKVLLIVNTATGCGLTPQYQGLQELYERYQDQGFEILDFPCNQFMGQAPGSAEEINT
FCSLHFQTTFPRFAKIKVNGKEADPLYVWLKDHKSGPLGKRIEWNFAKFLIGRDGQVFERFSSKTDPKQIEEAIQTLL

Sequences:

>Translated_158_residues
MTSLYDFSVLNQNNQATPLDSYRGKVLLIVNTATGCGLTPQYQGLQELYERYQDQGFEILDFPCNQFMGQAPGSAEEINT
FCSLHFQTTFPRFAKIKVNGKEADPLYVWLKDHKSGPLGKRIEWNFAKFLIGRDGQVFERFSSKTDPKQIEEAIQTLL
>Mature_157_residues
TSLYDFSVLNQNNQATPLDSYRGKVLLIVNTATGCGLTPQYQGLQELYERYQDQGFEILDFPCNQFMGQAPGSAEEINTF
CSLHFQTTFPRFAKIKVNGKEADPLYVWLKDHKSGPLGKRIEWNFAKFLIGRDGQVFERFSSKTDPKQIEEAIQTLL

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=153, Percent_Identity=41.8300653594771, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI90903240, Length=155, Percent_Identity=41.2903225806452, Blast_Score=116, Evalue=7e-27,
Organism=Homo sapiens, GI15618997, Length=156, Percent_Identity=36.5384615384615, Blast_Score=107, Evalue=4e-24,
Organism=Homo sapiens, GI192455698, Length=159, Percent_Identity=35.2201257861635, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI90903238, Length=130, Percent_Identity=43.0769230769231, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI4557629, Length=177, Percent_Identity=34.4632768361582, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI41406084, Length=182, Percent_Identity=34.0659340659341, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI32967607, Length=181, Percent_Identity=31.4917127071823, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI6006001, Length=177, Percent_Identity=32.7683615819209, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI33186887, Length=154, Percent_Identity=33.7662337662338, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1788003, Length=178, Percent_Identity=39.8876404494382, Blast_Score=134, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17506887, Length=159, Percent_Identity=46.5408805031447, Blast_Score=150, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17535473, Length=159, Percent_Identity=45.9119496855346, Blast_Score=143, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193210707, Length=161, Percent_Identity=40.9937888198758, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71993584, Length=157, Percent_Identity=35.6687898089172, Blast_Score=113, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI193209493, Length=167, Percent_Identity=35.9281437125749, Blast_Score=93, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17550320, Length=167, Percent_Identity=35.3293413173653, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=43.421052631579, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193210709, Length=72, Percent_Identity=44.4444444444444, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17507603, Length=104, Percent_Identity=38.4615384615385, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322228, Length=159, Percent_Identity=51.5723270440252, Blast_Score=174, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6319721, Length=158, Percent_Identity=51.8987341772152, Blast_Score=172, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322826, Length=159, Percent_Identity=44.6540880503145, Blast_Score=144, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24656777, Length=160, Percent_Identity=41.875, Blast_Score=129, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24656772, Length=160, Percent_Identity=41.875, Blast_Score=129, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24656767, Length=160, Percent_Identity=41.875, Blast_Score=129, Evalue=9e-31,
Organism=Drosophila melanogaster, GI85726443, Length=158, Percent_Identity=41.7721518987342, Blast_Score=120, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 18040; Mature: 17908

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLYDFSVLNQNNQATPLDSYRGKVLLIVNTATGCGLTPQYQGLQELYERYQDQGFEIL
CCCCCCCCEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEE
DFPCNQFMGQAPGSAEEINTFCSLHFQTTFPRFAKIKVNGKEADPLYVWLKDHKSGPLGK
ECCHHHHHCCCCCCHHHHHHHHEEEEECCCCCEEEEEECCCCCCEEEEEEECCCCCCCCC
RIEWNFAKFLIGRDGQVFERFSSKTDPKQIEEAIQTLL
CEECCHHEEEECCCCHHHHHHCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
TSLYDFSVLNQNNQATPLDSYRGKVLLIVNTATGCGLTPQYQGLQELYERYQDQGFEIL
CCCCCCCEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEE
DFPCNQFMGQAPGSAEEINTFCSLHFQTTFPRFAKIKVNGKEADPLYVWLKDHKSGPLGK
ECCHHHHHCCCCCCHHHHHHHHEEEEECCCCCEEEEEECCCCCCEEEEEEECCCCCCCCC
RIEWNFAKFLIGRDGQVFERFSSKTDPKQIEEAIQTLL
CEECCHHEEEECCCCHHHHHHCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]