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The map label for this gene is bceR [H]

Identifier: 116516130

GI number: 116516130

Start: 1462369

End: 1463046

Strand: Reverse

Name: bceR [H]

Synonym: SPD_1446

Alternate gene names: 116516130

Gene position: 1463046-1462369 (Counterclockwise)

Preceding gene: 116515825

Following gene: 116516868

Centisome position: 71.5

GC content: 42.77

Gene sequence:

>678_bases
ATGCACAAGATTTTATTAATAGAAGATGATCAGGTCATTCGTCAACAGATTGGGAAAATGCTCTCTGAATGGGGATTTGA
AGTGGTCCTGGTAGAAGACTTTATGGAAGTTTTGAGTCTATTTGTTCAGTCGGAACCTCATCTGGTCCTCATGGATATTG
GTTTGCCCTTGTTTAATGGTTATCACTGGTGTCAGGAAATCCGCAAGATTTCCAAGGTACCTATCATGTTTCTTTCTTCG
AGAGACCAGGCTATGGATATTGTCATGGCAATCAATATGGGGGCGGATGACTTTGTGACCAAGCCTTTTGACCAGCAGGT
TCTTTTAGCTAAGGTTCAGGGCTTGTTGCGTCGTTCCTATGAGTTTGGGCGTGATGAGAGTTTGCTGGAATATGCTGGTG
TTATCCTCAATACCAAATCCATGGATTTACATTATCAAGGGCAAGTCTTGAATTTGACCAAGAATGAATTCCAGATTTTA
CGCGTGTTATTTGAGCATGCAGGCAACATCGTAGCACGTGACGACCTGATGCGGGAACTTTGGAACAGTGACTTTTTCAT
TGATGATAATACCCTCTCTGTCAATGTGGCTCGTTTGCGTAAAAAGTTGGAGGAGCAGGGATTGGTAGGATTTATCGAGA
CCAAGAAAGGAATAGGGTACGGATTGAAGCATGCTTGA

Upstream 100 bases:

>100_bases
CATAGCCTGTTTGTACTGGCTAAAAACAGGCTATTTCAAATTCAGTTTCAGACCATCTAGCATGGAAAAATCTGTTATAA
TAATGGAAAAGGAGAAGCGC

Downstream 100 bases:

>100_bases
TTGGAAACAATTTTTTCTAGCCTATCTGCGCTCCCGTAGTCGTCTTTTTATCTATCTGCTTTCTTTGGCATTTCTTGTCT
TACTCTTTCAGTTTTTATTT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSS
RDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA

Sequences:

>Translated_225_residues
MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSS
RDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA
>Mature_225_residues
MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSS
RDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA

Specific function: Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. When activated by BceS, binds to the upstream region of the bceAB promoter and up-regulates the expression of these two genes [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=33.7899543378995, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=28.9592760180996, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=29.7297297297297, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1788394, Length=219, Percent_Identity=27.8538812785388, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=27.8761061946903, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=30.1801801801802, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=31.0810810810811, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=29.2035398230088, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=29.8245614035088, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=28.7671232876712, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=31.2217194570136, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=28.8888888888889, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=32.1266968325792, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788550, Length=105, Percent_Identity=29.5238095238095, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=31.6831683168317, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25965; Mature: 25965

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNG
CCEEEEECCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHCCCCCEEEEECCCHHHCH
YHWCQEIRKISKVPIMFLSSRDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSY
HHHHHHHHHHHCCCEEEECCCCHHEEEEEEEECCCCHHCCCCCCHHHHHHHHHHHHHHHH
EFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQILRVLFEHAGNIVARDDLMREL
HCCCCCHHHHHHHHHEECCCCCEEECCEEEECCHHHHHHHHHHHHHHCCEEEHHHHHHHH
WNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA
CCCCEEEECCCEEEEHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNG
CCEEEEECCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHCCCCCEEEEECCCHHHCH
YHWCQEIRKISKVPIMFLSSRDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSY
HHHHHHHHHHHCCCEEEECCCCHHEEEEEEEECCCCHHCCCCCCHHHHHHHHHHHHHHHH
EFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQILRVLFEHAGNIVARDDLMREL
HCCCCCHHHHHHHHHEECCCCCEEECCEEEECCHHHHHHHHHHHHHHCCEEEHHHHHHHH
WNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA
CCCCEEEECCCEEEEHHHHHHHHHHCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]