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The map label for this gene is pnpS [H]

Identifier: 116515950

GI number: 116515950

Start: 1880410

End: 1881741

Strand: Direct

Name: pnpS [H]

Synonym: SPD_1909

Alternate gene names: 116515950

Gene position: 1880410-1881741 (Clockwise)

Preceding gene: 116516111

Following gene: 116516790

Centisome position: 91.9

GC content: 42.19

Gene sequence:

>1332_bases
ATGAAACGCTACCTTCAATTTTGGCTAGTCAATCTAAGTGTTAGCCTCATTCTGATTGCAGGGATGGCATTAACTTGGAT
CAGTAAAGGCATCGGTCTCTTTCTTCTAGCCCTTTCTTTGGGACAAGGTGGCTACTGGCTCTTTTGCCTTTGGAAATGGG
AAGTTGCTTTTGAGACCTTGCACCAACCTCTCTTGACCAGTAGTGAATACTTTTTAGAAAAAGGGCAAGAAGACTTAAAG
TCTTTGGCTCAGTATGTGTCTGCCCTAAAAACCAAAGTCTCCCAACAGGATCAGCAATACAAGGACCTAGCCGAAACAAT
GGAGGTTCTTCTGTCGCACCTAACCATGGGGACGTTTTTAGTTTCCGCTCAAGGTCAGATGTTATTATCCAGTCGCTCTC
TGCCTCATTATTTTCCCGATGTGGACGGCGACATAAGTTCACTTGATGACCTCAAACGGATGGATATTCGAAATTTAGTT
CACCAAGCCTTTGATCAAAAAACAAGGTTAAAACAAGAAGTAAGTGGGTTTCATGAGGGTGACTTGATTTTAGAAGTGAC
AGCAGTTCCCGTTTTTAGCCCCACCCAATCTGTGGAAGCTGTGCTCGTCTTGCTATATGATTTAACAACGATTAGAACTT
ATGAAAAGTTAAATTTAGCCTTTGTCTCAAATGCCTCCCATGAATTGAGGACACCAGTTACTTCGATTAAGGGCTTTGCT
GAAACCATTAAGGGGATGTCAGCTGAAGAAGAAGCGCTCAAGGATGACTTTCTAGACATTATTTACAAAGAAAGCTTGCG
TCTTGAGCATATTGTTGAGCATCTTCTTACCTTATCTAAGGCTCAACAAATGCCTATACAATGGACGACCCTTTCTTTGG
CAGAATTTGTACAGGATTTGACTCAAAGCTTGCAACCTCAGCTCAAGAAGAAGGATTTACAGCTAAAGGTGCAGGTGCCA
GATGATGTCACCCTCGTATCAGATAGTCAATTACTTTCCCAAATCTTACTCAATCTTTTATCCAATGCCATCCGTTACAC
TGAACAAGGGGGAAAAATTGAGGTCAAGACCCAAAAGGTGAACGAAGGCATTAAGATTTCTGTATCAGATACAGGGATTG
GTATTAGTCAATTAGAGCAGGATCGTATTTTTGAACGTTTTTACCGAGTTAATAAAGGTCGAAGCAGACAAACTGGTGGC
ACTGGTCTTGGCCTTGCCATTGTCAAAGAACTCAGTCAATTATTAGGTGGCCAAGTCACGGTGACAAGTCAGCTTGGCAG
AGGCAGTTGCTTCACGATTTTTCTTCCTAACCAATCTTTCGCACAGGACTAA

Upstream 100 bases:

>100_bases
TCATATTGGTAAGTTGAGGGAAAAAATTGAAGACAATCCTAAAGCCCCTCAATTTATTCGAACCATTCGGGGTTATGGTT
ATAAGTTCAAGGAGTTATAG

Downstream 100 bases:

>100_bases
TAATTTTTAAAGCTATTTTTAGGAGCAGCCATTTTTCAAAAGTGGCTTTTTTTGATTCTTTACACAATCTTTACATGAAT
CAGGGATAAACCTTTACAAA

Product: sensor histidine kinase PnpS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MKRYLQFWLVNLSVSLILIAGMALTWISKGIGLFLLALSLGQGGYWLFCLWKWEVAFETLHQPLLTSSEYFLEKGQEDLK
SLAQYVSALKTKVSQQDQQYKDLAETMEVLLSHLTMGTFLVSAQGQMLLSSRSLPHYFPDVDGDISSLDDLKRMDIRNLV
HQAFDQKTRLKQEVSGFHEGDLILEVTAVPVFSPTQSVEAVLVLLYDLTTIRTYEKLNLAFVSNASHELRTPVTSIKGFA
ETIKGMSAEEEALKDDFLDIIYKESLRLEHIVEHLLTLSKAQQMPIQWTTLSLAEFVQDLTQSLQPQLKKKDLQLKVQVP
DDVTLVSDSQLLSQILLNLLSNAIRYTEQGGKIEVKTQKVNEGIKISVSDTGIGISQLEQDRIFERFYRVNKGRSRQTGG
TGLGLAIVKELSQLLGGQVTVTSQLGRGSCFTIFLPNQSFAQD

Sequences:

>Translated_443_residues
MKRYLQFWLVNLSVSLILIAGMALTWISKGIGLFLLALSLGQGGYWLFCLWKWEVAFETLHQPLLTSSEYFLEKGQEDLK
SLAQYVSALKTKVSQQDQQYKDLAETMEVLLSHLTMGTFLVSAQGQMLLSSRSLPHYFPDVDGDISSLDDLKRMDIRNLV
HQAFDQKTRLKQEVSGFHEGDLILEVTAVPVFSPTQSVEAVLVLLYDLTTIRTYEKLNLAFVSNASHELRTPVTSIKGFA
ETIKGMSAEEEALKDDFLDIIYKESLRLEHIVEHLLTLSKAQQMPIQWTTLSLAEFVQDLTQSLQPQLKKKDLQLKVQVP
DDVTLVSDSQLLSQILLNLLSNAIRYTEQGGKIEVKTQKVNEGIKISVSDTGIGISQLEQDRIFERFYRVNKGRSRQTGG
TGLGLAIVKELSQLLGGQVTVTSQLGRGSCFTIFLPNQSFAQD
>Mature_443_residues
MKRYLQFWLVNLSVSLILIAGMALTWISKGIGLFLLALSLGQGGYWLFCLWKWEVAFETLHQPLLTSSEYFLEKGQEDLK
SLAQYVSALKTKVSQQDQQYKDLAETMEVLLSHLTMGTFLVSAQGQMLLSSRSLPHYFPDVDGDISSLDDLKRMDIRNLV
HQAFDQKTRLKQEVSGFHEGDLILEVTAVPVFSPTQSVEAVLVLLYDLTTIRTYEKLNLAFVSNASHELRTPVTSIKGFA
ETIKGMSAEEEALKDDFLDIIYKESLRLEHIVEHLLTLSKAQQMPIQWTTLSLAEFVQDLTQSLQPQLKKKDLQLKVQVP
DDVTLVSDSQLLSQILLNLLSNAIRYTEQGGKIEVKTQKVNEGIKISVSDTGIGISQLEQDRIFERFYRVNKGRSRQTGG
TGLGLAIVKELSQLLGGQVTVTSQLGRGSCFTIFLPNQSFAQD

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=262, Percent_Identity=31.2977099236641, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI48994928, Length=274, Percent_Identity=30.2919708029197, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1789149, Length=242, Percent_Identity=34.297520661157, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=32.7188940092166, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI145693157, Length=220, Percent_Identity=34.0909090909091, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786783, Length=221, Percent_Identity=33.4841628959276, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=26.8115942028986, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=31.858407079646, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790861, Length=202, Percent_Identity=32.1782178217822, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=30, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87081816, Length=222, Percent_Identity=31.5315315315315, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=27.5229357798165, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790346, Length=219, Percent_Identity=32.8767123287671, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=31.6017316017316, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI87082128, Length=222, Percent_Identity=27.027027027027, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788279, Length=243, Percent_Identity=27.5720164609054, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790551, Length=274, Percent_Identity=29.1970802919708, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790300, Length=231, Percent_Identity=26.4069264069264, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=209, Percent_Identity=30.622009569378, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787374, Length=223, Percent_Identity=22.4215246636771, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49756; Mature: 49756

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRYLQFWLVNLSVSLILIAGMALTWISKGIGLFLLALSLGQGGYWLFCLWKWEVAFETL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHH
HQPLLTSSEYFLEKGQEDLKSLAQYVSALKTKVSQQDQQYKDLAETMEVLLSHLTMGTFL
HHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSAQGQMLLSSRSLPHYFPDVDGDISSLDDLKRMDIRNLVHQAFDQKTRLKQEVSGFHEG
HHCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DLILEVTAVPVFSPTQSVEAVLVLLYDLTTIRTYEKLNLAFVSNASHELRTPVTSIKGFA
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHCHHHHHHHHH
ETIKGMSAEEEALKDDFLDIIYKESLRLEHIVEHLLTLSKAQQMPIQWTTLSLAEFVQDL
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHH
TQSLQPQLKKKDLQLKVQVPDDVTLVSDSQLLSQILLNLLSNAIRYTEQGGKIEVKTQKV
HHHHCHHHCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
NEGIKISVSDTGIGISQLEQDRIFERFYRVNKGRSRQTGGTGLGLAIVKELSQLLGGQVT
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEE
VTSQLGRGSCFTIFLPNQSFAQD
EEECCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MKRYLQFWLVNLSVSLILIAGMALTWISKGIGLFLLALSLGQGGYWLFCLWKWEVAFETL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHH
HQPLLTSSEYFLEKGQEDLKSLAQYVSALKTKVSQQDQQYKDLAETMEVLLSHLTMGTFL
HHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSAQGQMLLSSRSLPHYFPDVDGDISSLDDLKRMDIRNLVHQAFDQKTRLKQEVSGFHEG
HHCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DLILEVTAVPVFSPTQSVEAVLVLLYDLTTIRTYEKLNLAFVSNASHELRTPVTSIKGFA
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHCHHHHHHHHH
ETIKGMSAEEEALKDDFLDIIYKESLRLEHIVEHLLTLSKAQQMPIQWTTLSLAEFVQDL
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHH
TQSLQPQLKKKDLQLKVQVPDDVTLVSDSQLLSQILLNLLSNAIRYTEQGGKIEVKTQKV
HHHHCHHHCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
NEGIKISVSDTGIGISQLEQDRIFERFYRVNKGRSRQTGGTGLGLAIVKELSQLLGGQVT
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEE
VTSQLGRGSCFTIFLPNQSFAQD
EEECCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]