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The map label for this gene is ykgC [H]

Identifier: 116515420

GI number: 116515420

Start: 1434508

End: 1435824

Strand: Direct

Name: ykgC [H]

Synonym: SPD_1415

Alternate gene names: 116515420

Gene position: 1434508-1435824 (Clockwise)

Preceding gene: 116516331

Following gene: 116516543

Centisome position: 70.11

GC content: 41.61

Gene sequence:

>1317_bases
ATGTTAACATACGATTTAATTGTTATTGGATTTGGTAAAGCTGGTAAAACACTAGCTGGTAAATTGGCTTCAGCTGGCAA
AAAAGTTGCCCTCGTTGAACGTAGCAAAGCTATGTACGGTGGAACTTGTATCAACATCGGTTGTATCCCAACTAAAACTT
TGCTGGTTGCTGCTGAGAAAGACTTGTCTTTTGAAGAAGTCATTGCTACCAAAAACACGATCACTGGTCGCCTCAACGGT
AAAAACTATACGACTGTTGCTGGTACTGGCGTCGATATCTTTGATGCTGAAGCTCACTTCCTTTCAAATAAAGTCATCGA
AATCCAAGCTGGTGATGAAAAACAAGAATTGACTGCTGAAACTATCGTCATCAACACTGGTGCTGTTTCAAACGTCTTGC
CAATCCCTGGACTTGCTACAAGCAAAAACGTCTTTGACTCAACAGGTATCCAAAGCTTGGATAAATTGCCTGAAAAACTT
GGAGTCCTTGGTGGCGGAAATATCGGTCTTGAATTTGCTGGCCTTTACAATAAACTAGGAAGCAAGGTTACAGTCCTAGA
TACCTTGGATACATTCCTACCTCGTGCAGAACCTTCCATCGCAGCTCTTGCTAAACAATACCTGGAAGAAGACGGTATTG
AATTGCTTCAAAATATCCATACTACTGAAATCAAAAACGATGGTGACCAAGTGCTTGTCGTAACTGAAGACGAAACTTAC
CGTTTCGACGCCCTTCTCTACGCAACTGGACGCAAACCAAATGTAGAACCACTTCAACTTGAAAATACAGATATTGAACT
AACTGAACGTGGTGCTATTAAAGTAGACAAACACTGTCAAACAAACGTTCCTGGTGTCTTTGCAGTTGGAGATGTCAACG
GTGGCCTTCAATTTACTTACATTTCACTTGATGACTTCCGTGTTGTTTACAGCTACCTTGCTGGAGATGGCAGCTACACA
CTTGAGGACCGTCTCAATGTGCCAAATACTATGTTCATCACACCTGCACTTTCACAAGTTGGTTTGACTGAAAGCCAAGC
AGCTGATTTGAAACTTCCATACGCAGTGAAAGAAATCCCTGTTGCAGCCATGCCTCGTGGTCACGTAAATGGAGACCTTC
GCGGAGCTTTCAAAGCTGTTGTTAATACTGAAACAAAAGAAATTCTTGGTGCAAGCATCTTCTCAGAAGGTTCTCAAGAA
ATCATCAACATCATTACTGTTGCTATGGACAACAAGATTCCTTACACTTACTTCACAAAACAAATCTTCACTCACCCAAC
CTTGGCTGAGAACTTGAATGACTTGTTTGCGATTTAA

Upstream 100 bases:

>100_bases
TTTGCCTAGAAAGCGTTTTCATTTTTTGTCTTTTTCGTAGCAGAATTGTGCAAAAGTTTTTTTCTTGTGCTAGAATGTAA
TTCGAATAGGAGGAAGATAA

Downstream 100 bases:

>100_bases
GTTGAAATCTCATCTTAACTGACAGCCCTCTTTGGGCTGTTTTTACTTCTACGAAACACCAAATCTGTCTTTTCCCTCTT
TTGTGATATAATAGAAACAT

Product: pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MLTYDLIVIGFGKAGKTLAGKLASAGKKVALVERSKAMYGGTCINIGCIPTKTLLVAAEKDLSFEEVIATKNTITGRLNG
KNYTTVAGTGVDIFDAEAHFLSNKVIEIQAGDEKQELTAETIVINTGAVSNVLPIPGLATSKNVFDSTGIQSLDKLPEKL
GVLGGGNIGLEFAGLYNKLGSKVTVLDTLDTFLPRAEPSIAALAKQYLEEDGIELLQNIHTTEIKNDGDQVLVVTEDETY
RFDALLYATGRKPNVEPLQLENTDIELTERGAIKVDKHCQTNVPGVFAVGDVNGGLQFTYISLDDFRVVYSYLAGDGSYT
LEDRLNVPNTMFITPALSQVGLTESQAADLKLPYAVKEIPVAAMPRGHVNGDLRGAFKAVVNTETKEILGASIFSEGSQE
IINIITVAMDNKIPYTYFTKQIFTHPTLAENLNDLFAI

Sequences:

>Translated_438_residues
MLTYDLIVIGFGKAGKTLAGKLASAGKKVALVERSKAMYGGTCINIGCIPTKTLLVAAEKDLSFEEVIATKNTITGRLNG
KNYTTVAGTGVDIFDAEAHFLSNKVIEIQAGDEKQELTAETIVINTGAVSNVLPIPGLATSKNVFDSTGIQSLDKLPEKL
GVLGGGNIGLEFAGLYNKLGSKVTVLDTLDTFLPRAEPSIAALAKQYLEEDGIELLQNIHTTEIKNDGDQVLVVTEDETY
RFDALLYATGRKPNVEPLQLENTDIELTERGAIKVDKHCQTNVPGVFAVGDVNGGLQFTYISLDDFRVVYSYLAGDGSYT
LEDRLNVPNTMFITPALSQVGLTESQAADLKLPYAVKEIPVAAMPRGHVNGDLRGAFKAVVNTETKEILGASIFSEGSQE
IINIITVAMDNKIPYTYFTKQIFTHPTLAENLNDLFAI
>Mature_438_residues
MLTYDLIVIGFGKAGKTLAGKLASAGKKVALVERSKAMYGGTCINIGCIPTKTLLVAAEKDLSFEEVIATKNTITGRLNG
KNYTTVAGTGVDIFDAEAHFLSNKVIEIQAGDEKQELTAETIVINTGAVSNVLPIPGLATSKNVFDSTGIQSLDKLPEKL
GVLGGGNIGLEFAGLYNKLGSKVTVLDTLDTFLPRAEPSIAALAKQYLEEDGIELLQNIHTTEIKNDGDQVLVVTEDETY
RFDALLYATGRKPNVEPLQLENTDIELTERGAIKVDKHCQTNVPGVFAVGDVNGGLQFTYISLDDFRVVYSYLAGDGSYT
LEDRLNVPNTMFITPALSQVGLTESQAADLKLPYAVKEIPVAAMPRGHVNGDLRGAFKAVVNTETKEILGASIFSEGSQE
IINIITVAMDNKIPYTYFTKQIFTHPTLAENLNDLFAI

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=463, Percent_Identity=29.3736501079914, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=27.7056277056277, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI22035672, Length=386, Percent_Identity=28.2383419689119, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI33519430, Length=367, Percent_Identity=27.2479564032698, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI33519428, Length=367, Percent_Identity=27.2479564032698, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI33519426, Length=367, Percent_Identity=27.2479564032698, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI148277071, Length=367, Percent_Identity=27.2479564032698, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI148277065, Length=367, Percent_Identity=27.2479564032698, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI291045266, Length=440, Percent_Identity=25.9090909090909, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI87081717, Length=439, Percent_Identity=46.9248291571754, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1786307, Length=449, Percent_Identity=28.5077951002227, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=28.9416846652268, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789915, Length=434, Percent_Identity=27.8801843317972, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32565766, Length=456, Percent_Identity=28.5087719298246, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17557007, Length=476, Percent_Identity=25.4201680672269, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=436, Percent_Identity=25.4587155963303, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71983429, Length=436, Percent_Identity=25.4587155963303, Blast_Score=112, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6321091, Length=468, Percent_Identity=27.3504273504274, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=27.8969957081545, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6325240, Length=471, Percent_Identity=25.6900212314225, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=29.4759825327511, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24640553, Length=480, Percent_Identity=27.0833333333333, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24640549, Length=480, Percent_Identity=27.0833333333333, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24640551, Length=480, Percent_Identity=27.0833333333333, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17737741, Length=482, Percent_Identity=26.1410788381743, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 47175; Mature: 47175

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYDLIVIGFGKAGKTLAGKLASAGKKVALVERSKAMYGGTCINIGCIPTKTLLVAAEK
CEEEEEEEEEECCCCCHHHHHHHHCCCEEEEEECCCHHCCCEEEEECCCCCCEEEEEECC
DLSFEEVIATKNTITGRLNGKNYTTVAGTGVDIFDAEAHFLSNKVIEIQAGDEKQELTAE
CCCHHHHHHCCCCEEEEECCCEEEEEEECCCEEECCCHHHHCCEEEEEEECCCHHHEEEE
TIVINTGAVSNVLPIPGLATSKNVFDSTGIQSLDKLPEKLGVLGGGNIGLEFAGLYNKLG
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHC
SKVTVLDTLDTFLPRAEPSIAALAKQYLEEDGIELLQNIHTTEIKNDGDQVLVVTEDETY
CEEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCEEEEEECCCCE
RFDALLYATGRKPNVEPLQLENTDIELTERGAIKVDKHCQTNVPGVFAVGDVNGGLQFTY
EEEEEEEECCCCCCCCCEEECCCCEEEECCCCEEECCCCCCCCCCEEEEECCCCCEEEEE
ISLDDFRVVYSYLAGDGSYTLEDRLNVPNTMFITPALSQVGLTESQAADLKLPYAVKEIP
EECHHHHHHHHHHCCCCCEEEHHCCCCCCEEEEECCHHHCCCCCCCCCCEECCCHHHHCC
VAAMPRGHVNGDLRGAFKAVVNTETKEILGASIFSEGSQEIINIITVAMDNKIPYTYFTK
EEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHEEEEEECCCCCHHHHHH
QIFTHPTLAENLNDLFAI
HHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLTYDLIVIGFGKAGKTLAGKLASAGKKVALVERSKAMYGGTCINIGCIPTKTLLVAAEK
CEEEEEEEEEECCCCCHHHHHHHHCCCEEEEEECCCHHCCCEEEEECCCCCCEEEEEECC
DLSFEEVIATKNTITGRLNGKNYTTVAGTGVDIFDAEAHFLSNKVIEIQAGDEKQELTAE
CCCHHHHHHCCCCEEEEECCCEEEEEEECCCEEECCCHHHHCCEEEEEEECCCHHHEEEE
TIVINTGAVSNVLPIPGLATSKNVFDSTGIQSLDKLPEKLGVLGGGNIGLEFAGLYNKLG
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHC
SKVTVLDTLDTFLPRAEPSIAALAKQYLEEDGIELLQNIHTTEIKNDGDQVLVVTEDETY
CEEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCEEEEEECCCCE
RFDALLYATGRKPNVEPLQLENTDIELTERGAIKVDKHCQTNVPGVFAVGDVNGGLQFTY
EEEEEEEECCCCCCCCCEEECCCCEEEECCCCEEECCCCCCCCCCEEEEECCCCCEEEEE
ISLDDFRVVYSYLAGDGSYTLEDRLNVPNTMFITPALSQVGLTESQAADLKLPYAVKEIP
EECHHHHHHHHHHCCCCCEEEHHCCCCCCEEEEECCHHHCCCCCCCCCCEECCCHHHHCC
VAAMPRGHVNGDLRGAFKAVVNTETKEILGASIFSEGSQEIINIITVAMDNKIPYTYFTK
EEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHEEEEEECCCCCHHHHHH
QIFTHPTLAENLNDLFAI
HHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]