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The map label for this gene is iolS [H]

Identifier: 116496246

GI number: 116496246

Start: 2808194

End: 2809123

Strand: Direct

Name: iolS [H]

Synonym: LSEI_2825

Alternate gene names: 116496246

Gene position: 2808194-2809123 (Clockwise)

Preceding gene: 116496245

Following gene: 116496252

Centisome position: 96.99

GC content: 46.13

Gene sequence:

>930_bases
ATGGCAATGACAACGACAATTGGTAAAAGTACGGTCACAACCGGGAAACTAGGTTTAGGCACCAATAAAGTCGGCGGCCA
CAACTTGTTCCCTAATCTGCATGACGAAGATGGCATCGCCGTCGTGAAAGCCGCGCTTGACCACGGCATTGACATGCTCG
ATACCGCTTATATGTATGGTTTAGGACAGTCGGAAAAATTAATCGGTGAAGCCACACAAGGCTATGATCGCAGCAAAATT
ATTCTGGCAACCAAGGCAGCACAGGATCCGCACAATGATCTCAAACCAAATAACGATCCCAAATTTTTAACGCAGGCAAT
TGATGATGCTTTGTTACGCCTTAAAACCGATTACCTTGATATTTTCTATATTCATTTTCCTGATGACAAAACTGACAAAG
CGGAGGCGGTCAATGCCATTGCCAATGCCCGCAAGGCCGGCAAGGTGCGGGCGATCGGCGTTTCTAACTTCTCATTAGAC
CAAATCAAAGAGGCCAACCAAGACAATCAGGTTGATGTCGTTGAAGACAATTACAGTTTAGTACATCGCGATGCTGAGCA
AAACCTGTTCCCGTATTTGAATGAACACCAGATCAGTTTCGTCCCATACTTTCCACTCGCATCCGGCTTGTTAACTGGTA
AGTATGGCCTTGATGATGCTGACAAGTTTAGTCGACGTTTCTCGGCAGATCAGTTCAAGACCATTCTTGCCGCTTTGCGA
GAAGTCGATGGCATCGCTGATGCCCATCAGGCAACCTTGGCTCAGGTTTTCTTGGCTTGGTACATGATGAATCCGGCCAT
TGCGGTTGTGATTCCCGGTGCCCGCCTACCTGAACAAGCTACAAGCAATGCTAAAGCTTTAGACGTCAATTTACGCGATG
CTGAATATGCATCTATTGACGAGTTGTTCAAAAAATTCCGTACTGAATAA

Upstream 100 bases:

>100_bases
TGCGAACCATCGGATTTTTCCATCAAAGGCGAATAGATAGCGCTTGCAAGTTTCTATTACTTTTTTTACACTAAGCATGA
ATGGCTAAGGAGGTCACAAA

Downstream 100 bases:

>100_bases
TCGCGCATTGTTCTAGGCTACAGACTTCGCACAATCCAAAAAGCAGCCCGCTTCCAGCATGTCACACATGCGGAAACGAG
CTGCTTCTTTTTATTATCGA

Product: Aryl-alcohol dehydrogenase related enzyme

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MAMTTTIGKSTVTTGKLGLGTNKVGGHNLFPNLHDEDGIAVVKAALDHGIDMLDTAYMYGLGQSEKLIGEATQGYDRSKI
ILATKAAQDPHNDLKPNNDPKFLTQAIDDALLRLKTDYLDIFYIHFPDDKTDKAEAVNAIANARKAGKVRAIGVSNFSLD
QIKEANQDNQVDVVEDNYSLVHRDAEQNLFPYLNEHQISFVPYFPLASGLLTGKYGLDDADKFSRRFSADQFKTILAALR
EVDGIADAHQATLAQVFLAWYMMNPAIAVVIPGARLPEQATSNAKALDVNLRDAEYASIDELFKKFRTE

Sequences:

>Translated_309_residues
MAMTTTIGKSTVTTGKLGLGTNKVGGHNLFPNLHDEDGIAVVKAALDHGIDMLDTAYMYGLGQSEKLIGEATQGYDRSKI
ILATKAAQDPHNDLKPNNDPKFLTQAIDDALLRLKTDYLDIFYIHFPDDKTDKAEAVNAIANARKAGKVRAIGVSNFSLD
QIKEANQDNQVDVVEDNYSLVHRDAEQNLFPYLNEHQISFVPYFPLASGLLTGKYGLDDADKFSRRFSADQFKTILAALR
EVDGIADAHQATLAQVFLAWYMMNPAIAVVIPGARLPEQATSNAKALDVNLRDAEYASIDELFKKFRTE
>Mature_308_residues
AMTTTIGKSTVTTGKLGLGTNKVGGHNLFPNLHDEDGIAVVKAALDHGIDMLDTAYMYGLGQSEKLIGEATQGYDRSKII
LATKAAQDPHNDLKPNNDPKFLTQAIDDALLRLKTDYLDIFYIHFPDDKTDKAEAVNAIANARKAGKVRAIGVSNFSLDQ
IKEANQDNQVDVVEDNYSLVHRDAEQNLFPYLNEHQISFVPYFPLASGLLTGKYGLDDADKFSRRFSADQFKTILAALRE
VDGIADAHQATLAQVFLAWYMMNPAIAVVIPGARLPEQATSNAKALDVNLRDAEYASIDELFKKFRTE

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436964, Length=304, Percent_Identity=26.9736842105263, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI27436966, Length=304, Percent_Identity=26.9736842105263, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI27436962, Length=304, Percent_Identity=26.9736842105263, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI223718702, Length=206, Percent_Identity=33.0097087378641, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI27436969, Length=303, Percent_Identity=26.4026402640264, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4504825, Length=303, Percent_Identity=26.4026402640264, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI41152114, Length=190, Percent_Identity=32.6315789473684, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI27436971, Length=305, Percent_Identity=26.8852459016393, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI41327764, Length=184, Percent_Identity=33.695652173913, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI223718708, Length=127, Percent_Identity=31.496062992126, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788070, Length=315, Percent_Identity=28.5714285714286, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87081735, Length=313, Percent_Identity=30.0319488817891, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789199, Length=346, Percent_Identity=29.7687861271676, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1788081, Length=268, Percent_Identity=30.2238805970149, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789375, Length=322, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787674, Length=311, Percent_Identity=25.4019292604502, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082198, Length=285, Percent_Identity=24.5614035087719, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786400, Length=284, Percent_Identity=27.8169014084507, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI48994888, Length=285, Percent_Identity=24.5614035087719, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17537077, Length=284, Percent_Identity=27.112676056338, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561300, Length=302, Percent_Identity=24.5033112582781, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561298, Length=302, Percent_Identity=24.8344370860927, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537075, Length=284, Percent_Identity=26.056338028169, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212645785, Length=215, Percent_Identity=24.6511627906977, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552492, Length=207, Percent_Identity=28.5024154589372, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538386, Length=308, Percent_Identity=25.3246753246753, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=303, Percent_Identity=24.7524752475248, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319958, Length=286, Percent_Identity=21.3286713286713, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323998, Length=286, Percent_Identity=22.027972027972, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24646159, Length=167, Percent_Identity=31.1377245508982, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24644950, Length=304, Percent_Identity=25.3289473684211, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646155, Length=159, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 34039; Mature: 33908

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMTTTIGKSTVTTGKLGLGTNKVGGHNLFPNLHDEDGIAVVKAALDHGIDMLDTAYMYG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHC
LGQSEKLIGEATQGYDRSKIILATKAAQDPHNDLKPNNDPKFLTQAIDDALLRLKTDYLD
CCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
IFYIHFPDDKTDKAEAVNAIANARKAGKVRAIGVSNFSLDQIKEANQDNQVDVVEDNYSL
EEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCEEEEECCHHH
VHRDAEQNLFPYLNEHQISFVPYFPLASGLLTGKYGLDDADKFSRRFSADQFKTILAALR
EECCCHHCCCCCCCCCCEEEEECHHHHCCCEECCCCCCCHHHHHHHCCHHHHHHHHHHHH
EVDGIADAHQATLAQVFLAWYMMNPAIAVVIPGARLPEQATSNAKALDVNLRDAEYASID
HHHCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHCCCCEEEEEECCCCCHHHHH
ELFKKFRTE
HHHHHHCCC
>Mature Secondary Structure 
AMTTTIGKSTVTTGKLGLGTNKVGGHNLFPNLHDEDGIAVVKAALDHGIDMLDTAYMYG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHC
LGQSEKLIGEATQGYDRSKIILATKAAQDPHNDLKPNNDPKFLTQAIDDALLRLKTDYLD
CCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
IFYIHFPDDKTDKAEAVNAIANARKAGKVRAIGVSNFSLDQIKEANQDNQVDVVEDNYSL
EEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCEEEEECCHHH
VHRDAEQNLFPYLNEHQISFVPYFPLASGLLTGKYGLDDADKFSRRFSADQFKTILAALR
EECCCHHCCCCCCCCCCEEEEECHHHHCCCEECCCCCCCHHHHHHHCCHHHHHHHHHHHH
EVDGIADAHQATLAQVFLAWYMMNPAIAVVIPGARLPEQATSNAKALDVNLRDAEYASID
HHHCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHCCCCEEEEEECCCCCHHHHH
ELFKKFRTE
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]