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The map label for this gene is qor [C]

Identifier: 116496209

GI number: 116496209

Start: 2768420

End: 2769457

Strand: Direct

Name: qor [C]

Synonym: LSEI_2787

Alternate gene names: 116496209

Gene position: 2768420-2769457 (Clockwise)

Preceding gene: 116496202

Following gene: 116496216

Centisome position: 95.62

GC content: 47.21

Gene sequence:

>1038_bases
ATGACCAAAACCATGCAGGCCGCGCTTATCACGCATTATAAACAGGCTATGCCTGAAATTCAAAATGTCCCTTTACCCAC
TGTGCGACCAAATGATGTTTTGGTGCGCATTGTGGCAGCAAGCATTAATCCAATTGATCTCAAAACGAAAGACGGCAAGC
TGCGACTATTATTAAAATACCAGATGCCATTGATTCTTGGCAGCGATTTTTCAGGTATCGTCACAAAAGTCGGAACCAAC
GTGACTCGTTTTAAAGTCGGCGACGCCGTTTTTGGCCGACCACAAAAAGACCGGATCGGAACATTTGCAGATTTTCTTGC
GATTGATCAACACGATATTGCTTTGAAACCCAGTCGGCTGACATTTGAAGAAGCTGCCGCCTTACCCCTTGTCAGTCTCA
CCAGTTATCAAGCGCTACACGACTTGATGCACTTAACGCCTGGTCAAAAAGTTCTGATTCAAGCCGGAGCCGGTGGTGTC
GGTACCGTCGCGATTCAAATTGCCAAAGCCTTTGGTGCAGAGGTCGCCACCACCACGAGTAGTCAGAATATCGCTTTTGT
TAAATCACTAGGCGCCGATCACGTCATTGATTATCACCGTGTGCCATTTCAGAATGTTCTGTCGGACTATGACGGCGTTT
TTGACACACTCGGCGGCACCAGTCTCGCGAATGCGTTTCAAATCGTCAAACCCGGCGGCACGATTGTCAGTGTTTCTGGC
ATCCCTGATGAACAGTTCAGTGACGCTTATAATGTCCCATTTTGGAAAAAAACAGCCTTTCGTCTGGCAAATCACCGTAT
CAGCAAGCTCGCTCGGAAAACCGGCGTCACCTATCGTTTCCTCTTCATGCATCCCAGCGGTTCAGAACTGGAAAAAATAG
GCGAACTCGTCGAAAATGACAAACTTCGCCCTATTGTTGATCGCGTTCTCCCATTTGCTCAGCTTCCTGAGGCATTTGCC
TATTCACAGGCTGGTCACGCCAAAGGAAAAATCATTTTAAAGCTGGTCGATAACCCTAACTCACTTTTGCAGGTATAA

Upstream 100 bases:

>100_bases
TTTTTTTAAGCGACACCTTGATAATTGACTTTAAAATGCAAGTGCTCTATATTCCTTGTTATTGGTTCAAAAAAATAAAC
CATTAGTCGAGGAATATGTC

Downstream 100 bases:

>100_bases
ATCGCGAAATTGTGCAATCTCACCTGCTGATAGCTTGAGTCCTTCGCGTAAGTATTGCTGAAATGGCCCAAATTGCTGAT
CAATTACTTGAAAATAACGC

Product: NADPH:quinone reductase related Zn-dependent oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTKTMQAALITHYKQAMPEIQNVPLPTVRPNDVLVRIVAASINPIDLKTKDGKLRLLLKYQMPLILGSDFSGIVTKVGTN
VTRFKVGDAVFGRPQKDRIGTFADFLAIDQHDIALKPSRLTFEEAAALPLVSLTSYQALHDLMHLTPGQKVLIQAGAGGV
GTVAIQIAKAFGAEVATTTSSQNIAFVKSLGADHVIDYHRVPFQNVLSDYDGVFDTLGGTSLANAFQIVKPGGTIVSVSG
IPDEQFSDAYNVPFWKKTAFRLANHRISKLARKTGVTYRFLFMHPSGSELEKIGELVENDKLRPIVDRVLPFAQLPEAFA
YSQAGHAKGKIILKLVDNPNSLLQV

Sequences:

>Translated_345_residues
MTKTMQAALITHYKQAMPEIQNVPLPTVRPNDVLVRIVAASINPIDLKTKDGKLRLLLKYQMPLILGSDFSGIVTKVGTN
VTRFKVGDAVFGRPQKDRIGTFADFLAIDQHDIALKPSRLTFEEAAALPLVSLTSYQALHDLMHLTPGQKVLIQAGAGGV
GTVAIQIAKAFGAEVATTTSSQNIAFVKSLGADHVIDYHRVPFQNVLSDYDGVFDTLGGTSLANAFQIVKPGGTIVSVSG
IPDEQFSDAYNVPFWKKTAFRLANHRISKLARKTGVTYRFLFMHPSGSELEKIGELVENDKLRPIVDRVLPFAQLPEAFA
YSQAGHAKGKIILKLVDNPNSLLQV
>Mature_344_residues
TKTMQAALITHYKQAMPEIQNVPLPTVRPNDVLVRIVAASINPIDLKTKDGKLRLLLKYQMPLILGSDFSGIVTKVGTNV
TRFKVGDAVFGRPQKDRIGTFADFLAIDQHDIALKPSRLTFEEAAALPLVSLTSYQALHDLMHLTPGQKVLIQAGAGGVG
TVAIQIAKAFGAEVATTTSSQNIAFVKSLGADHVIDYHRVPFQNVLSDYDGVFDTLGGTSLANAFQIVKPGGTIVSVSGI
PDEQFSDAYNVPFWKKTAFRLANHRISKLARKTGVTYRFLFMHPSGSELEKIGELVENDKLRPIVDRVLPFAQLPEAFAY
SQAGHAKGKIILKLVDNPNSLLQV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=372, Percent_Identity=32.7956989247312, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI18379349, Length=324, Percent_Identity=27.7777777777778, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI67078404, Length=234, Percent_Identity=31.6239316239316, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI194239674, Length=232, Percent_Identity=26.7241379310345, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI13236495, Length=232, Percent_Identity=26.7241379310345, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI22538446, Length=345, Percent_Identity=26.3768115942029, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI22538444, Length=345, Percent_Identity=26.3768115942029, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI194239676, Length=191, Percent_Identity=28.7958115183246, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI24308257, Length=354, Percent_Identity=24.8587570621469, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI67078406, Length=216, Percent_Identity=30.5555555555556, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI90669511, Length=161, Percent_Identity=34.1614906832298, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI28557745, Length=367, Percent_Identity=26.7029972752044, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1790485, Length=241, Percent_Identity=31.1203319502075, Blast_Score=92, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71987554, Length=362, Percent_Identity=29.2817679558011, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17507255, Length=242, Percent_Identity=30.9917355371901, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17536829, Length=219, Percent_Identity=28.7671232876712, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17556000, Length=258, Percent_Identity=25.968992248062, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=224, Percent_Identity=27.6785714285714, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324195, Length=231, Percent_Identity=29.8701298701299, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319520, Length=229, Percent_Identity=26.6375545851528, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24581339, Length=349, Percent_Identity=28.6532951289398, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24581341, Length=349, Percent_Identity=28.6532951289398, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45550423, Length=304, Percent_Identity=25.3289473684211, Blast_Score=81, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 37602; Mature: 37471

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTMQAALITHYKQAMPEIQNVPLPTVRPNDVLVRIVAASINPIDLKTKDGKLRLLLKY
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEEEECCCCCEEEEECCCCEEEEEEE
QMPLILGSDFSGIVTKVGTNVTRFKVGDAVFGRPQKDRIGTFADFLAIDQHDIALKPSRL
CCCEEECCCCHHHHHHHCCCEEEEEECCHHCCCCCHHHCCHHHHHHEECCCCCEECCCCC
TFEEAAALPLVSLTSYQALHDLMHLTPGQKVLIQAGAGGVGTVAIQIAKAFGAEVATTTS
CHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEECCC
SQNIAFVKSLGADHVIDYHRVPFQNVLSDYDGVFDTLGGTSLANAFQIVKPGGTIVSVSG
CCCCHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHEEEECCCCCEEEECC
IPDEQFSDAYNVPFWKKTAFRLANHRISKLARKTGVTYRFLFMHPSGSELEKIGELVEND
CCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCC
KLRPIVDRVLPFAQLPEAFAYSQAGHAKGKIILKLVDNPNSLLQV
CCHHHHHHHCCHHHCCHHHHHCCCCCCCCEEEEEEECCCHHHHCC
>Mature Secondary Structure 
TKTMQAALITHYKQAMPEIQNVPLPTVRPNDVLVRIVAASINPIDLKTKDGKLRLLLKY
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEEEECCCCCEEEEECCCCEEEEEEE
QMPLILGSDFSGIVTKVGTNVTRFKVGDAVFGRPQKDRIGTFADFLAIDQHDIALKPSRL
CCCEEECCCCHHHHHHHCCCEEEEEECCHHCCCCCHHHCCHHHHHHEECCCCCEECCCCC
TFEEAAALPLVSLTSYQALHDLMHLTPGQKVLIQAGAGGVGTVAIQIAKAFGAEVATTTS
CHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEECCC
SQNIAFVKSLGADHVIDYHRVPFQNVLSDYDGVFDTLGGTSLANAFQIVKPGGTIVSVSG
CCCCHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHEEEECCCCCEEEECC
IPDEQFSDAYNVPFWKKTAFRLANHRISKLARKTGVTYRFLFMHPSGSELEKIGELVEND
CCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCC
KLRPIVDRVLPFAQLPEAFAYSQAGHAKGKIILKLVDNPNSLLQV
CCHHHHHHHCCHHHCCHHHHHCCCCCCCCEEEEEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA