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The map label for this gene is uvrA [H]

Identifier: 116496064

GI number: 116496064

Start: 2622072

End: 2624600

Strand: Direct

Name: uvrA [H]

Synonym: LSEI_2637

Alternate gene names: 116496064

Gene position: 2622072-2624600 (Clockwise)

Preceding gene: 116496063

Following gene: 116496068

Centisome position: 90.56

GC content: 52.55

Gene sequence:

>2529_bases
ATGGCAATTCCCGATCATATCAGTGTTCGCGGCGCTTACGTTAACAACTTGAAGCATCTCAATGTTGATATTCCACTTAA
CAAACTGGTGGCGATCACTGGTCGGTCTGGTTCCGGTAAAAGTTCATTAGCCATGGGCGTGTTATACGCTGAAGGTATGC
GCCGCTACATGAGTGCCTTGTCCACCTACACCCGCCGGCGCCTTGGCCAAACAAGTCTTGCTGCTGCTGACTCAGTACGC
CACATTCCTAGTGCCATCGCTTTGCGGCAGCGGCCAACCGTTCCAGGCATCCGCTCAACTGTCGGTACGGCCACAGAAGC
GCTCAACGTCATTCGCCTCATGTTTTCCCGTCTCGGCTCGCCGGTTTGTCCTAATGGTCACCGCGTGTCGCCAACCCTCG
ATATTGCCAAGGCAATGGATCTGCCCAATGACGGTGAAAGCGGTATGGGCATGATCACTTGTCCGACCTGTGGCGTCCGT
TTCATGGCTTTTGCTGCTGAAGATTTCGCCTTCAATTCAACTGGCGCCTGCCCGACATGCGGCGGTACTGGTCAAGCGCG
CACACTGGCCGCCAACCGGCTCATCCCTGATCGAACACTGACAATCCGTCAAGGTGCCGTGGCCTCGTGGCGCTTGCCCG
GTCGCAATTTTATGCCTTTTGTCGCACAAGCAATCGGCATTGATATTGATACGCCTTTCCAGGACCTGCCAAAAGATCAG
CAAGAACAGGTTTGGCACGGTGAACGTAAAAAATACGCCATCAATATCCCCAGCAAAACCGGCAAAATTTTTCATATGGA
CCATGCACAGTACGAGAATGCCTTCAATGCGGTCGAAGATTCTTTAGCGACGACCAAAAATGAACGCGCCATTCAGCGGC
TGAATCGCTTCTATGAGTTTGGCATCTGCCCGACCTGCCATGGCAGCCGATTTTCCCCGAAATTATTGAGCCAGCACCTA
GTGGATCAAAACATTGCTCAGGTTAGTGATATGACTTTAACGCAATTAGCCGCGTTCATTCCCGAAATCTATCACTGGTT
GCCAGCAGATATGCAGTCACTGGCGCACGATATTATCCAAGAACTGACGCAATTGCTTAAGCCCATCATGGACCTTGGCC
TCAGTTACCTGACCCTGAGTCGAGCCGCGGCTTCCTTATCGACTGGTGAATTGCAACGCATTCAGCTCAGTCGCACGCTT
CGGACTGAAACGACCGGCGTCCTTTACGTCCTTGATGAACCGTCCATCGGCCTGCATGCTGCAAACGTTTCTGGATTGCT
AGAAGTCATGCACGGTTTGGTCAATCAAGGCAACTCGCTGGTCGTTGTGGATCACAACACCGCCATCATTGAGGCAGCCG
ATCAAGTGATTGAGATTGGTCCCGGTGCAGGCGTTGCTGGCGGCCGACTCATTGATCAAGGTAGCCCTGAAGCGATCAGC
CATGATACCCATTCGTTGATTGCACCCTTTTTAACCGGAGCGGCTCCCTTGATTGTTCGCCCGCAAGCTGGTGAACAAGA
AATTAAGCAAACCAAACAACTGCAATTAACCGTAACTGATCGATTTAACCTTCATGACCTGCATGTCCATTTTCCAGTTA
ACTGCTTCTCAGTGGTATCCGGCTTTTCTGGTGCTGGCAAGTCAACTTTGATTTTTGACGCCCTAGTACCAGCGCTGTCA
GCAACTGCTGACCAACCAGCTCCAGCATTTGTTCGTGATCTTGACCGCGGCGGCCTGCGCCATGTAGTTGCGATTGATGC
TACGCCGGTCGGTAAAAATGTCCGCTCAACCGTCGCCACCTACACAGACATTCTCGACCATCTGCGGCACCTTTTCGCCA
GTTTGCCTGATGCCAAAGCCAAGCACTATACGAGTAGCCATTTCTCTTACAACGTCAAAGCCGGCGCGTGCCCGACATGC
GGCGGTACCGGCGTCATTAACTTAGATATCCAGTATCTGCCTGACATGCAGCAAACTTGCCCGACTTGTCACGGCCGTCG
CTACAACCCCGAGGTTCTGAAAATCAAATGGCAGCAGCACAGCATCGCCGACTTGCTAGATCTGGACGTGGACTCCGCCT
TGACCGTTCTGAAAGACGAACCGGCTATTACTCACACATTGCAAACCCTGCATGACATGGGCCTCGGTTATTTGCATTTA
GGTGAAAGTACCCCGACGCTGTCTGGCGGTGAAGCGCAGCGCCTGAAGCTAGTTGCCCACATGGGACGCTCCCAAAAAGA
CACGCTTTTTGTCTTCGATGAACCATCGGTAGGTCTACACCCCCTGGATGTTCAAACGTTGATCGCTGTTTTTCAACGGT
TGCTCAAAACCGGTGCAACGGTTATTGCCATCGAACACGATCTAGACGTCATCGCTAACGCTGATTATGTCTTGGATCTC
GGACCAAAAGGCGGTGCAGAAGGTGGCCGCATCATGGCTGCTGGCACACCGCAAGCAATCGCCAAACAAGGGAAAGGTGA
AACTGCCCCTTACTTGGCGGGCCATCTGGCGGCCTTTCACGTTAAGTAG

Upstream 100 bases:

>100_bases
TTGCCGTTTTTCTAGGAGCGTTACAATGACATTATCAGGACGTAGCTAGCCCGATTTTGTCAGTAGCCGGCTATGTCTAT
CTTTTTAAAGGAGTGGTTTG

Downstream 100 bases:

>100_bases
GCTTGACAAAAAGAGATGCCTCGGAAAGTGATAACCGAGACATCTCTTTTTCATACATCAACTTTAAACGTTCAAGATCG
AATCAATGTGGCTGATTTCT

Product: excinuclease ATPase subunit

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 842; Mature: 841

Protein sequence:

>842_residues
MAIPDHISVRGAYVNNLKHLNVDIPLNKLVAITGRSGSGKSSLAMGVLYAEGMRRYMSALSTYTRRRLGQTSLAAADSVR
HIPSAIALRQRPTVPGIRSTVGTATEALNVIRLMFSRLGSPVCPNGHRVSPTLDIAKAMDLPNDGESGMGMITCPTCGVR
FMAFAAEDFAFNSTGACPTCGGTGQARTLAANRLIPDRTLTIRQGAVASWRLPGRNFMPFVAQAIGIDIDTPFQDLPKDQ
QEQVWHGERKKYAINIPSKTGKIFHMDHAQYENAFNAVEDSLATTKNERAIQRLNRFYEFGICPTCHGSRFSPKLLSQHL
VDQNIAQVSDMTLTQLAAFIPEIYHWLPADMQSLAHDIIQELTQLLKPIMDLGLSYLTLSRAAASLSTGELQRIQLSRTL
RTETTGVLYVLDEPSIGLHAANVSGLLEVMHGLVNQGNSLVVVDHNTAIIEAADQVIEIGPGAGVAGGRLIDQGSPEAIS
HDTHSLIAPFLTGAAPLIVRPQAGEQEIKQTKQLQLTVTDRFNLHDLHVHFPVNCFSVVSGFSGAGKSTLIFDALVPALS
ATADQPAPAFVRDLDRGGLRHVVAIDATPVGKNVRSTVATYTDILDHLRHLFASLPDAKAKHYTSSHFSYNVKAGACPTC
GGTGVINLDIQYLPDMQQTCPTCHGRRYNPEVLKIKWQQHSIADLLDLDVDSALTVLKDEPAITHTLQTLHDMGLGYLHL
GESTPTLSGGEAQRLKLVAHMGRSQKDTLFVFDEPSVGLHPLDVQTLIAVFQRLLKTGATVIAIEHDLDVIANADYVLDL
GPKGGAEGGRIMAAGTPQAIAKQGKGETAPYLAGHLAAFHVK

Sequences:

>Translated_842_residues
MAIPDHISVRGAYVNNLKHLNVDIPLNKLVAITGRSGSGKSSLAMGVLYAEGMRRYMSALSTYTRRRLGQTSLAAADSVR
HIPSAIALRQRPTVPGIRSTVGTATEALNVIRLMFSRLGSPVCPNGHRVSPTLDIAKAMDLPNDGESGMGMITCPTCGVR
FMAFAAEDFAFNSTGACPTCGGTGQARTLAANRLIPDRTLTIRQGAVASWRLPGRNFMPFVAQAIGIDIDTPFQDLPKDQ
QEQVWHGERKKYAINIPSKTGKIFHMDHAQYENAFNAVEDSLATTKNERAIQRLNRFYEFGICPTCHGSRFSPKLLSQHL
VDQNIAQVSDMTLTQLAAFIPEIYHWLPADMQSLAHDIIQELTQLLKPIMDLGLSYLTLSRAAASLSTGELQRIQLSRTL
RTETTGVLYVLDEPSIGLHAANVSGLLEVMHGLVNQGNSLVVVDHNTAIIEAADQVIEIGPGAGVAGGRLIDQGSPEAIS
HDTHSLIAPFLTGAAPLIVRPQAGEQEIKQTKQLQLTVTDRFNLHDLHVHFPVNCFSVVSGFSGAGKSTLIFDALVPALS
ATADQPAPAFVRDLDRGGLRHVVAIDATPVGKNVRSTVATYTDILDHLRHLFASLPDAKAKHYTSSHFSYNVKAGACPTC
GGTGVINLDIQYLPDMQQTCPTCHGRRYNPEVLKIKWQQHSIADLLDLDVDSALTVLKDEPAITHTLQTLHDMGLGYLHL
GESTPTLSGGEAQRLKLVAHMGRSQKDTLFVFDEPSVGLHPLDVQTLIAVFQRLLKTGATVIAIEHDLDVIANADYVLDL
GPKGGAEGGRIMAAGTPQAIAKQGKGETAPYLAGHLAAFHVK
>Mature_841_residues
AIPDHISVRGAYVNNLKHLNVDIPLNKLVAITGRSGSGKSSLAMGVLYAEGMRRYMSALSTYTRRRLGQTSLAAADSVRH
IPSAIALRQRPTVPGIRSTVGTATEALNVIRLMFSRLGSPVCPNGHRVSPTLDIAKAMDLPNDGESGMGMITCPTCGVRF
MAFAAEDFAFNSTGACPTCGGTGQARTLAANRLIPDRTLTIRQGAVASWRLPGRNFMPFVAQAIGIDIDTPFQDLPKDQQ
EQVWHGERKKYAINIPSKTGKIFHMDHAQYENAFNAVEDSLATTKNERAIQRLNRFYEFGICPTCHGSRFSPKLLSQHLV
DQNIAQVSDMTLTQLAAFIPEIYHWLPADMQSLAHDIIQELTQLLKPIMDLGLSYLTLSRAAASLSTGELQRIQLSRTLR
TETTGVLYVLDEPSIGLHAANVSGLLEVMHGLVNQGNSLVVVDHNTAIIEAADQVIEIGPGAGVAGGRLIDQGSPEAISH
DTHSLIAPFLTGAAPLIVRPQAGEQEIKQTKQLQLTVTDRFNLHDLHVHFPVNCFSVVSGFSGAGKSTLIFDALVPALSA
TADQPAPAFVRDLDRGGLRHVVAIDATPVGKNVRSTVATYTDILDHLRHLFASLPDAKAKHYTSSHFSYNVKAGACPTCG
GTGVINLDIQYLPDMQQTCPTCHGRRYNPEVLKIKWQQHSIADLLDLDVDSALTVLKDEPAITHTLQTLHDMGLGYLHLG
ESTPTLSGGEAQRLKLVAHMGRSQKDTLFVFDEPSVGLHPLDVQTLIAVFQRLLKTGATVIAIEHDLDVIANADYVLDLG
PKGGAEGGRIMAAGTPQAIAKQGKGETAPYLAGHLAAFHVK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=701, Percent_Identity=37.3751783166904, Blast_Score=431, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 90894; Mature: 90763

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPDHISVRGAYVNNLKHLNVDIPLNKLVAITGRSGSGKSSLAMGVLYAEGMRRYMSAL
CCCCCCCEECCHHHCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
STYTRRRLGQTSLAAADSVRHIPSAIALRQRPTVPGIRSTVGTATEALNVIRLMFSRLGS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PVCPNGHRVSPTLDIAKAMDLPNDGESGMGMITCPTCGVRFMAFAAEDFAFNSTGACPTC
CCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCC
GGTGQARTLAANRLIPDRTLTIRQGAVASWRLPGRNFMPFVAQAIGIDIDTPFQDLPKDQ
CCCCCHHHHHHHCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHCCCCCCCHHHCCCCH
QEQVWHGERKKYAINIPSKTGKIFHMDHAQYENAFNAVEDSLATTKNERAIQRLNRFYEF
HHHHHCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
GICPTCHGSRFSPKLLSQHLVDQNIAQVSDMTLTQLAAFIPEIYHWLPADMQSLAHDIIQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ELTQLLKPIMDLGLSYLTLSRAAASLSTGELQRIQLSRTLRTETTGVLYVLDEPSIGLHA
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEE
ANVSGLLEVMHGLVNQGNSLVVVDHNTAIIEAADQVIEIGPGAGVAGGRLIDQGSPEAIS
HHHHHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHEEECCCCCCCCCEEECCCCCCCCC
HDTHSLIAPFLTGAAPLIVRPQAGEQEIKQTKQLQLTVTDRFNLHDLHVHFPVNCFSVVS
CCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHEEEEEEECCCCEEEEEEECCCHHHHHHC
GFSGAGKSTLIFDALVPALSATADQPAPAFVRDLDRGGLRHVVAIDATPVGKNVRSTVAT
CCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHH
YTDILDHLRHLFASLPDAKAKHYTSSHFSYNVKAGACPTCGGTGVINLDIQYLPDMQQTC
HHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEHCCCCHHHHC
PTCHGRRYNPEVLKIKWQQHSIADLLDLDVDSALTVLKDEPAITHTLQTLHDMGLGYLHL
CCCCCCCCCCCEEEEEECCCCHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEE
GESTPTLSGGEAQRLKLVAHMGRSQKDTLFVFDEPSVGLHPLDVQTLIAVFQRLLKTGAT
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCE
VIAIEHDLDVIANADYVLDLGPKGGAEGGRIMAAGTPQAIAKQGKGETAPYLAGHLAAFH
EEEEECCCCEEECCCEEEEECCCCCCCCCEEEECCCHHHHHHCCCCCCCCHHHHHHEEEE
VK
CC
>Mature Secondary Structure 
AIPDHISVRGAYVNNLKHLNVDIPLNKLVAITGRSGSGKSSLAMGVLYAEGMRRYMSAL
CCCCCCEECCHHHCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
STYTRRRLGQTSLAAADSVRHIPSAIALRQRPTVPGIRSTVGTATEALNVIRLMFSRLGS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PVCPNGHRVSPTLDIAKAMDLPNDGESGMGMITCPTCGVRFMAFAAEDFAFNSTGACPTC
CCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCC
GGTGQARTLAANRLIPDRTLTIRQGAVASWRLPGRNFMPFVAQAIGIDIDTPFQDLPKDQ
CCCCCHHHHHHHCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHCCCCCCCHHHCCCCH
QEQVWHGERKKYAINIPSKTGKIFHMDHAQYENAFNAVEDSLATTKNERAIQRLNRFYEF
HHHHHCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
GICPTCHGSRFSPKLLSQHLVDQNIAQVSDMTLTQLAAFIPEIYHWLPADMQSLAHDIIQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ELTQLLKPIMDLGLSYLTLSRAAASLSTGELQRIQLSRTLRTETTGVLYVLDEPSIGLHA
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEE
ANVSGLLEVMHGLVNQGNSLVVVDHNTAIIEAADQVIEIGPGAGVAGGRLIDQGSPEAIS
HHHHHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHEEECCCCCCCCCEEECCCCCCCCC
HDTHSLIAPFLTGAAPLIVRPQAGEQEIKQTKQLQLTVTDRFNLHDLHVHFPVNCFSVVS
CCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHEEEEEEECCCCEEEEEEECCCHHHHHHC
GFSGAGKSTLIFDALVPALSATADQPAPAFVRDLDRGGLRHVVAIDATPVGKNVRSTVAT
CCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHH
YTDILDHLRHLFASLPDAKAKHYTSSHFSYNVKAGACPTCGGTGVINLDIQYLPDMQQTC
HHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEHCCCCHHHHC
PTCHGRRYNPEVLKIKWQQHSIADLLDLDVDSALTVLKDEPAITHTLQTLHDMGLGYLHL
CCCCCCCCCCCEEEEEECCCCHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEE
GESTPTLSGGEAQRLKLVAHMGRSQKDTLFVFDEPSVGLHPLDVQTLIAVFQRLLKTGAT
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCE
VIAIEHDLDVIANADYVLDLGPKGGAEGGRIMAAGTPQAIAKQGKGETAPYLAGHLAAFH
EEEEECCCCEEECCCEEEEECCCCCCCCCEEEECCCHHHHHHCCCCCCCCHHHHHHEEEE
VK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8675016 [H]