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The map label for this gene is bceR [H]

Identifier: 116495220

GI number: 116495220

Start: 1734496

End: 1735170

Strand: Direct

Name: bceR [H]

Synonym: LSEI_1740

Alternate gene names: 116495220

Gene position: 1734496-1735170 (Clockwise)

Preceding gene: 116495217

Following gene: 116495221

Centisome position: 59.91

GC content: 39.7

Gene sequence:

>675_bases
GTGTTTAAAATCATGATCGTAGAGGACGATCAGACGATTAGTGGGCTGATCGCTGATAACTTAAAAAAATGGCAATTTGA
TCCAGTTGTGGTAACCGATTTTAATGCTGTATTTGATGACTTTTTGCAAGAAAAACCCCATTTAGTCTTATTGGATATTA
ATCTACCAGTTTTTGACGGCTATTATTGGGTTCAAAAAATCCGTGAAGTATCAAAGGTCCCTGTGATTTTCATTTCTAGT
CGTAACACGAATATGGATATGGTCATGGCAATGAATATGGGCGCTGACGACTTTTTGAATAAGCCGTTTGCCATGGAAGT
GTTGATCGCAAAAATCAACGCCTTGCTTCGACGAGCCTACAATTATGCTGATCAAGGAACCGATGTTTTGGAACACAACG
GCTTGATGTTGAACCTCAAAAACGGTATGGCACAAATTGGCGAAAACGAAATTAACCTGTCAAAAAATGAATATAAACTG
TTACAAATCTTGATCCGGCAACACGGTCAAATCGTCAGCCGTTCCCGGTTATTAAAGGACTTATGGCAAGACGAGCGATT
TGTTGATGACAATACACTTACCGTCAACATTAATCGCCTGCGCAAAAAAATCGAGGAAGCCGGGTTGAAAGATTATATTC
AAACCAAGGTTGGACAAGGTTACATCGTTCCTTAG

Upstream 100 bases:

>100_bases
GGACAAACCCAGCTCATAAAAACTGGTCTTATTGACCTTGTTCGCGCTTGTGCTTCCTTCCCAAAACTTATACCATTAGA
GCAGAAATGGAGTTGGTCAC

Downstream 100 bases:

>100_bases
GAGGCTGGCAGATGCGGTTTCGTGATTATTTAAAGGATCATTTAAGCCCGATTGGTGGCTATATTCTTTGTGTTGGTCTG
GCGGCCTTGATCATCTGGCT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MFKIMIVEDDQTISGLIADNLKKWQFDPVVVTDFNAVFDDFLQEKPHLVLLDINLPVFDGYYWVQKIREVSKVPVIFISS
RNTNMDMVMAMNMGADDFLNKPFAMEVLIAKINALLRRAYNYADQGTDVLEHNGLMLNLKNGMAQIGENEINLSKNEYKL
LQILIRQHGQIVSRSRLLKDLWQDERFVDDNTLTVNINRLRKKIEEAGLKDYIQTKVGQGYIVP

Sequences:

>Translated_224_residues
MFKIMIVEDDQTISGLIADNLKKWQFDPVVVTDFNAVFDDFLQEKPHLVLLDINLPVFDGYYWVQKIREVSKVPVIFISS
RNTNMDMVMAMNMGADDFLNKPFAMEVLIAKINALLRRAYNYADQGTDVLEHNGLMLNLKNGMAQIGENEINLSKNEYKL
LQILIRQHGQIVSRSRLLKDLWQDERFVDDNTLTVNINRLRKKIEEAGLKDYIQTKVGQGYIVP
>Mature_224_residues
MFKIMIVEDDQTISGLIADNLKKWQFDPVVVTDFNAVFDDFLQEKPHLVLLDINLPVFDGYYWVQKIREVSKVPVIFISS
RNTNMDMVMAMNMGADDFLNKPFAMEVLIAKINALLRRAYNYADQGTDVLEHNGLMLNLKNGMAQIGENEINLSKNEYKL
LQILIRQHGQIVSRSRLLKDLWQDERFVDDNTLTVNINRLRKKIEEAGLKDYIQTKVGQGYIVP

Specific function: Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. When activated by BceS, binds to the upstream region of the bceAB promoter and up-regulates the expression of these two genes [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=31.5315315315315, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=28.9592760180996, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=28.9473684210526, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=36.5638766519824, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=29.5454545454545, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=29.1479820627803, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1787375, Length=187, Percent_Identity=32.620320855615, Blast_Score=100, Evalue=5e-23,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=30.3030303030303, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=28.6343612334802, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=26.3636363636364, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=30.5676855895196, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=27.9279279279279, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=27.8761061946903, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=30.6034482758621, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25897; Mature: 25897

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKIMIVEDDQTISGLIADNLKKWQFDPVVVTDFNAVFDDFLQEKPHLVLLDINLPVFDG
CEEEEEEECCCHHHHHHHHCHHHCCCCCEEEECHHHHHHHHHHCCCCEEEEEECCCCCCC
YYWVQKIREVSKVPVIFISSRNTNMDMVMAMNMGADDFLNKPFAMEVLIAKINALLRRAY
HHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHH
NYADQGTDVLEHNGLMLNLKNGMAQIGENEINLSKNEYKLLQILIRQHGQIVSRSRLLKD
HHCCCCCHHHHCCCEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
LWQDERFVDDNTLTVNINRLRKKIEEAGLKDYIQTKVGQGYIVP
HHCCCCEECCCEEEEEHHHHHHHHHHCCHHHHHHHHCCCCEECC
>Mature Secondary Structure
MFKIMIVEDDQTISGLIADNLKKWQFDPVVVTDFNAVFDDFLQEKPHLVLLDINLPVFDG
CEEEEEEECCCHHHHHHHHCHHHCCCCCEEEECHHHHHHHHHHCCCCEEEEEECCCCCCC
YYWVQKIREVSKVPVIFISSRNTNMDMVMAMNMGADDFLNKPFAMEVLIAKINALLRRAY
HHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHH
NYADQGTDVLEHNGLMLNLKNGMAQIGENEINLSKNEYKLLQILIRQHGQIVSRSRLLKD
HHCCCCCHHHHCCCEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
LWQDERFVDDNTLTVNINRLRKKIEEAGLKDYIQTKVGQGYIVP
HHCCCCEECCCEEEEEHHHHHHHHHHCCHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]