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The map label for this gene is qor [C]

Identifier: 116495176

GI number: 116495176

Start: 1689876

End: 1690844

Strand: Direct

Name: qor [C]

Synonym: LSEI_1695

Alternate gene names: 116495176

Gene position: 1689876-1690844 (Clockwise)

Preceding gene: 116495175

Following gene: 116495177

Centisome position: 58.37

GC content: 48.09

Gene sequence:

>969_bases
ATGCAACGTTTTGGTTTTGAACAGTATGGTGATCCGAGCGTTTTTGAAACCATTGAGGCGCCGATTCCCGAACCAAAAAC
TGGCCAAGTACAATTGCAGGTTCTTGGCTTTGGCTTGAATCCCTACGATGCTTCACTGCGTCGTGGTGAACAGGCGGCTT
TTCGAAAAGTTAAGTTCCCAGTTGTCCCCGGCACAGATGTTCTTGGGCGAATTACCAAACTCGGCGAAGGGGTGACTGAC
TTTGCTATTGGTGATCTTGTCTTGAATTATCGACCAATTGGCGGTTACAGCGAGTATGTCACCGCCTCAACTTCAAAAAT
TTACAAAAAACCGACTGCCTTAAGCTTTTTGGACGCTGCTGCACTACCGCAAGTTGGCTTAGCTGCTTTTAACATTTTGC
ACTATATGCTGTCACTTAAGCCTGGCCAAACTTTGGCAGTCATTGGCGCAAGCGGCGGTGTTGGTGCTATCTTGGTGCAG
CTCGCCAAGTTTGAAAAATTAAATGTCATTGCCGTTGCAGGTGCCCAACACCACGACTATTTGCAACAACTCGGGGCCGA
TCAGATTTACAGCTATACAGATGATTTACCTGACAGCCGTGCTGATGCTGTGGTCAACGCCGTTTTTGGCGCTGCAGACC
ACGGTGCCTCGCTAAAGCTTGTCAAAGCTGGCGGTCAATATGTGACGACCGCTTATGCTGACGTTGATGTTAGCAGCAAG
CCCGGCACAACCCACCTGCAATTAAACCCATCGAAGGACTATTCTGTTCATGATGGCTTTGCCTATTTAGTTGATGTCGC
CCAAAAATGGGGTCTGCAAGTTCGTGTAGCGCAATCATTTGCTTTTAACGTGGATGGCGTCATTGCTGCGCATGAAATGT
TGGAAACACACCACGCCCCGGGCAAGTTGATTGTGATGCAAGATCGTCATGTCACCCATCCGGTTCGTAAAGACATCAAT
CAACTTTAA

Upstream 100 bases:

>100_bases
TGGGCAAAGTCACAATTTGAATGAAGAAGAATTGACAAACGCCAAAAGCTGGCTGGCAAAAAGTGGTCGGTTAGCTGATT
GGCGACGGAGGTGAAAGGCT

Downstream 100 bases:

>100_bases
ACAAAAATTGGGTTAACGCCTTGTCCCGCTTGTTTTCACGCCGTATGATAAACGGGTGAACGAAAGGCGGGACAACATGA
AAATTGCAGTTTATTGTGGC

Product: NADPH:quinone reductase related Zn-dependent oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MQRFGFEQYGDPSVFETIEAPIPEPKTGQVQLQVLGFGLNPYDASLRRGEQAAFRKVKFPVVPGTDVLGRITKLGEGVTD
FAIGDLVLNYRPIGGYSEYVTASTSKIYKKPTALSFLDAAALPQVGLAAFNILHYMLSLKPGQTLAVIGASGGVGAILVQ
LAKFEKLNVIAVAGAQHHDYLQQLGADQIYSYTDDLPDSRADAVVNAVFGAADHGASLKLVKAGGQYVTTAYADVDVSSK
PGTTHLQLNPSKDYSVHDGFAYLVDVAQKWGLQVRVAQSFAFNVDGVIAAHEMLETHHAPGKLIVMQDRHVTHPVRKDIN
QL

Sequences:

>Translated_322_residues
MQRFGFEQYGDPSVFETIEAPIPEPKTGQVQLQVLGFGLNPYDASLRRGEQAAFRKVKFPVVPGTDVLGRITKLGEGVTD
FAIGDLVLNYRPIGGYSEYVTASTSKIYKKPTALSFLDAAALPQVGLAAFNILHYMLSLKPGQTLAVIGASGGVGAILVQ
LAKFEKLNVIAVAGAQHHDYLQQLGADQIYSYTDDLPDSRADAVVNAVFGAADHGASLKLVKAGGQYVTTAYADVDVSSK
PGTTHLQLNPSKDYSVHDGFAYLVDVAQKWGLQVRVAQSFAFNVDGVIAAHEMLETHHAPGKLIVMQDRHVTHPVRKDIN
QL
>Mature_322_residues
MQRFGFEQYGDPSVFETIEAPIPEPKTGQVQLQVLGFGLNPYDASLRRGEQAAFRKVKFPVVPGTDVLGRITKLGEGVTD
FAIGDLVLNYRPIGGYSEYVTASTSKIYKKPTALSFLDAAALPQVGLAAFNILHYMLSLKPGQTLAVIGASGGVGAILVQ
LAKFEKLNVIAVAGAQHHDYLQQLGADQIYSYTDDLPDSRADAVVNAVFGAADHGASLKLVKAGGQYVTTAYADVDVSSK
PGTTHLQLNPSKDYSVHDGFAYLVDVAQKWGLQVRVAQSFAFNVDGVIAAHEMLETHHAPGKLIVMQDRHVTHPVRKDIN
QL

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239676, Length=190, Percent_Identity=32.6315789473684, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI194239674, Length=190, Percent_Identity=32.6315789473684, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI13236495, Length=190, Percent_Identity=32.6315789473684, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI24308257, Length=227, Percent_Identity=27.7533039647577, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI18379349, Length=236, Percent_Identity=30.0847457627119, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI47519420, Length=227, Percent_Identity=29.0748898678414, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI22538446, Length=224, Percent_Identity=27.6785714285714, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI22538444, Length=224, Percent_Identity=27.6785714285714, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1790485, Length=195, Percent_Identity=29.2307692307692, Blast_Score=74, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17507255, Length=189, Percent_Identity=31.2169312169312, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71987554, Length=186, Percent_Identity=31.7204301075269, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319945, Length=214, Percent_Identity=30.8411214953271, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323493, Length=215, Percent_Identity=29.7674418604651, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45550423, Length=201, Percent_Identity=26.3681592039801, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 34706; Mature: 34706

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRFGFEQYGDPSVFETIEAPIPEPKTGQVQLQVLGFGLNPYDASLRRGEQAAFRKVKFP
CCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEEEEEECCCCHHHHHHCCCHHHHHEEECC
VVPGTDVLGRITKLGEGVTDFAIGDLVLNYRPIGGYSEYVTASTSKIYKKPTALSFLDAA
CCCCCHHHHHHHHHCCCHHHHHHHHHEEEEECCCCCHHHHCCCHHHHHCCCCHHHHHHHH
ALPQVGLAAFNILHYMLSLKPGQTLAVIGASGGVGAILVQLAKFEKLNVIAVAGAQHHDY
HCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCHHHH
LQQLGADQIYSYTDDLPDSRADAVVNAVFGAADHGASLKLVKAGGQYVTTAYADVDVSSK
HHHCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEEECCCC
PGTTHLQLNPSKDYSVHDGFAYLVDVAQKWGLQVRVAQSFAFNVDGVIAAHEMLETHHAP
CCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEEHHEECCCHHHHHHHHHHHCCCC
GKLIVMQDRHVTHPVRKDINQL
CEEEEEECCCCCCHHHHHHHCC
>Mature Secondary Structure
MQRFGFEQYGDPSVFETIEAPIPEPKTGQVQLQVLGFGLNPYDASLRRGEQAAFRKVKFP
CCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEEEEEECCCCHHHHHHCCCHHHHHEEECC
VVPGTDVLGRITKLGEGVTDFAIGDLVLNYRPIGGYSEYVTASTSKIYKKPTALSFLDAA
CCCCCHHHHHHHHHCCCHHHHHHHHHEEEEECCCCCHHHHCCCHHHHHCCCCHHHHHHHH
ALPQVGLAAFNILHYMLSLKPGQTLAVIGASGGVGAILVQLAKFEKLNVIAVAGAQHHDY
HCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCHHHH
LQQLGADQIYSYTDDLPDSRADAVVNAVFGAADHGASLKLVKAGGQYVTTAYADVDVSSK
HHHCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEEECCCC
PGTTHLQLNPSKDYSVHDGFAYLVDVAQKWGLQVRVAQSFAFNVDGVIAAHEMLETHHAP
CCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEEHHEECCCHHHHHHHHHHHCCCC
GKLIVMQDRHVTHPVRKDINQL
CEEEEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA