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The map label for this gene is msrA [H]

Identifier: 116494879

GI number: 116494879

Start: 1381631

End: 1382107

Strand: Direct

Name: msrA [H]

Synonym: LSEI_1393

Alternate gene names: 116494879

Gene position: 1381631-1382107 (Clockwise)

Preceding gene: 116494878

Following gene: 116494880

Centisome position: 47.72

GC content: 49.69

Gene sequence:

>477_bases
ATGGTTGAACCCTTTGAAGAGCAGCCGGGCATTTTGAATGTAGTGTCCGGCTACACTGGCGGCCATGTCGCCAACCCCAC
CTATGAACAGGTTTCGTCTCACACCACTGGACATACTGAAGCTGTAGAAATCACCTTCGATGCCGACACCATTAGCTATC
CGAAGTTGTTGGACATCTATTGGCAGCAAACCGATCCGACAGATGCTATGGGTCAGTTTCAGGATCGCGGCGATAATTAT
CGACCGGTGATTTTTGTGAAGGATGATGCCCAACGCGAAGCTGCAGAGGCTTCAAAAACGGCCTTAGCTGCTAGTGGGCG
CTTCAGTGATCCGATTGTGACGCAAATAGAAGCTGCCAAGCCGTTTTATCCGGCTGAGCCTGAGCACCAACAGTTTTATG
CTAAGAATCCCCGCCGTTATGCATTAGAACATGCGCAACGGCAGGCTTTTATCGACAAAACATGGAAGGATCAATAA

Upstream 100 bases:

>100_bases
TTCGCAGTTTACCTCCCGGATAATCAGTGATCATTGGAAAGAAGCTGAATATTTTATGAAAAAAGAAACAGCTATTTTTG
CTGGGGGATGTTTTTGGTGT

Downstream 100 bases:

>100_bases
TGCATCGGACTTTTTACGAATATCTCATGACCCTGCGTAACCCCAATGACCATAGTGAAATCGCTGAATTTGCGAAAAAT
GCCTTTTTGGATCAAAGCTT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MVEPFEEQPGILNVVSGYTGGHVANPTYEQVSSHTTGHTEAVEITFDADTISYPKLLDIYWQQTDPTDAMGQFQDRGDNY
RPVIFVKDDAQREAAEASKTALAASGRFSDPIVTQIEAAKPFYPAEPEHQQFYAKNPRRYALEHAQRQAFIDKTWKDQ

Sequences:

>Translated_158_residues
MVEPFEEQPGILNVVSGYTGGHVANPTYEQVSSHTTGHTEAVEITFDADTISYPKLLDIYWQQTDPTDAMGQFQDRGDNY
RPVIFVKDDAQREAAEASKTALAASGRFSDPIVTQIEAAKPFYPAEPEHQQFYAKNPRRYALEHAQRQAFIDKTWKDQ
>Mature_158_residues
MVEPFEEQPGILNVVSGYTGGHVANPTYEQVSSHTTGHTEAVEITFDADTISYPKLLDIYWQQTDPTDAMGQFQDRGDNY
RPVIFVKDDAQREAAEASKTALAASGRFSDPIVTQIEAAKPFYPAEPEHQQFYAKNPRRYALEHAQRQAFIDKTWKDQ

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=136, Percent_Identity=38.2352941176471, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI6912516, Length=136, Percent_Identity=38.2352941176471, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI208609993, Length=110, Percent_Identity=38.1818181818182, Blast_Score=78, Evalue=4e-15,
Organism=Escherichia coli, GI1790665, Length=136, Percent_Identity=43.3823529411765, Blast_Score=110, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17533973, Length=130, Percent_Identity=33.0769230769231, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320881, Length=138, Percent_Identity=28.9855072463768, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24664627, Length=123, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45553131, Length=123, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 17855; Mature: 17855

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEPFEEQPGILNVVSGYTGGHVANPTYEQVSSHTTGHTEAVEITFDADTISYPKLLDIY
CCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEE
WQQTDPTDAMGQFQDRGDNYRPVIFVKDDAQREAAEASKTALAASGRFSDPIVTQIEAAK
ECCCCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHEECCCC
PFYPAEPEHQQFYAKNPRRYALEHAQRQAFIDKTWKDQ
CCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVEPFEEQPGILNVVSGYTGGHVANPTYEQVSSHTTGHTEAVEITFDADTISYPKLLDIY
CCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEE
WQQTDPTDAMGQFQDRGDNYRPVIFVKDDAQREAAEASKTALAASGRFSDPIVTQIEAAK
ECCCCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHEECCCC
PFYPAEPEHQQFYAKNPRRYALEHAQRQAFIDKTWKDQ
CCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA