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The map label for this gene is msrA2 [H]

Identifier: 116494696

GI number: 116494696

Start: 1183133

End: 1183963

Strand: Direct

Name: msrA2 [H]

Synonym: LSEI_1202

Alternate gene names: 116494696

Gene position: 1183133-1183963 (Clockwise)

Preceding gene: 116494695

Following gene: 116494697

Centisome position: 40.86

GC content: 51.02

Gene sequence:

>831_bases
ATGGAGCGAGACGTATTTTTAGCTAAGGTGACTAACTTGATGCTTGCACCGGGAACGCGTGCATTTGAGCGCGAACAATT
GCGCCAGGCCAAACATTTGGTAGAGGCCGGGCGACCAGTGGCGGAAGGCTGGGCGCAACTTGAATCATCTTTGCGGCCAT
TGGCGATGCGTGATAACCTGACCCCGGATGTGGCTGACTTTTATCGAGCAGAGACCGGTGATCCAGCAGGGGCTGTGCAG
ACAGATTTGAGTGCCCATTTTGATCGCGACGTGCCGTTTCAGGAGCGGGCCATTTTTGCTGGCGGTTGTTTCTGGTGTAT
GGTTGAACCATTCGTCGATTTGCCTGGTATCACCGCAGTCACTTCGGGGTACACTGGCGGGCATAGCGCACATCCCACTT
ATGAACAAGTGATCGGCGGCTATACCGGGCATGTTGAAGCCGTTGAAATTATTTTTGATACCCGCAAAATGAGCTACGCA
GCATTAGTGGCGCTTTATTTTCAGTTAACTGATCCGACTGATGCACTGGGGCAATTTCAAGATCGCGGCAGTCAATATCG
TCCTGTGATTTTTGTCAAAGACGATACGCAACGCCAGATAGCGGAAGCGGCTAAGGCTGAATTGGCTGCTTCTGGGCGTT
ATTTGCGGCCAATCATCACTGCAATTGAACCTGTTGCGACTTTTTGGCCAGCCGAGAACTATCATCAAGACTTTTATAAA
AAGAATCCGAAGCGCTACCAGATGGTTGAACGGACGCGCCGCCAGTTTCTTCAATTTCAGCGTGCACAAGGCAACCTGCG
GGTGATGTTGAAACGGCGTAAAAAGGCATAA

Upstream 100 bases:

>100_bases
TGGGCTGGCCTCGTTTTTGTGACCGTGATAACTTAGTAAAAATAGGCAAGCTTATTCATCGTCGTTAACTTGATAAGCAC
ATTTAAAAGGAGCTGGTGAC

Downstream 100 bases:

>100_bases
ATTCTTGCAGTCAAATGGCAGTTGTTGTTGAAACGGAGGTAGTGGCCTATGCGGGAACCGATACGACATTGGACGCAAAA
GAATATGCCTGATCTTCACG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MERDVFLAKVTNLMLAPGTRAFEREQLRQAKHLVEAGRPVAEGWAQLESSLRPLAMRDNLTPDVADFYRAETGDPAGAVQ
TDLSAHFDRDVPFQERAIFAGGCFWCMVEPFVDLPGITAVTSGYTGGHSAHPTYEQVIGGYTGHVEAVEIIFDTRKMSYA
ALVALYFQLTDPTDALGQFQDRGSQYRPVIFVKDDTQRQIAEAAKAELAASGRYLRPIITAIEPVATFWPAENYHQDFYK
KNPKRYQMVERTRRQFLQFQRAQGNLRVMLKRRKKA

Sequences:

>Translated_276_residues
MERDVFLAKVTNLMLAPGTRAFEREQLRQAKHLVEAGRPVAEGWAQLESSLRPLAMRDNLTPDVADFYRAETGDPAGAVQ
TDLSAHFDRDVPFQERAIFAGGCFWCMVEPFVDLPGITAVTSGYTGGHSAHPTYEQVIGGYTGHVEAVEIIFDTRKMSYA
ALVALYFQLTDPTDALGQFQDRGSQYRPVIFVKDDTQRQIAEAAKAELAASGRYLRPIITAIEPVATFWPAENYHQDFYK
KNPKRYQMVERTRRQFLQFQRAQGNLRVMLKRRKKA
>Mature_276_residues
MERDVFLAKVTNLMLAPGTRAFEREQLRQAKHLVEAGRPVAEGWAQLESSLRPLAMRDNLTPDVADFYRAETGDPAGAVQ
TDLSAHFDRDVPFQERAIFAGGCFWCMVEPFVDLPGITAVTSGYTGGHSAHPTYEQVIGGYTGHVEAVEIIFDTRKMSYA
ALVALYFQLTDPTDALGQFQDRGSQYRPVIFVKDDTQRQIAEAAKAELAASGRYLRPIITAIEPVATFWPAENYHQDFYK
KNPKRYQMVERTRRQFLQFQRAQGNLRVMLKRRKKA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=160, Percent_Identity=35, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI208609995, Length=160, Percent_Identity=35, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=34.5794392523364, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1790665, Length=167, Percent_Identity=38.9221556886228, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17533973, Length=180, Percent_Identity=28.8888888888889, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=165, Percent_Identity=29.6969696969697, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664627, Length=147, Percent_Identity=32.6530612244898, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45553131, Length=142, Percent_Identity=32.3943661971831, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 31269; Mature: 31269

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure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CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]