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The map label for this gene is atpA

Identifier: 116494660

GI number: 116494660

Start: 1147384

End: 1148913

Strand: Direct

Name: atpA

Synonym: LSEI_1164

Alternate gene names: 116494660

Gene position: 1147384-1148913 (Clockwise)

Preceding gene: 116494659

Following gene: 116494661

Centisome position: 39.63

GC content: 48.56

Gene sequence:

>1530_bases
ATGAGCATCAAGACTGAGGAAATCAGTTCTCTGATCAAAAAACAACTTGAAGGATATCAGGACGATTTGGCGGCTGAAGA
AGTCGGCACTGTGACTTACATCGGTGATGGGATCGCACGTGCGACTGGGCTGGAAAATGCCATGGCCAACGAATTGCTCC
AATTTAGCAACGGCTCATACGGGATGGCGTTAAACCTTGAAACGAACGATGTCGGGATCATTATCTTAGGTGACTTCGAT
GAGATTCGCGAAGGCGACCAAGTGAAACGCACTGGCCGAATCATGGAAGTTCCTGTCGGGGATGCCATGATCGGGCGAGT
TGTCAATTCTTTGGGTCAGCCGGTCGACGGTTTAGGCGCGATTAAGACGGATAAAACCCGTCCGATCGAGTTTAAGGCGC
CAGGTGTTATGCAACGCAAATCCGTATCAGAACCGTTACAAACCGGTTTGAAAGCGATTGACGCGCTGGTACCGATTGGC
CGTGGTCAGCGTGAGTTGATCATTGGTGACCGGAAAACCGGGAAAACATCAATTGCGATTGATACCATTTTGAACCAAAA
AGATCAAAACATGATCTGTGTGTACGTTGCGATTGGGCAAAAGGACAGTACGGTTCGAGCTCAAGTTGAAACGTTGAAAA
AATATGGTGCGATGGATTATACCATCGTGCTGACTGCTGGCCCATCTGAACCTGCACCAATGCTGTATATCGCGCCTTAT
GCCGGTGCAGCGATGGGTGAAGAGTTCATGTATAACGGCAAGCACGTCTTGATCGTGTATGATGATTTGAGCAAACAGGC
AACCTCATATCGTGAGCTGTCCTTGCTGCTCCGTCGTCCGCCTGGTCGTGAAGCCTATCCTGGGGATATTTTCTATACCC
ACAGTCGCTTGTTGGAACGTGCTGCTAAATTGAGTGATAAACTCGGCGGCGGTTCTATGACGGCGCTGCCGGTTATTGAA
ACTCAGGCAGGCGATATTTCCGCGTACATCCCGACTAACGTTATTTCTATCACGGATGGTCAGATCTTCTTACAAAGCGA
TCTGTTCTATGCGGGTACACGTCCAGCCATTGATGCTGGTGCTTCTGTTTCCCGTGTTGGTGGTGATGCGCAGGTCAAGG
CGATGAAGAAAGTTGCCGGGACATTGCGGTTGGATCTGGCATCCTTCCGTGAACTGGAAGCCTTCACGCAATTTGGTTCT
GATTTGGATGCAGCAACGCAAGCTAAGTTGAATCGTGGTCGCCGAACGGTTGAAGTGCTGAAGCAGCCTGTTCACAAACC
GTTACCGGTTGAAAAGCAGGTTATCATTCTTTACGCATTAACCCATGGCTTCCTTGATCCAATTCCGATTGAAGACATTA
CTCGCTTCCAAGATGAACTGTTTGATTTCTTCGATAGCAATGCAGCTGATTTGCTCAAGCAGATTCGTGACACCGGTAAT
TTACCGGATACCGATAAACTTGATGCACAAATCAAGGCTTTTGCCGGCGGATTCCAAACGAGTAAACAACTTGCTGCAGC
GAAAGACTAA

Upstream 100 bases:

>100_bases
GCACGCGGTTCGGTTATCGATGGTACGGTCAAGCACCGTTTCGATAAGATGAAAGCTGCACTGCTGGCAGACTAATGAGT
AAGTAAAAGAGGTGAACCGG

Downstream 100 bases:

>100_bases
GGAGGTGCCGCATGGCTGAATCATTAATGGACATTAAGCGCAAGATCGCATCGACCAAGAAAACCGGTCAGATCACGCAA
GCCATGCAGATGGTTTCTGG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSIKTEEISSLIKKQLEGYQDDLAAEEVGTVTYIGDGIARATGLENAMANELLQFSNGSYGMALNLETNDVGIIILGDFD
EIREGDQVKRTGRIMEVPVGDAMIGRVVNSLGQPVDGLGAIKTDKTRPIEFKAPGVMQRKSVSEPLQTGLKAIDALVPIG
RGQRELIIGDRKTGKTSIAIDTILNQKDQNMICVYVAIGQKDSTVRAQVETLKKYGAMDYTIVLTAGPSEPAPMLYIAPY
AGAAMGEEFMYNGKHVLIVYDDLSKQATSYRELSLLLRRPPGREAYPGDIFYTHSRLLERAAKLSDKLGGGSMTALPVIE
TQAGDISAYIPTNVISITDGQIFLQSDLFYAGTRPAIDAGASVSRVGGDAQVKAMKKVAGTLRLDLASFRELEAFTQFGS
DLDAATQAKLNRGRRTVEVLKQPVHKPLPVEKQVIILYALTHGFLDPIPIEDITRFQDELFDFFDSNAADLLKQIRDTGN
LPDTDKLDAQIKAFAGGFQTSKQLAAAKD

Sequences:

>Translated_509_residues
MSIKTEEISSLIKKQLEGYQDDLAAEEVGTVTYIGDGIARATGLENAMANELLQFSNGSYGMALNLETNDVGIIILGDFD
EIREGDQVKRTGRIMEVPVGDAMIGRVVNSLGQPVDGLGAIKTDKTRPIEFKAPGVMQRKSVSEPLQTGLKAIDALVPIG
RGQRELIIGDRKTGKTSIAIDTILNQKDQNMICVYVAIGQKDSTVRAQVETLKKYGAMDYTIVLTAGPSEPAPMLYIAPY
AGAAMGEEFMYNGKHVLIVYDDLSKQATSYRELSLLLRRPPGREAYPGDIFYTHSRLLERAAKLSDKLGGGSMTALPVIE
TQAGDISAYIPTNVISITDGQIFLQSDLFYAGTRPAIDAGASVSRVGGDAQVKAMKKVAGTLRLDLASFRELEAFTQFGS
DLDAATQAKLNRGRRTVEVLKQPVHKPLPVEKQVIILYALTHGFLDPIPIEDITRFQDELFDFFDSNAADLLKQIRDTGN
LPDTDKLDAQIKAFAGGFQTSKQLAAAKD
>Mature_508_residues
SIKTEEISSLIKKQLEGYQDDLAAEEVGTVTYIGDGIARATGLENAMANELLQFSNGSYGMALNLETNDVGIIILGDFDE
IREGDQVKRTGRIMEVPVGDAMIGRVVNSLGQPVDGLGAIKTDKTRPIEFKAPGVMQRKSVSEPLQTGLKAIDALVPIGR
GQRELIIGDRKTGKTSIAIDTILNQKDQNMICVYVAIGQKDSTVRAQVETLKKYGAMDYTIVLTAGPSEPAPMLYIAPYA
GAAMGEEFMYNGKHVLIVYDDLSKQATSYRELSLLLRRPPGREAYPGDIFYTHSRLLERAAKLSDKLGGGSMTALPVIET
QAGDISAYIPTNVISITDGQIFLQSDLFYAGTRPAIDAGASVSRVGGDAQVKAMKKVAGTLRLDLASFRELEAFTQFGSD
LDAATQAKLNRGRRTVEVLKQPVHKPLPVEKQVIILYALTHGFLDPIPIEDITRFQDELFDFFDSNAADLLKQIRDTGNL
PDTDKLDAQIKAFAGGFQTSKQLAAAKD

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=505, Percent_Identity=57.029702970297, Blast_Score=579, Evalue=1e-165,
Organism=Homo sapiens, GI4757810, Length=505, Percent_Identity=57.029702970297, Blast_Score=579, Evalue=1e-165,
Organism=Homo sapiens, GI19913426, Length=300, Percent_Identity=27.6666666666667, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI19913428, Length=300, Percent_Identity=27.3333333333333, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI32189394, Length=418, Percent_Identity=25.1196172248804, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1790172, Length=513, Percent_Identity=49.7076023391813, Blast_Score=523, Evalue=1e-150,
Organism=Escherichia coli, GI1788251, Length=272, Percent_Identity=31.9852941176471, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1790170, Length=318, Percent_Identity=26.4150943396226, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71988063, Length=495, Percent_Identity=58.1818181818182, Blast_Score=586, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI71988080, Length=494, Percent_Identity=57.8947368421053, Blast_Score=585, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI71988074, Length=494, Percent_Identity=53.6437246963563, Blast_Score=528, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17510931, Length=325, Percent_Identity=28.6153846153846, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17570191, Length=348, Percent_Identity=26.1494252873563, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI25144756, Length=373, Percent_Identity=24.6648793565684, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17509265, Length=52, Percent_Identity=57.6923076923077, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71988068, Length=72, Percent_Identity=40.2777777777778, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=500, Percent_Identity=57.2, Blast_Score=576, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319603, Length=303, Percent_Identity=26.7326732673267, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322581, Length=373, Percent_Identity=25.7372654155496, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24658560, Length=508, Percent_Identity=55.9055118110236, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI281361666, Length=301, Percent_Identity=27.2425249169435, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646341, Length=301, Percent_Identity=27.2425249169435, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17136796, Length=301, Percent_Identity=27.2425249169435, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24638766, Length=422, Percent_Identity=25.3554502369668, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28574560, Length=409, Percent_Identity=26.4058679706601, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_LACC3 (Q03A20)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806394.1
- ProteinModelPortal:   Q03A20
- SMR:   Q03A20
- STRING:   Q03A20
- GeneID:   4420200
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_1164
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- PhylomeDB:   Q03A20
- ProtClustDB:   PRK09281
- BioCyc:   LCAS321967:LSEI_1164-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55301; Mature: 55170

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKTEEISSLIKKQLEGYQDDLAAEEVGTVTYIGDGIARATGLENAMANELLQFSNGSY
CCCCHHHHHHHHHHHHCCHHHHHHHHHCCEEEEECCCHHHHHCHHHHHHHHHHHHCCCCE
GMALNLETNDVGIIILGDFDEIREGDQVKRTGRIMEVPVGDAMIGRVVNSLGQPVDGLGA
EEEEEEECCCEEEEEECCHHHHHCCCHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCCCC
IKTDKTRPIEFKAPGVMQRKSVSEPLQTGLKAIDALVPIGRGQRELIIGDRKTGKTSIAI
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEH
DTILNQKDQNMICVYVAIGQKDSTVRAQVETLKKYGAMDYTIVLTAGPSEPAPMLYIAPY
HHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEEECCC
AGAAMGEEFMYNGKHVLIVYDDLSKQATSYRELSLLLRRPPGREAYPGDIFYTHSRLLER
CCCHHCHHHEECCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHH
AAKLSDKLGGGSMTALPVIETQAGDISAYIPTNVISITDGQIFLQSDLFYAGTRPAIDAG
HHHHHHHCCCCCEEEEEEEEECCCCEEEECCCCEEEEECCEEEEECCEEECCCCCCCCCC
ASVSRVGGDAQVKAMKKVAGTLRLDLASFRELEAFTQFGSDLDAATQAKLNRGRRTVEVL
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHH
KQPVHKPLPVEKQVIILYALTHGFLDPIPIEDITRFQDELFDFFDSNAADLLKQIRDTGN
HHHCCCCCCCCCCEEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
LPDTDKLDAQIKAFAGGFQTSKQLAAAKD
CCCCCHHHHHHHHHHCCCHHHHHHHCCCC
>Mature Secondary Structure 
SIKTEEISSLIKKQLEGYQDDLAAEEVGTVTYIGDGIARATGLENAMANELLQFSNGSY
CCCHHHHHHHHHHHHCCHHHHHHHHHCCEEEEECCCHHHHHCHHHHHHHHHHHHCCCCE
GMALNLETNDVGIIILGDFDEIREGDQVKRTGRIMEVPVGDAMIGRVVNSLGQPVDGLGA
EEEEEEECCCEEEEEECCHHHHHCCCHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCCCC
IKTDKTRPIEFKAPGVMQRKSVSEPLQTGLKAIDALVPIGRGQRELIIGDRKTGKTSIAI
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEH
DTILNQKDQNMICVYVAIGQKDSTVRAQVETLKKYGAMDYTIVLTAGPSEPAPMLYIAPY
HHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEEECCC
AGAAMGEEFMYNGKHVLIVYDDLSKQATSYRELSLLLRRPPGREAYPGDIFYTHSRLLER
CCCHHCHHHEECCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHH
AAKLSDKLGGGSMTALPVIETQAGDISAYIPTNVISITDGQIFLQSDLFYAGTRPAIDAG
HHHHHHHCCCCCEEEEEEEEECCCCEEEECCCCEEEEECCEEEEECCEEECCCCCCCCCC
ASVSRVGGDAQVKAMKKVAGTLRLDLASFRELEAFTQFGSDLDAATQAKLNRGRRTVEVL
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHH
KQPVHKPLPVEKQVIILYALTHGFLDPIPIEDITRFQDELFDFFDSNAADLLKQIRDTGN
HHHCCCCCCCCCCEEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
LPDTDKLDAQIKAFAGGFQTSKQLAAAKD
CCCCCHHHHHHHHHHCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA