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The map label for this gene is pepO [H]

Identifier: 116494567

GI number: 116494567

Start: 1050203

End: 1052107

Strand: Direct

Name: pepO [H]

Synonym: LSEI_1065

Alternate gene names: 116494567

Gene position: 1050203-1052107 (Clockwise)

Preceding gene: 116494565

Following gene: 116494568

Centisome position: 36.27

GC content: 49.5

Gene sequence:

>1905_bases
ATGTCATTACCACGTATTCAAGATGATTTATATATGGCGGTCAACGGGACTTGGCAGCAGAACACGGTGATCCCGCCTGA
CAAAAGCGTCGTGAGTGCTGACAGTGATCTAACTGATAGCATTCGAATCAAGTTGGTAGCCGATTTGAAGAAAATAAACG
CGGCACCACAAGCCGCCGATTCACCACTGCAAAATGCCGTACGACTATTTGCTAAGGCTAACGATAAAGTTCGACGCAAC
CAACTCGGCATGACACCGGTTCGTGCACGGCTGGATAAAATTGCTGGGCTTAAAACGCTGGCCCAGTTTCGTGCAGCACT
GCCAAAACTACTGGCGGGGCAATATGTGTTGCCAGTAAGCCCGTACGTTGATGCTGATATGCACGATGCGGCTCACAATA
TTTTGAATCTTGGTGGTCCGGCCACGATTTTACCTGACGCTGCCATGTATCAAACCGATGATGCAGAGAATGCGGCAGAT
TTAGCTGCATGGTCGAAAATGGTCGCGACGCTTTTGGGTGAGGCCGGTTTTGACCAGACAGCACAAGCGCACTATGTGGC
GGCGGCTAAAAGCTTTGATCGCCGATTGGCTGCGTTCATTCCGGCAAATGTCGATTTTGCTGTTGATAGCACCTTTGACA
ATCCGCTAACCTGGACTGAATTTGTAGAAGATGCTGGTTTCTTAGGCATTCCCGAAGCTTTGGCTGCTAAAATGCCGCAG
ACACCGACGAAGGTCAACGCCGTGGTGCCTGCTTATCTGCCGCATCTGTCGACATTAATCACCGAAGCAAACTATCCAGA
ATGGCAAGCATGGATGCTGATTAGCGAACTATTGGCTTGTGCTGATTATTTAAGCGATGATAGCCGCCAACTTGCTGGTC
AATATGACCGTTTTTTGGCTGGACAGCCTGAGCCCGAAGCTTGGGAAAAGCATGCTTTTGGAGTTGCCAACGACTATTTT
GATGATGCAATTGGTCAGTACTATGGCCAGACTTATTTTGGCGCGGATGCGAAAGCGGATATTACCGCGATGGTCAAGGA
AATTTTGCAACAATATCAAGTTCAACTTGAACACAATACTTGGTTAAGCCCAGCGACTAAGCAGAAGGCTATCCGCAAAT
TAGCGACTATGAAAATTAAAATGGGTTATCCAGATCAACTTTTCCCGCTTTACGCGACCCTGCATGTCGAGCCAGAGGCT
GATTTACTGCCGACCATTTTGCAATTGAGCCAGCAGACGCAAGACTTTTGGCTTCAGCAGGTGGGTCAGCCAGTGGATCG
CAATGTTTGGGGGATGCCGGGGCACCTTGTGAATGCCTGCTACGATCCGATGAAAAATGACATCACCTTCCCAGCCGGGA
TTTTACAGCCGCCATACTACTCACTGAACTGGACCCGAGCGCAAAATCTTGGCGGTACCGGTGCTACCATCGGTCACGAG
ATTTCACATTCGTTCGATAATAATGGCGCCTTGTATGATGAATATGGCACGTTAAATAATTGGTGGACGGTTGAGGACAA
ACAAGCCTTCGACAAGTTAGTGACAGCTATTGCGGATCAATTTGACGGTTTATTGTATGAAGGCGTCAAAGTGAATGGTC
GACTGACGGTTAGCGAAAACATCGCCGATAATGCCGGCATGGCGGTGGCGTTGGACTTGTTAGGGGATTCGGCTGACCCG
AAAGTGCTGCAAGACTTCTTTATTGCCTATGCTCGTTCTTGGGCGACCAAAATGCGGCCAGAGCGCGCTAAAACGGTGTT
GCGGCAAGATGTCCATGCCCCGGCGACCTTGCGGGTTAATGTCCCTGTGCAAAACTTTGAGGCGTGGTATCAAGCTTTCG
ATGTACAGCCGACCGATGGTATGTATCGATTGCCCGCAAAGCGCGTCACGATTTGGCGTCGGTAG

Upstream 100 bases:

>100_bases
CGCTTGCTTAGTCAAACTATGCTTGCATTATCGCATTTAAAAACCGCAGGAGCAGCATCGGATTTTGGTTCGACGAATGC
GCTTAAAAGGAGGAATTTTG

Downstream 100 bases:

>100_bases
CATTTAAACACATTTGTTTTAAATAAAACCGATATTAGTAGGCCTATCTTGTGCCTGAAATCGCCTCATAACGCTGTGTG
TCAGTTATTAGTTGTCTTTA

Product: neutral endopeptidase

Products: NA

Alternate protein names: Endopeptidase O [H]

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MSLPRIQDDLYMAVNGTWQQNTVIPPDKSVVSADSDLTDSIRIKLVADLKKINAAPQAADSPLQNAVRLFAKANDKVRRN
QLGMTPVRARLDKIAGLKTLAQFRAALPKLLAGQYVLPVSPYVDADMHDAAHNILNLGGPATILPDAAMYQTDDAENAAD
LAAWSKMVATLLGEAGFDQTAQAHYVAAAKSFDRRLAAFIPANVDFAVDSTFDNPLTWTEFVEDAGFLGIPEALAAKMPQ
TPTKVNAVVPAYLPHLSTLITEANYPEWQAWMLISELLACADYLSDDSRQLAGQYDRFLAGQPEPEAWEKHAFGVANDYF
DDAIGQYYGQTYFGADAKADITAMVKEILQQYQVQLEHNTWLSPATKQKAIRKLATMKIKMGYPDQLFPLYATLHVEPEA
DLLPTILQLSQQTQDFWLQQVGQPVDRNVWGMPGHLVNACYDPMKNDITFPAGILQPPYYSLNWTRAQNLGGTGATIGHE
ISHSFDNNGALYDEYGTLNNWWTVEDKQAFDKLVTAIADQFDGLLYEGVKVNGRLTVSENIADNAGMAVALDLLGDSADP
KVLQDFFIAYARSWATKMRPERAKTVLRQDVHAPATLRVNVPVQNFEAWYQAFDVQPTDGMYRLPAKRVTIWRR

Sequences:

>Translated_634_residues
MSLPRIQDDLYMAVNGTWQQNTVIPPDKSVVSADSDLTDSIRIKLVADLKKINAAPQAADSPLQNAVRLFAKANDKVRRN
QLGMTPVRARLDKIAGLKTLAQFRAALPKLLAGQYVLPVSPYVDADMHDAAHNILNLGGPATILPDAAMYQTDDAENAAD
LAAWSKMVATLLGEAGFDQTAQAHYVAAAKSFDRRLAAFIPANVDFAVDSTFDNPLTWTEFVEDAGFLGIPEALAAKMPQ
TPTKVNAVVPAYLPHLSTLITEANYPEWQAWMLISELLACADYLSDDSRQLAGQYDRFLAGQPEPEAWEKHAFGVANDYF
DDAIGQYYGQTYFGADAKADITAMVKEILQQYQVQLEHNTWLSPATKQKAIRKLATMKIKMGYPDQLFPLYATLHVEPEA
DLLPTILQLSQQTQDFWLQQVGQPVDRNVWGMPGHLVNACYDPMKNDITFPAGILQPPYYSLNWTRAQNLGGTGATIGHE
ISHSFDNNGALYDEYGTLNNWWTVEDKQAFDKLVTAIADQFDGLLYEGVKVNGRLTVSENIADNAGMAVALDLLGDSADP
KVLQDFFIAYARSWATKMRPERAKTVLRQDVHAPATLRVNVPVQNFEAWYQAFDVQPTDGMYRLPAKRVTIWRR
>Mature_633_residues
SLPRIQDDLYMAVNGTWQQNTVIPPDKSVVSADSDLTDSIRIKLVADLKKINAAPQAADSPLQNAVRLFAKANDKVRRNQ
LGMTPVRARLDKIAGLKTLAQFRAALPKLLAGQYVLPVSPYVDADMHDAAHNILNLGGPATILPDAAMYQTDDAENAADL
AAWSKMVATLLGEAGFDQTAQAHYVAAAKSFDRRLAAFIPANVDFAVDSTFDNPLTWTEFVEDAGFLGIPEALAAKMPQT
PTKVNAVVPAYLPHLSTLITEANYPEWQAWMLISELLACADYLSDDSRQLAGQYDRFLAGQPEPEAWEKHAFGVANDYFD
DAIGQYYGQTYFGADAKADITAMVKEILQQYQVQLEHNTWLSPATKQKAIRKLATMKIKMGYPDQLFPLYATLHVEPEAD
LLPTILQLSQQTQDFWLQQVGQPVDRNVWGMPGHLVNACYDPMKNDITFPAGILQPPYYSLNWTRAQNLGGTGATIGHEI
SHSFDNNGALYDEYGTLNNWWTVEDKQAFDKLVTAIADQFDGLLYEGVKVNGRLTVSENIADNAGMAVALDLLGDSADPK
VLQDFFIAYARSWATKMRPERAKTVLRQDVHAPATLRVNVPVQNFEAWYQAFDVQPTDGMYRLPAKRVTIWRR

Specific function: Unknown

COG id: COG3590

COG function: function code O; Predicted metalloendopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M13 family [H]

Homologues:

Organism=Homo sapiens, GI116256333, Length=695, Percent_Identity=24.1726618705036, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI116256331, Length=695, Percent_Identity=24.1726618705036, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI116256329, Length=695, Percent_Identity=24.1726618705036, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI116256327, Length=695, Percent_Identity=24.1726618705036, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI239049391, Length=677, Percent_Identity=25.4062038404727, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI157426891, Length=670, Percent_Identity=26.4179104477612, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI153945761, Length=668, Percent_Identity=25, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI153945771, Length=668, Percent_Identity=25, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI82617560, Length=668, Percent_Identity=25, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI153945836, Length=668, Percent_Identity=25, Blast_Score=176, Evalue=8e-44,
Organism=Homo sapiens, GI4503443, Length=678, Percent_Identity=23.3038348082596, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI164519136, Length=678, Percent_Identity=23.3038348082596, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI164519140, Length=679, Percent_Identity=23.2695139911635, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI164519138, Length=679, Percent_Identity=23.2695139911635, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI90403592, Length=331, Percent_Identity=31.4199395770393, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI4557691, Length=407, Percent_Identity=24.5700245700246, Blast_Score=94, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI25148650, Length=330, Percent_Identity=33.030303030303, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI86562497, Length=332, Percent_Identity=31.6265060240964, Blast_Score=178, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17533333, Length=383, Percent_Identity=30.8093994778068, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17564342, Length=357, Percent_Identity=28.8515406162465, Blast_Score=166, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71987442, Length=663, Percent_Identity=24.8868778280543, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI32563993, Length=346, Percent_Identity=31.2138728323699, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17534401, Length=314, Percent_Identity=29.2993630573248, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71994787, Length=327, Percent_Identity=28.7461773700306, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17570047, Length=344, Percent_Identity=25.2906976744186, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71988640, Length=235, Percent_Identity=26.8085106382979, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17533319, Length=341, Percent_Identity=26.099706744868, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17532485, Length=331, Percent_Identity=26.2839879154079, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71998977, Length=327, Percent_Identity=24.7706422018349, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71998975, Length=290, Percent_Identity=25.5172413793103, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71986891, Length=324, Percent_Identity=22.8395061728395, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193204436, Length=303, Percent_Identity=25.4125412541254, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24643425, Length=673, Percent_Identity=25.111441307578, Blast_Score=205, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24640050, Length=668, Percent_Identity=26.1976047904192, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24640052, Length=668, Percent_Identity=26.1976047904192, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI45550777, Length=555, Percent_Identity=26.3063063063063, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI45551938, Length=558, Percent_Identity=26.1648745519713, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17737761, Length=681, Percent_Identity=24.2290748898678, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI221474862, Length=337, Percent_Identity=27.0029673590504, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24650487, Length=421, Percent_Identity=23.2779097387173, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24650889, Length=293, Percent_Identity=27.6450511945392, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281362760, Length=360, Percent_Identity=24.1666666666667, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24650765, Length=349, Percent_Identity=24.0687679083095, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24650883, Length=282, Percent_Identity=24.822695035461, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24650885, Length=285, Percent_Identity=26.6666666666667, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355943, Length=333, Percent_Identity=22.8228228228228, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641622, Length=321, Percent_Identity=28.9719626168224, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000718
- InterPro:   IPR018497
- InterPro:   IPR008753 [H]

Pfam domain/function: PF01431 Peptidase_M13; PF05649 Peptidase_M13_N [H]

EC number: NA

Molecular weight: Translated: 70378; Mature: 70247

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPRIQDDLYMAVNGTWQQNTVIPPDKSVVSADSDLTDSIRIKLVADLKKINAAPQAAD
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHEEEHHHHHHHHCCCCCCCC
SPLQNAVRLFAKANDKVRRNQLGMTPVRARLDKIAGLKTLAQFRAALPKLLAGQYVLPVS
HHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
PYVDADMHDAAHNILNLGGPATILPDAAMYQTDDAENAADLAAWSKMVATLLGEAGFDQT
CCCCCCHHHHHHHHHHCCCCCEECCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
AQAHYVAAAKSFDRRLAAFIPANVDFAVDSTFDNPLTWTEFVEDAGFLGIPEALAAKMPQ
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHCCCCCCCCHHHHHCCCC
TPTKVNAVVPAYLPHLSTLITEANYPEWQAWMLISELLACADYLSDDSRQLAGQYDRFLA
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
GQPEPEAWEKHAFGVANDYFDDAIGQYYGQTYFGADAKADITAMVKEILQQYQVQLEHNT
CCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCC
WLSPATKQKAIRKLATMKIKMGYPDQLFPLYATLHVEPEADLLPTILQLSQQTQDFWLQQ
CCCCHHHHHHHHHHHHEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
VGQPVDRNVWGMPGHLVNACYDPMKNDITFPAGILQPPYYSLNWTRAQNLGGTGATIGHE
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHH
ISHSFDNNGALYDEYGTLNNWWTVEDKQAFDKLVTAIADQFDGLLYEGVKVNGRLTVSEN
HHHCCCCCCCEEECCCCCCCEEECCHHHHHHHHHHHHHHHHCCCEECCEEECCEEEEECC
IADNAGMAVALDLLGDSADPKVLQDFFIAYARSWATKMRPERAKTVLRQDVHAPATLRVN
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEE
VPVQNFEAWYQAFDVQPTDGMYRLPAKRVTIWRR
CCHHHHHHHHHHHCCCCCCCCEECCHHHEECCCC
>Mature Secondary Structure 
SLPRIQDDLYMAVNGTWQQNTVIPPDKSVVSADSDLTDSIRIKLVADLKKINAAPQAAD
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHEEEHHHHHHHHCCCCCCCC
SPLQNAVRLFAKANDKVRRNQLGMTPVRARLDKIAGLKTLAQFRAALPKLLAGQYVLPVS
HHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
PYVDADMHDAAHNILNLGGPATILPDAAMYQTDDAENAADLAAWSKMVATLLGEAGFDQT
CCCCCCHHHHHHHHHHCCCCCEECCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
AQAHYVAAAKSFDRRLAAFIPANVDFAVDSTFDNPLTWTEFVEDAGFLGIPEALAAKMPQ
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHCCCCCCCCHHHHHCCCC
TPTKVNAVVPAYLPHLSTLITEANYPEWQAWMLISELLACADYLSDDSRQLAGQYDRFLA
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
GQPEPEAWEKHAFGVANDYFDDAIGQYYGQTYFGADAKADITAMVKEILQQYQVQLEHNT
CCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCC
WLSPATKQKAIRKLATMKIKMGYPDQLFPLYATLHVEPEADLLPTILQLSQQTQDFWLQQ
CCCCHHHHHHHHHHHHEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
VGQPVDRNVWGMPGHLVNACYDPMKNDITFPAGILQPPYYSLNWTRAQNLGGTGATIGHE
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHH
ISHSFDNNGALYDEYGTLNNWWTVEDKQAFDKLVTAIADQFDGLLYEGVKVNGRLTVSEN
HHHCCCCCCCEEECCCCCCCEEECCHHHHHHHHHHHHHHHHCCCEECCEEECCEEEEECC
IADNAGMAVALDLLGDSADPKVLQDFFIAYARSWATKMRPERAKTVLRQDVHAPATLRVN
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEE
VPVQNFEAWYQAFDVQPTDGMYRLPAKRVTIWRR
CCHHHHHHHHHHHCCCCCCCCEECCHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9726890 [H]