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The map label for this gene is glmS [H]

Identifier: 116494523

GI number: 116494523

Start: 1005288

End: 1007099

Strand: Direct

Name: glmS [H]

Synonym: LSEI_1019

Alternate gene names: 116494523

Gene position: 1005288-1007099 (Clockwise)

Preceding gene: 116494522

Following gene: 116494524

Centisome position: 34.72

GC content: 47.19

Gene sequence:

>1812_bases
ATGTGTGGAATCGTTGGCGTTATCGGTAAAAAGAATGCAACGCAGATCTTGCTTAAGGGATTAGAGAAGTTGGAATACCG
CGGCTATGATTCAGCCGGCATTTACGTGAATGACCAAGCCGGCCATGATCATTTAATTAAGCGCGTCGGCCATATTTCCA
ATCTTGAAGAAGCGGTTACGCCTGATGTTCAAGGAGTTATGGGGATTGGCCATACACGCTGGGCAACTAATGGCGGCCCT
ACCGAAGCCAACGCCCATCCGCATGTTTCCAATGACGAACGGTTTTATCTGGTGCATAACGGCGTTGTGACCAATGCTAA
CGAACTGAAGCAGCAGTACTTGCAAGACATTGAATTACAGAGTGATACGGATACCGAAGTTGTTGTTCAGCTGATTGCCT
TGTTTGCCCGCGAAGGTCTGTCTGCTAAGGAAGCACTGCGCAAAACCTTGAAAATGATCCAAGGTTCTTATGCTTTCTCG
ATGGTTGATCGCCTTGACCCAACAGTGCTGTATGTTGCTAAAAACAAGAGTCCATTACTGATTGGCCGTGGTAAAGGCTT
TAATGTGGTGGCTTCTGATGCCTTGGCAATGCTTAGTGAAACCGATCAGTTTGTTGAACTGAAGGATCAGGAAATCGTGA
CCTTGACGGCTGATGCCATTCACATTGAAACGATTGACGGCAAAGTTGAGGAACGTAAGCCATTCACCGTTAAAGTTGAT
GATGGTGAAGTTTCTAAAGGTACGTACCCATTCTTCATGCTTAAAGAAATTGACGAACAGCCAATCGTTATGCGGCGTTT
GGTCGAAAAATATACCGATGATCATGGCAACATCGTTTTGCCAGAAGATTTGCTGAAAGCTTTACAGCAAGCTGATCGTT
TGTATATCGTTGCGGCTGGTACCAGTTATCATGCCGGTTTAGTCGGTGCACCTTTGTTCGAACAATTGGCAGGTATTCCG
ACAGAAGTGCATGTTGCTTCTGAGTTTGCCTATCATCAACCACTGTTGTCCAAGCACCCACTGTTCATTTTCCTAACCCA
AAGTGGGGAAACTGCTGATATCCGTCAGGTCCTTGTTTCAGTCAAGGAACGCGGTTATCAGACATTAACGATCACAAACG
TTGCCAGCTCAACGCTTGCTCGTGAAGCAACCTTTATGTTGCAGTTGCATGGCGGCCCAGAAATTGCGGTTGCTTCTACC
AAAGCTTACACGGCACAAATCGCCGTTGAAGCGCTTGTATCGAAAGCAGTCGGCGAGGCTAAAGGATTGCAGGCTGCTAA
GGACTTCGATGTGATCCATGAACTTGGGTTGGCAGCAACTGGTCAGCAGGCTTTGATTGACCAAAAGGATCGCATCCATG
AACTAGCAACTGACATGTTCAAGACCACGCGCAATGCTTTCTACATTGGCCGTGGCGATGATTACTATGCCAGCATGGAA
GCAGCATTGAAACTCAAGGAAATCAGTTATGTTCAGGCAGAAGGCTTTGCGGCTGGTGAATTGAAGCATGGTACGATTGC
TTTGATTGAAAAGAATACGCCAGTGGTTGCAATCATTTCTGATCCGGTTACAGCAGCGCGCACTCGCAGCAATGCGGACG
AGGTGCAAGCTCGCGGTGCCAAGGTGCTTCATATCGCAATGGCTAGTCAAGCCCAAGATGGTGACCAAATCGTTGTCGAT
GAAATCAATCCATTACTTGCACCGCTTTTGACGATTATCCCGGCACAGCTCTTGGCTTACTTTACTAGTGCGGATCGTGG
TTACGATGTTGACCGTCCGCGTAATCTGGCTAAGTCAGTGACCGTTGAATAA

Upstream 100 bases:

>100_bases
TATAGCCTATTAAAAACTATAGTTAGCTTTGCTTTTAACAATACCAATAAAAAAATCTGTCTAAACCAATTTTTAGACAA
AAATGAAAAGGATGTTGACT

Downstream 100 bases:

>100_bases
TCGCTAAGGATTTCATTTGGTGATCGGTGTCATTCATGTCAAGATGTGGATTCAATCCCCAGCTTGGTGTCTGACGTCGT
AGCGGATCGTGATCCATGTA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MCGIVGVIGKKNATQILLKGLEKLEYRGYDSAGIYVNDQAGHDHLIKRVGHISNLEEAVTPDVQGVMGIGHTRWATNGGP
TEANAHPHVSNDERFYLVHNGVVTNANELKQQYLQDIELQSDTDTEVVVQLIALFAREGLSAKEALRKTLKMIQGSYAFS
MVDRLDPTVLYVAKNKSPLLIGRGKGFNVVASDALAMLSETDQFVELKDQEIVTLTADAIHIETIDGKVEERKPFTVKVD
DGEVSKGTYPFFMLKEIDEQPIVMRRLVEKYTDDHGNIVLPEDLLKALQQADRLYIVAAGTSYHAGLVGAPLFEQLAGIP
TEVHVASEFAYHQPLLSKHPLFIFLTQSGETADIRQVLVSVKERGYQTLTITNVASSTLAREATFMLQLHGGPEIAVAST
KAYTAQIAVEALVSKAVGEAKGLQAAKDFDVIHELGLAATGQQALIDQKDRIHELATDMFKTTRNAFYIGRGDDYYASME
AALKLKEISYVQAEGFAAGELKHGTIALIEKNTPVVAIISDPVTAARTRSNADEVQARGAKVLHIAMASQAQDGDQIVVD
EINPLLAPLLTIIPAQLLAYFTSADRGYDVDRPRNLAKSVTVE

Sequences:

>Translated_603_residues
MCGIVGVIGKKNATQILLKGLEKLEYRGYDSAGIYVNDQAGHDHLIKRVGHISNLEEAVTPDVQGVMGIGHTRWATNGGP
TEANAHPHVSNDERFYLVHNGVVTNANELKQQYLQDIELQSDTDTEVVVQLIALFAREGLSAKEALRKTLKMIQGSYAFS
MVDRLDPTVLYVAKNKSPLLIGRGKGFNVVASDALAMLSETDQFVELKDQEIVTLTADAIHIETIDGKVEERKPFTVKVD
DGEVSKGTYPFFMLKEIDEQPIVMRRLVEKYTDDHGNIVLPEDLLKALQQADRLYIVAAGTSYHAGLVGAPLFEQLAGIP
TEVHVASEFAYHQPLLSKHPLFIFLTQSGETADIRQVLVSVKERGYQTLTITNVASSTLAREATFMLQLHGGPEIAVAST
KAYTAQIAVEALVSKAVGEAKGLQAAKDFDVIHELGLAATGQQALIDQKDRIHELATDMFKTTRNAFYIGRGDDYYASME
AALKLKEISYVQAEGFAAGELKHGTIALIEKNTPVVAIISDPVTAARTRSNADEVQARGAKVLHIAMASQAQDGDQIVVD
EINPLLAPLLTIIPAQLLAYFTSADRGYDVDRPRNLAKSVTVE
>Mature_603_residues
MCGIVGVIGKKNATQILLKGLEKLEYRGYDSAGIYVNDQAGHDHLIKRVGHISNLEEAVTPDVQGVMGIGHTRWATNGGP
TEANAHPHVSNDERFYLVHNGVVTNANELKQQYLQDIELQSDTDTEVVVQLIALFAREGLSAKEALRKTLKMIQGSYAFS
MVDRLDPTVLYVAKNKSPLLIGRGKGFNVVASDALAMLSETDQFVELKDQEIVTLTADAIHIETIDGKVEERKPFTVKVD
DGEVSKGTYPFFMLKEIDEQPIVMRRLVEKYTDDHGNIVLPEDLLKALQQADRLYIVAAGTSYHAGLVGAPLFEQLAGIP
TEVHVASEFAYHQPLLSKHPLFIFLTQSGETADIRQVLVSVKERGYQTLTITNVASSTLAREATFMLQLHGGPEIAVAST
KAYTAQIAVEALVSKAVGEAKGLQAAKDFDVIHELGLAATGQQALIDQKDRIHELATDMFKTTRNAFYIGRGDDYYASME
AALKLKEISYVQAEGFAAGELKHGTIALIEKNTPVVAIISDPVTAARTRSNADEVQARGAKVLHIAMASQAQDGDQIVVD
EINPLLAPLLTIIPAQLLAYFTSADRGYDVDRPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=29.9707602339181, Blast_Score=309, Evalue=4e-84,
Organism=Homo sapiens, GI205277386, Length=688, Percent_Identity=32.703488372093, Blast_Score=306, Evalue=4e-83,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=39.8042414355628, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1788651, Length=269, Percent_Identity=30.4832713754647, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539970, Length=425, Percent_Identity=32, Blast_Score=219, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17532897, Length=426, Percent_Identity=31.2206572769953, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17532899, Length=426, Percent_Identity=31.2206572769953, Blast_Score=209, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6322745, Length=428, Percent_Identity=33.411214953271, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6323731, Length=427, Percent_Identity=26.463700234192, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6323730, Length=235, Percent_Identity=32.7659574468085, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357745, Length=694, Percent_Identity=30.2593659942363, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65813; Mature: 65813

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGVIGKKNATQILLKGLEKLEYRGYDSAGIYVNDQAGHDHLIKRVGHISNLEEAVT
CCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCHHHHHC
PDVQGVMGIGHTRWATNGGPTEANAHPHVSNDERFYLVHNGVVTNANELKQQYLQDIELQ
CCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCEECCHHHHHHHHHHHCCCC
SDTDTEVVVQLIALFAREGLSAKEALRKTLKMIQGSYAFSMVDRLDPTVLYVAKNKSPLL
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCCEEE
IGRGKGFNVVASDALAMLSETDQFVELKDQEIVTLTADAIHIETIDGKVEERKPFTVKVD
EECCCCCEEHHHHHHHHHHCCCHHEEECCCEEEEEEECEEEEEEECCCHHCCCCEEEEEC
DGEVSKGTYPFFMLKEIDEQPIVMRRLVEKYTDDHGNIVLPEDLLKALQQADRLYIVAAG
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEECCHHHHHHHHCCCEEEEEEEC
TSYHAGLVGAPLFEQLAGIPTEVHVASEFAYHQPLLSKHPLFIFLTQSGETADIRQVLVS
CCCCCCCCCCHHHHHHCCCCCEEEHHHHHHHHCCHHCCCCEEEEEECCCCCHHHHHHHHH
VKERGYQTLTITNVASSTLAREATFMLQLHGGPEIAVASTKAYTAQIAVEALVSKAVGEA
HHHCCCEEEEEEHHHHHHHHHCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
KGLQAAKDFDVIHELGLAATGQQALIDQKDRIHELATDMFKTTRNAFYIGRGDDYYASME
HCCCHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHH
AALKLKEISYVQAEGFAAGELKHGTIALIEKNTPVVAIISDPVTAARTRSNADEVQARGA
HHHHHHHHHEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHCCCCHHHHHHCCC
KVLHIAMASQAQDGDQIVVDEINPLLAPLLTIIPAQLLAYFTSADRGYDVDRPRNLAKSV
EEEEEEECCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHC
TVE
CCC
>Mature Secondary Structure
MCGIVGVIGKKNATQILLKGLEKLEYRGYDSAGIYVNDQAGHDHLIKRVGHISNLEEAVT
CCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCHHHHHC
PDVQGVMGIGHTRWATNGGPTEANAHPHVSNDERFYLVHNGVVTNANELKQQYLQDIELQ
CCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCEECCHHHHHHHHHHHCCCC
SDTDTEVVVQLIALFAREGLSAKEALRKTLKMIQGSYAFSMVDRLDPTVLYVAKNKSPLL
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCCEEE
IGRGKGFNVVASDALAMLSETDQFVELKDQEIVTLTADAIHIETIDGKVEERKPFTVKVD
EECCCCCEEHHHHHHHHHHCCCHHEEECCCEEEEEEECEEEEEEECCCHHCCCCEEEEEC
DGEVSKGTYPFFMLKEIDEQPIVMRRLVEKYTDDHGNIVLPEDLLKALQQADRLYIVAAG
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEECCHHHHHHHHCCCEEEEEEEC
TSYHAGLVGAPLFEQLAGIPTEVHVASEFAYHQPLLSKHPLFIFLTQSGETADIRQVLVS
CCCCCCCCCCHHHHHHCCCCCEEEHHHHHHHHCCHHCCCCEEEEEECCCCCHHHHHHHHH
VKERGYQTLTITNVASSTLAREATFMLQLHGGPEIAVASTKAYTAQIAVEALVSKAVGEA
HHHCCCEEEEEEHHHHHHHHHCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
KGLQAAKDFDVIHELGLAATGQQALIDQKDRIHELATDMFKTTRNAFYIGRGDDYYASME
HCCCHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHH
AALKLKEISYVQAEGFAAGELKHGTIALIEKNTPVVAIISDPVTAARTRSNADEVQARGA
HHHHHHHHHEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHCCCCHHHHHHCCC
KVLHIAMASQAQDGDQIVVDEINPLLAPLLTIIPAQLLAYFTSADRGYDVDRPRNLAKSV
EEEEEEECCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHC
TVE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]