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The map label for this gene is ung

Identifier: 116494499

GI number: 116494499

Start: 980595

End: 981281

Strand: Direct

Name: ung

Synonym: LSEI_0995

Alternate gene names: 116494499

Gene position: 980595-981281 (Clockwise)

Preceding gene: 116494496

Following gene: 116494500

Centisome position: 33.87

GC content: 50.66

Gene sequence:

>687_bases
TTGAAAACATTAATACATAATGACTGGCAGACGGTGCTGGAACCGGTATTTGAAAGTCCTGAGTATGCTCAACTGCATGC
GTTCTTAAAAGAAGAATACGCGACAAAAACGATTTACCCTGAAATGCACCATATTTTTCAGGCATTCGAATGGACACCTT
TCCATGATGTGAAGGTGGTCATTCTAGGCCAGGACCCTTACCACAATCCGCGGCAGGCGGTTGGTGCGAGCTTTGCGGTG
GCGCCCGGTGTCGCTTTGCCGCCGTCTTTGCAAAACATTTATAAAGAGTTGCAAAGCGATTTAGGCTATCCACCGGTCCA
TCATGGTTATTTGAAGGCTTGGGCGGACCAAGGCGTTCTATTGTTGAATGCCGTTTTGACGGTACAAGCCGGCGAAGCCT
ATTCCCATCAGAATCATGGCTGGGAAGAGTTGACAGATGCTGCCATTGCTGCCTTGTCTGCACGCGGCGGCGTTGTGTTC
ATCCTGTGGGGGAACGCGGCCAAAAAAAAGGCGGCCGTGATTGATACGAGCAAGAACGCGATTATTGCATCAGCGCACCC
AAGCCCGTTATCTGCATCTCGTGGCTTCTTTGGCAGTCGCCCGTTTTCGCGCACCAATGCGGCACTAGAAAAAATGGGCG
AGGCCCCGATTAATTGGCAGTTACCAGAAACGGTGAAGGCGGATTAA

Upstream 100 bases:

>100_bases
TTGTCATGGTGCGGTTACGCCTCCAATTCTAGCATGAAAAAGCGTTTCCCGGTAGCAAACCCGCGGTGATTCTTGTACAC
TATTTGCGGAGGTGCACGTC

Downstream 100 bases:

>100_bases
CCTGAATTGACTAGCCTTAAGTGGCTCAGACACACTGTTTTTCCATTGTCTTCGACTAGTCACGACCCGATAAAAACGGT
ATGATGAACAAGAATAAAGC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKTLIHNDWQTVLEPVFESPEYAQLHAFLKEEYATKTIYPEMHHIFQAFEWTPFHDVKVVILGQDPYHNPRQAVGASFAV
APGVALPPSLQNIYKELQSDLGYPPVHHGYLKAWADQGVLLLNAVLTVQAGEAYSHQNHGWEELTDAAIAALSARGGVVF
ILWGNAAKKKAAVIDTSKNAIIASAHPSPLSASRGFFGSRPFSRTNAALEKMGEAPINWQLPETVKAD

Sequences:

>Translated_228_residues
MKTLIHNDWQTVLEPVFESPEYAQLHAFLKEEYATKTIYPEMHHIFQAFEWTPFHDVKVVILGQDPYHNPRQAVGASFAV
APGVALPPSLQNIYKELQSDLGYPPVHHGYLKAWADQGVLLLNAVLTVQAGEAYSHQNHGWEELTDAAIAALSARGGVVF
ILWGNAAKKKAAVIDTSKNAIIASAHPSPLSASRGFFGSRPFSRTNAALEKMGEAPINWQLPETVKAD
>Mature_228_residues
MKTLIHNDWQTVLEPVFESPEYAQLHAFLKEEYATKTIYPEMHHIFQAFEWTPFHDVKVVILGQDPYHNPRQAVGASFAV
APGVALPPSLQNIYKELQSDLGYPPVHHGYLKAWADQGVLLLNAVLTVQAGEAYSHQNHGWEELTDAAIAALSARGGVVF
ILWGNAAKKKAAVIDTSKNAIIASAHPSPLSASRGFFGSRPFSRTNAALEKMGEAPINWQLPETVKAD

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI6224979, Length=214, Percent_Identity=49.5327102803738, Blast_Score=208, Evalue=4e-54,
Organism=Homo sapiens, GI19718751, Length=214, Percent_Identity=49.5327102803738, Blast_Score=207, Evalue=4e-54,
Organism=Escherichia coli, GI1788934, Length=214, Percent_Identity=50.9345794392523, Blast_Score=214, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17556304, Length=224, Percent_Identity=45.9821428571429, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=42.6160337552743, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_LACC3 (Q03AI1)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806233.1
- ProteinModelPortal:   Q03AI1
- SMR:   Q03AI1
- STRING:   Q03AI1
- GeneID:   4418948
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_0995
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- PhylomeDB:   Q03AI1
- ProtClustDB:   PRK05254
- BioCyc:   LCAS321967:LSEI_0995-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25092; Mature: 25092

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLIHNDWQTVLEPVFESPEYAQLHAFLKEEYATKTIYPEMHHIFQAFEWTPFHDVKVV
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEE
ILGQDPYHNPRQAVGASFAVAPGVALPPSLQNIYKELQSDLGYPPVHHGYLKAWADQGVL
EECCCCCCCHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEE
LLNAVLTVQAGEAYSHQNHGWEELTDAAIAALSARGGVVFILWGNAAKKKAAVIDTSKNA
EEHHHHHEECCCHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCE
IIASAHPSPLSASRGFFGSRPFSRTNAALEKMGEAPINWQLPETVKAD
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTLIHNDWQTVLEPVFESPEYAQLHAFLKEEYATKTIYPEMHHIFQAFEWTPFHDVKVV
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEE
ILGQDPYHNPRQAVGASFAVAPGVALPPSLQNIYKELQSDLGYPPVHHGYLKAWADQGVL
EECCCCCCCHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEE
LLNAVLTVQAGEAYSHQNHGWEELTDAAIAALSARGGVVFILWGNAAKKKAAVIDTSKNA
EEHHHHHEECCCHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCE
IIASAHPSPLSASRGFFGSRPFSRTNAALEKMGEAPINWQLPETVKAD
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA