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The map label for this gene is ymfI [H]

Identifier: 116494426

GI number: 116494426

Start: 895867

End: 896595

Strand: Direct

Name: ymfI [H]

Synonym: LSEI_0919

Alternate gene names: 116494426

Gene position: 895867-896595 (Clockwise)

Preceding gene: 116494425

Following gene: 116494427

Centisome position: 30.94

GC content: 46.5

Gene sequence:

>729_bases
ATGCGAGCAGCTTTGATTGTTGGTGCGTCGGGTGACATTGGCCAAGCGGTGGCTAAAAAGTTGGCCCACGATGGCTGGTC
ATTGTACCTGCACTATTTTGAACACGAACAAGTGGTTACCAGCCAAATTGCGACTTTTCAAGCGGCGTATCCGAATCAGG
ATTTTATTCCGTTACAGTATGATTTAACTGATGATCGTCATTTGGATGATTTGACGGCCCAGCTTTTTAGCCTGGACGCG
GTCATTTTTGCGGCAGGGATGACGTATTATCATTTATTTAAAGATACAACCGTTTCTGAGTTAACAACTTTGATGCGCGT
GCATCTATTGACGCCGATGGCTCTTTTAACGAAGATCGAGCACAAATTAGCACAGTCCGGTCATGGCCGTGTTGTCTTTA
TCGGGTCTGTCTATGGTGGCGCAGGTTCAGCTATGGAAGTGGCCTATAGTACTGTCAAAGGCGCGCAAAGTGCCTTTGCA
AAAGCCTATGCTCAGGAAGTGGCCAGTCTGGGCATCACGGTCAATGTGGTCGCGCCCGGTGCAGTGACAACAAAAATGAA
CACTAAAATGTTTGATCAAGCGACCTTGACCAAGGTTCGAGAGGAAATTCCTGCTGCACGATTTGCGACCCCACAAGATA
TTAGTTACTATGTGACTATGCTAGTTGCAAAAGATGCTGCTTATCTAACAGGACAAACTTTATATGTTACAGGTGGCTGG
CGAATCTAG

Upstream 100 bases:

>100_bases
TTTTGAGCAGCATCACGCTAGCGGATTTACAAGCTATGATTGATCAGGTTTTTCAGGCGAAAGCATTGACCGTTTTAGAT
ATGATTCCGGAGGCAGATTG

Downstream 100 bases:

>100_bases
GAAACAAAGGATTTCTTAAGTCTTGCAGTTGGTTTTTCATGATATACTGAAAATGGTCAATAAAAAATAGCGGGTGAATA
AAACTTATGGATGAAATTGG

Product: 3-oxoacyl-acyl carrier protein reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MRAALIVGASGDIGQAVAKKLAHDGWSLYLHYFEHEQVVTSQIATFQAAYPNQDFIPLQYDLTDDRHLDDLTAQLFSLDA
VIFAAGMTYYHLFKDTTVSELTTLMRVHLLTPMALLTKIEHKLAQSGHGRVVFIGSVYGGAGSAMEVAYSTVKGAQSAFA
KAYAQEVASLGITVNVVAPGAVTTKMNTKMFDQATLTKVREEIPAARFATPQDISYYVTMLVAKDAAYLTGQTLYVTGGW
RI

Sequences:

>Translated_242_residues
MRAALIVGASGDIGQAVAKKLAHDGWSLYLHYFEHEQVVTSQIATFQAAYPNQDFIPLQYDLTDDRHLDDLTAQLFSLDA
VIFAAGMTYYHLFKDTTVSELTTLMRVHLLTPMALLTKIEHKLAQSGHGRVVFIGSVYGGAGSAMEVAYSTVKGAQSAFA
KAYAQEVASLGITVNVVAPGAVTTKMNTKMFDQATLTKVREEIPAARFATPQDISYYVTMLVAKDAAYLTGQTLYVTGGW
RI
>Mature_242_residues
MRAALIVGASGDIGQAVAKKLAHDGWSLYLHYFEHEQVVTSQIATFQAAYPNQDFIPLQYDLTDDRHLDDLTAQLFSLDA
VIFAAGMTYYHLFKDTTVSELTTLMRVHLLTPMALLTKIEHKLAQSGHGRVVFIGSVYGGAGSAMEVAYSTVKGAQSAFA
KAYAQEVASLGITVNVVAPGAVTTKMNTKMFDQATLTKVREEIPAARFATPQDISYYVTMLVAKDAAYLTGQTLYVTGGW
RI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=247, Percent_Identity=28.3400809716599, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI15277342, Length=246, Percent_Identity=26.0162601626016, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI32483357, Length=243, Percent_Identity=26.3374485596708, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI66933014, Length=188, Percent_Identity=22.8723404255319, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=240, Percent_Identity=31.25, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367175, Length=256, Percent_Identity=27.34375, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082160, Length=246, Percent_Identity=24.390243902439, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=27.3469387755102, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1789208, Length=247, Percent_Identity=23.0769230769231, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790717, Length=176, Percent_Identity=23.8636363636364, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI2367365, Length=250, Percent_Identity=23.6, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=242, Percent_Identity=28.099173553719, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=256, Percent_Identity=25.78125, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=25.7142857142857, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=258, Percent_Identity=24.8062015503876, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=273, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=256, Percent_Identity=23.828125, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17508651, Length=251, Percent_Identity=25.0996015936255, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=256, Percent_Identity=23.4375, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=25.6704980842912, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=252, Percent_Identity=26.5873015873016, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=256, Percent_Identity=23.046875, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=23.3463035019455, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21355319, Length=244, Percent_Identity=25, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24643142, Length=242, Percent_Identity=24.7933884297521, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 26368; Mature: 26368

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAALIVGASGDIGQAVAKKLAHDGWSLYLHYFEHEQVVTSQIATFQAAYPNQDFIPLQY
CCEEEEEECCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHEECCCCCCCEEEEE
DLTDDRHLDDLTAQLFSLDAVIFAAGMTYYHLFKDTTVSELTTLMRVHLLTPMALLTKIE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
HKLAQSGHGRVVFIGSVYGGAGSAMEVAYSTVKGAQSAFAKAYAQEVASLGITVNVVAPG
HHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
AVTTKMNTKMFDQATLTKVREEIPAARFATPQDISYYVTMLVAKDAAYLTGQTLYVTGGW
EEEECCCHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHCCCHHCCCCEEEEECCC
RI
CC
>Mature Secondary Structure
MRAALIVGASGDIGQAVAKKLAHDGWSLYLHYFEHEQVVTSQIATFQAAYPNQDFIPLQY
CCEEEEEECCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHEECCCCCCCEEEEE
DLTDDRHLDDLTAQLFSLDAVIFAAGMTYYHLFKDTTVSELTTLMRVHLLTPMALLTKIE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
HKLAQSGHGRVVFIGSVYGGAGSAMEVAYSTVKGAQSAFAKAYAQEVASLGITVNVVAPG
HHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
AVTTKMNTKMFDQATLTKVREEIPAARFATPQDISYYVTMLVAKDAAYLTGQTLYVTGGW
EEEECCCHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHCCCHHCCCCEEEEECCC
RI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]