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The map label for this gene is thiD [H]

Identifier: 116493869

GI number: 116493869

Start: 302791

End: 303618

Strand: Direct

Name: thiD [H]

Synonym: LSEI_0301

Alternate gene names: 116493869

Gene position: 302791-303618 (Clockwise)

Preceding gene: 116493868

Following gene: 116493870

Centisome position: 10.46

GC content: 52.78

Gene sequence:

>828_bases
ATGACCGTTAATCGCACACCGCAAGTCGTCACCATCGCTGGTTCCGATTCCGGTGGCGGGGCAGGGTTGCAAGCGGACTT
GAAAACTTTTCAGGCCCGACACGTCTTTGGGATGAGTATTGTGGTAGCACTGACGGCGCAGAATACGTATGGGGTCCAGG
CCAGTCTGCCGATTCCGGCGGGCTTCATTGACGCCCAGTTTCAATCGTTAGCTGCCGATTTTGACATTCGCGCAGCCAAA
ACGGGGATGTTAGCGGATCGTGAGCATGTCGAAGCCGTTGTCCGCAATTTGCAACAGGTTGATTTTGGCCCGCTGATTGT
CGATCCAGTGATGGTAGCCAAGGGCGGCGCGACGTTACTTGCCTCGGAAGCTGTCGTCACCATCAAAGAACAGCTGCTCC
CGTTGGCGGATGTGGTGACGCCAAATCTACCCGAAGCAGAAATTCTCGTGGGTAAAAAAATTGTGACCAATGCGGATATG
GTTCAGGCGGCGCGTACGATTCAAACACTTGGCGTCAAGCATGTCATTATTAAAGGGGGCCATCGTCAGAATCACAAGGC
CGAGGATCTGATTCTATTGGCCGACGGGACGTGTTATTGGCTCAGTGCACCACGAATTGCCACTGCGAACACGCATGGAA
CCGGTGATACTTTCTCAGCATGTATCGCTGCAGAGTTAGCAAAAGGGCAGCCATTGAAAGCAGCTATCATGACAGCCAAA
GCCTTTCTGCAAGGCGCCATCAGCCAAGGCATTTCAGTTGGCCATGGTCATGGCCCGACAAATCACTGGGCAAAGTTGAG
TGAAAAAGTGAGTTTGCGTCAAGGTTAA

Upstream 100 bases:

>100_bases
GGGATCGCCGGGGTTGCGATTGTGAGCGAAATCATGCAGGCACCTGATATCGCTCACAAAGTGCAGGCTTTGCGCACAAA
ATTAAAGGCGGTGTTACCAA

Downstream 100 bases:

>100_bases
GAAGGGGTGCCGAAGATAGAAATGTCTTCGGCGTTTTTTGAAAAAGTCGATTTTTTCAATCATGTTGTTGTGAAACGTTG
CCAATCCCTGCAAAATAGCC

Product: hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MTVNRTPQVVTIAGSDSGGGAGLQADLKTFQARHVFGMSIVVALTAQNTYGVQASLPIPAGFIDAQFQSLAADFDIRAAK
TGMLADREHVEAVVRNLQQVDFGPLIVDPVMVAKGGATLLASEAVVTIKEQLLPLADVVTPNLPEAEILVGKKIVTNADM
VQAARTIQTLGVKHVIIKGGHRQNHKAEDLILLADGTCYWLSAPRIATANTHGTGDTFSACIAAELAKGQPLKAAIMTAK
AFLQGAISQGISVGHGHGPTNHWAKLSEKVSLRQG

Sequences:

>Translated_275_residues
MTVNRTPQVVTIAGSDSGGGAGLQADLKTFQARHVFGMSIVVALTAQNTYGVQASLPIPAGFIDAQFQSLAADFDIRAAK
TGMLADREHVEAVVRNLQQVDFGPLIVDPVMVAKGGATLLASEAVVTIKEQLLPLADVVTPNLPEAEILVGKKIVTNADM
VQAARTIQTLGVKHVIIKGGHRQNHKAEDLILLADGTCYWLSAPRIATANTHGTGDTFSACIAAELAKGQPLKAAIMTAK
AFLQGAISQGISVGHGHGPTNHWAKLSEKVSLRQG
>Mature_274_residues
TVNRTPQVVTIAGSDSGGGAGLQADLKTFQARHVFGMSIVVALTAQNTYGVQASLPIPAGFIDAQFQSLAADFDIRAAKT
GMLADREHVEAVVRNLQQVDFGPLIVDPVMVAKGGATLLASEAVVTIKEQLLPLADVVTPNLPEAEILVGKKIVTNADMV
QAARTIQTLGVKHVIIKGGHRQNHKAEDLILLADGTCYWLSAPRIATANTHGTGDTFSACIAAELAKGQPLKAAIMTAKA
FLQGAISQGISVGHGHGPTNHWAKLSEKVSLRQG

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=257, Percent_Identity=41.6342412451362, Blast_Score=192, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6325378, Length=272, Percent_Identity=30.1470588235294, Blast_Score=126, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6324517, Length=273, Percent_Identity=31.5018315018315, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324997, Length=277, Percent_Identity=31.4079422382672, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28807; Mature: 28675

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVNRTPQVVTIAGSDSGGGAGLQADLKTFQARHVFGMSIVVALTAQNTYGVQASLPIPA
CCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCEEEEEEEEECCCCCEEEECCCCC
GFIDAQFQSLAADFDIRAAKTGMLADREHVEAVVRNLQQVDFGPLIVDPVMVAKGGATLL
CHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEECCEEEECCCCEEE
ASEAVVTIKEQLLPLADVVTPNLPEAEILVGKKIVTNADMVQAARTIQTLGVKHVIIKGG
EHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCHHHCCHHHHHHHHHHHHHCCEEEEEECC
HRQNHKAEDLILLADGTCYWLSAPRIATANTHGTGDTFSACIAAELAKGQPLKAAIMTAK
CCCCCCCCCEEEEECCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
AFLQGAISQGISVGHGHGPTNHWAKLSEKVSLRQG
HHHHHHHHCCCEECCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TVNRTPQVVTIAGSDSGGGAGLQADLKTFQARHVFGMSIVVALTAQNTYGVQASLPIPA
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCEEEEEEEEECCCCCEEEECCCCC
GFIDAQFQSLAADFDIRAAKTGMLADREHVEAVVRNLQQVDFGPLIVDPVMVAKGGATLL
CHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEECCEEEECCCCEEE
ASEAVVTIKEQLLPLADVVTPNLPEAEILVGKKIVTNADMVQAARTIQTLGVKHVIIKGG
EHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCHHHCCHHHHHHHHHHHHHCCEEEEEECC
HRQNHKAEDLILLADGTCYWLSAPRIATANTHGTGDTFSACIAAELAKGQPLKAAIMTAK
CCCCCCCCCEEEEECCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
AFLQGAISQGISVGHGHGPTNHWAKLSEKVSLRQG
HHHHHHHHCCCEECCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]