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The map label for this gene is glcR [H]

Identifier: 116493821

GI number: 116493821

Start: 251612

End: 252370

Strand: Direct

Name: glcR [H]

Synonym: LSEI_0250

Alternate gene names: 116493821

Gene position: 251612-252370 (Clockwise)

Preceding gene: 116493818

Following gene: 116493822

Centisome position: 8.69

GC content: 47.04

Gene sequence:

>759_bases
GTGGCAATGTATCGGGAAAAACGTTTTGAAGAGATAAAAAAACTGTTGGCAGCACGCAGCGAGTTGAGTATCGAGGATAT
TATGAAGGCAGTTGGTGTTTCACGAGATACCGCACGCCGAGATATTGTTGCGCTTGATGCGCAAGGCGTTGCGAGACGAA
CTCGTGGCGGGTTGGTGTCTCTTAGCTTTGGTCACACGATTCCCAGCTACTCTGCGCGGCTGAAACGATTTTCAACTCAG
AAAACAAAGATGGCTAAGTCAGCATTGACGTTAATCAAACCTGGCGGCGTTTATTTCATTGATGATTCGACAACCTTATT
AAAATTGTCGCAGTCCATTCGACAACCGGTGACAGTTTACACGCACAGTTTAGACAATGCGATCGCACTTTCAGTTGAAG
AACGTGTTAATTTACATCTTTTTGGTGGCAAACTGGATCATCACGCCCGGTTCTTCTTTGAACCAACGATGCTTGAAACA
CTTCGCCGAATCGCCTTTGATGCGGCATTTATCGGTGCAACGGCTATTGCCGAAGATGGGGTTTACTTTTCTTATATGGA
AGATGCTCAGGTGAAGCAGGCGGCGGCGTTATCAGCACGCCGGGTGGTCGTGGTTTCTGAAACCGAAAAGTTTCAGATTG
AAGCACCTTATCGCGGGCTGGAACTCGGCCAGATTACCACACTTATTACGGATAAAAAATTATCGCAGACGCACAAACAA
TGGTTTGCCCCACAGACACAGTTTCTGCTCGGCGACTAA

Upstream 100 bases:

>100_bases
CTTTAACTCTGATCGTTCATGATACAATTCAATGACTGGCCTAAACGGTGCTTTTGAGAATCAGGTATAATGAAGCTGAA
CTGTCAAGGAGGCCGAATTC

Downstream 100 bases:

>100_bases
CAACTGCTTGACTAAAAAAGGATTGATACCTATTCAACAGCTAATAAATGATCCGGGGATTCGCACGAGTGAGGAGGTGC
GTTCATGGTAAAGCCACTCG

Product: lactose transport regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MAMYREKRFEEIKKLLAARSELSIEDIMKAVGVSRDTARRDIVALDAQGVARRTRGGLVSLSFGHTIPSYSARLKRFSTQ
KTKMAKSALTLIKPGGVYFIDDSTTLLKLSQSIRQPVTVYTHSLDNAIALSVEERVNLHLFGGKLDHHARFFFEPTMLET
LRRIAFDAAFIGATAIAEDGVYFSYMEDAQVKQAAALSARRVVVVSETEKFQIEAPYRGLELGQITTLITDKKLSQTHKQ
WFAPQTQFLLGD

Sequences:

>Translated_252_residues
MAMYREKRFEEIKKLLAARSELSIEDIMKAVGVSRDTARRDIVALDAQGVARRTRGGLVSLSFGHTIPSYSARLKRFSTQ
KTKMAKSALTLIKPGGVYFIDDSTTLLKLSQSIRQPVTVYTHSLDNAIALSVEERVNLHLFGGKLDHHARFFFEPTMLET
LRRIAFDAAFIGATAIAEDGVYFSYMEDAQVKQAAALSARRVVVVSETEKFQIEAPYRGLELGQITTLITDKKLSQTHKQ
WFAPQTQFLLGD
>Mature_251_residues
AMYREKRFEEIKKLLAARSELSIEDIMKAVGVSRDTARRDIVALDAQGVARRTRGGLVSLSFGHTIPSYSARLKRFSTQK
TKMAKSALTLIKPGGVYFIDDSTTLLKLSQSIRQPVTVYTHSLDNAIALSVEERVNLHLFGGKLDHHARFFFEPTMLETL
RRIAFDAAFIGATAIAEDGVYFSYMEDAQVKQAAALSARRVVVVSETEKFQIEAPYRGLELGQITTLITDKKLSQTHKQW
FAPQTQFLLGD

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789519, Length=235, Percent_Identity=28.936170212766, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI226510968, Length=252, Percent_Identity=27.3809523809524, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787063, Length=238, Percent_Identity=27.7310924369748, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789059, Length=241, Percent_Identity=24.0663900414938, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790753, Length=246, Percent_Identity=25.2032520325203, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789170, Length=230, Percent_Identity=24.7826086956522, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28249; Mature: 28118

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMYREKRFEEIKKLLAARSELSIEDIMKAVGVSRDTARRDIVALDAQGVARRTRGGLVS
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHCCEEEECCCHHHHHHCCCEEE
LSFGHTIPSYSARLKRFSTQKTKMAKSALTLIKPGGVYFIDDSTTLLKLSQSIRQPVTVY
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHHHHHHHHHCCCEEEE
THSLDNAIALSVEERVNLHLFGGKLDHHARFFFEPTMLETLRRIAFDAAFIGATAIAEDG
EECCCCEEEEEEECCEEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCC
VYFSYMEDAQVKQAAALSARRVVVVSETEKFQIEAPYRGLELGQITTLITDKKLSQTHKQ
EEEEECCHHHHHHHHHHHHCEEEEEECCCEEEEECCCCCCCHHHHHEEHCCHHHHHHHHH
WFAPQTQFLLGD
HCCCCCCEECCC
>Mature Secondary Structure 
AMYREKRFEEIKKLLAARSELSIEDIMKAVGVSRDTARRDIVALDAQGVARRTRGGLVS
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHCCEEEECCCHHHHHHCCCEEE
LSFGHTIPSYSARLKRFSTQKTKMAKSALTLIKPGGVYFIDDSTTLLKLSQSIRQPVTVY
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHHHHHHHHHCCCEEEE
THSLDNAIALSVEERVNLHLFGGKLDHHARFFFEPTMLETLRRIAFDAAFIGATAIAEDG
EECCCCEEEEEEECCEEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCC
VYFSYMEDAQVKQAAALSARRVVVVSETEKFQIEAPYRGLELGQITTLITDKKLSQTHKQ
EEEEECCHHHHHHHHHHHHCEEEEEECCCEEEEECCCCCCCHHHHHEEHCCHHHHHHHHH
WFAPQTQFLLGD
HCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]