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The map label for this gene is dnaC [H]

Identifier: 116493689

GI number: 116493689

Start: 110531

End: 111919

Strand: Direct

Name: dnaC [H]

Synonym: LSEI_0117

Alternate gene names: 116493689

Gene position: 110531-111919 (Clockwise)

Preceding gene: 116493688

Following gene: 116493690

Centisome position: 3.82

GC content: 48.45

Gene sequence:

>1389_bases
ATGGATAATCAATTAATTGACCAGCAGCCGCCGCATAGTGACGAAGCAGAACGTGCCGTCCTTGGCGGCATTTTTCTGAA
TGCTGACACATTGCCGGATGCACAAGAGTATGTCACGGCGGATGACTTCTATAAGAAAGCACACCGGCTGTTGTTCCAAG
CTATGACCGATCTACAGGATAACGGCACAGCGATTGATACGGTTACGGTGTCGGATTATCTGGACAATCATAACAACCTC
GATGATATTGGCGGGGTTGGTTATATTACAGATTTGGTTGCGGCGACGCCTATTGCCAGTAACGTGGTATACTACGCCAA
AATCGTGCAGCAGAAGAGCACGTTACGCAAACTGATTAGTACGGCGCAAAACATTGCCAGTCGCAGCTATACGGAACAAG
ACGATGTTGAAGGACTAGTTGAAGACGCCGAGCGCCAGATTATGGATGTCTCGGAGAACCGCAATCAGGCCGGCTTCAAA
CAGATCAAAGATGTGCTGAATCAGGCTATGGCGCAGATTGATCAGTTGTATCAAAATGATCAGGCAATCACCGGGTTGCC
AACCGGTTTCCGTGATTTGGACAAAATCACGACGGGGCTGCATGAGGACGAAATGATTATTTTAGCGGCGCGGCCTGCTG
TCGGGAAAACCGCATTTGCTTTGAACATTGCCCAAAATGTTGGGACGAAAACAGACAAAAGTGTCGCCATTTTCAGTTTG
GAAATGGGCGCTGAACAGCTGGTAAACCGGATGTTGTGTTCAGAAGGTAGTATTGATGCTAATCACCTGCGAACTGGTCA
GCTGAATGAAGAAGAATGGCAGAACTTGATTATCGCCATGGGTAGCTTGAGTAAGGCGAAGATCTATATGGATGACACGC
CAGGCATCAGAATGGCGGAGATTCGCGCGAAGTGTCGGCGGCTAGCGCGTGAGCAAGGTGATTTAGGGCTGATTATCATT
GATTATTTGCAGTTGATTGAAGGTTCTGGCCAAGAAAACCGCCAACAGGAAGTCAGCGCCGTTTCCCGGCAGTTGAAAAA
ACTGGCGAAGGAATTGCATGTACCCGTGATTGCGTTGTCCCAGCTGAGTCGTGGCGTTGAACAGCGACAGGATAAGCGGC
CGGTGTTGAGCGATATTCGTGAATCCGGTTCGATCGAACAGGATGCCGATATTGTGGCTTTCCTGTATCGTGATGACTAT
TACCGCGATGCAGAAGGCGATGAGGATGACGACGATCAAGGCGGCAATGATGACGGGGATGACAATGTTGGTGAAGTTGA
AGTCATCATTGAGAAAAATCGTTCAGGCCCGCGTGGTACCGTCAAGTTGTTGTTTGTGAAGTCGTATAACAAGTTTACGA
ATATTGCCTATAATGGTCCGGATCAATAA

Upstream 100 bases:

>100_bases
GACTGTATGCGGTGATGCTTGTCTTGACTGCGGGTTTAACGTAGACTGTTAGGGATAAGCGACAAAAAATGTTTGACGAT
TAATCTGAAGGAGGACGCGC

Downstream 100 bases:

>100_bases
ACCATTAGCAAGAAAGATTAGAAAGTTATTTTTAGATTTAAGCGCAAGAAAGTGAGGGATGCCGCATGGATGCCATTTTG
ATGAGTTTAATGACAGCACT

Product: replicative DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MDNQLIDQQPPHSDEAERAVLGGIFLNADTLPDAQEYVTADDFYKKAHRLLFQAMTDLQDNGTAIDTVTVSDYLDNHNNL
DDIGGVGYITDLVAATPIASNVVYYAKIVQQKSTLRKLISTAQNIASRSYTEQDDVEGLVEDAERQIMDVSENRNQAGFK
QIKDVLNQAMAQIDQLYQNDQAITGLPTGFRDLDKITTGLHEDEMIILAARPAVGKTAFALNIAQNVGTKTDKSVAIFSL
EMGAEQLVNRMLCSEGSIDANHLRTGQLNEEEWQNLIIAMGSLSKAKIYMDDTPGIRMAEIRAKCRRLAREQGDLGLIII
DYLQLIEGSGQENRQQEVSAVSRQLKKLAKELHVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYRDDY
YRDAEGDEDDDDQGGNDDGDDNVGEVEVIIEKNRSGPRGTVKLLFVKSYNKFTNIAYNGPDQ

Sequences:

>Translated_462_residues
MDNQLIDQQPPHSDEAERAVLGGIFLNADTLPDAQEYVTADDFYKKAHRLLFQAMTDLQDNGTAIDTVTVSDYLDNHNNL
DDIGGVGYITDLVAATPIASNVVYYAKIVQQKSTLRKLISTAQNIASRSYTEQDDVEGLVEDAERQIMDVSENRNQAGFK
QIKDVLNQAMAQIDQLYQNDQAITGLPTGFRDLDKITTGLHEDEMIILAARPAVGKTAFALNIAQNVGTKTDKSVAIFSL
EMGAEQLVNRMLCSEGSIDANHLRTGQLNEEEWQNLIIAMGSLSKAKIYMDDTPGIRMAEIRAKCRRLAREQGDLGLIII
DYLQLIEGSGQENRQQEVSAVSRQLKKLAKELHVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYRDDY
YRDAEGDEDDDDQGGNDDGDDNVGEVEVIIEKNRSGPRGTVKLLFVKSYNKFTNIAYNGPDQ
>Mature_462_residues
MDNQLIDQQPPHSDEAERAVLGGIFLNADTLPDAQEYVTADDFYKKAHRLLFQAMTDLQDNGTAIDTVTVSDYLDNHNNL
DDIGGVGYITDLVAATPIASNVVYYAKIVQQKSTLRKLISTAQNIASRSYTEQDDVEGLVEDAERQIMDVSENRNQAGFK
QIKDVLNQAMAQIDQLYQNDQAITGLPTGFRDLDKITTGLHEDEMIILAARPAVGKTAFALNIAQNVGTKTDKSVAIFSL
EMGAEQLVNRMLCSEGSIDANHLRTGQLNEEEWQNLIIAMGSLSKAKIYMDDTPGIRMAEIRAKCRRLAREQGDLGLIII
DYLQLIEGSGQENRQQEVSAVSRQLKKLAKELHVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYRDDY
YRDAEGDEDDDDQGGNDDGDDNVGEVEVIIEKNRSGPRGTVKLLFVKSYNKFTNIAYNGPDQ

Specific function: Participates In Initiation And Elongation During Chromosome Replication; It Exhibits DNA-Dependent ATPase Activity And Contains Distinct Active Sites For ATP Binding, DNA Binding, And Interaction With DNAc Protein, Primase, And Other Prepriming Proteins.

COG id: COG0305

COG function: function code L; Replicative DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SF4 helicase domain [H]

Homologues:

Organism=Escherichia coli, GI1790486, Length=457, Percent_Identity=45.0765864332604, Blast_Score=390, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR007692
- InterPro:   IPR007694
- InterPro:   IPR007693
- InterPro:   IPR016136 [H]

Pfam domain/function: PF00772 DnaB; PF03796 DnaB_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 51323; Mature: 51323

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNQLIDQQPPHSDEAERAVLGGIFLNADTLPDAQEYVTADDFYKKAHRLLFQAMTDLQD
CCCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCC
NGTAIDTVTVSDYLDNHNNLDDIGGVGYITDLVAATPIASNVVYYAKIVQQKSTLRKLIS
CCCEEEEEEHHHHHCCCCCHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
TAQNIASRSYTEQDDVEGLVEDAERQIMDVSENRNQAGFKQIKDVLNQAMAQIDQLYQND
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
QAITGLPTGFRDLDKITTGLHEDEMIILAARPAVGKTAFALNIAQNVGTKTDKSVAIFSL
CCEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHEEHHHHCCCCCCCCEEEEEE
EMGAEQLVNRMLCSEGSIDANHLRTGQLNEEEWQNLIIAMGSLSKAKIYMDDTPGIRMAE
CCCHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHH
IRAKCRRLAREQGDLGLIIIDYLQLIEGSGQENRQQEVSAVSRQLKKLAKELHVPVIALS
HHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
QLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYRDDYYRDAEGDEDDDDQGGNDDGD
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
DNVGEVEVIIEKNRSGPRGTVKLLFVKSYNKFTNIAYNGPDQ
CCCCEEEEEEECCCCCCCCEEEEEEEECCCCHHCCCCCCCCC
>Mature Secondary Structure
MDNQLIDQQPPHSDEAERAVLGGIFLNADTLPDAQEYVTADDFYKKAHRLLFQAMTDLQD
CCCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCC
NGTAIDTVTVSDYLDNHNNLDDIGGVGYITDLVAATPIASNVVYYAKIVQQKSTLRKLIS
CCCEEEEEEHHHHHCCCCCHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
TAQNIASRSYTEQDDVEGLVEDAERQIMDVSENRNQAGFKQIKDVLNQAMAQIDQLYQND
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
QAITGLPTGFRDLDKITTGLHEDEMIILAARPAVGKTAFALNIAQNVGTKTDKSVAIFSL
CCEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHEEHHHHCCCCCCCCEEEEEE
EMGAEQLVNRMLCSEGSIDANHLRTGQLNEEEWQNLIIAMGSLSKAKIYMDDTPGIRMAE
CCCHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHH
IRAKCRRLAREQGDLGLIIIDYLQLIEGSGQENRQQEVSAVSRQLKKLAKELHVPVIALS
HHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
QLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYRDDYYRDAEGDEDDDDQGGNDDGD
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
DNVGEVEVIIEKNRSGPRGTVKLLFVKSYNKFTNIAYNGPDQ
CCCCEEEEEEECCCCCCCCEEEEEEEECCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 1312531 [H]