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The map label for this gene is ycnB [H]

Identifier: 116493323

GI number: 116493323

Start: 1563098

End: 1564576

Strand: Direct

Name: ycnB [H]

Synonym: PEPE_1595

Alternate gene names: 116493323

Gene position: 1563098-1564576 (Clockwise)

Preceding gene: 116493313

Following gene: 116493324

Centisome position: 85.3

GC content: 40.97

Gene sequence:

>1479_bases
ATGCCACAAGCAATTGACGCACATGGTAAACCCTATAAGAGATCCTTATTGATCCTTGTGCTATTAATAGGTACTTTTTG
TACCGTTTTGAACCAAACAATTTTAACCACCGCATTTCCTACATTAATGGATGCTTTTGATATCAGTACTTCTACTGTTC
AATGGTTGACAACTGGATTTTTGATGGTTAACGGTATCATGATTCCCATTAGTGCCTGGTTAACAAGTCGTGTTCCTTCT
AAACGACTTTATTTATCTGCTATGGCTGTTTTCCTAATTGGAACCATTCTATGTTACACAGCTCCTACGTTCCAAGTTTT
ACTTGCCGGACGTTTAATCCAGGCTCTCGGAGTTGGTGTTACCATGCCACTCCTCCAAACTCTAATGTTGACAATTTTCC
CAGCTAACCAACGTGGTTCAGCCATGGGTCTTGCCGGATTAGTTATTGGGGTAGCTCCAGCAATTGGTCCTACTCTTTCT
GGATGGATTATTGATAACTATCACTGGAGAACCCTATTCGGAATGATTATTCCAATCGTATTTATCGTTCTAATCGCTGG
TCTATTATTTATGAAAGACGTTTTGGAAACCGACAAGAAGAAGCTAGATTGGATTTCAGCTGCTTTATCTACAATTGGAT
TTGGTAGTTTACTCTTTGGTTTCTCCGAAGTTGGAGACAAAGGCTGGGGTGACGCAGTAGTTATTACTACATTAATCGTT
GGTGTTATCTTTGTTATTTTATTTGGTATCCGCCAATTGAGATTAGAAAAACCATTCCTTGATTTACGTGTACTAAAGAT
TCCAGAATTTTCAATTTCTGCTACTTTAAGTTCAGTTTCAATGATTGCCATGGTGGGGGCTGAAATGGTACTTCCACTTT
ATATTCAAACCGTGCGTGGCGAATCAGCTTTCCATTCAGGTTTAACACTATTGCCGGGTGCTTTAATGATGGGATTCCTA
AGCCCTATTACTGGTCGCCTATTTGATAAAATTGGTGCCCGTCGTCTAGCAATCACTGGAATGTTCCTCTTAACTGCCGG
AACGCTTCCATTTGCTTTCATTACTAAGACTACACCAATGATTTATATCATTGTCTTGTATGCTGTTCGAATGGCCGGAA
TTGCGATGGCAATGATGCCTGTAACAACTGCTGGTATGAACTCTCTTCCATTTGAAAAGATGGGTCATGGTACTGCGGTT
AATAACACTCTTCGTCAAGTAGCCAGTTCTGTTGGAACAGCCATCTTGGTTAGTGTCTTGACCAACGTTACCAAGAACCA
AATGCCTGGTAAGCATCTTCTCTCAGCCCAACCACTCGCTTACAAAGATCAAGCATTTGACGCAACCGTTGCTGGTTACC
ATGCGACATTCTGGATTGCTATTGGCTTTAGTGCCCTTGGTTTAATCATCGCATTCTTTGTAAGTCGTAAAGCAGGCAGC
ACTGCCAAAGTACAACCTCAAGCAGGAGGTAATAAATAA

Upstream 100 bases:

>100_bases
TAATTATAACTTCTCTAACATCTTTGTCAAACAAGTTGACAAAGATGTTATGATAACTTATAGTATTAAAGAAAAGTTTT
TGAAAAGAGGTTGTAAGCTT

Downstream 100 bases:

>100_bases
TGATTATCTTTCTTTTAATTATCGCAGTCATCGCAACGTTCCTTTCGATGACACTTATCTCTAAAACAGCTGTCCGTGTT
ATTTGTTCTGCTATTTCTGC

Product: major facilitator superfamily permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MPQAIDAHGKPYKRSLLILVLLIGTFCTVLNQTILTTAFPTLMDAFDISTSTVQWLTTGFLMVNGIMIPISAWLTSRVPS
KRLYLSAMAVFLIGTILCYTAPTFQVLLAGRLIQALGVGVTMPLLQTLMLTIFPANQRGSAMGLAGLVIGVAPAIGPTLS
GWIIDNYHWRTLFGMIIPIVFIVLIAGLLFMKDVLETDKKKLDWISAALSTIGFGSLLFGFSEVGDKGWGDAVVITTLIV
GVIFVILFGIRQLRLEKPFLDLRVLKIPEFSISATLSSVSMIAMVGAEMVLPLYIQTVRGESAFHSGLTLLPGALMMGFL
SPITGRLFDKIGARRLAITGMFLLTAGTLPFAFITKTTPMIYIIVLYAVRMAGIAMAMMPVTTAGMNSLPFEKMGHGTAV
NNTLRQVASSVGTAILVSVLTNVTKNQMPGKHLLSAQPLAYKDQAFDATVAGYHATFWIAIGFSALGLIIAFFVSRKAGS
TAKVQPQAGGNK

Sequences:

>Translated_492_residues
MPQAIDAHGKPYKRSLLILVLLIGTFCTVLNQTILTTAFPTLMDAFDISTSTVQWLTTGFLMVNGIMIPISAWLTSRVPS
KRLYLSAMAVFLIGTILCYTAPTFQVLLAGRLIQALGVGVTMPLLQTLMLTIFPANQRGSAMGLAGLVIGVAPAIGPTLS
GWIIDNYHWRTLFGMIIPIVFIVLIAGLLFMKDVLETDKKKLDWISAALSTIGFGSLLFGFSEVGDKGWGDAVVITTLIV
GVIFVILFGIRQLRLEKPFLDLRVLKIPEFSISATLSSVSMIAMVGAEMVLPLYIQTVRGESAFHSGLTLLPGALMMGFL
SPITGRLFDKIGARRLAITGMFLLTAGTLPFAFITKTTPMIYIIVLYAVRMAGIAMAMMPVTTAGMNSLPFEKMGHGTAV
NNTLRQVASSVGTAILVSVLTNVTKNQMPGKHLLSAQPLAYKDQAFDATVAGYHATFWIAIGFSALGLIIAFFVSRKAGS
TAKVQPQAGGNK
>Mature_491_residues
PQAIDAHGKPYKRSLLILVLLIGTFCTVLNQTILTTAFPTLMDAFDISTSTVQWLTTGFLMVNGIMIPISAWLTSRVPSK
RLYLSAMAVFLIGTILCYTAPTFQVLLAGRLIQALGVGVTMPLLQTLMLTIFPANQRGSAMGLAGLVIGVAPAIGPTLSG
WIIDNYHWRTLFGMIIPIVFIVLIAGLLFMKDVLETDKKKLDWISAALSTIGFGSLLFGFSEVGDKGWGDAVVITTLIVG
VIFVILFGIRQLRLEKPFLDLRVLKIPEFSISATLSSVSMIAMVGAEMVLPLYIQTVRGESAFHSGLTLLPGALMMGFLS
PITGRLFDKIGARRLAITGMFLLTAGTLPFAFITKTTPMIYIIVLYAVRMAGIAMAMMPVTTAGMNSLPFEKMGHGTAVN
NTLRQVASSVGTAILVSVLTNVTKNQMPGKHLLSAQPLAYKDQAFDATVAGYHATFWIAIGFSALGLIIAFFVSRKAGST
AKVQPQAGGNK

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=477, Percent_Identity=30.6079664570231, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI87081983, Length=435, Percent_Identity=28.0459770114943, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1788710, Length=401, Percent_Identity=29.6758104738155, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1790195, Length=443, Percent_Identity=23.0248306997743, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788392, Length=396, Percent_Identity=23.2323232323232, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323735, Length=325, Percent_Identity=24.9230769230769, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52835; Mature: 52704

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQAIDAHGKPYKRSLLILVLLIGTFCTVLNQTILTTAFPTLMDAFDISTSTVQWLTTGF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LMVNGIMIPISAWLTSRVPSKRLYLSAMAVFLIGTILCYTAPTFQVLLAGRLIQALGVGV
HHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCH
TMPLLQTLMLTIFPANQRGSAMGLAGLVIGVAPAIGPTLSGWIIDNYHWRTLFGMIIPIV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHH
FIVLIAGLLFMKDVLETDKKKLDWISAALSTIGFGSLLFGFSEVGDKGWGDAVVITTLIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GVIFVILFGIRQLRLEKPFLDLRVLKIPEFSISATLSSVSMIAMVGAEMVLPLYIQTVRG
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ESAFHSGLTLLPGALMMGFLSPITGRLFDKIGARRLAITGMFLLTAGTLPFAFITKTTPM
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHCCCHH
IYIIVLYAVRMAGIAMAMMPVTTAGMNSLPFEKMGHGTAVNNTLRQVASSVGTAILVSVL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
TNVTKNQMPGKHLLSAQPLAYKDQAFDATVAGYHATFWIAIGFSALGLIIAFFVSRKAGS
HHHHHCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TAKVQPQAGGNK
CCEECCCCCCCC
>Mature Secondary Structure 
PQAIDAHGKPYKRSLLILVLLIGTFCTVLNQTILTTAFPTLMDAFDISTSTVQWLTTGF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH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CCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]