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The map label for this gene is htpX

Identifier: 116493292

GI number: 116493292

Start: 1533446

End: 1534342

Strand: Reverse

Name: htpX

Synonym: PEPE_1564

Alternate gene names: 116493292

Gene position: 1534342-1533446 (Counterclockwise)

Preceding gene: 116493293

Following gene: 116493291

Centisome position: 83.73

GC content: 41.03

Gene sequence:

>897_bases
ATGTTATATCAACAGATTGCAAGTAATAAGCGAAAGACCGTTTATGTGATGATCGGTTTTGCTATCTTAGTATTGTTTAT
TGGTGCTGCAGTTGGTTATGTTTTCTATGATAGTGCAATGGCAGGGATTATTATGGCGGCAGTAATTGCCGCTATTTATA
TGGCCATGATGATTGCCAATTCTACTAATGTCGTGATGGGAATGAATCACGCAACTGAAATTAGTGAAGCCGATCATCCG
GAAATTTGGCATATTGTAGAAGACATGGCCTTGGTAGCTAATATACCAATGCCCAAGGTTTATATTGTTAACGATGCCAG
CCCTAATGCATTTGCAACAGGAAATAGCCCTAAAAATGCTGCCGTAGCAGTGACTACTGGTATTTTAGAACGGCTTAATC
GAGAAGAACTTGAAGGCGTAATTGGACACGAAGTTTCACACATTCGAAATTATGATATTCGCCTTTCGACCATCGCCTTG
GCATTATCTTCGGCGATCGCAATGCTAGTAAATATTGGAATGCGCTCATTTTGGTGGGGCGGGGGACGACGTCGCAATGA
TAATGACAATGAAGGCGGAAGTTTGGAAATTGTGATGATGATTATTTCCATCGTATTGGTTATTTTAGGTCCAATTGCCA
CAACTATCGCTCAATTGGCTTTATCACGAAATCGAGAATATCTCGCCGATGCCTCTAGCGTTGAATTAACACGTAACCCA
CTGGGGCTAATCCATGCTCTACAAAAGATATCGGTCAGTGAACCGATGAAAGAAGCCGATCCAAGTAGTGCTGCACTTTA
TATCTCTGATCCATTTAAAAAGAAACGTACCATGGCACATCTATTTGATACGCATCCACCAATTGAAGATCGCATTCAAC
GTTTGGAAAGAATGTAA

Upstream 100 bases:

>100_bases
TGGGATGGGTGGATTTAAGCCGGTTGATTATCTTCAAGTTCCTGAAGAAGAAACTAAAAACCCAACCGTTTCATTTGATA
AATAATTAAGAGGTCGATTA

Downstream 100 bases:

>100_bases
GTATATAGTTAATTGAAAGAGAGTTATGGGATCATGCGTGATGACTATATTTTTGTACATTTAGAATCAATTGTTAATTT
AATTTATTCGCGCGGGATTA

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MLYQQIASNKRKTVYVMIGFAILVLFIGAAVGYVFYDSAMAGIIMAAVIAAIYMAMMIANSTNVVMGMNHATEISEADHP
EIWHIVEDMALVANIPMPKVYIVNDASPNAFATGNSPKNAAVAVTTGILERLNREELEGVIGHEVSHIRNYDIRLSTIAL
ALSSAIAMLVNIGMRSFWWGGGRRRNDNDNEGGSLEIVMMIISIVLVILGPIATTIAQLALSRNREYLADASSVELTRNP
LGLIHALQKISVSEPMKEADPSSAALYISDPFKKKRTMAHLFDTHPPIEDRIQRLERM

Sequences:

>Translated_298_residues
MLYQQIASNKRKTVYVMIGFAILVLFIGAAVGYVFYDSAMAGIIMAAVIAAIYMAMMIANSTNVVMGMNHATEISEADHP
EIWHIVEDMALVANIPMPKVYIVNDASPNAFATGNSPKNAAVAVTTGILERLNREELEGVIGHEVSHIRNYDIRLSTIAL
ALSSAIAMLVNIGMRSFWWGGGRRRNDNDNEGGSLEIVMMIISIVLVILGPIATTIAQLALSRNREYLADASSVELTRNP
LGLIHALQKISVSEPMKEADPSSAALYISDPFKKKRTMAHLFDTHPPIEDRIQRLERM
>Mature_298_residues
MLYQQIASNKRKTVYVMIGFAILVLFIGAAVGYVFYDSAMAGIIMAAVIAAIYMAMMIANSTNVVMGMNHATEISEADHP
EIWHIVEDMALVANIPMPKVYIVNDASPNAFATGNSPKNAAVAVTTGILERLNREELEGVIGHEVSHIRNYDIRLSTIAL
ALSSAIAMLVNIGMRSFWWGGGRRRNDNDNEGGSLEIVMMIISIVLVILGPIATTIAQLALSRNREYLADASSVELTRNP
LGLIHALQKISVSEPMKEADPSSAALYISDPFKKKRTMAHLFDTHPPIEDRIQRLERM

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=222, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_PEDPA (Q03DY7)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_805027.1
- ProteinModelPortal:   Q03DY7
- SMR:   Q03DY7
- STRING:   Q03DY7
- MEROPS:   M48.004
- GeneID:   4417196
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1564
- NMPDR:   fig|278197.10.peg.1373
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   IWHIVED
- PhylomeDB:   Q03DY7
- ProtClustDB:   PRK04897
- BioCyc:   PPEN278197:PEPE_1564-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 32711; Mature: 32711

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 144-144

Signals:

None

Transmembrane regions:

HASH(0x184aea98)-; HASH(0x1872291c)-; HASH(0x18ac4018)-; HASH(0x18a6e09c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYQQIASNKRKTVYVMIGFAILVLFIGAAVGYVFYDSAMAGIIMAAVIAAIYMAMMIAN
CCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
STNVVMGMNHATEISEADHPEIWHIVEDMALVANIPMPKVYIVNDASPNAFATGNSPKNA
CCCEEEECCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEECCCCCCCC
AVAVTTGILERLNREELEGVIGHEVSHIRNYDIRLSTIALALSSAIAMLVNIGMRSFWWG
EEHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGRRRNDNDNEGGSLEIVMMIISIVLVILGPIATTIAQLALSRNREYLADASSVELTRNP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEECCCH
LGLIHALQKISVSEPMKEADPSSAALYISDPFKKKRTMAHLFDTHPPIEDRIQRLERM
HHHHHHHHHHHHCCCHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCH
>Mature Secondary Structure
MLYQQIASNKRKTVYVMIGFAILVLFIGAAVGYVFYDSAMAGIIMAAVIAAIYMAMMIAN
CCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
STNVVMGMNHATEISEADHPEIWHIVEDMALVANIPMPKVYIVNDASPNAFATGNSPKNA
CCCEEEECCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEECCCCCCCC
AVAVTTGILERLNREELEGVIGHEVSHIRNYDIRLSTIALALSSAIAMLVNIGMRSFWWG
EEHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGRRRNDNDNEGGSLEIVMMIISIVLVILGPIATTIAQLALSRNREYLADASSVELTRNP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEECCCH
LGLIHALQKISVSEPMKEADPSSAALYISDPFKKKRTMAHLFDTHPPIEDRIQRLERM
HHHHHHHHHHHHCCCHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA