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The map label for this gene is pepC [H]

Identifier: 116493245

GI number: 116493245

Start: 1473958

End: 1475304

Strand: Direct

Name: pepC [H]

Synonym: PEPE_1507

Alternate gene names: 116493245

Gene position: 1473958-1475304 (Clockwise)

Preceding gene: 116493244

Following gene: 116493250

Centisome position: 80.44

GC content: 38.68

Gene sequence:

>1347_bases
TTGAGTAAAGAAATTTCACAAAATTTAATTGACCGTTTTAAACAAGAATATAACGGTCGTAAAGAAGCTAAAGTTATTGA
ACGCACAGTTACTAAAAATGGAATTCTTAATTCCAGTCGTAACCTTGCAGCTGATGTTCAAAGCACACCCGTTTTTTCAA
TTGATTTAGATACCGGTGATGTTGCGAATCAGAAACAAAGTGGTCGTTGTTGGATGTTTGCCGCTTTGAATACTATGCGT
CATGACATGAAAAACCAATTCAAAGTTCCTGGCAATTTTGAATTATCCCAAAATTATACTTTTTTCTGGGATAAGTTTGA
AAAATCAAATTGGTTCTACGAAAATATCATTAATACGGCCGAGCTTGATACTGATGACCGTAAAGTGGCCTTCTTATTAA
ATGAACCTCAAGGTGATGGTGGCCAATGGGATATGCTCTGCGCATTAATTGAAAAATACGGTGTAGTTCCTCAATCGGCC
TACCCTGAAACTTATAATAGTTCAAAATCTCGTGAATTTGACACATTGCTAAATGAAAAGTTACGCAAAGATGCAGTTAC
ATTACGTAATTTAGTTAATTCAGGAGCAAGTCGTACAGACATTGATGAACGTAAGCAACAAATGCTTAGTGAAGTCTATC
GCATGGCTTCTTACAGTTTCGGAGAACCACCTGTTCAATTCGATTGGGAATATCGTGACGCCGATCAAAATTATCATCGT
GAAGCAGGTATTACGCCTAAAGCATTTTATGATAAGTATGTAGGTTGGAACCTTTCCGAATATATTTCCATCATTAATGC
GCCAACTGCTGACAAACCTTACAACCAAACATATACAATTGATATGCTTGGCAATGTCGTAAATGGACGCCAAGTTAAAC
ATCTAAACCTTGCTATGGACGACTTCAAGCAGGCGGCCATCAACCAACTTAAAGCTGGACAATCAGTGTGGTTTGGTTGC
GATGTTGGTCAACACTCTGAGGCTCGTGAAAAGGGACTTTTGGACCTAGATGTTTTTGCTGAAGATGAGTTGTTTGATAT
CGATCTTTCAATGTCTAAAGCTGAACGTTTAGACTACAAAGAGAGTTTAATGACTCACGCTATGGTACTTACTGGTGTCG
ATCTTGTCGCTGGTCAACCAACTAAATGGAAAGTTGAAAATAGTTGGGGTAAAAAAGTCGGTGAAAAAGGCTATATGGTA
ATGTCCGATGCTTGGATGGACGAATACTGTTACCAAGTAGTTGTTCAAAAACAATTCTTAACCGAAGCGCAACGTCAAGC
GCAGGCTCAAACACCTACCGTCTTGAAACCTTGGGACCCAATGGGATCTTTGGCTTATCAAGATTAA

Upstream 100 bases:

>100_bases
TGGTCCAGAAGTTTTGACTGCTCGACCATAATTCTAATCATTTACTAATTTTTTTAATTAGCGTATAATCATCACCAATA
TTAGGATGGAGTTGAAGATA

Downstream 100 bases:

>100_bases
TAAATAATTTTATCAATAAAAAAGCGACTAGCTGTGGACCAAATGAAAATCGGTCCTTAACTAGTCGCTTTTTTACTACT
CCATATTTGAAAAGGGATGC

Product: aminopeptidase C

Products: NA

Alternate protein names: Bleomycin hydrolase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSKEISQNLIDRFKQEYNGRKEAKVIERTVTKNGILNSSRNLAADVQSTPVFSIDLDTGDVANQKQSGRCWMFAALNTMR
HDMKNQFKVPGNFELSQNYTFFWDKFEKSNWFYENIINTAELDTDDRKVAFLLNEPQGDGGQWDMLCALIEKYGVVPQSA
YPETYNSSKSREFDTLLNEKLRKDAVTLRNLVNSGASRTDIDERKQQMLSEVYRMASYSFGEPPVQFDWEYRDADQNYHR
EAGITPKAFYDKYVGWNLSEYISIINAPTADKPYNQTYTIDMLGNVVNGRQVKHLNLAMDDFKQAAINQLKAGQSVWFGC
DVGQHSEAREKGLLDLDVFAEDELFDIDLSMSKAERLDYKESLMTHAMVLTGVDLVAGQPTKWKVENSWGKKVGEKGYMV
MSDAWMDEYCYQVVVQKQFLTEAQRQAQAQTPTVLKPWDPMGSLAYQD

Sequences:

>Translated_448_residues
MSKEISQNLIDRFKQEYNGRKEAKVIERTVTKNGILNSSRNLAADVQSTPVFSIDLDTGDVANQKQSGRCWMFAALNTMR
HDMKNQFKVPGNFELSQNYTFFWDKFEKSNWFYENIINTAELDTDDRKVAFLLNEPQGDGGQWDMLCALIEKYGVVPQSA
YPETYNSSKSREFDTLLNEKLRKDAVTLRNLVNSGASRTDIDERKQQMLSEVYRMASYSFGEPPVQFDWEYRDADQNYHR
EAGITPKAFYDKYVGWNLSEYISIINAPTADKPYNQTYTIDMLGNVVNGRQVKHLNLAMDDFKQAAINQLKAGQSVWFGC
DVGQHSEAREKGLLDLDVFAEDELFDIDLSMSKAERLDYKESLMTHAMVLTGVDLVAGQPTKWKVENSWGKKVGEKGYMV
MSDAWMDEYCYQVVVQKQFLTEAQRQAQAQTPTVLKPWDPMGSLAYQD
>Mature_447_residues
SKEISQNLIDRFKQEYNGRKEAKVIERTVTKNGILNSSRNLAADVQSTPVFSIDLDTGDVANQKQSGRCWMFAALNTMRH
DMKNQFKVPGNFELSQNYTFFWDKFEKSNWFYENIINTAELDTDDRKVAFLLNEPQGDGGQWDMLCALIEKYGVVPQSAY
PETYNSSKSREFDTLLNEKLRKDAVTLRNLVNSGASRTDIDERKQQMLSEVYRMASYSFGEPPVQFDWEYRDADQNYHRE
AGITPKAFYDKYVGWNLSEYISIINAPTADKPYNQTYTIDMLGNVVNGRQVKHLNLAMDDFKQAAINQLKAGQSVWFGCD
VGQHSEAREKGLLDLDVFAEDELFDIDLSMSKAERLDYKESLMTHAMVLTGVDLVAGQPTKWKVENSWGKKVGEKGYMVM
SDAWMDEYCYQVVVQKQFLTEAQRQAQAQTPTVLKPWDPMGSLAYQD

Specific function: Unknown

COG id: COG3579

COG function: function code E; Aminopeptidase C

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C1 family [H]

Homologues:

Organism=Homo sapiens, GI4557367, Length=441, Percent_Identity=39.9092970521542, Blast_Score=353, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6324090, Length=463, Percent_Identity=36.5010799136069, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI161077632, Length=450, Percent_Identity=36.6666666666667, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24640588, Length=450, Percent_Identity=36.6666666666667, Blast_Score=315, Evalue=4e-86,
Organism=Drosophila melanogaster, GI161077630, Length=360, Percent_Identity=40.2777777777778, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI20130175, Length=412, Percent_Identity=26.9417475728155, Blast_Score=169, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000169
- InterPro:   IPR004134 [H]

Pfam domain/function: PF03051 Peptidase_C1_2 [H]

EC number: =3.4.22.40 [H]

Molecular weight: Translated: 51432; Mature: 51301

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00139 THIOL_PROTEASE_CYS ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEISQNLIDRFKQEYNGRKEAKVIERTVTKNGILNSSRNLAADVQSTPVFSIDLDTGD
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEECCCCC
VANQKQSGRCWMFAALNTMRHDMKNQFKVPGNFELSQNYTFFWDKFEKSNWFYENIINTA
CCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCHHHCCCHH
ELDTDDRKVAFLLNEPQGDGGQWDMLCALIEKYGVVPQSAYPETYNSSKSREFDTLLNEK
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
LRKDAVTLRNLVNSGASRTDIDERKQQMLSEVYRMASYSFGEPPVQFDWEYRDADQNYHR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHH
EAGITPKAFYDKYVGWNLSEYISIINAPTADKPYNQTYTIDMLGNVVNGRQVKHLNLAMD
HCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHH
DFKQAAINQLKAGQSVWFGCDVGQHSEAREKGLLDLDVFAEDELFDIDLSMSKAERLDYK
HHHHHHHHHHHCCCCEEEECCCCCCCHHHHCCCEEEEEECCCCEEEECCCHHHHHHCCHH
ESLMTHAMVLTGVDLVAGQPTKWKVENSWGKKVGEKGYMVMSDAWMDEYCYQVVVQKQFL
HHHHHHHHHHHCHHHHCCCCCCEEECCCHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHH
TEAQRQAQAQTPTVLKPWDPMGSLAYQD
HHHHHHHHCCCCCEECCCCCCCCCCCCC
>Mature Secondary Structure 
SKEISQNLIDRFKQEYNGRKEAKVIERTVTKNGILNSSRNLAADVQSTPVFSIDLDTGD
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEECCCCC
VANQKQSGRCWMFAALNTMRHDMKNQFKVPGNFELSQNYTFFWDKFEKSNWFYENIINTA
CCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCHHHCCCHH
ELDTDDRKVAFLLNEPQGDGGQWDMLCALIEKYGVVPQSAYPETYNSSKSREFDTLLNEK
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
LRKDAVTLRNLVNSGASRTDIDERKQQMLSEVYRMASYSFGEPPVQFDWEYRDADQNYHR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHH
EAGITPKAFYDKYVGWNLSEYISIINAPTADKPYNQTYTIDMLGNVVNGRQVKHLNLAMD
HCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHH
DFKQAAINQLKAGQSVWFGCDVGQHSEAREKGLLDLDVFAEDELFDIDLSMSKAERLDYK
HHHHHHHHHHHCCCCEEEECCCCCCCHHHHCCCEEEEEECCCCEEEECCCHHHHHHCCHH
ESLMTHAMVLTGVDLVAGQPTKWKVENSWGKKVGEKGYMVMSDAWMDEYCYQVVVQKQFL
HHHHHHHHHHHCHHHHCCCCCCEEECCCHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHH
TEAQRQAQAQTPTVLKPWDPMGSLAYQD
HHHHHHHHCCCCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7851736 [H]