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The map label for this gene is purC

Identifier: 116493203

GI number: 116493203

Start: 1439388

End: 1440116

Strand: Reverse

Name: purC

Synonym: PEPE_1465

Alternate gene names: 116493203

Gene position: 1440116-1439388 (Counterclockwise)

Preceding gene: 116493204

Following gene: 116493202

Centisome position: 78.59

GC content: 34.71

Gene sequence:

>729_bases
ATGAAGAAGACCACGTTGATTAAAGAAGGCAAAGCAAAAAGACTTTACAATACAGATGAAAAGGATTTGGTGTGGGTTGA
ATATATGGATCAAGCAACTGCCCTAAATGGAAAACGTAAAGATCACATTGCTGGTAAAGGTGAATTGAATAACCAAATCG
ATTGTATTTTATTCGAGCAATTAGTTGCAAAAGGGATTCACACGGACTTTGTCCAAAAACTTTCAAACAACGAACAATTG
AATCGTAAAGTAAAAATTATTCCACTAGAGGTAGTCGTGCGTAACGCGGCATCAGGCAGTTTCCAACGTAAGTTTGATGT
TTCGTATCTACAAGCATTTGACCAGCCTGTTGTGGAATTTTTTTATAAATCTGATGAATTAGATGACCCATTTATTAATA
CTAATAAAGCAATTGCGTTGAAAATCATTGACTTAGAAGAGAGTCAACGATTGGAAAAGATGGCGTTAGAAATTAATCAA
ATTTTAAAAGAACGCTTTGCTAAAGCCCATTTGCAACTGGTTGATTTTAAGGTTGAATTTGGTAAAACCGCAGATGACGA
AATTGTATTAGCAGATGAAATATCACCAGACTCATGTCGCTTGGTTGATTTAACAACTAAAGAATCACTTGATAAAGATG
TTTTTCGTAAAAAAACTGGAGATTTAGTGACCGTCTATCAGGAAGTTTTAAATCGCTTGAATAATTCACAGGAGGAAGTT
CATGGATAA

Upstream 100 bases:

>100_bases
AAAGTCGAGTGAATCGAAAAATGGGACACATCACAATATTAGGTGATATTCAAAAAAGCTTAGATTCAATTAAATCAGAA
AACATTTGGGAGATAAAATA

Downstream 100 bases:

>100_bases
CGCCAAAATTTACGTTACTTACAAAGAATCGATCTTAGATCCCCAAGGAGAAGCAATTAAAACAGCGTTACATCGATTAA
ACTACGAAAATGTTAAAGCT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MKKTTLIKEGKAKRLYNTDEKDLVWVEYMDQATALNGKRKDHIAGKGELNNQIDCILFEQLVAKGIHTDFVQKLSNNEQL
NRKVKIIPLEVVVRNAASGSFQRKFDVSYLQAFDQPVVEFFYKSDELDDPFINTNKAIALKIIDLEESQRLEKMALEINQ
ILKERFAKAHLQLVDFKVEFGKTADDEIVLADEISPDSCRLVDLTTKESLDKDVFRKKTGDLVTVYQEVLNRLNNSQEEV
HG

Sequences:

>Translated_242_residues
MKKTTLIKEGKAKRLYNTDEKDLVWVEYMDQATALNGKRKDHIAGKGELNNQIDCILFEQLVAKGIHTDFVQKLSNNEQL
NRKVKIIPLEVVVRNAASGSFQRKFDVSYLQAFDQPVVEFFYKSDELDDPFINTNKAIALKIIDLEESQRLEKMALEINQ
ILKERFAKAHLQLVDFKVEFGKTADDEIVLADEISPDSCRLVDLTTKESLDKDVFRKKTGDLVTVYQEVLNRLNNSQEEV
HG
>Mature_242_residues
MKKTTLIKEGKAKRLYNTDEKDLVWVEYMDQATALNGKRKDHIAGKGELNNQIDCILFEQLVAKGIHTDFVQKLSNNEQL
NRKVKIIPLEVVVRNAASGSFQRKFDVSYLQAFDQPVVEFFYKSDELDDPFINTNKAIALKIIDLEESQRLEKMALEINQ
ILKERFAKAHLQLVDFKVEFGKTADDEIVLADEISPDSCRLVDLTTKESLDKDVFRKKTGDLVTVYQEVLNRLNNSQEEV
HG

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=202, Percent_Identity=35.6435643564356, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI5453539, Length=202, Percent_Identity=35.6435643564356, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI119220559, Length=209, Percent_Identity=33.9712918660287, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI1788820, Length=234, Percent_Identity=35.4700854700855, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17531275, Length=220, Percent_Identity=34.0909090909091, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI18860083, Length=220, Percent_Identity=33.1818181818182, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24583917, Length=219, Percent_Identity=29.6803652968037, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_PEDPA (Q03E76)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804938.1
- ProteinModelPortal:   Q03E76
- SMR:   Q03E76
- STRING:   Q03E76
- GeneID:   4417316
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1465
- NMPDR:   fig|278197.10.peg.1290
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- PhylomeDB:   Q03E76
- BioCyc:   PPEN278197:PEPE_1465-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27794; Mature: 27794

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTTLIKEGKAKRLYNTDEKDLVWVEYMDQATALNGKRKDHIAGKGELNNQIDCILFEQ
CCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
LVAKGIHTDFVQKLSNNEQLNRKVKIIPLEVVVRNAASGSFQRKFDVSYLQAFDQPVVEF
HHHCCCHHHHHHHHCCCHHHCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
FYKSDELDDPFINTNKAIALKIIDLEESQRLEKMALEINQILKERFAKAHLQLVDFKVEF
HHCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
GKTADDEIVLADEISPDSCRLVDLTTKESLDKDVFRKKTGDLVTVYQEVLNRLNNSQEEV
CCCCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHH
HG
CC
>Mature Secondary Structure
MKKTTLIKEGKAKRLYNTDEKDLVWVEYMDQATALNGKRKDHIAGKGELNNQIDCILFEQ
CCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
LVAKGIHTDFVQKLSNNEQLNRKVKIIPLEVVVRNAASGSFQRKFDVSYLQAFDQPVVEF
HHHCCCHHHHHHHHCCCHHHCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
FYKSDELDDPFINTNKAIALKIIDLEESQRLEKMALEINQILKERFAKAHLQLVDFKVEF
HHCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
GKTADDEIVLADEISPDSCRLVDLTTKESLDKDVFRKKTGDLVTVYQEVLNRLNNSQEEV
CCCCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHH
HG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA