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The map label for this gene is ezrA [H]

Identifier: 116493043

GI number: 116493043

Start: 1287467

End: 1289176

Strand: Reverse

Name: ezrA [H]

Synonym: PEPE_1295

Alternate gene names: 116493043

Gene position: 1289176-1287467 (Counterclockwise)

Preceding gene: 116493049

Following gene: 116493042

Centisome position: 70.36

GC content: 35.56

Gene sequence:

>1710_bases
ATGATCATGGTATTGATTGCAATCATAGTGGTAGCAATTCTAGTTTATTTAGGAATTGTTTCATATCAACGTTATTTACT
TAAACAAATCGATGAATTATTAGATCGAAAAGCAGACATCAGTGAATCACCGGTGCGTCAAAAACTAATGGAAGTTTCCT
CCATGAATCTAACTGGATCATCGGCTATTGGGTTAGATAACATTCGAAATGACTACCAGGAAATTATTGATCATCGATTA
CCAGAAATTGAAGACATTGCTAACCATTCGAAACAAGATGTCAATGATATGAAGATTTTCGAAGCGCGTAAGGATGTTAC
GACGGTTAGTGAATCTTTAGATGCAATTGACGAAGAAACGCGACGTCTTAACGATCAGTTGGATAATATTAAACGTACGG
ATCAAGAACAACGAGATGCGGTTAAGGTCTTACGCATGAAGTATGAAGAAATTAGAAAAACACTTCTAGCTAAGAACCTA
ACGCTTGGTCCAAGCATTGATTTATTAGAAGAAAAATTAGCTCGTTTAGATGATGAATTTGAAATGTTCAGTGGAACCGT
AGAAGCTGGAGATCATGAAAAGGCTGAAGGCCAACTCCAAAAACTTCGAACAAGTACAGAACAATTAGAAGCACAAATTC
AAAACGTTCCACCTTTATATGAAGAACTAACTAATGTATTTCCAGAGCAAATTGCTGAAATCAAAGATGGCTACGATCAA
TTGATTAATCATAACTATGCCTTTGAAGATGATATCGTTGATGACGAGCTGGGTGCTATTAAAGCTAAGATTTCAGATAA
TCTTGAAACCCTTGGTAACTTACGTTTAGATGCTGTACGTGATAACAATAAGTCAATTGAAATTAGAATTGACGATTTAT
ACAGTATCTTACAAACTGAGATTGATGCACGTAAGTCAGTTGAGCATAATTTTGATGTAATTACTCGCTTCTTAGATCAC
GCTGAAAAACAGAATAAAGTTTTGTTAGCAGAAGTGGAACGCATGGATCAAAGTTATGTTTTGAGTGATGATCAGTTGGT
ATTAGGTCAAAACTTAGATGCTGAATTAAATGAAATTCGTAATGAACATGATCGTGATACAGAACAAATTACTAACCAAC
CGGTTGTTTACTCAGAAATTGTGGAACGTTTAAAAGCTGAAAATGACCAACTTTCTGAGATTGAAGATCAACAAGCTAAA
TTAAATGATGAACTTCAAAGCCTTGTAGATAGTGAAAAAGATGCCCGTGCAAGAATGCAACAATATGACGGTGAACTCCA
TAACATCAAACGTCACGTTGAAAGTCTTAACCTTCCAGGTATTCCAGAAGGATACATGGATTACTTCTTTGTGGTTAGTG
ATGAGATTGAAAAAGTTGGGAGCGATATGAATCAAGTTCGAGTTAATATAGACAAAATTAACCGAGAACTTGATATGGTA
AGTACGGATATTCAAACTCTTACTAAGAAGACCACTGATCTGACAGACGATGCCGCTATCAGTGAGTTAGCAATTCAATA
CGCTAATCGTTATCGTCATACCGATCAAGATATCGAAGATGCTATTTTACGAGCTCAAAAGCTTTTTGATACGGACCATC
GTTACAATGAAAGTTTAACTGTAATTACAAAAGCACTAGAAGAAGTTGAACCAGGTGCAGTGGATAATATCACAGACAAT
TACTACCAACAAAAACGAACTGAATATTAG

Upstream 100 bases:

>100_bases
ATGATATAATTAATTAGGTAAATTCTAAATTGAAGAAAGTTAAAAGGCAAGTTTTTTATCAATTGAATTGAGTGAAGTTA
AGAAGGATGGGATTTTAGTT

Downstream 100 bases:

>100_bases
AAAATAAAATGCTATCGTACTTAGTGCGATGGCATTTTACTTTGAAGATCTAAATATTTAGATTACTTTAATTTTGTAAG
TATATTTTTCTGTTATAATT

Product: septation ring formation regulator EzrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MIMVLIAIIVVAILVYLGIVSYQRYLLKQIDELLDRKADISESPVRQKLMEVSSMNLTGSSAIGLDNIRNDYQEIIDHRL
PEIEDIANHSKQDVNDMKIFEARKDVTTVSESLDAIDEETRRLNDQLDNIKRTDQEQRDAVKVLRMKYEEIRKTLLAKNL
TLGPSIDLLEEKLARLDDEFEMFSGTVEAGDHEKAEGQLQKLRTSTEQLEAQIQNVPPLYEELTNVFPEQIAEIKDGYDQ
LINHNYAFEDDIVDDELGAIKAKISDNLETLGNLRLDAVRDNNKSIEIRIDDLYSILQTEIDARKSVEHNFDVITRFLDH
AEKQNKVLLAEVERMDQSYVLSDDQLVLGQNLDAELNEIRNEHDRDTEQITNQPVVYSEIVERLKAENDQLSEIEDQQAK
LNDELQSLVDSEKDARARMQQYDGELHNIKRHVESLNLPGIPEGYMDYFFVVSDEIEKVGSDMNQVRVNIDKINRELDMV
STDIQTLTKKTTDLTDDAAISELAIQYANRYRHTDQDIEDAILRAQKLFDTDHRYNESLTVITKALEEVEPGAVDNITDN
YYQQKRTEY

Sequences:

>Translated_569_residues
MIMVLIAIIVVAILVYLGIVSYQRYLLKQIDELLDRKADISESPVRQKLMEVSSMNLTGSSAIGLDNIRNDYQEIIDHRL
PEIEDIANHSKQDVNDMKIFEARKDVTTVSESLDAIDEETRRLNDQLDNIKRTDQEQRDAVKVLRMKYEEIRKTLLAKNL
TLGPSIDLLEEKLARLDDEFEMFSGTVEAGDHEKAEGQLQKLRTSTEQLEAQIQNVPPLYEELTNVFPEQIAEIKDGYDQ
LINHNYAFEDDIVDDELGAIKAKISDNLETLGNLRLDAVRDNNKSIEIRIDDLYSILQTEIDARKSVEHNFDVITRFLDH
AEKQNKVLLAEVERMDQSYVLSDDQLVLGQNLDAELNEIRNEHDRDTEQITNQPVVYSEIVERLKAENDQLSEIEDQQAK
LNDELQSLVDSEKDARARMQQYDGELHNIKRHVESLNLPGIPEGYMDYFFVVSDEIEKVGSDMNQVRVNIDKINRELDMV
STDIQTLTKKTTDLTDDAAISELAIQYANRYRHTDQDIEDAILRAQKLFDTDHRYNESLTVITKALEEVEPGAVDNITDN
YYQQKRTEY
>Mature_569_residues
MIMVLIAIIVVAILVYLGIVSYQRYLLKQIDELLDRKADISESPVRQKLMEVSSMNLTGSSAIGLDNIRNDYQEIIDHRL
PEIEDIANHSKQDVNDMKIFEARKDVTTVSESLDAIDEETRRLNDQLDNIKRTDQEQRDAVKVLRMKYEEIRKTLLAKNL
TLGPSIDLLEEKLARLDDEFEMFSGTVEAGDHEKAEGQLQKLRTSTEQLEAQIQNVPPLYEELTNVFPEQIAEIKDGYDQ
LINHNYAFEDDIVDDELGAIKAKISDNLETLGNLRLDAVRDNNKSIEIRIDDLYSILQTEIDARKSVEHNFDVITRFLDH
AEKQNKVLLAEVERMDQSYVLSDDQLVLGQNLDAELNEIRNEHDRDTEQITNQPVVYSEIVERLKAENDQLSEIEDQQAK
LNDELQSLVDSEKDARARMQQYDGELHNIKRHVESLNLPGIPEGYMDYFFVVSDEIEKVGSDMNQVRVNIDKINRELDMV
STDIQTLTKKTTDLTDDAAISELAIQYANRYRHTDQDIEDAILRAQKLFDTDHRYNESLTVITKALEEVEPGAVDNITDN
YYQQKRTEY

Specific function: Negative regulator of ftsZ ring formation; modulates the frequency and position of ftsZ ring formation. Inhibits ftsZ ring formation at polar sites. Interacts either with ftsZ or with one of its binding partners to promote depolymerization [H]

COG id: COG4477

COG function: function code D; Negative regulator of septation ring formation

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein. Note=Colocalized with ftsZ to the nascent septal site [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ezrA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010379 [H]

Pfam domain/function: PF06160 EzrA [H]

EC number: NA

Molecular weight: Translated: 65642; Mature: 65642

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMVLIAIIVVAILVYLGIVSYQRYLLKQIDELLDRKADISESPVRQKLMEVSSMNLTGS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
SAIGLDNIRNDYQEIIDHRLPEIEDIANHSKQDVNDMKIFEARKDVTTVSESLDAIDEET
CCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLNDQLDNIKRTDQEQRDAVKVLRMKYEEIRKTLLAKNLTLGPSIDLLEEKLARLDDEF
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHH
EMFSGTVEAGDHEKAEGQLQKLRTSTEQLEAQIQNVPPLYEELTNVFPEQIAEIKDGYDQ
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LINHNYAFEDDIVDDELGAIKAKISDNLETLGNLRLDAVRDNNKSIEIRIDDLYSILQTE
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEHHHHHHHHHHH
IDARKSVEHNFDVITRFLDHAEKQNKVLLAEVERMDQSYVLSDDQLVLGQNLDAELNEIR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHCCCCCCEEECCCCCHHHHHHH
NEHDRDTEQITNQPVVYSEIVERLKAENDQLSEIEDQQAKLNDELQSLVDSEKDARARMQ
HHCCCCHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QYDGELHNIKRHVESLNLPGIPEGYMDYFFVVSDEIEKVGSDMNQVRVNIDKINRELDMV
HHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
STDIQTLTKKTTDLTDDAAISELAIQYANRYRHTDQDIEDAILRAQKLFDTDHRYNESLT
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHCCHHH
VITKALEEVEPGAVDNITDNYYQQKRTEY
HHHHHHHHCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MIMVLIAIIVVAILVYLGIVSYQRYLLKQIDELLDRKADISESPVRQKLMEVSSMNLTGS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
SAIGLDNIRNDYQEIIDHRLPEIEDIANHSKQDVNDMKIFEARKDVTTVSESLDAIDEET
CCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLNDQLDNIKRTDQEQRDAVKVLRMKYEEIRKTLLAKNLTLGPSIDLLEEKLARLDDEF
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHH
EMFSGTVEAGDHEKAEGQLQKLRTSTEQLEAQIQNVPPLYEELTNVFPEQIAEIKDGYDQ
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LINHNYAFEDDIVDDELGAIKAKISDNLETLGNLRLDAVRDNNKSIEIRIDDLYSILQTE
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEHHHHHHHHHHH
IDARKSVEHNFDVITRFLDHAEKQNKVLLAEVERMDQSYVLSDDQLVLGQNLDAELNEIR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHCCCCCCEEECCCCCHHHHHHH
NEHDRDTEQITNQPVVYSEIVERLKAENDQLSEIEDQQAKLNDELQSLVDSEKDARARMQ
HHCCCCHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QYDGELHNIKRHVESLNLPGIPEGYMDYFFVVSDEIEKVGSDMNQVRVNIDKINRELDMV
HHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
STDIQTLTKKTTDLTDDAAISELAIQYANRYRHTDQDIEDAILRAQKLFDTDHRYNESLT
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHCCHHH
VITKALEEVEPGAVDNITDNYYQQKRTEY
HHHHHHHHCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]