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The map label for this gene is mtnN [H]

Identifier: 116492936

GI number: 116492936

Start: 1175466

End: 1176167

Strand: Reverse

Name: mtnN [H]

Synonym: PEPE_1175

Alternate gene names: 116492936

Gene position: 1176167-1175466 (Counterclockwise)

Preceding gene: 116492937

Following gene: 116492935

Centisome position: 64.19

GC content: 38.18

Gene sequence:

>702_bases
ATGAAATATGGTGTAATTTGTGCCATGGAAGAAGAAATTAAGACGCTTCTTGACACGCTAGAACTTGAAAAAGAAACCAA
TATCAATGGAATCATTTTTTATGAAGGAAAAATTAGTAATGTAGATGTAGTTCTGGTGCGTTCGGGAATCGGTAAAGTTG
AGGCTGGAATTACAGCAGCAATTTTAGTTACCAATTTTAACGCAGATGCCTTAATTCATTCAGGTTCTGCAGGCGGAATT
GGGGAAGGACTAGAAGTTGGAGACGTGGTGCTATCAACTGAAGTGGCGTACCACGACGTAGATGCAACAGCATTTGGCTA
TGAATATGGTCAACTCCCACAACAAGACAGTGCTAGATTTAAGGCTGATGCGTCATTGATTCATCAATTTGAATTAGCAG
CTCAGAATCGTAATTTAAATACAAAAAAAGGTCTAATTGTTACTGGTGATCAATTTATTGCTAGTGCTGATAAAGTTAAA
ACTATTCTAAAAAACTTTCCAGATGCTTTATGTTGTGAAATGGAAGGTGCGGCAGTCGGACAGGTGGCTCATCAATTTGA
CAAACCATTTATTGTGGTACGTGCTATGTCTGATACCGGTAGTGATGATGCGGATGTTTCTTTTGACGAATTTATTATTG
ACGCTGGAAAGCGCTCCGCATCAATGCTGATTGATTTATTTAAGATGGAAGGGAATAAATAA

Upstream 100 bases:

>100_bases
GGGCATTGGCTAAGAAGTTAAACATCGCAATAGCAGGATTAGGAATTGGAATCATATTAGTTTTCTTAATTTTATTTTTT
GTAGGATAGGTGAGTAAAGT

Downstream 100 bases:

>100_bases
TGCAACAAGTATATTTAGATAATGCAGCTACAACGCCAACGGATGCCGCGGTAGTTGAAGTAATATCTAATGAATTATTA
AATAACTGGGGTAATGCATC

Product: methylthioadenosine nucleosidase

Products: NA

Alternate protein names: MTA/SAH nucleosidase; MTAN; 5'-methylthioadenosine nucleosidase; MTA nucleosidase; S-adenosylhomocysteine nucleosidase; AdoHcy nucleosidase; SAH nucleosidase; SRH nucleosidase [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKYGVICAMEEEIKTLLDTLELEKETNINGIIFYEGKISNVDVVLVRSGIGKVEAGITAAILVTNFNADALIHSGSAGGI
GEGLEVGDVVLSTEVAYHDVDATAFGYEYGQLPQQDSARFKADASLIHQFELAAQNRNLNTKKGLIVTGDQFIASADKVK
TILKNFPDALCCEMEGAAVGQVAHQFDKPFIVVRAMSDTGSDDADVSFDEFIIDAGKRSASMLIDLFKMEGNK

Sequences:

>Translated_233_residues
MKYGVICAMEEEIKTLLDTLELEKETNINGIIFYEGKISNVDVVLVRSGIGKVEAGITAAILVTNFNADALIHSGSAGGI
GEGLEVGDVVLSTEVAYHDVDATAFGYEYGQLPQQDSARFKADASLIHQFELAAQNRNLNTKKGLIVTGDQFIASADKVK
TILKNFPDALCCEMEGAAVGQVAHQFDKPFIVVRAMSDTGSDDADVSFDEFIIDAGKRSASMLIDLFKMEGNK
>Mature_233_residues
MKYGVICAMEEEIKTLLDTLELEKETNINGIIFYEGKISNVDVVLVRSGIGKVEAGITAAILVTNFNADALIHSGSAGGI
GEGLEVGDVVLSTEVAYHDVDATAFGYEYGQLPQQDSARFKADASLIHQFELAAQNRNLNTKKGLIVTGDQFIASADKVK
TILKNFPDALCCEMEGAAVGQVAHQFDKPFIVVRAMSDTGSDDADVSFDEFIIDAGKRSASMLIDLFKMEGNK

Specific function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively [H]

COG id: COG0775

COG function: function code F; Nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786354, Length=228, Percent_Identity=45.6140350877193, Blast_Score=184, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010049
- InterPro:   IPR018017
- InterPro:   IPR000845 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =3.2.2.9 [H]

Molecular weight: Translated: 25078; Mature: 25078

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYGVICAMEEEIKTLLDTLELEKETNINGIIFYEGKISNVDVVLVRSGIGKVEAGITAA
CCCEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCEEE
ILVTNFNADALIHSGSAGGIGEGLEVGDVVLSTEVAYHDVDATAFGYEYGQLPQQDSARF
EEEEECCCCEEEECCCCCCCCCCCCCCCEEEECEEEEECCCCCEECCHHCCCCCCCCCHH
KADASLIHQFELAAQNRNLNTKKGLIVTGDQFIASADKVKTILKNFPDALCCEMEGAAVG
HHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCCHHH
QVAHQFDKPFIVVRAMSDTGSDDADVSFDEFIIDAGKRSASMLIDLFKMEGNK
HHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHEECCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKYGVICAMEEEIKTLLDTLELEKETNINGIIFYEGKISNVDVVLVRSGIGKVEAGITAA
CCCEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCEEE
ILVTNFNADALIHSGSAGGIGEGLEVGDVVLSTEVAYHDVDATAFGYEYGQLPQQDSARF
EEEEECCCCEEEECCCCCCCCCCCCCCCEEEECEEEEECCCCCEECCHHCCCCCCCCCHH
KADASLIHQFELAAQNRNLNTKKGLIVTGDQFIASADKVKTILKNFPDALCCEMEGAAVG
HHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCCHHH
QVAHQFDKPFIVVRAMSDTGSDDADVSFDEFIIDAGKRSASMLIDLFKMEGNK
HHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHEECCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA