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The map label for this gene is coaD

Identifier: 116492913

GI number: 116492913

Start: 1152021

End: 1152497

Strand: Reverse

Name: coaD

Synonym: PEPE_1152

Alternate gene names: 116492913

Gene position: 1152497-1152021 (Counterclockwise)

Preceding gene: 116492914

Following gene: 116492912

Centisome position: 62.9

GC content: 36.27

Gene sequence:

>477_bases
ATGACAAAGGCTCTTTATGTTGGAAGTTTTGACCCAATTACTAATGGCCATCTAGATATTATTAAACGTGCTGCTAAAAT
TTTTGATGAATTAACGGTGGTAGTGGCGATTAACACCAACAAATCGGCTTTATTTACACCACAGGAACGCGTGAACTTAA
TTACGCAAGTGACTAGAGACCTTGAAAATGTTGCTTGTAAATCGGTAACAGGATTAACGGCTGAAACTTTTACACAGGAA
AAAGCAGATGTTTTGGTTCGAGGCGTTCGCAATGGGGAAGATTTAAACTTTGAAATTCAGGTGGCTGGAATGAATCAATA
TTTAAATCAAGAAGTTGAGACGGTATTTATACCAGCTAATTCTAAGTGGGAATTTACCTCGTCTAGTTTAATTAAAGAAG
TTGTAAAAATGGGCGGAAGCATTAAAGGCCTAGTCCCTGAAACTGTAGAAGTATTATTAAAATCAAGACTAAAATGA

Upstream 100 bases:

>100_bases
GATGAAGTTGAATTGCCAGAGAAAATTGGATATTTAAATCGTGTACGTGAACAACATTATGGAATTACCAAAATTGTAAT
TTATAAGGGAGAATAATACG

Downstream 100 bases:

>100_bases
CTATTTAAAGGATTGGAAAATAAATTCCAATCTTTTTTTGTATCTTCTGTTAGCTAAGGAGGTGCAAAAATGTTGGAAGA
AATTTGGGAAAAATATCAAA

Product: phosphopantetheine adenylyltransferase

Products: NA

Alternate protein names: Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MTKALYVGSFDPITNGHLDIIKRAAKIFDELTVVVAINTNKSALFTPQERVNLITQVTRDLENVACKSVTGLTAETFTQE
KADVLVRGVRNGEDLNFEIQVAGMNQYLNQEVETVFIPANSKWEFTSSSLIKEVVKMGGSIKGLVPETVEVLLKSRLK

Sequences:

>Translated_158_residues
MTKALYVGSFDPITNGHLDIIKRAAKIFDELTVVVAINTNKSALFTPQERVNLITQVTRDLENVACKSVTGLTAETFTQE
KADVLVRGVRNGEDLNFEIQVAGMNQYLNQEVETVFIPANSKWEFTSSSLIKEVVKMGGSIKGLVPETVEVLLKSRLK
>Mature_157_residues
TKALYVGSFDPITNGHLDIIKRAAKIFDELTVVVAINTNKSALFTPQERVNLITQVTRDLENVACKSVTGLTAETFTQEK
ADVLVRGVRNGEDLNFEIQVAGMNQYLNQEVETVFIPANSKWEFTSSSLIKEVVKMGGSIKGLVPETVEVLLKSRLK

Specific function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

COG id: COG0669

COG function: function code H; Phosphopantetheine adenylyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial CoaD family

Homologues:

Organism=Escherichia coli, GI1790065, Length=155, Percent_Identity=41.2903225806452, Blast_Score=138, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAD_PEDPA (Q03F16)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804648.1
- ProteinModelPortal:   Q03F16
- SMR:   Q03F16
- STRING:   Q03F16
- GeneID:   4417834
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1152
- NMPDR:   fig|278197.10.peg.1012
- eggNOG:   COG0669
- HOGENOM:   HBG288308
- OMA:   VRQIAAM
- PhylomeDB:   Q03F16
- BioCyc:   PPEN278197:PEPE_1152-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00151
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR001980
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR01020
- TIGRFAMs:   TIGR01510
- TIGRFAMs:   TIGR00125

Pfam domain/function: PF01467 CTP_transf_2

EC number: =2.7.7.3

Molecular weight: Translated: 17473; Mature: 17342

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKALYVGSFDPITNGHLDIIKRAAKIFDELTVVVAINTNKSALFTPQERVNLITQVTRD
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHEEEEEEEECCCCEEECCHHHHHHHHHHHHH
LENVACKSVTGLTAETFTQEKADVLVRGVRNGEDLNFEIQVAGMNQYLNQEVETVFIPAN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHCCCCCEEEEECCC
SKWEFTSSSLIKEVVKMGGSIKGLVPETVEVLLKSRLK
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TKALYVGSFDPITNGHLDIIKRAAKIFDELTVVVAINTNKSALFTPQERVNLITQVTRD
CCEEEECCCCCCCCCHHHHHHHHHHHHHHEEEEEEEECCCCEEECCHHHHHHHHHHHHH
LENVACKSVTGLTAETFTQEKADVLVRGVRNGEDLNFEIQVAGMNQYLNQEVETVFIPAN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHCCCCCEEEEECCC
SKWEFTSSSLIKEVVKMGGSIKGLVPETVEVLLKSRLK
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA