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The map label for this gene is mro [H]

Identifier: 116492822

GI number: 116492822

Start: 1055975

End: 1057000

Strand: Direct

Name: mro [H]

Synonym: PEPE_1059

Alternate gene names: 116492822

Gene position: 1055975-1057000 (Clockwise)

Preceding gene: 116492821

Following gene: 116492836

Centisome position: 57.63

GC content: 31.19

Gene sequence:

>1026_bases
ATGAAACATACTTTAGTTAATAAATACCAAACACTAGATGATAAAAATTACTATCGTATTTCTATGTTTAATAAAAATGG
TGTTCAAGTTGATATTTTAAATTATGGTGCAACTCTTGAACATTTTTTTGTACCTGGTCGAACATCTGAAAAGGACAACA
TTATTTTAAGTTTAGAACGCCCAGAATATTATGATAAAGAACGGAATTATCTCGGTGGTACTGTTGGTAGAGTTATTGGT
AGAATTGCACATGGTCACTGGCAAGATGAAGATAACACAATACAATTTGAATTAAATGATGACCCTAATCATGCACATGG
GGGATCAAAAGGATTCGATACGCAAGTATTCGGCTTTACTATTAAAGAAAATGAAAACTGTAGTATCCTTAAATTACATC
TATTAGATCCGGATAATTATAATAACTATCCTGGGAATTTAAGCATTTATGTAACTTACACGTTAACAAACGAAAATACA
TTAATTTATGAAATAGAAGCTATTTCAGATAAAAAAACTTTATGTAATCCAGCAAATCATAGCTATTTTAATCTAAATAG
CGGTAAAGATATACTAGACCAATATCTAACTTTAGATGCTGACTATTATTTACCACTGGACAAAAATAGTATTCCAACCG
GCGAACAAAAATCAGTCACTAATACTCCATTTGATTTTCGAAAACCCAAATTACTTGGTAAAGCAATTACTTCTTTAGAT
TCACAAATAAGAGAACAATTAGGACTTAATCATCCTTTCTTGCTCAACCGAAATAATAATATTGCAGCAGTATTAGAAAG
CTTAGATCATCAGCGTAGATTGAGTGTGGAAACAACTGCCCCATCAATTGTTGTTTATACTGGTAACCATTTTAATAATA
GTGGATTTGCACAGAATATTGGCCAATATGGTGGAGTTGCTTTAGAGACCCAATTTCCACCAAGTAATGATGAATCTTTG
TCTTCAATTGTGTTGCTACCATATCAAAAATTTTATAGTCGAACTAGTTGGTGTATAGAATTTTGA

Upstream 100 bases:

>100_bases
TAATCATCAAGGGATGCTCAGACACTGTTCGTTCAAAAAATTTAGTTTATAATATAAAAGCACTCATGTGAGTGCTTTTA
TTAATTGGAGGAATTTCGAA

Downstream 100 bases:

>100_bases
TGTCTTAATTAATCGTATTCCATATAAAATAAGAGTTGAATTTCTGAATAAACTACAGAAATCCAACTCTTATTTTTAGT
ACAACCGTGTGTCTTTCATT

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKHTLVNKYQTLDDKNYYRISMFNKNGVQVDILNYGATLEHFFVPGRTSEKDNIILSLERPEYYDKERNYLGGTVGRVIG
RIAHGHWQDEDNTIQFELNDDPNHAHGGSKGFDTQVFGFTIKENENCSILKLHLLDPDNYNNYPGNLSIYVTYTLTNENT
LIYEIEAISDKKTLCNPANHSYFNLNSGKDILDQYLTLDADYYLPLDKNSIPTGEQKSVTNTPFDFRKPKLLGKAITSLD
SQIREQLGLNHPFLLNRNNNIAAVLESLDHQRRLSVETTAPSIVVYTGNHFNNSGFAQNIGQYGGVALETQFPPSNDESL
SSIVLLPYQKFYSRTSWCIEF

Sequences:

>Translated_341_residues
MKHTLVNKYQTLDDKNYYRISMFNKNGVQVDILNYGATLEHFFVPGRTSEKDNIILSLERPEYYDKERNYLGGTVGRVIG
RIAHGHWQDEDNTIQFELNDDPNHAHGGSKGFDTQVFGFTIKENENCSILKLHLLDPDNYNNYPGNLSIYVTYTLTNENT
LIYEIEAISDKKTLCNPANHSYFNLNSGKDILDQYLTLDADYYLPLDKNSIPTGEQKSVTNTPFDFRKPKLLGKAITSLD
SQIREQLGLNHPFLLNRNNNIAAVLESLDHQRRLSVETTAPSIVVYTGNHFNNSGFAQNIGQYGGVALETQFPPSNDESL
SSIVLLPYQKFYSRTSWCIEF
>Mature_341_residues
MKHTLVNKYQTLDDKNYYRISMFNKNGVQVDILNYGATLEHFFVPGRTSEKDNIILSLERPEYYDKERNYLGGTVGRVIG
RIAHGHWQDEDNTIQFELNDDPNHAHGGSKGFDTQVFGFTIKENENCSILKLHLLDPDNYNNYPGNLSIYVTYTLTNENT
LIYEIEAISDKKTLCNPANHSYFNLNSGKDILDQYLTLDADYYLPLDKNSIPTGEQKSVTNTPFDFRKPKLLGKAITSLD
SQIREQLGLNHPFLLNRNNNIAAVLESLDHQRRLSVETTAPSIVVYTGNHFNNSGFAQNIGQYGGVALETQFPPSNDESL
SSIVLLPYQKFYSRTSWCIEF

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=318, Percent_Identity=33.0188679245283, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1786971, Length=308, Percent_Identity=32.1428571428571, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17557428, Length=299, Percent_Identity=26.4214046822742, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI115533334, Length=299, Percent_Identity=26.4214046822742, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6322004, Length=318, Percent_Identity=28.3018867924528, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319493, Length=290, Percent_Identity=25.5172413793103, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324399, Length=320, Percent_Identity=26.5625, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24668278, Length=329, Percent_Identity=29.483282674772, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24583720, Length=326, Percent_Identity=27.3006134969325, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24668282, Length=334, Percent_Identity=27.5449101796407, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24659048, Length=332, Percent_Identity=28.9156626506024, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24641876, Length=284, Percent_Identity=26.4084507042254, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38873; Mature: 38873

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTLVNKYQTLDDKNYYRISMFNKNGVQVDILNYGATLEHFFVPGRTSEKDNIILSLER
CCCCCCCHHHCCCCCCEEEEEEECCCCCEEEEEECCCEEEEEECCCCCCCCCCEEEEECC
PEYYDKERNYLGGTVGRVIGRIAHGHWQDEDNTIQFELNDDPNHAHGGSKGFDTQVFGFT
CCHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEE
IKENENCSILKLHLLDPDNYNNYPGNLSIYVTYTLTNENTLIYEIEAISDKKTLCNPANH
EECCCCCCEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEEEECCCCCHHCCCCCC
SYFNLNSGKDILDQYLTLDADYYLPLDKNSIPTGEQKSVTNTPFDFRKPKLLGKAITSLD
CEEEECCCHHHHHHHHEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
SQIREQLGLNHPFLLNRNNNIAAVLESLDHQRRLSVETTAPSIVVYTGNHFNNSGFAQNI
HHHHHHHCCCCCEEEECCCCHHHHHHHHCHHHEEEEEECCCEEEEEECCCCCCCCHHHHH
GQYGGVALETQFPPSNDESLSSIVLLPYQKFYSRTSWCIEF
HHHCCEEEEECCCCCCCCCCEEEEEEECHHHCCCCCEEEEC
>Mature Secondary Structure
MKHTLVNKYQTLDDKNYYRISMFNKNGVQVDILNYGATLEHFFVPGRTSEKDNIILSLER
CCCCCCCHHHCCCCCCEEEEEEECCCCCEEEEEECCCEEEEEECCCCCCCCCCEEEEECC
PEYYDKERNYLGGTVGRVIGRIAHGHWQDEDNTIQFELNDDPNHAHGGSKGFDTQVFGFT
CCHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEE
IKENENCSILKLHLLDPDNYNNYPGNLSIYVTYTLTNENTLIYEIEAISDKKTLCNPANH
EECCCCCCEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEEEECCCCCHHCCCCCC
SYFNLNSGKDILDQYLTLDADYYLPLDKNSIPTGEQKSVTNTPFDFRKPKLLGKAITSLD
CEEEECCCHHHHHHHHEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
SQIREQLGLNHPFLLNRNNNIAAVLESLDHQRRLSVETTAPSIVVYTGNHFNNSGFAQNI
HHHHHHHCCCCCEEEECCCCHHHHHHHHCHHHEEEEEECCCEEEEEECCCCCCCCHHHHH
GQYGGVALETQFPPSNDESLSSIVLLPYQKFYSRTSWCIEF
HHHCCEEEEECCCCCCCCCCEEEEEEECHHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]