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The map label for this gene is fhs

Identifier: 116492703

GI number: 116492703

Start: 939717

End: 941378

Strand: Direct

Name: fhs

Synonym: PEPE_0939

Alternate gene names: 116492703

Gene position: 939717-941378 (Clockwise)

Preceding gene: 116492702

Following gene: 116492704

Centisome position: 51.28

GC content: 40.31

Gene sequence:

>1662_bases
ATGAATGATATTGAAATTTCCCAGAATGCTGAAATGTTACCAATTCAAACAATTGCTAAACAAGCCGGATTTGATGAAAA
GGTAGTCGAACCTTATGGTCATTACAAGGCCAAAATTGATATTTTTTCCGAGAAACCAAATACGCAACTTGGAAAATTGG
TTCTGGTCACCTCGATTAATCCAACGCCCGCTGGAGAAGGTAAATCGACCGTAACCGTTGGATTAGGTGATGCTTTAAAT
GACTTGACGGGGTCAGCAATGATTGCCTTACGTGAACCCTCCCAAGGTCCCGTTATGGGTATGAAAGGTGGTGCCACCGG
CGGAGGTTACTCCCAAGTAATTCCGATGGACGACATCAATTTGCATTTTACTGGTGATATGCATGCTTTGACTGCAGCTA
ATAATACTTTAGCAGCTTTGATTGACAATCATCTTCAGCAAGGAAATGAACTCAATATCGATCCTCGAACCATCGTTTGG
CGTCGCTGTTTAGACATTAATGACCGCGCACTACGTAATATAGTTATTGGATTGGGAGGGCGCTTTAGTGGTGTGCCTCG
AGAAGATAAATTTGACATTACCGTAGCCAGCGAACTAATGGCTATCTTGTGCCTAGCCCAAGATTTAAAGGATTTAAAGG
AACGGATTAACCGTATTTTGATTGCTAATAACTATGATGGTCAACCCATCTTTGTTAAAGACCTACACGTTGGTGGCGCC
ATTGCTACGTTGCTAAAAGATGCGATTAAGCCTAATTTAGTGCAAACCCTTGGTCATACTCCCGCCATAATTCATGGTGG
ACCTTTTGCTAATATTGCTCATGGGTGCAACAGTGTTTTAGCCACGAAAACTGCTTTACGACATGCAAAATATACTGTAA
CTGAAGCTGGTTTTGGAGCTGATTTGGGAGCTGAAAAATTCCTCGATATCAAAACCCCTGTCCTGGGAAAGCAACCTGAT
GCAATTGTAATTGTGGCAACGGTACGAGCCTTAAAATACAATGGCGGAGCTAAACTAGCTGATTTAAAAATTGAAGATGT
GGAAGCTCTCCAAAAAGGTTACATTAATTTACAACGTCATATCAAAAATATGCAACGTTATAACATCCCTGTAACTGTTT
CAATTAATCATTTTATTAGTGATACAGACCAAGAGGTTAACACGCTAGTTAAGTTGATTGAAGCGGAAGGTATATCTGCA
ATTGTTACCGATGCGTGGGCCAAGGGTGGTGCAGGTTCTAAAGATTTAGCCAATGAAGTGATTGCCTTGGCTGATACTAA
TCAGGGACCAATGACTAAGTTATACGATAACAATGGCCGAATCGAAGACAAAATTAAAACAATTGTTCAAAAAATATATG
GTGGTAGTGATGTAGAATATTCACCACAAGCACTTAAGAAAATTAAAGAATGTGTAGCAAATGGTTGGGATCATCTCCCA
ATTTGTATGGCAAAATCCCAGTATTCATTTTCAGATGATCCTAAACAGTTAGGAGCACCAAGTGACTTTGTTATGCATGT
TAACGATATTAACATTCGACTAGGAGCAGGATTCTTAGTCGTTCAAACTGGTAAGGTGCTTACTATGCCAGGACTTCCCA
AGCATCCTGCCGCATTAGATATCGACATCGATAGTAAAGGAGAAATTACCGGATTATTCTAG

Upstream 100 bases:

>100_bases
CTAAGTTTTGACTATGGCAATAAAAGATATAAACTATTAATGAGTCGTAAGTCATCAGATAAATTATTTAAAGCTTTGAC
AAAAAAGGGGTAGAAGATTA

Downstream 100 bases:

>100_bases
TAATTAAAGTTTTATGAAATGGTTTAGTTATATAGTTGGTTTATTACTTTTAGTAATTGATCAGCTGGTAAAAAGCGCTG
TTAGTAATCAGATTGCTTTA

Product: formate-tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MNDIEISQNAEMLPIQTIAKQAGFDEKVVEPYGHYKAKIDIFSEKPNTQLGKLVLVTSINPTPAGEGKSTVTVGLGDALN
DLTGSAMIALREPSQGPVMGMKGGATGGGYSQVIPMDDINLHFTGDMHALTAANNTLAALIDNHLQQGNELNIDPRTIVW
RRCLDINDRALRNIVIGLGGRFSGVPREDKFDITVASELMAILCLAQDLKDLKERINRILIANNYDGQPIFVKDLHVGGA
IATLLKDAIKPNLVQTLGHTPAIIHGGPFANIAHGCNSVLATKTALRHAKYTVTEAGFGADLGAEKFLDIKTPVLGKQPD
AIVIVATVRALKYNGGAKLADLKIEDVEALQKGYINLQRHIKNMQRYNIPVTVSINHFISDTDQEVNTLVKLIEAEGISA
IVTDAWAKGGAGSKDLANEVIALADTNQGPMTKLYDNNGRIEDKIKTIVQKIYGGSDVEYSPQALKKIKECVANGWDHLP
ICMAKSQYSFSDDPKQLGAPSDFVMHVNDINIRLGAGFLVVQTGKVLTMPGLPKHPAALDIDIDSKGEITGLF

Sequences:

>Translated_553_residues
MNDIEISQNAEMLPIQTIAKQAGFDEKVVEPYGHYKAKIDIFSEKPNTQLGKLVLVTSINPTPAGEGKSTVTVGLGDALN
DLTGSAMIALREPSQGPVMGMKGGATGGGYSQVIPMDDINLHFTGDMHALTAANNTLAALIDNHLQQGNELNIDPRTIVW
RRCLDINDRALRNIVIGLGGRFSGVPREDKFDITVASELMAILCLAQDLKDLKERINRILIANNYDGQPIFVKDLHVGGA
IATLLKDAIKPNLVQTLGHTPAIIHGGPFANIAHGCNSVLATKTALRHAKYTVTEAGFGADLGAEKFLDIKTPVLGKQPD
AIVIVATVRALKYNGGAKLADLKIEDVEALQKGYINLQRHIKNMQRYNIPVTVSINHFISDTDQEVNTLVKLIEAEGISA
IVTDAWAKGGAGSKDLANEVIALADTNQGPMTKLYDNNGRIEDKIKTIVQKIYGGSDVEYSPQALKKIKECVANGWDHLP
ICMAKSQYSFSDDPKQLGAPSDFVMHVNDINIRLGAGFLVVQTGKVLTMPGLPKHPAALDIDIDSKGEITGLF
>Mature_553_residues
MNDIEISQNAEMLPIQTIAKQAGFDEKVVEPYGHYKAKIDIFSEKPNTQLGKLVLVTSINPTPAGEGKSTVTVGLGDALN
DLTGSAMIALREPSQGPVMGMKGGATGGGYSQVIPMDDINLHFTGDMHALTAANNTLAALIDNHLQQGNELNIDPRTIVW
RRCLDINDRALRNIVIGLGGRFSGVPREDKFDITVASELMAILCLAQDLKDLKERINRILIANNYDGQPIFVKDLHVGGA
IATLLKDAIKPNLVQTLGHTPAIIHGGPFANIAHGCNSVLATKTALRHAKYTVTEAGFGADLGAEKFLDIKTPVLGKQPD
AIVIVATVRALKYNGGAKLADLKIEDVEALQKGYINLQRHIKNMQRYNIPVTVSINHFISDTDQEVNTLVKLIEAEGISA
IVTDAWAKGGAGSKDLANEVIALADTNQGPMTKLYDNNGRIEDKIKTIVQKIYGGSDVEYSPQALKKIKECVANGWDHLP
ICMAKSQYSFSDDPKQLGAPSDFVMHVNDINIRLGAGFLVVQTGKVLTMPGLPKHPAALDIDIDSKGEITGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=622, Percent_Identity=41.6398713826367, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=42.6494345718901, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI310124614, Length=84, Percent_Identity=44.047619047619, Blast_Score=81, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=42.443729903537, Blast_Score=423, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=42.443729903537, Blast_Score=423, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319558, Length=633, Percent_Identity=42.1800947867299, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321643, Length=628, Percent_Identity=42.0382165605096, Blast_Score=426, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24645718, Length=621, Percent_Identity=41.3848631239936, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI17137370, Length=621, Percent_Identity=41.3848631239936, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI62472483, Length=621, Percent_Identity=41.3848631239936, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI45551871, Length=621, Percent_Identity=41.3848631239936, Blast_Score=423, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_PEDPA (Q03FM6)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804438.1
- ProteinModelPortal:   Q03FM6
- SMR:   Q03FM6
- STRING:   Q03FM6
- GeneID:   4417751
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0939
- NMPDR:   fig|278197.10.peg.834
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- PhylomeDB:   Q03FM6
- BioCyc:   PPEN278197:PEPE_0939-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59600; Mature: 59600

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDIEISQNAEMLPIQTIAKQAGFDEKVVEPYGHYKAKIDIFSEKPNTQLGKLVLVTSIN
CCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEEECC
PTPAGEGKSTVTVGLGDALNDLTGSAMIALREPSQGPVMGMKGGATGGGYSQVIPMDDIN
CCCCCCCCCEEEEECCHHHHHCCCCEEEEEECCCCCCEEECCCCCCCCCCEEEEECCCCE
LHFTGDMHALTAANNTLAALIDNHLQQGNELNIDPRTIVWRRCLDINDRALRNIVIGLGG
EEEECCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHEEEECCC
RFSGVPREDKFDITVASELMAILCLAQDLKDLKERINRILIANNYDGQPIFVKDLHVGGA
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCEEEEEEECCCHH
IATLLKDAIKPNLVQTLGHTPAIIHGGPFANIAHGCNSVLATKTALRHAKYTVTEAGFGA
HHHHHHHHHCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCC
DLGAEKFLDIKTPVLGKQPDAIVIVATVRALKYNGGAKLADLKIEDVEALQKGYINLQRH
CCCCHHEEECCCCCCCCCCCCEEEEEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHH
IKNMQRYNIPVTVSINHFISDTDQEVNTLVKLIEAEGISAIVTDAWAKGGAGSKDLANEV
HHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCHHHHHHE
IALADTNQGPMTKLYDNNGRIEDKIKTIVQKIYGGSDVEYSPQALKKIKECVANGWDHLP
EEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCE
ICMAKSQYSFSDDPKQLGAPSDFVMHVNDINIRLGAGFLVVQTGKVLTMPGLPKHPAALD
EEEECCCCCCCCCHHHHCCCCCEEEEEEEEEEEECCCEEEEECCCEEECCCCCCCCCEEE
IDIDSKGEITGLF
EEECCCCCEEECC
>Mature Secondary Structure
MNDIEISQNAEMLPIQTIAKQAGFDEKVVEPYGHYKAKIDIFSEKPNTQLGKLVLVTSIN
CCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEEECC
PTPAGEGKSTVTVGLGDALNDLTGSAMIALREPSQGPVMGMKGGATGGGYSQVIPMDDIN
CCCCCCCCCEEEEECCHHHHHCCCCEEEEEECCCCCCEEECCCCCCCCCCEEEEECCCCE
LHFTGDMHALTAANNTLAALIDNHLQQGNELNIDPRTIVWRRCLDINDRALRNIVIGLGG
EEEECCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHEEEECCC
RFSGVPREDKFDITVASELMAILCLAQDLKDLKERINRILIANNYDGQPIFVKDLHVGGA
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCEEEEEEECCCHH
IATLLKDAIKPNLVQTLGHTPAIIHGGPFANIAHGCNSVLATKTALRHAKYTVTEAGFGA
HHHHHHHHHCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCC
DLGAEKFLDIKTPVLGKQPDAIVIVATVRALKYNGGAKLADLKIEDVEALQKGYINLQRH
CCCCHHEEECCCCCCCCCCCCEEEEEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHH
IKNMQRYNIPVTVSINHFISDTDQEVNTLVKLIEAEGISAIVTDAWAKGGAGSKDLANEV
HHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCHHHHHHE
IALADTNQGPMTKLYDNNGRIEDKIKTIVQKIYGGSDVEYSPQALKKIKECVANGWDHLP
EEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCE
ICMAKSQYSFSDDPKQLGAPSDFVMHVNDINIRLGAGFLVVQTGKVLTMPGLPKHPAALD
EEEECCCCCCCCCHHHHCCCCCEEEEEEEEEEEECCCEEEEECCCEEECCCCCCCCCEEE
IDIDSKGEITGLF
EEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA