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The map label for this gene is ldhD [H]

Identifier: 116492642

GI number: 116492642

Start: 875199

End: 876194

Strand: Direct

Name: ldhD [H]

Synonym: PEPE_0876

Alternate gene names: 116492642

Gene position: 875199-876194 (Clockwise)

Preceding gene: 116492641

Following gene: 116492643

Centisome position: 47.76

GC content: 37.35

Gene sequence:

>996_bases
ATGAAAATTATTGCTTATGGCATTCGAGATGACGAAAAACCTTACCTAGAAGAATGGGTTAAAGATAATAAAATTGAAGT
AAAGGCTGTTAGCGAATTGTTGGACTCCAACACGATTGAACAAGCTAAGGGTTATGACGGAGTTGTTGCATATCAACAGA
AACCTTATACAGATGATTTGTTCGATAAAATGAATGAATTCGGGATTCATGCCTTTTCGCTTCGTAACGTTGGTGTTGAT
AATGTTCCAGTTGAGGCTTTAAAGCGAAATAATATTAAGATTACCAATGTTCCAGCGTACTCTCCAATGGCGATTGCAGA
ACTTTCAGTAACCCAACTCCTAGCTTTAATTCGTCGAATTCCAGAATTTGATGCTAAGATGGCTCGTGGTGATTTCAGAT
GGGAACCAGATATTGCTCTAGAACTTAACCAAATGACAGTAGGAGTTATTGGTACCGGAAGAATTGGGCGTGCGGCCATT
AATATCTTTAAAGGCTTTGGAGCTAAAGTGATTGCTTATGATGTTTTCCGAAATTCAGAACTTGAAAAAGAAGGAATCTA
TGTTGACTCGCTTGAAGAACTTTATCGTCAAGTAGATGTTATTACCTTACATGTTCCCGCTTTAAAAGATAACTACCATA
TGTTAAATGATGAAGCGTTCGCACAGATGCATGATGGGGTATTTGTTCTAAATTTTGCTCGCGGTAGCTTGATTGACACG
AAGGCATTACTTAAGGCTTTAGATAGTGGTAAGGTGGCTGGTGCGGCACTAGATACCTATGAAGACGAAGTAGGTATTTT
TGATGTGGATCACCAAAATGACCCAATCAATGATCCCGTATTTAATGATTTATACAGTAGACGTAATGTAAAAATCACAC
CACATGCGGCTTTTTATACTAAGCCAGCAGTTAAAAATATGGTACAAATTGCTCTTGAAAATAATAAAGCACTAATTGAA
AAAGGTGCTGCAAGAAATGAAGTTAAGTTTGACTAA

Upstream 100 bases:

>100_bases
TTAACGACTAATTTAATAGTTTGAATACTGTAATATTTTTTGAATCATGATACAGTATGTAAAACAAATTATTTAGCCAA
GTCTGAGAGGAGAATTTTTG

Downstream 100 bases:

>100_bases
TATTTAGCTTGAAATGCGACTTTAGTTAGGTTAAAATTATATTCGGCCTGTAGGTCAAAAACACACTTGATTGGAAGTTG
ACGGAGTGCTCAACTAGTTT

Product: D-lactate dehydrogenase, LdhA

Products: NA

Alternate protein names: D-LDH; D-specific D-2-hydroxyacid dehydrogenase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKIIAYGIRDDEKPYLEEWVKDNKIEVKAVSELLDSNTIEQAKGYDGVVAYQQKPYTDDLFDKMNEFGIHAFSLRNVGVD
NVPVEALKRNNIKITNVPAYSPMAIAELSVTQLLALIRRIPEFDAKMARGDFRWEPDIALELNQMTVGVIGTGRIGRAAI
NIFKGFGAKVIAYDVFRNSELEKEGIYVDSLEELYRQVDVITLHVPALKDNYHMLNDEAFAQMHDGVFVLNFARGSLIDT
KALLKALDSGKVAGAALDTYEDEVGIFDVDHQNDPINDPVFNDLYSRRNVKITPHAAFYTKPAVKNMVQIALENNKALIE
KGAARNEVKFD

Sequences:

>Translated_331_residues
MKIIAYGIRDDEKPYLEEWVKDNKIEVKAVSELLDSNTIEQAKGYDGVVAYQQKPYTDDLFDKMNEFGIHAFSLRNVGVD
NVPVEALKRNNIKITNVPAYSPMAIAELSVTQLLALIRRIPEFDAKMARGDFRWEPDIALELNQMTVGVIGTGRIGRAAI
NIFKGFGAKVIAYDVFRNSELEKEGIYVDSLEELYRQVDVITLHVPALKDNYHMLNDEAFAQMHDGVFVLNFARGSLIDT
KALLKALDSGKVAGAALDTYEDEVGIFDVDHQNDPINDPVFNDLYSRRNVKITPHAAFYTKPAVKNMVQIALENNKALIE
KGAARNEVKFD
>Mature_331_residues
MKIIAYGIRDDEKPYLEEWVKDNKIEVKAVSELLDSNTIEQAKGYDGVVAYQQKPYTDDLFDKMNEFGIHAFSLRNVGVD
NVPVEALKRNNIKITNVPAYSPMAIAELSVTQLLALIRRIPEFDAKMARGDFRWEPDIALELNQMTVGVIGTGRIGRAAI
NIFKGFGAKVIAYDVFRNSELEKEGIYVDSLEELYRQVDVITLHVPALKDNYHMLNDEAFAQMHDGVFVLNFARGSLIDT
KALLKALDSGKVAGAALDTYEDEVGIFDVDHQNDPINDPVFNDLYSRRNVKITPHAAFYTKPAVKNMVQIALENNKALIE
KGAARNEVKFD

Specific function: Has both D-lactate and D-glycerate dehydrogenase activities. Equally active on pyruvate and hydroxypyruvate [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=297, Percent_Identity=32.6599326599327, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI61743967, Length=239, Percent_Identity=33.0543933054393, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI4557497, Length=239, Percent_Identity=33.0543933054393, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI145580578, Length=243, Percent_Identity=32.5102880658436, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI4557499, Length=243, Percent_Identity=32.5102880658436, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI145580575, Length=243, Percent_Identity=32.5102880658436, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI6912396, Length=267, Percent_Identity=28.0898876404494, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1787645, Length=323, Percent_Identity=35.2941176470588, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1789279, Length=263, Percent_Identity=30.0380228136882, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI87082289, Length=264, Percent_Identity=28.030303030303, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87081824, Length=200, Percent_Identity=26.5, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=294, Percent_Identity=29.2517006802721, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI25147481, Length=253, Percent_Identity=26.8774703557312, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320925, Length=316, Percent_Identity=27.2151898734177, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=255, Percent_Identity=29.4117647058824, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=264, Percent_Identity=28.7878787878788, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=211, Percent_Identity=27.0142180094787, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=183, Percent_Identity=27.8688524590164, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921140, Length=239, Percent_Identity=33.8912133891213, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24646446, Length=252, Percent_Identity=32.1428571428571, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646448, Length=252, Percent_Identity=32.1428571428571, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646452, Length=252, Percent_Identity=32.1428571428571, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646450, Length=252, Percent_Identity=32.1428571428571, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI62472511, Length=252, Percent_Identity=32.1428571428571, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45552429, Length=285, Percent_Identity=26.6666666666667, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24585514, Length=285, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574282, Length=285, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574284, Length=285, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45551003, Length=285, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574286, Length=242, Percent_Identity=27.6859504132231, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571528, Length=246, Percent_Identity=28.8617886178862, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 37204; Mature: 37204

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIAYGIRDDEKPYLEEWVKDNKIEVKAVSELLDSNTIEQAKGYDGVVAYQQKPYTDDL
CEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCHHH
FDKMNEFGIHAFSLRNVGVDNVPVEALKRNNIKITNVPAYSPMAIAELSVTQLLALIRRI
HHHHHHHCCEEEEECCCCCCCCCHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHC
PEFDAKMARGDFRWEPDIALELNQMTVGVIGTGRIGRAAINIFKGFGAKVIAYDVFRNSE
CHHHHHHHCCCCCCCCCEEEEEEEEEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCC
LEKEGIYVDSLEELYRQVDVITLHVPALKDNYHMLNDEAFAQMHDGVFVLNFARGSLIDT
CCCCCCCHHHHHHHHHHHEEEEEEECCCCCCCEECCHHHHHHHCCCEEEEEECCCCCCHH
KALLKALDSGKVAGAALDTYEDEVGIFDVDHQNDPINDPVFNDLYSRRNVKITPHAAFYT
HHHHHHHHCCCCCCHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHCCCEEECCCHHHHC
KPAVKNMVQIALENNKALIEKGAARNEVKFD
CHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKIIAYGIRDDEKPYLEEWVKDNKIEVKAVSELLDSNTIEQAKGYDGVVAYQQKPYTDDL
CEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCHHH
FDKMNEFGIHAFSLRNVGVDNVPVEALKRNNIKITNVPAYSPMAIAELSVTQLLALIRRI
HHHHHHHCCEEEEECCCCCCCCCHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHC
PEFDAKMARGDFRWEPDIALELNQMTVGVIGTGRIGRAAINIFKGFGAKVIAYDVFRNSE
CHHHHHHHCCCCCCCCCEEEEEEEEEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCC
LEKEGIYVDSLEELYRQVDVITLHVPALKDNYHMLNDEAFAQMHDGVFVLNFARGSLIDT
CCCCCCCHHHHHHHHHHHEEEEEEECCCCCCCEECCHHHHHHHCCCEEEEEECCCCCCHH
KALLKALDSGKVAGAALDTYEDEVGIFDVDHQNDPINDPVFNDLYSRRNVKITPHAAFYT
HHHHHHHHCCCCCCHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHCCCEEECCCHHHHC
KPAVKNMVQIALENNKALIEKGAARNEVKFD
CHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7539419 [H]