BacMap

Definition	Pediococcus pentosaceus ATCC 25745, complete genome.
Accession	NC_008525
Length	1,832,387

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The map label for this gene is accC [H]

Identifier: 116492628

GI number: 116492628

Start: 864506

End: 865873

Strand: Direct

Name: accC [H]

Synonym: PEPE_0862

Alternate gene names: 116492628

Gene position: 864506-865873 (Clockwise)

Preceding gene: 116492627

Following gene: 116492629

Centisome position: 47.18

GC content: 37.79

Gene sequence:

>1368_bases
ATGTTTCAAAAGGTTTTAGTTGCTAATCGTGGTGAAATCGCGGTCCAAATTATCCGCGCCTTACACGAAATGGATATCGC
TGCAGTTAGTGTCTATTCTACAGCTGATGAGAATAGTTTATTCGTTAAATTAGCGGATGAAGCCGTCTGCATTGGAGGGC
CTCAACCTGCTGATTCATATTTAAACATGTTTAATATTATCAGTGCTGCCGTCTTAACTGGCTGTGATGCGATCCATCCA
GGTTACGGATTTTTATCCGAAAATGCGGAATTCGCTCGATTATGTAAAGAAAGTAATCTGGTATTTATTGGACCGCACTA
TAAAACCATTGACTTGATGGGAAATAAGTCTCGGGCGCGTGAAACGATGATTAGTGCGAATGTTCCGGTTATTCCGGGAA
GCAACGGCATGGTTCGCGATTTAGAGAATGCCATGGTGGTGGCTAAGCAAATTGGTTATCCAATTATGCTTAAAGCTGCT
GATGGTGGTGGCGGAAAAGGGATTCGTCGAATTAATTCACCAGAAGACCTTAAAAAGGCTTATCAAGAAGCGAAGCGGGA
AGCTGAAACTTCTTTTGGTAATTCTGATTTATACATTGAAAAAATCATTGAAAATGCTAAACATATTGAAATGCAAGTTA
TTGCAGATCAGTTTGGTCATTATGTATTTTTACCTGAACGTGATTGTTCGCTGCAACGAAATAACCAGAAAGTAATTGAA
GAAACACCATGCGCCACTATTTCACATTCTGAACGCGAAAGTTTAGGTGATATTGTAGTTCGGGCTGCAAAGGCCATCAA
TTATTATAATACTGGTACAATTGAGTTTTTGATGGATGAAAATCATAATTTTTATTTCATGGAAATGAATACTCGACTTC
AAGTTGAGCATACAGTTACTGAAGAGGTAACGGGAATTGAATTAATCAAAGAACAAATTAAGATTGCTGAAGGATTGAAA
CTTGATTTCAGCCAAGCAGACGTTGAAATTTTAGGCCATGCAATTGAATGTCGAATTAATGCCGAAGACCCAAGCAATGG
TTTTATGCCATCGGCGGGGACCATTAAGCATCTATTTTTCCCAGATGGAACAATGGGTGTACGCATTGATTCGGGAATTA
CATATGGTAGCATGATCCCACCATTTTACGATTCAATGATTTCAAAAATAATTGTTAAAATGCCAAATCGGGTTCAAGCG
ACTAGAAAAATGCGTCGTGTTTTAGATGAATTTGAAATCGAAGGTGTAACTTCAAATAAGGCATTCTTAGAGGCTTTACT
AGTTGATAAGGGATTTGAACAAGGATTGTTTACGACTAAATATATTGAAAATGTCTTTTTGAAAGAGTGGTTAAGTAATG
CAAAATAA

Upstream 100 bases:

>100_bases
AAATCGGTACTGGTCATGGGGTTATTGTTAATGAAAATAACGAACTGATCTGTGAAGCTGATTTAACTTTCATTGTGGGC
TAGGAACAGGGAGGCTATCT

Downstream 100 bases:

>100_bases
ATTCTCACTTCCTACTCAAGATGAAATTGTTAAGCGATTGAAGAAAATTCCAGAAGGTTTGTGGCGCGAATGTTCTAATT
GTCACGAAAAGTTTTATTAC

Product: biotin carboxylase / acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MFQKVLVANRGEIAVQIIRALHEMDIAAVSVYSTADENSLFVKLADEAVCIGGPQPADSYLNMFNIISAAVLTGCDAIHP
GYGFLSENAEFARLCKESNLVFIGPHYKTIDLMGNKSRARETMISANVPVIPGSNGMVRDLENAMVVAKQIGYPIMLKAA
DGGGGKGIRRINSPEDLKKAYQEAKREAETSFGNSDLYIEKIIENAKHIEMQVIADQFGHYVFLPERDCSLQRNNQKVIE
ETPCATISHSERESLGDIVVRAAKAINYYNTGTIEFLMDENHNFYFMEMNTRLQVEHTVTEEVTGIELIKEQIKIAEGLK
LDFSQADVEILGHAIECRINAEDPSNGFMPSAGTIKHLFFPDGTMGVRIDSGITYGSMIPPFYDSMISKIIVKMPNRVQA
TRKMRRVLDEFEIEGVTSNKAFLEALLVDKGFEQGLFTTKYIENVFLKEWLSNAK

Sequences:

>Translated_455_residues
MFQKVLVANRGEIAVQIIRALHEMDIAAVSVYSTADENSLFVKLADEAVCIGGPQPADSYLNMFNIISAAVLTGCDAIHP
GYGFLSENAEFARLCKESNLVFIGPHYKTIDLMGNKSRARETMISANVPVIPGSNGMVRDLENAMVVAKQIGYPIMLKAA
DGGGGKGIRRINSPEDLKKAYQEAKREAETSFGNSDLYIEKIIENAKHIEMQVIADQFGHYVFLPERDCSLQRNNQKVIE
ETPCATISHSERESLGDIVVRAAKAINYYNTGTIEFLMDENHNFYFMEMNTRLQVEHTVTEEVTGIELIKEQIKIAEGLK
LDFSQADVEILGHAIECRINAEDPSNGFMPSAGTIKHLFFPDGTMGVRIDSGITYGSMIPPFYDSMISKIIVKMPNRVQA
TRKMRRVLDEFEIEGVTSNKAFLEALLVDKGFEQGLFTTKYIENVFLKEWLSNAK
>Mature_455_residues
MFQKVLVANRGEIAVQIIRALHEMDIAAVSVYSTADENSLFVKLADEAVCIGGPQPADSYLNMFNIISAAVLTGCDAIHP
GYGFLSENAEFARLCKESNLVFIGPHYKTIDLMGNKSRARETMISANVPVIPGSNGMVRDLENAMVVAKQIGYPIMLKAA
DGGGGKGIRRINSPEDLKKAYQEAKREAETSFGNSDLYIEKIIENAKHIEMQVIADQFGHYVFLPERDCSLQRNNQKVIE
ETPCATISHSERESLGDIVVRAAKAINYYNTGTIEFLMDENHNFYFMEMNTRLQVEHTVTEEVTGIELIKEQIKIAEGLK
LDFSQADVEILGHAIECRINAEDPSNGFMPSAGTIKHLFFPDGTMGVRIDSGITYGSMIPPFYDSMISKIIVKMPNRVQA
TRKMRRVLDEFEIEGVTSNKAFLEALLVDKGFEQGLFTTKYIENVFLKEWLSNAK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=439, Percent_Identity=46.4692482915718, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI189095269, Length=446, Percent_Identity=46.4125560538117, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI295821183, Length=446, Percent_Identity=46.4125560538117, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI65506442, Length=446, Percent_Identity=46.4125560538117, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=43.2735426008969, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=43.2735426008969, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=43.2735426008969, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI38679960, Length=506, Percent_Identity=28.2608695652174, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI38679977, Length=506, Percent_Identity=28.2608695652174, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI38679967, Length=506, Percent_Identity=28.2608695652174, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI38679974, Length=506, Percent_Identity=28.2608695652174, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI38679971, Length=506, Percent_Identity=28.2608695652174, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=28.8235294117647, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=47.2972972972973, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71987519, Length=443, Percent_Identity=45.823927765237, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17567343, Length=446, Percent_Identity=44.8430493273543, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=44.5190156599553, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133931226, Length=486, Percent_Identity=28.3950617283951, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI71997168, Length=438, Percent_Identity=30.365296803653, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71997163, Length=438, Percent_Identity=30.365296803653, Blast_Score=197, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6319685, Length=440, Percent_Identity=41.3636363636364, Blast_Score=351, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6319695, Length=449, Percent_Identity=42.0935412026726, Blast_Score=339, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=42.8571428571429, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6323863, Length=477, Percent_Identity=31.4465408805031, Blast_Score=229, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=29.8245614035088, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=43.018018018018, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=43.2735426008969, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=43.2735426008969, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=43.2735426008969, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=43.2735426008969, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=43.2735426008969, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=43.2735426008969, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=43.2735426008969, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=43.2735426008969, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=43.2735426008969, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=43.2735426008969, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=42.8921568627451, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI161076409, Length=511, Percent_Identity=29.5499021526419, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24586458, Length=506, Percent_Identity=29.4466403162055, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI161076407, Length=511, Percent_Identity=29.5499021526419, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24586460, Length=511, Percent_Identity=29.5499021526419, Blast_Score=228, Evalue=7e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50722; Mature: 50722

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKVLVANRGEIAVQIIRALHEMDIAAVSVYSTADENSLFVKLADEAVCIGGPQPADSY
CCCCEEECCCCHHHHHHHHHHHHCCHHEEEEEECCCCCEEEEEEECCEEEECCCCCHHHH
LNMFNIISAAVLTGCDAIHPGYGFLSENAEFARLCKESNLVFIGPHYKTIDLMGNKSRAR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCEEEEEECCCCHHHH
ETMISANVPVIPGSNGMVRDLENAMVVAKQIGYPIMLKAADGGGGKGIRRINSPEDLKKA
HHHHCCCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
YQEAKREAETSFGNSDLYIEKIIENAKHIEMQVIADQFGHYVFLPERDCSLQRNNQKVIE
HHHHHHHHHHCCCCCCHHHHHHHCCHHHEEHEEEHHHHCCEEEEECCCCCCCCCCCHHHH
ETPCATISHSERESLGDIVVRAAKAINYYNTGTIEFLMDENHNFYFMEMNTRLQVEHTVT
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEEEEEEHHH
EEVTGIELIKEQIKIAEGLKLDFSQADVEILGHAIECRINAEDPSNGFMPSAGTIKHLFF
HHHHHHHHHHHHHHHHCCCEECCCCCCHHHCCEEEEEEECCCCCCCCCCCCCCCEEEEEC
PDGTMGVRIDSGITYGSMIPPFYDSMISKIIVKMPNRVQATRKMRRVLDEFEIEGVTSNK
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCH
AFLEALLVDKGFEQGLFTTKYIENVFLKEWLSNAK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFQKVLVANRGEIAVQIIRALHEMDIAAVSVYSTADENSLFVKLADEAVCIGGPQPADSY
CCCCEEECCCCHHHHHHHHHHHHCCHHEEEEEECCCCCEEEEEEECCEEEECCCCCHHHH
LNMFNIISAAVLTGCDAIHPGYGFLSENAEFARLCKESNLVFIGPHYKTIDLMGNKSRAR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCEEEEEECCCCHHHH
ETMISANVPVIPGSNGMVRDLENAMVVAKQIGYPIMLKAADGGGGKGIRRINSPEDLKKA
HHHHCCCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
YQEAKREAETSFGNSDLYIEKIIENAKHIEMQVIADQFGHYVFLPERDCSLQRNNQKVIE
HHHHHHHHHHCCCCCCHHHHHHHCCHHHEEHEEEHHHHCCEEEEECCCCCCCCCCCHHHH
ETPCATISHSERESLGDIVVRAAKAINYYNTGTIEFLMDENHNFYFMEMNTRLQVEHTVT
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEEEEEEHHH
EEVTGIELIKEQIKIAEGLKLDFSQADVEILGHAIECRINAEDPSNGFMPSAGTIKHLFF
HHHHHHHHHHHHHHHHCCCEECCCCCCHHHCCEEEEEEECCCCCCCCCCCCCCCEEEEEC
PDGTMGVRIDSGITYGSMIPPFYDSMISKIIVKMPNRVQATRKMRRVLDEFEIEGVTSNK
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCH
AFLEALLVDKGFEQGLFTTKYIENVFLKEWLSNAK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]