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The map label for this gene is mco [H]

Identifier: 116492302

GI number: 116492302

Start: 555105

End: 556634

Strand: Direct

Name: mco [H]

Synonym: PEPE_0502

Alternate gene names: 116492302

Gene position: 555105-556634 (Clockwise)

Preceding gene: 116492300

Following gene: 116492303

Centisome position: 30.29

GC content: 48.17

Gene sequence:

>1530_bases
ATGAAAAACTATACGGACTATTTCTTTGATGAGCCAGCGTTTGATCTACACGATGGTGGGTACGTGCCGCTTGAGGTCAG
TGATGCGCCTGAGAAGCCCTTAAATGTGCCGCCGTTGTTGAAACCGGATAAAGAGACAGCGACCGACGTTTATTACACGG
TGACAACAGAGGCTGGGGAAACACAACTGTTGCCAGGGGCGAAGACCAAGACGTGGGGCTATAATGCCAGTCTGTTAGGT
CAGACGATTGTGTATCGCCGTGGTCAACATACGCATGTGACATTGAAAAACACCCTGCCTGAGTTGACCACTTTTCATTG
GCATGGGGCTAATGTCAGTGGCCCTTATGTTGATGGCGGATGCCATGCGCCGCTTTATCCGGGTGAAAGTAAGCATATCG
ACTTCACATTGGACCAACCGGCGACGACTTTGTGGCTGCACGCGCATCCATGCCCATCCACGGCCGAGCAGGTTTGGCAT
GGTTTGGCTGCCATGGTGATTGTCAAAGACGACCATGAAGCCAGCCTGCCATTGCCAAGGAACTATGGCGTTAACGATAT
TCCAGTCATTTTGCAAGATCGACGTTTTCACGAAAACAATCAGTGGGACTACCGGGCTGATTATGATCCTGACGGTGTTG
CTGGGCCAACCGCAATGATTAACGGTACAATCAATCCCTATTTTGATGTCACCACGCAAAAGGTCCGGTTGCGTTTTCTA
GATGGTGCTAATCGCCGTGAATGGCGGTTGCATTTTTCTAATGACTTACCATTTACGCAAATTGGTGGAGATGGCTCATT
GTTACCGGATCCGGTCAAATTCACCCATCTAATGCTAACTTGTGCTGAGCGTGCCGAAGTGATTGTTGATTTTGGCCAAT
ACCATGAAGGCGATGTGGTTACCTTATATACGGATGATGTGCCATTGTTAAAGTTCCGCATTCATGCGTTCAAACCGGAT
CAGACAACTTTGCCTGATAAGTTGTTCGACGTGAAGGCACCAGTGGTTGATCCGGATTTGCCAGTTCGCCATGTTGTGAT
GCAGGGAATGGACGAAAGTGTCGCGATCGATGGTAAAAAATTTGCTATGCAGCGGATTGATGCCACGCAGGCGATTGGCA
AAGCCCAGTACTGGGATGTTACCAATAGCAATGATGCGCCTGGAATGGTTCATCCATTCCATGTGCATGGAACCCAATTC
TTAGTCTTGTCGCGGAATGGGCATGCGCCGTATCCAAATGAACATGGTTTCAAAGATACCGTTGGCGTGAATCCTGGGGA
AACGGTTCGGCTGCTGGTTCGCTTTGATCTGCCAGGGGTTTATATGTATCACTGTCATATCATTGAGCACGAAGATGGCG
GCATGATGGCACAGATTGAAGCATTCGATCCAGCCAAGCCAAAGCAAGAATATAAATTGATGGATATGGATACGTTAATG
ATGGCCTTGGCTAAAGAACGTGGCGTCAAACCATCTGAGATTTGGATGGGCGGTATGCAGTCTTATGAAAAAATGGGAAT
GAAAATGTAA

Upstream 100 bases:

>100_bases
AGACCTATACCATTTTTCGCTACTACTTTAGATTAATTCTAAATTATGTTTATGGCAACCCTAAAAAATGTTAAAATTCT
TGTCAGAGGGGGAAATCACG

Downstream 100 bases:

>100_bases
ACGTCCCACAATACTAATATAGAAAAGATGATTTTAATATGCACTCTCCAACGATCAAACATCGCGGGGCTTTTGTCGCC
ACGTTACTGACAGGTACCTT

Product: putative multicopper oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MKNYTDYFFDEPAFDLHDGGYVPLEVSDAPEKPLNVPPLLKPDKETATDVYYTVTTEAGETQLLPGAKTKTWGYNASLLG
QTIVYRRGQHTHVTLKNTLPELTTFHWHGANVSGPYVDGGCHAPLYPGESKHIDFTLDQPATTLWLHAHPCPSTAEQVWH
GLAAMVIVKDDHEASLPLPRNYGVNDIPVILQDRRFHENNQWDYRADYDPDGVAGPTAMINGTINPYFDVTTQKVRLRFL
DGANRREWRLHFSNDLPFTQIGGDGSLLPDPVKFTHLMLTCAERAEVIVDFGQYHEGDVVTLYTDDVPLLKFRIHAFKPD
QTTLPDKLFDVKAPVVDPDLPVRHVVMQGMDESVAIDGKKFAMQRIDATQAIGKAQYWDVTNSNDAPGMVHPFHVHGTQF
LVLSRNGHAPYPNEHGFKDTVGVNPGETVRLLVRFDLPGVYMYHCHIIEHEDGGMMAQIEAFDPAKPKQEYKLMDMDTLM
MALAKERGVKPSEIWMGGMQSYEKMGMKM

Sequences:

>Translated_509_residues
MKNYTDYFFDEPAFDLHDGGYVPLEVSDAPEKPLNVPPLLKPDKETATDVYYTVTTEAGETQLLPGAKTKTWGYNASLLG
QTIVYRRGQHTHVTLKNTLPELTTFHWHGANVSGPYVDGGCHAPLYPGESKHIDFTLDQPATTLWLHAHPCPSTAEQVWH
GLAAMVIVKDDHEASLPLPRNYGVNDIPVILQDRRFHENNQWDYRADYDPDGVAGPTAMINGTINPYFDVTTQKVRLRFL
DGANRREWRLHFSNDLPFTQIGGDGSLLPDPVKFTHLMLTCAERAEVIVDFGQYHEGDVVTLYTDDVPLLKFRIHAFKPD
QTTLPDKLFDVKAPVVDPDLPVRHVVMQGMDESVAIDGKKFAMQRIDATQAIGKAQYWDVTNSNDAPGMVHPFHVHGTQF
LVLSRNGHAPYPNEHGFKDTVGVNPGETVRLLVRFDLPGVYMYHCHIIEHEDGGMMAQIEAFDPAKPKQEYKLMDMDTLM
MALAKERGVKPSEIWMGGMQSYEKMGMKM
>Mature_509_residues
MKNYTDYFFDEPAFDLHDGGYVPLEVSDAPEKPLNVPPLLKPDKETATDVYYTVTTEAGETQLLPGAKTKTWGYNASLLG
QTIVYRRGQHTHVTLKNTLPELTTFHWHGANVSGPYVDGGCHAPLYPGESKHIDFTLDQPATTLWLHAHPCPSTAEQVWH
GLAAMVIVKDDHEASLPLPRNYGVNDIPVILQDRRFHENNQWDYRADYDPDGVAGPTAMINGTINPYFDVTTQKVRLRFL
DGANRREWRLHFSNDLPFTQIGGDGSLLPDPVKFTHLMLTCAERAEVIVDFGQYHEGDVVTLYTDDVPLLKFRIHAFKPD
QTTLPDKLFDVKAPVVDPDLPVRHVVMQGMDESVAIDGKKFAMQRIDATQAIGKAQYWDVTNSNDAPGMVHPFHVHGTQF
LVLSRNGHAPYPNEHGFKDTVGVNPGETVRLLVRFDLPGVYMYHCHIIEHEDGGMMAQIEAFDPAKPKQEYKLMDMDTLM
MALAKERGVKPSEIWMGGMQSYEKMGMKM

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=494, Percent_Identity=35.0202429149798, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1789394, Length=462, Percent_Identity=31.8181818181818, Blast_Score=207, Evalue=2e-54,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 57299; Mature: 57299

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNYTDYFFDEPAFDLHDGGYVPLEVSDAPEKPLNVPPLLKPDKETATDVYYTVTTEAGE
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCC
TQLLPGAKTKTWGYNASLLGQTIVYRRGQHTHVTLKNTLPELTTFHWHGANVSGPYVDGG
EEECCCCCCCCCCCCHHHHHCCHHHCCCCCEEEEECCCCCCCEEEEECCCCCCCCEECCC
CHAPLYPGESKHIDFTLDQPATTLWLHAHPCPSTAEQVWHGLAAMVIVKDDHEASLPLPR
CCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHCCEEEEEEEECCCCCCCCCCC
NYGVNDIPVILQDRRFHENNQWDYRADYDPDGVAGPTAMINGTINPYFDVTTQKVRLRFL
CCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCCCCEEEECCCCCEEECEEEEEEEEEE
DGANRREWRLHFSNDLPFTQIGGDGSLLPDPVKFTHLMLTCAERAEVIVDFGQYHEGDVV
CCCCCEEEEEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCEE
TLYTDDVPLLKFRIHAFKPDQTTLPDKLFDVKAPVVDPDLPVRHVVMQGMDESVAIDGKK
EEEECCCCEEEEEEEEECCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHCCCCCEEECCHH
FAMQRIDATQAIGKAQYWDVTNSNDAPGMVHPFHVHGTQFLVLSRNGHAPYPNEHGFKDT
HHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCEEEEEEECCCCCCCCCCCCCCCC
VGVNPGETVRLLVRFDLPGVYMYHCHIIEHEDGGMMAQIEAFDPAKPKQEYKLMDMDTLM
CCCCCCCEEEEEEEECCCCEEEEEEEEEEECCCCEEEEEECCCCCCCHHHEEEECHHHHH
MALAKERGVKPSEIWMGGMQSYEKMGMKM
HHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNYTDYFFDEPAFDLHDGGYVPLEVSDAPEKPLNVPPLLKPDKETATDVYYTVTTEAGE
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCC
TQLLPGAKTKTWGYNASLLGQTIVYRRGQHTHVTLKNTLPELTTFHWHGANVSGPYVDGG
EEECCCCCCCCCCCCHHHHHCCHHHCCCCCEEEEECCCCCCCEEEEECCCCCCCCEECCC
CHAPLYPGESKHIDFTLDQPATTLWLHAHPCPSTAEQVWHGLAAMVIVKDDHEASLPLPR
CCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHCCEEEEEEEECCCCCCCCCCC
NYGVNDIPVILQDRRFHENNQWDYRADYDPDGVAGPTAMINGTINPYFDVTTQKVRLRFL
CCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCCCCEEEECCCCCEEECEEEEEEEEEE
DGANRREWRLHFSNDLPFTQIGGDGSLLPDPVKFTHLMLTCAERAEVIVDFGQYHEGDVV
CCCCCEEEEEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCEE
TLYTDDVPLLKFRIHAFKPDQTTLPDKLFDVKAPVVDPDLPVRHVVMQGMDESVAIDGKK
EEEECCCCEEEEEEEEECCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHCCCCCEEECCHH
FAMQRIDATQAIGKAQYWDVTNSNDAPGMVHPFHVHGTQFLVLSRNGHAPYPNEHGFKDT
HHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCEEEEEEECCCCCCCCCCCCCCCC
VGVNPGETVRLLVRFDLPGVYMYHCHIIEHEDGGMMAQIEAFDPAKPKQEYKLMDMDTLM
CCCCCCCEEEEEEEECCCCEEEEEEEEEEECCCCEEEEEECCCCCCCHHHEEEECHHHHH
MALAKERGVKPSEIWMGGMQSYEKMGMKM
HHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA