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The map label for this gene is polC [H]

Identifier: 116492274

GI number: 116492274

Start: 523906

End: 524442

Strand: Reverse

Name: polC [H]

Synonym: PEPE_0472

Alternate gene names: 116492274

Gene position: 524442-523906 (Counterclockwise)

Preceding gene: 116492282

Following gene: 116492270

Centisome position: 28.62

GC content: 38.73

Gene sequence:

>537_bases
TTGAACTTTATCGCAATGGACTTTGAAACAGCAGCTCCTACTCGTGCAAGCGCCTGTTCAATTGCACTGACTGTTGTTCA
AAATGATGTCATTACAGACGAACTTTACTCATTAATTAACCCTGAAACTGAATTTAATTGGCGCAATGTCCAAGTTCATG
GCATTCATCAAGCCGATGTGAGTGATGCACCCACATTTCCAGAACTCTGGCCCGTCGTTAAACAGTTCTTTACACCCGAC
AAACTGGTTGTGGCCCACAATGCAACTTTTGATAATAGTGTCCTTAAAAAAACTTTAGAACGTTATCAAATTAATCGACT
ACCATATCAAACACTAGATACTTTACGAACTTCCAAAAGCTTCTATCCAGATTACACCAATCATAAACTTAATACGATTT
GTGATAATCTTGGAATTGATTTGCAGCACCATCATAATGCACTGGATGATAGCCGTGCCTGTGCGAATATCTTATTACAT
CAAGAACATCAATTTGGAGCCGATGCCTTAGCTAGTTTTATTCGTCCGATTAAGTAA

Upstream 100 bases:

>100_bases
AATCCGATCACTCCAACTTTAATCATCTTAATTAGCTCCTTTACTCGCTCACTTTTATTCGTTAAACTATAGGTTAAATC
AATAAAGGAAAGTGATTCAA

Downstream 100 bases:

>100_bases
GGGATAATTCCATTTTTATAATTTGACGCCCCTGACCATCCATGGTTGGGGGCGTTTTAGTTTGAAAACCTAGGTTTTGG
TAAATTTGAATAGCATACTG

Product: DNA polymerase III, epsilon subunit related 3'-5' exonuclease

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MNFIAMDFETAAPTRASACSIALTVVQNDVITDELYSLINPETEFNWRNVQVHGIHQADVSDAPTFPELWPVVKQFFTPD
KLVVAHNATFDNSVLKKTLERYQINRLPYQTLDTLRTSKSFYPDYTNHKLNTICDNLGIDLQHHHNALDDSRACANILLH
QEHQFGADALASFIRPIK

Sequences:

>Translated_178_residues
MNFIAMDFETAAPTRASACSIALTVVQNDVITDELYSLINPETEFNWRNVQVHGIHQADVSDAPTFPELWPVVKQFFTPD
KLVVAHNATFDNSVLKKTLERYQINRLPYQTLDTLRTSKSFYPDYTNHKLNTICDNLGIDLQHHHNALDDSRACANILLH
QEHQFGADALASFIRPIK
>Mature_178_residues
MNFIAMDFETAAPTRASACSIALTVVQNDVITDELYSLINPETEFNWRNVQVHGIHQADVSDAPTFPELWPVVKQFFTPD
KLVVAHNATFDNSVLKKTLERYQINRLPYQTLDTLRTSKSFYPDYTNHKLNTICDNLGIDLQHHHNALDDSRACANILLH
QEHQFGADALASFIRPIK

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP; PF01336 tRNA_anti [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 20267; Mature: 20267

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFIAMDFETAAPTRASACSIALTVVQNDVITDELYSLINPETEFNWRNVQVHGIHQADV
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCC
SDAPTFPELWPVVKQFFTPDKLVVAHNATFDNSVLKKTLERYQINRLPYQTLDTLRTSKS
CCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
FYPDYTNHKLNTICDNLGIDLQHHHNALDDSRACANILLHQEHQFGADALASFIRPIK
CCCCCCCCHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNFIAMDFETAAPTRASACSIALTVVQNDVITDELYSLINPETEFNWRNVQVHGIHQADV
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCC
SDAPTFPELWPVVKQFFTPDKLVVAHNATFDNSVLKKTLERYQINRLPYQTLDTLRTSKS
CCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
FYPDYTNHKLNTICDNLGIDLQHHHNALDDSRACANILLHQEHQFGADALASFIRPIK
CCCCCCCCHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]