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The map label for this gene is fumC [H]

Identifier: 116492017

GI number: 116492017

Start: 249343

End: 250725

Strand: Direct

Name: fumC [H]

Synonym: PEPE_0209

Alternate gene names: 116492017

Gene position: 249343-250725 (Clockwise)

Preceding gene: 116492016

Following gene: 116492018

Centisome position: 13.61

GC content: 42.73

Gene sequence:

>1383_bases
ATGGAAAAATATCGTACAGAAGAAGATACCCTTGGGCCCGTCCAAATCCCAGTAGACGCACTTTGGGGAGCCCAAACTGA
AAGAAGTCGTCATAATTTTGCGACTGGTGCCAAGATGCCCCTGGAAATTATCAAAGCTCTTCTACAGATTAAAAAAGCGG
CAGCCATCGCTAATAAAAAGGAACAATCAATGGCTGCTGAAAAAGCGGATTTAATTGTAGTAGCTATTGATCGTCTGCTA
GCACTGGATGATGCTGAATTACGGAAAGATTTTCCGCTGGTAGTTTATCAAACTGGTTCGGGAACGCAAACTAACATGAA
TGTAAACGAAGTGGTGGCCCATATGGCTGCTAAAATTAATGCGGAAATAGAAATTTTGCCTAATGATGATGTTAACCATG
GACAAAGTTCAAACGATATTTTCCCAACGGCCATGAATATTACAGCTGCAGTAGCGGTAGTACGCTTGGAAGAGGCAGTT
CAACATTTAATTGAACAATTAGACCAAAAACAAAAGCAATATTGGAACGTGGTTAAAATTGGACGAACTCACCTCCAGGA
TGCGACTCCACTAACTTTTGGGCAAGAAATTAGTGGATGGAAGAGCGCCCTTGAACATGATTTGGAATACTTAAAAGAAC
TTAATTCAACGCTAAGTGAATTGGCAATGGGGGGTACAGCGGTCGGAACGGGTTTAAATGCAGCTCCGCATTTTTCGTCC
ATAATTGCAGCTCAGATGAGCGAAGTCTACCACTTTGAATTTACGGCGGATTCTAACAAATTTTATGGACTAGCACATCA
CTCCGGTTTGAATGTGGTTCACGGAGCGATTAAAACTTTGGCGAGTGATTTGATGAAAATTGCTAATGATATTCGGTTCT
TGGGTAGTGGTCCGCGGGCAGGATATGGCGAGTTGAAACTACCAGCAAACGAGCCCGGATCATCAATCATGCCAGGTAAA
GTCAATCCAACTCAAGCAGAGGCCCTTACCATGGCGGCAGTGCGGGTTATGGCTAATGACGTTGCGATTGATTTAGCTGC
AAGCCAGGGCAATTTTGAAATGAATGTTTATAAACCAGTTATCATCAGCTCTTTCTTGGAATCAACCACTCTATTAGAAG
GTACGATTCGTAGTTTTACCGACTTGATGATCGCTGGATTAGAAGTTAATGCGGAACGGATGGAAGAATTAGTTAACCAT
TCCTTGATGACAGTTACCGCCTTATCTCCTCATATTGGCTACCACGATAGTGCTAAAATCGCTCAGCAGGCTGAAAAAGA
TGGGACCACGCTGAAAGAAGCTGCCCTAAAATCTGGTAAAGTTACCGCTGAGCAATTTGATCAGTGGGTGGTTCCCATTG
AGATGACTAATTATGATAAATAG

Upstream 100 bases:

>100_bases
ATTTTAAATTTCACTGGTGCTTTATCGGGAGTCCTTTATAATAAAAACGAAGCAAATTAGTAGGAATGCGACTTAGACAA
TTAATTTCGGAGGTCATAAT

Downstream 100 bases:

>100_bases
AGGAGTAAAAAGATGACTTTAGAGCCTGTAAAATATAAAAAGTTTATTGCGCCACTAGTTGTAGGTGTGATTCTATGGCT
ATTATCACCAGTCAAGCCGG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MEKYRTEEDTLGPVQIPVDALWGAQTERSRHNFATGAKMPLEIIKALLQIKKAAAIANKKEQSMAAEKADLIVVAIDRLL
ALDDAELRKDFPLVVYQTGSGTQTNMNVNEVVAHMAAKINAEIEILPNDDVNHGQSSNDIFPTAMNITAAVAVVRLEEAV
QHLIEQLDQKQKQYWNVVKIGRTHLQDATPLTFGQEISGWKSALEHDLEYLKELNSTLSELAMGGTAVGTGLNAAPHFSS
IIAAQMSEVYHFEFTADSNKFYGLAHHSGLNVVHGAIKTLASDLMKIANDIRFLGSGPRAGYGELKLPANEPGSSIMPGK
VNPTQAEALTMAAVRVMANDVAIDLAASQGNFEMNVYKPVIISSFLESTTLLEGTIRSFTDLMIAGLEVNAERMEELVNH
SLMTVTALSPHIGYHDSAKIAQQAEKDGTTLKEAALKSGKVTAEQFDQWVVPIEMTNYDK

Sequences:

>Translated_460_residues
MEKYRTEEDTLGPVQIPVDALWGAQTERSRHNFATGAKMPLEIIKALLQIKKAAAIANKKEQSMAAEKADLIVVAIDRLL
ALDDAELRKDFPLVVYQTGSGTQTNMNVNEVVAHMAAKINAEIEILPNDDVNHGQSSNDIFPTAMNITAAVAVVRLEEAV
QHLIEQLDQKQKQYWNVVKIGRTHLQDATPLTFGQEISGWKSALEHDLEYLKELNSTLSELAMGGTAVGTGLNAAPHFSS
IIAAQMSEVYHFEFTADSNKFYGLAHHSGLNVVHGAIKTLASDLMKIANDIRFLGSGPRAGYGELKLPANEPGSSIMPGK
VNPTQAEALTMAAVRVMANDVAIDLAASQGNFEMNVYKPVIISSFLESTTLLEGTIRSFTDLMIAGLEVNAERMEELVNH
SLMTVTALSPHIGYHDSAKIAQQAEKDGTTLKEAALKSGKVTAEQFDQWVVPIEMTNYDK
>Mature_460_residues
MEKYRTEEDTLGPVQIPVDALWGAQTERSRHNFATGAKMPLEIIKALLQIKKAAAIANKKEQSMAAEKADLIVVAIDRLL
ALDDAELRKDFPLVVYQTGSGTQTNMNVNEVVAHMAAKINAEIEILPNDDVNHGQSSNDIFPTAMNITAAVAVVRLEEAV
QHLIEQLDQKQKQYWNVVKIGRTHLQDATPLTFGQEISGWKSALEHDLEYLKELNSTLSELAMGGTAVGTGLNAAPHFSS
IIAAQMSEVYHFEFTADSNKFYGLAHHSGLNVVHGAIKTLASDLMKIANDIRFLGSGPRAGYGELKLPANEPGSSIMPGK
VNPTQAEALTMAAVRVMANDVAIDLAASQGNFEMNVYKPVIISSFLESTTLLEGTIRSFTDLMIAGLEVNAERMEELVNH
SLMTVTALSPHIGYHDSAKIAQQAEKDGTTLKEAALKSGKVTAEQFDQWVVPIEMTNYDK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=49.8915401301518, Blast_Score=428, Evalue=1e-120,
Organism=Escherichia coli, GI1787896, Length=462, Percent_Identity=49.1341991341991, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI87082375, Length=452, Percent_Identity=35.1769911504425, Blast_Score=288, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI17553882, Length=464, Percent_Identity=49.1379310344828, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI32565146, Length=322, Percent_Identity=51.8633540372671, Blast_Score=330, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=48.5961123110151, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=48.3801295896328, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=47.4137931034483, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=47.4137931034483, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=45.7883369330454, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=43.0735930735931, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50124; Mature: 50124

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKYRTEEDTLGPVQIPVDALWGAQTERSRHNFATGAKMPLEIIKALLQIKKAAAIANKK
CCCCCCCCCCCCCEEECHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCHH
EQSMAAEKADLIVVAIDRLLALDDAELRKDFPLVVYQTGSGTQTNMNVNEVVAHMAAKIN
HHHHHHHHCCEEEEEHHHHHHCCCHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCC
AEIEILPNDDVNHGQSSNDIFPTAMNITAAVAVVRLEEAVQHLIEQLDQKQKQYWNVVKI
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRTHLQDATPLTFGQEISGWKSALEHDLEYLKELNSTLSELAMGGTAVGTGLNAAPHFSS
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHH
IIAAQMSEVYHFEFTADSNKFYGLAHHSGLNVVHGAIKTLASDLMKIANDIRFLGSGPRA
HHHHHHHHHEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GYGELKLPANEPGSSIMPGKVNPTQAEALTMAAVRVMANDVAIDLAASQGNFEMNVYKPV
CCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEHHHH
IISSFLESTTLLEGTIRSFTDLMIAGLEVNAERMEELVNHSLMTVTALSPHIGYHDSAKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHH
AQQAEKDGTTLKEAALKSGKVTAEQFDQWVVPIEMTNYDK
HHHHHHCCCHHHHHHHHCCCCCHHHHCCEEEEEEECCCCC
>Mature Secondary Structure
MEKYRTEEDTLGPVQIPVDALWGAQTERSRHNFATGAKMPLEIIKALLQIKKAAAIANKK
CCCCCCCCCCCCCEEECHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCHH
EQSMAAEKADLIVVAIDRLLALDDAELRKDFPLVVYQTGSGTQTNMNVNEVVAHMAAKIN
HHHHHHHHCCEEEEEHHHHHHCCCHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCC
AEIEILPNDDVNHGQSSNDIFPTAMNITAAVAVVRLEEAVQHLIEQLDQKQKQYWNVVKI
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRTHLQDATPLTFGQEISGWKSALEHDLEYLKELNSTLSELAMGGTAVGTGLNAAPHFSS
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHH
IIAAQMSEVYHFEFTADSNKFYGLAHHSGLNVVHGAIKTLASDLMKIANDIRFLGSGPRA
HHHHHHHHHEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GYGELKLPANEPGSSIMPGKVNPTQAEALTMAAVRVMANDVAIDLAASQGNFEMNVYKPV
CCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEHHHH
IISSFLESTTLLEGTIRSFTDLMIAGLEVNAERMEELVNHSLMTVTALSPHIGYHDSAKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHH
AQQAEKDGTTLKEAALKSGKVTAEQFDQWVVPIEMTNYDK
HHHHHHCCCHHHHHHHHCCCCCHHHHCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]